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Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel
  • Publisher :Unknown
  • Release Date :2016-03-10
  • Total pages :868
  • ISBN : 9780128005101
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Summary : Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher :Unknown
  • Release Date :2002-05-15
  • Total pages :677
  • ISBN : 0121995046
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Summary : Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher :Unknown
  • Release Date :2002-05-28
  • Total pages :890
  • ISBN : 9780080525969
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Summary : Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors. Key Features * Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors * Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement * Demonstrates noninvasive imaging of adenovirus-mediated gene transfer * Discusses utility of adenoviral vectors in animal disease models * Considers Federal Drug Administration regulations for human clinical trials

Current Issues in Molecular Virology

Current Issues in Molecular Virology
  • Author : Victor Romanowski
  • Publisher :Unknown
  • Release Date :2013-11-20
  • Total pages :296
  • ISBN : 9789535112075
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Summary : This book is a collection of chapters dealing with examples of RNA and DNA viruses, and issues such as how these gene packages have learnt to take advantage of their hosts, molecular recognition events that hosts may use to counterattack the viruses, and how researchers have developed strategies to use viruses or their parts as tools for different purposes.

Cancer Gene Therapy

Cancer Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher :Unknown
  • Release Date :2007-11-03
  • Total pages :490
  • ISBN : 9781592597857
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Summary : A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
  • Author : Otto-Wilhelm Merten,Mohamed Al-Rubeai
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :450
  • ISBN : 1617790958
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Summary : The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular Biology series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Therapeutic Applications of Adenoviruses

Therapeutic Applications of Adenoviruses
  • Author : Philip Ng,Nicola Brunetti-Pierri
  • Publisher :Unknown
  • Release Date :2016-12-12
  • Total pages :256
  • ISBN : 9781498745499
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Summary : Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
  • Author : Roland W. Herzog,Sergei Zolotukhin
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :388
  • ISBN : 9789814280914
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Summary : Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy
  • Author : David T. Curiel
  • Publisher :Unknown
  • Release Date :2016-03-10
  • Total pages :868
  • ISBN : 9780128005101
GET BOOK HERE

Summary : Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Gene Therapy for Viral Infections

Gene Therapy for Viral Infections
  • Author : Patrick Arbuthnot
  • Publisher :Unknown
  • Release Date :2015-06-01
  • Total pages :392
  • ISBN : 9780124114524
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Summary : Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy
  • Author : Curtis A. Machida
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :608
  • ISBN : 9781592593040
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Summary : Comprehensive and highly practical, Viral Vectors for Gene Therapy provides researchers with the basic tools needed to design targeted gene delivery vectors, and clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system.

Tumor Metastasis

Tumor Metastasis
  • Author : Ke Xu
  • Publisher :Unknown
  • Release Date :2016-09-14
  • Total pages :266
  • ISBN : 9789535126300
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Summary :

Challenges in Delivery of Therapeutic Genomics and Proteomics

Challenges in Delivery of Therapeutic Genomics and Proteomics
  • Author : Ambikanandan Misra
  • Publisher :Unknown
  • Release Date :2010-09-09
  • Total pages :686
  • ISBN : 0123849659
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Summary : Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

Advances in Molecular Retrovirology

Advances in Molecular Retrovirology
  • Author : Shailendra K. Saxena
  • Publisher :Unknown
  • Release Date :2016-03-16
  • Total pages :202
  • ISBN : 9789535122616
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Summary : This book gives a comprehensive overview of recent advances in Retrovirology, as well as general concepts of molecular biology of retroviral infections, immunopathology, diagnosis, and prevention, to current clinical recommendations in management of retroviruses, including endogenous retroviruses, highlighting the ongoing issues, recent advances, with future directions in diagnostic approaches and therapeutic strategies.

The Molecular Repertoire of Adenoviruses III

The Molecular Repertoire of Adenoviruses III
  • Author : Walter Doerfler,Petra Böhm
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :310
  • ISBN : 9783642795862
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Summary : For decades this virus system has served--and continues to do so--to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological and epidemiological investigation in mammalian molecular biology. In the first of the three volumes, we present an overview of adenovirus research. In the second volume, we turn our attention to such topics as DNA replication, recombination and integration and post-trans- criptional control. This, the third volume then looks at transformation and E1A, adenovirus genetics, pathogenesis and gene therapy.

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Peter Walden,Uwe Trefzer,Wolfram Sterry,Farzin Farzaneh
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :568
  • ISBN : 9781461553571
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Summary : The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

Gene Therapy

Gene Therapy
  • Author : Mauro Giacca
  • Publisher :Unknown
  • Release Date :2010-11-01
  • Total pages :303
  • ISBN : 8847016436
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Summary : I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Viral Vectors

Viral Vectors
  • Author : Michael G. Kaplitt,Arthur D. Loewy
  • Publisher :Unknown
  • Release Date :1995-08-14
  • Total pages :486
  • ISBN : 9780080543574
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Summary : Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells. Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers. This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.

Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders

Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders
  • Author : Nicola Brunetti-Pierri
  • Publisher :Unknown
  • Release Date :2017-05-22
  • Total pages :220
  • ISBN : 9783319534572
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Summary : In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods. The authors discuss the strengths and weaknesses of available vectors in the clinical setting, and specifically focus on the challenges and possible solutions that researchers are testing in order to improve the safety of gene therapy for genetic diseases. This comprehensive and authoritative overview of vector development is a necessary text for researchers, toxicologists, pharmacologists, molecular biologists, physicians, and students in these fields.

Human Adenoviruses: From Villains To Vectors

Human Adenoviruses: From Villains To Vectors
  • Author : Flint S Jane,Nemerow Glen R
  • Publisher :Unknown
  • Release Date :2016-12-21
  • Total pages :416
  • ISBN : 9789813109810
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Summary : Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered. Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.

Genes and Resistance to Disease

Genes and Resistance to Disease
  • Author : V. Boulyjenkov,K. Berg,Y. Christen
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :180
  • ISBN : 9783642569470
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Summary : The advances in human genetics that have ocurred during the past 20 years have revolutionized our knowledge of the role played by inheritance in health and disase. It is clear that our DNA determines not only the emergence of catastrophic single-gene disorders, which affect millions of persons worldwide, but also interacts with environments to predispose individuals to cancer, allergy, hypertension, heart disease, diabetes, psychiatric disorders and even to some infectious diseases. Overall, the study of longevity and the demonstration of genes favouring a long lifespan suggest that such protective systems exist. In recent years, the study of genetic polymorphisms has made clear that some alleles have beneficial effects. These discoveries can substantially improve our understanding of the interactions between genetics and the environment, between pathogenetic mechanisms and new treatments.