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A Pharmacology Primer

A Pharmacology Primer
  • Author : Terrence P. Kenakin
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :214
  • ISBN : 0124041612
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Summary : Pharmaceutical companies continue to face a growing need for scientists trained in the basics of pharmacology. At GlaxoSmithKline, a pharmaceuticals world-leader, Terry Kenakin regularly teaches this course and has drawn on his valuable experience to write A Pharmacology Primer. This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. Important chapters cover: Drug Receptor Theory; Drug Antagonism; The Drug Discovery Process; Pharmacological Assay Formats; Statistics & Experimental Design; and many more! A Pharmacology Primer is stocked with helpful resources -- derivations of all formulae in every chapter, a glossary and appendices, scores of full-color illustrations -- that further enhance the value and utility of this book. * 185 illustrations and figures, four-color throughout * Bulleted lists at the end of each section sum up main topics * Glossary of Pharmacological Terms included for quick reference

A Pharmacology Primer

A Pharmacology Primer
  • Author : Terry Kenakin
  • Publisher :Unknown
  • Release Date :2018-10-26
  • Total pages :488
  • ISBN : 9780128139585
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Summary : A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

A Pharmacology Primer

A Pharmacology Primer
  • Author : Terry Kenakin
  • Publisher :Unknown
  • Release Date :2014-03-26
  • Total pages :450
  • ISBN : 9780124076891
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Summary : A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research. Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

Medication Workbook for Pharmacy Technicians: A Pharmacology Primer

Medication Workbook for Pharmacy Technicians: A Pharmacology Primer
  • Author : David R. Bright,Mary F. Powers
  • Publisher :Unknown
  • Release Date :2012-01-01
  • Total pages :360
  • ISBN : 9781617310904
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Summary : Officially endorsed by the American Pharmacists Association (APhA), this practical workbook provides a basic introduction to pharmacology and reinforces the use of medications for prospective technicians to work in a pharmacy and to help prepare them for the pharmacy technician national certification exams.

Elements of Pharmacology

Elements of Pharmacology
  • Author : P. J. Bentley
  • Publisher :Unknown
  • Release Date :1981-08-31
  • Total pages :154
  • ISBN : 0521280745
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Summary : Written primarily for students of medicine, pharmacy, and pharmacology, this introductory book provides a concise summary of the principles that underlie the science of pharmacology. It presents the basic concepts required for understanding the use, mechanisms of action, toxicity and side effects, and therapeutic application of drugs in man. Thus the book may also be of interest to medical practitioners and to biological and medical scientists. Among topics covered are the sources of drugs, the way they are administered and dealt with in the body, as well as concepts about the nature of their actions. The last include their chemical interactions with components of cells and the manner in which these lead to therapeutically desirable as well as undesirable and even toxic effects. In addition, clinically related subjects, such as drug interactions, teratogenic and carcinogenic effects are discussed. The development and testing of new drugs are also described. For easy reference, at the back of the book there is a glossary of drugs named in the text.

A Primer of Drug Action

A Primer of Drug Action
  • Author : Robert M. Julien, Ph.D.
  • Publisher :Unknown
  • Release Date :2013-08-06
  • Total pages :512
  • ISBN : 9781466851184
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Summary : Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular guide continues to lead the way through a rapidly changing field, providing readers with a clear, contemporary, and objective look at every drug and medication that either positively or adversely affects brain function. This edition includes important new information on -Herbal medications -Drug therapy for behavioral and anxiety disorders -Clinical practice guidelines for treating psychological disorders -Depression and the action of antidepressant drugs -The use of newer anticonvulsants in the treatment of bipolar disorder, pain syndromes, and behavioral disorders -Drug therapy for children, adolescents and the elderly -"New generation" antipsychotic agents Authoritative, comprehensive, and suitable for those with little background in biology, A Primer of Drug Action is an indispensable source of information for anyone interested in drug use, abuse, and education.

Julien's Primer of Drug Action

Julien's Primer of Drug Action
  • Author : Claire D. Advokat,Joseph E. Comaty,Robert M. Julien, Ph.D.
  • Publisher :Unknown
  • Release Date :2014-04-15
  • Total pages :614
  • ISBN : 9781464198861
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Summary : In its 40th anniversary edition, A Primer of Drug Action continues to evolve side by side with the field it covers, drawing on the expertise of its authors in medicine, basic science, and clinical science to offer the most current and comprehensive guide to psychopharmacology available.

Pharmacogenomics: A Primer for Clinicians

Pharmacogenomics: A Primer for Clinicians
  • Author : Jerika T. Lam,Mary A Gutierrez
  • Publisher :Unknown
  • Release Date :2020-12-22
  • Total pages :512
  • ISBN : 9781260457117
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Summary : An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.

Drug Discovery and Development - E-Book

Drug Discovery and Development - E-Book
  • Author : Raymond G Hill
  • Publisher :Unknown
  • Release Date :2012-07-20
  • Total pages :368
  • ISBN : 9780702053160
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Summary : The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

The Cult of Pharmacology

The Cult of Pharmacology
  • Author : Richard DeGrandpre
  • Publisher :Unknown
  • Release Date :2006-11-06
  • Total pages :312
  • ISBN : 9780822388197
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Summary : America had a radically different relationship with drugs a century ago. Drug prohibitions were few, and while alcohol was considered a menace, the public regularly consumed substances that are widely demonized today. Heroin was marketed by Bayer Pharmaceuticals, and marijuana was available as a tincture of cannabis sold by Parke Davis and Company. Exploring how this rather benign relationship with psychoactive drugs was transformed into one of confusion and chaos, The Cult of Pharmacology tells the dramatic story of how, as one legal drug after another fell from grace, new pharmaceutical substances took their place. Whether Valium or OxyContin at the pharmacy, cocaine or meth purchased on the street, or alcohol and tobacco from the corner store, drugs and drug use proliferated in twentieth-century America despite an escalating war on “drugs.” Richard DeGrandpre, a past fellow of the National Institute on Drug Abuse and author of the best-selling book Ritalin Nation, delivers a remarkably original interpretation of drugs by examining the seductive but ill-fated belief that they are chemically predestined to be either good or evil. He argues that the determination to treat the medically sanctioned use of drugs such as Miltown or Seconal separately from the illicit use of substances like heroin or ecstasy has blinded America to how drugs are transformed by the manner in which a culture deals with them. Bringing forth a wealth of scientific research showing the powerful influence of social and psychological factors on how the brain is affected by drugs, DeGrandpre demonstrates that psychoactive substances are not angels or demons irrespective of why, how, or by whom they are used. The Cult of Pharmacology is a bold and necessary new account of America’s complex relationship with drugs.

Principles of Pharmacology

Principles of Pharmacology
  • Author : D. T. Okpako
  • Publisher :Unknown
  • Release Date :1991-02-22
  • Total pages :574
  • ISBN : 0521340950
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Summary : This volume provides a useful and informative introduction to basic pharmacological principles and practice in the context of tropical medicine and diseases.

Regenerative Pharmacology

Regenerative Pharmacology
  • Author : George J. Christ,Karl-Erik Andersson
  • Publisher :Unknown
  • Release Date :2013-04-15
  • Total pages :229
  • ISBN : 9781107354739
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Summary : Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental and molecular biology; chemical and material sciences (i.e. nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. This book will draw attention to the critical role that pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. The first state-of-the-art book in this rapidly evolving field of research.

Primer on Transplantation

Primer on Transplantation
  • Author : American Society of Transplantation
  • Publisher :Unknown
  • Release Date :2010-12-15
  • Total pages :368
  • ISBN : 9781444391763
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Summary : Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: immunobiology pharmacology donor management infectious complications pediatric transplantation general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: Interactive Multiple-Choice Questions for each chapter Figures from the book as Powerpoints for downloading All chapters online

Pharmacology and Treatment of Substance Abuse

Pharmacology and Treatment of Substance Abuse
  • Author : Lee M. Cohen,Frank L. Collins, Jr.,Alice Young,Dennis E. McChargue,Thad R. Leffingwell,Katrina L. Cook
  • Publisher :Unknown
  • Release Date :2013-03-01
  • Total pages :704
  • ISBN : 9781135704001
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Summary : Given the prevalence of substance abuse in general clinical populations, it is important for healthcare providers to have knowledge and skill in the treatment of these problems. Evidence-Based Practice (EBP) involves the integration of the best evidence with clinical expertise and patient values. This text is designed as a bridge for practitioners that will provide up-to-date evidence reviews as well as information on how to best keep up with emerging trends in the field. The editors have gathered expert authors to provide a much needed summary of the current status of the evidence based practice for both the assessment and treatment of specific substance use disorders.

Essentials of Cardiac Anesthesia for Noncardiac Surgery E-Book

Essentials of Cardiac Anesthesia for Noncardiac Surgery E-Book
  • Author : Joel A. Kaplan
  • Publisher :Unknown
  • Release Date :2018-07-21
  • Total pages :796
  • ISBN : 9780323567121
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Summary : Provides guidance on the anesthetic diagnosis and management of the full range of cardiac lesions, helping minimize adverse outcomes and reduce complications for patients with common, complex, or uncommon cardiac conditions. Includes complete coverage of echocardiography and current monitoring techniques needed for thorough perioperative assessment – all from the anesthesiologist’s perspective. Discusses safe and effective perioperative anesthetic management of patients presenting with advanced levels of cardiac care such as drug-eluting stents, multiple antiplatelet drugs, ventricular assist devices, multiple drugs for end-stage heart failure, and implanted electrical devices that produce cardiac resynchronization therapy, as well as patients with complicated obstetric problems or other significant cardiovascular issues. Features a concise, easy-to-navigate format and Key Points boxes in each chapter that help you find answers quickly. Provides guidance on the anesthetic diagnosis and management of the full range of cardiac lesions, helping minimize adverse outcomes and reduce complications for patients with common, complex, or uncommon cardiac conditions. Includes complete coverage of echocardiography and current monitoring techniques needed for thorough perioperative assessment – all from the anesthesiologist’s perspective. Discusses safe and effective perioperative anesthetic management of patients presenting with advanced levels of cardiac care such as drug-eluting stents, multiple antiplatelet drugs, ventricular assist devices, multiple drugs for end-stage heart failure, and implanted electrical devices that produce cardiac resynchronization therapy, as well as patients with complicated obstetric problems or other significant cardiovascular issues. Features a concise, easy-to-navigate format and Key Points boxes in each chapter that help you find answers quickly.

Good Research Practice in Non-Clinical Pharmacology and Biomedicine

Good Research Practice in Non-Clinical Pharmacology and Biomedicine
  • Author : Anton Bespalov,Martin C. Michel,Thomas Steckler
  • Publisher :Unknown
  • Release Date :2020-01-01
  • Total pages :424
  • ISBN : 9783030336561
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Summary : This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Concise Clinical Pharmacology

Concise Clinical Pharmacology
  • Author : Ben Greenstein,Adam Greenstein
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :302
  • ISBN : 0853695768
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Summary : This is a concise study guide and thorough introduction to clinical pharmacology from which students can gain a rapid understanding of individual topics within the discipline, and from which they can review and revise certain topics before exams. This is achieved through self-contained two-page "spreads" for each topic, with concise text on the left and a diagram on the right to elaborate and reinforce the text. To further underpin the text, additional two page spreads have been included where appropriate, with case histories on the left and Q&As on the right. The text has a strong clinical focus and, in the main, sections relate to particular body systems or the therapy of a disease-class (eg, cancer). Pharmacological principles and mechanisms are covered, but the main focus is on the therapeutic use of the drugs. Sections cover basic principles of pharmacology, specialised pharmacology (inc. in pregnancy, paediatrics, geriatrics), and the vitamins. The text has been written primarily for pharmacy students, but will also be of interest to clinical medical students. The strong clinical focus should also appeal to practitioners.

A Primer of Drug Action

A Primer of Drug Action
  • Author : Robert M. Julien
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :548
  • ISBN : OCLC:906355191
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Summary :

Cannabis

Cannabis
  • Author : Ethan B Russo
  • Publisher :Unknown
  • Release Date :2014-06-11
  • Total pages :196
  • ISBN : 9781317955412
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Summary : Learn more about tomorrow’s alternative to today’s risk-laden prescription drugs! Cannabis: From Pariah to Prescription reviews the latest research from recent clinical trials with cannabis and cannabinoids—outlining their place and future as prescription medicines. This book addresses the “road back” for cannabis medicines and society’s reacceptance of cannabis as a prescription product. This book offers physicians, patients, scientists, and students a primer on this developing branch of pharmacology and therapeutics and is ideal for use in courses for medicine, psychopharmacology, alternative medicine, health policy, and pharmacology. Cannabis: From Pariah to Prescription assesses the genetics, horticulture, and biochemical processing of cannabis into cannabis-based medicine extracts (CBMEs). The book describes the important advanced technologies used to cultivate the genetically selected medical-grade cannabis cloned strains in glass houses. This book also discusses new advancements in drug delivery alternatives to traditional smoking, including the Advanced Delivery System (ADS)—a device that allows delivery of premeasured dosages while remaining secure, tamper-proof, and patient specific. In Cannabis: From Pariah to Prescription, the practical applications of cannabis pharmaceuticals are explored through a wide range of clinical studies, including: a thorough discussion of the latest in documented benefits and side effects when using cannabis, cannabinoids, or CBMEs a tolerability study via multiple administration routes to compare pharmacodynamic effects and pharmacokinetic characteristics a comparative study of the pharmacokinetic profiles administered in various areas of the buccal mucosa as well as an investigation of the pharmacokinetics of CBME administered orally a blind study assessing pharmacokinetic profile of CBME administered sublingually in various ratios of cannabinoids a review of several other recent trials involving CBME, THC, or cannabis a study reviewing the human clinical experience to date employing synthetic cannabinoids or CBME, suggesting future treatment in the areas of obstetrics, gynecology, and pediatrics Cannabis: From Pariah to Prescription provides extensive bibliographies to encourage your examination of previous studies and international literature. Europe remains on the cutting edge of new studies and research on cannabinoids, and much of the data in this book was collected in the United Kingdom. This meticulous resource also contains a list of abbreviations and definitions of terms from GW Pharmaceuticals to make the reading more accessible to a wide variety of readers.

Pharmacology - An Illustrated Review

Pharmacology - An Illustrated Review
  • Author : Mark A. Simmons
  • Publisher :Unknown
  • Release Date :2011-09-05
  • Total pages :440
  • ISBN : 9781604062069
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Summary : The perfect study tool for preparing for your courses or examinations - Pharmacology - An Illustrated Review's focused presentation and full-color illustrations makes learning the complex information essential to success easier. Sidebars make connections to underlying concepts in other basic sciences or apply the concepts presented in the clinical setting .Features: Succinct bullet-point text streamlines studying Hundreds of full-color illustrations reinforce clear explanatory text Numerous tables sum up crucial information for quick review Frequent sidebars build on and integrate learning across the basic sciences and apply this learning to the clinical setting 200 review questions with a rationale for why answers are right or wrong test mastery and help you prepare for exams An additional 200 review questions, all available online allow you to test yourself and get immediate feedback, quickly identifying areas for further study

Principles of CNS Drug Development

Principles of CNS Drug Development
  • Author : John Kelly
  • Publisher :Unknown
  • Release Date :2009-10-27
  • Total pages :324
  • ISBN : 0470682914
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Summary : This title acts as a primer, giving students and newcomers to the field an opportunity to learn about the breadth of the CNS drug discovery. The book outlines the core processes in drug discovery and development for CNS disorders, from evaluating drugs for desirable efficacy, safety and pharmacokinetic features in preclinical (using in vitro and in vivo models) and clinical experimentation to identifying future drug targets. Containing up-to-date experimental evidence and detailing the main impediments in the pipeline of CNS drug discovery and development, this is a key reference for those involved in all stages of CNS drug discovery. Key Features: Discusses in detail the key stages of CNS drug discovery, outlining the particular requirements and obstacles for CNS drugs Addresses safety concerns and future drug targets Provides succinct background information about the major CNS diseases Examples of specific drugs are used throughout to describe the development of a new drug from conception to clinical use and post-market surveillance Primary reasons for drug failure are given for each stage