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Advances and Challenges in Pharmaceutical Technology

Advances and Challenges in Pharmaceutical Technology
  • Author : Amit Kumar Nayak,Kunal Pal,Indranil Banerjee,Samarendra Maji,Upendranath Nanda
  • Publisher :Unknown
  • Release Date :2021-02-19
  • Total pages :568
  • ISBN : 9780128203002
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Summary : Advances and Challenges in Pharmaceutical Technology: Materials, Process Development and Drug Delivery Strategies examines recent advancements in pharmaceutical technology. The book discusses common formulation strategies, including the use of tools for statistical formulation optimization, Quality by design (QbD), process analytical technology, and the uses of various pharmaceutical biomaterials, including natural polymers, synthetic polymers, modified natural polymers, bioceramics, and other bioinorganics. In addition, the book covers rapid advancements in the field by providing a thorough understanding of pharmaceutical processes, formulation developments, explorations, and exploitation of various pharmaceutical biomaterials to formulate pharmaceutical dosage forms. Provides extensive information and analysis on recent advancements in the field of pharmaceutical technology Includes contributions from global leaders and experts in academia, industry and regulatory agencies Uses high quality illustrations, flow charts and tables to explain concepts and text to readers, along with practical examples and research case studies

Pulmonary Drug Delivery

Pulmonary Drug Delivery
  • Author : Ali Nokhodchi,Gary P. Martin
  • Publisher :Unknown
  • Release Date :2015-08-03
  • Total pages :384
  • ISBN : 9781118799543
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Summary : Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

Drying Technologies for Biotechnology and Pharmaceutical Applications

Drying Technologies for Biotechnology and Pharmaceutical Applications
  • Author : Satoshi Ohtake,Ken-ichi Izutsu,David Lechuga-Ballesteros
  • Publisher :Unknown
  • Release Date :2020-04-13
  • Total pages :400
  • ISBN : 9783527341122
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Summary : A comprehensive source of information about modern drying technologies that uniquely focus on the processing of pharmaceuticals and biologicals Drying technologies are an indispensable production step in the pharmaceutical industry and the knowledge of drying technologies and applications is absolutely essential for current drug product development. This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development. Drying Technologies for Biotechnology and Pharmaceutical Applications discusses the state-of-the-art of established drying technologies like freeze- and spray- drying and highlights limitations that need to be overcome to achieve the future state of pharmaceutical manufacturing. The book also describes promising next generation drying technologies, which are currently used in fields outside of pharmaceuticals, and how they can be implemented and adapted for future use in the pharmaceutical industry. In addition, it deals with the generation of synergistic effects (e.g. by applying process analytical technology) and provides an outlook toward future developments. -Presents a full technical overview of well established standard drying methods alongside various other drying technologies, possible improvements, limitations, synergies, and future directions -Outlines different drying technologies from an application-oriented point of view and with consideration of real world challenges in the field of drug product development -Edited by renowned experts from the pharmaceutical industry and assembled by leading experts from industry and academia Drying Technologies for Biotechnology and Pharmaceutical Applications is an important book for pharma engineers, process engineers, chemical engineers, and others who work in related industries.

Ocular Drug Delivery: Advances, Challenges and Applications

Ocular Drug Delivery: Advances, Challenges and Applications
  • Author : Richard T. Addo
  • Publisher :Unknown
  • Release Date :2016-11-16
  • Total pages :185
  • ISBN : 9783319476919
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Summary : The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye. Therefore, ocular drug delivery has been a major challenge to drug delivery researchers. There are on-going studies, in search of treatment especially for the diseases affecting the posterior segment of the eye. This book gives and overview of the background of ocular drug delivery and is unique for pharmacists, medical practitioners, students and drug delivery researchers.

Challenges in Protein Product Development

Challenges in Protein Product Development
  • Author : Nicholas W. Warne,Hanns-Christian Mahler
  • Publisher :Unknown
  • Release Date :2018-07-22
  • Total pages :599
  • ISBN : 9783319906034
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Summary : In this volume, the authors discuss the many significant challenges currently faced in biotechnology dosage form development, providing guidance, shared experience and thoughtful reflection on how best to address these potential concerns. As the field of therapeutic recombinant therapeutic proteins enters its fourth decade and the market for biopharmaceuticals becomes increasingly competitive, companies are increasingly dedicating resources to develop innovative biopharmaceuticals to address unmet medical needs. Often, the pharmaceutical development scientist is encountering challenging pharmaceutical properties of a given protein or by the demands placed on the product by stability, manufacturing and preclinical or clinical expectations, as well as the evolving regulatory expectations and landscape. Further, there have been new findings that require close assessment, as for example those related to excipient quality, processing, viscosity and device compatibility and administration, solubility and opalescence and container-closure selection. The literature varies widely in its discussion of these critical elements and consensus does not exist. This topic is receiving a great deal of attention within the biotechnology industry as well as with academic researchers and regulatory agencies globally. Therefore, this book is of interest for business leaders, researchers, formulation and process development scientists, analytical scientists, QA and QC officers, regulatory staff, manufacturing leaders and regulators active in the pharmaceutical and biotech industry, and expert reviewers in regulatory agencies.

Advances and Problems in the Philosophy of Technology

Advances and Problems in the Philosophy of Technology
  • Author : Hans Lenk,Académie internationale de philosophie des sciences. Conference
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :464
  • ISBN : STANFORD:36105112395376
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Summary : The Proceedings of the Karlsruhe Academic Session (1997) of the International Academy of the Philosophy of the Sciences cover the topic of philosophy of technology. Half a dozen of other pertinent topical papers have been added in order to extend the topics dealt with and to reach a rather comprehensive overview of this multi-ramified field. Nowadays philosophy of technology is not only confronted with new, anthropological and social as well as political problems to deal with, but also with methodological problems of the mutual interactions between science and technology, with problems of reliability and viability of technology assessment, e. g. with risks, environmental and social impact assessments. The importance and necessity of a philosophy and a practice-oriented ethics of technology will drastically rise and grow in the near future.

Pharmacy Practice in Developing Countries

Pharmacy Practice in Developing Countries
  • Author : Ahmed Fathelrahman,Mohamed Ibrahim,Albert Wertheimer
  • Publisher :Unknown
  • Release Date :2016-02-13
  • Total pages :516
  • ISBN : 9780128017111
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Summary : Pharmacy Practice in Developing Countries: Achievements and Challenges offers a detailed review of the history and development of pharmacy practice in developing countries across Africa, Asia, and South America. Pharmacy practice varies substantially from country to country due to variations in needs and expectations, culture, challenges, policy, regulations, available resources, and other factors. This book focuses on each country’s strengths and achievements, as well as areas of weakness, barriers to improvement and challenges. It sets out to establish a baseline for best practices, taking all of these factors into account and offering solutions and opportunities for the future. This book is a valuable resource for academics, researchers, practicing pharmacists, policy makers, and students involved in pharmacy practice worldwide as it provides lessons learned on a global scale and seeks to advance the pharmacy profession. Uses the latest research and statistics to document the history and development of pharmacy practice in developing countries Describes current practice across various pharmacy sectors to supply a valuable comparative analysis across countries in Africa, Asia, Europe, and South America Highlights areas of achievement, strengths, uniqueness, and future opportunities to provide a basis for learning and improvement Establishes a baseline for best practices and solutions

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents
  • Author : Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
  • Publisher :Unknown
  • Release Date :2020-04-07
  • Total pages :656
  • ISBN : 9780128199183
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Summary : Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Non-Biological Complex Drugs

Non-Biological Complex Drugs
  • Author : Daan J.A. Crommelin,Jon S. B. de Vlieger
  • Publisher :Unknown
  • Release Date :2015-06-24
  • Total pages :390
  • ISBN : 9783319162416
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Summary : The rise of bio- and nano-technology in the last decades has led to the emergence of a new and unique type of medicine known as non-biological complex drugs (NBCDs). This book illustrates the challenges associated with NBCD development, as well as the complexity of assessing the effects of manufacturing changes on innovator and follow-on batches of NBCDs. It also touches upon proven marketing authorization requirements for biosimilars that could be effective in evaluating follow-on NBCDs, including a demonstration of control over the manufacturing process and a need for detailed physico-chemical characterization and (pre)clinical tests. This book is meant to be used for years to come as a standard reference work for the development of NBCDs. Moreover, this book aims to stimulate discussions and further our thinking to ensure that decisions regarding the approval of complex drugs are made with relevant scientific data on the table.

Directory of Published Proceedings

Directory of Published Proceedings
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :229
  • ISBN : UOM:39015074109201
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Summary :

Amorphous Drugs

Amorphous Drugs
  • Author : Marzena Rams-Baron,Renata Jachowicz,Elena Boldyreva,Deliang Zhou,Witold Jamroz,Marian Paluch
  • Publisher :Unknown
  • Release Date :2018-02-09
  • Total pages :230
  • ISBN : 9783319720029
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Summary : This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

Formulating Poorly Water Soluble Drugs

Formulating Poorly Water Soluble Drugs
  • Author : Robert O. Williams III,Alan B. Watts,Dave A. Miller
  • Publisher :Unknown
  • Release Date :2011-12-04
  • Total pages :648
  • ISBN : 1461411440
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Summary : This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.

Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology

Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology
  • Author : Bharati, Shashi Lata,Chaurasia, Pankaj Kumar
  • Publisher :Unknown
  • Release Date :2018-05-11
  • Total pages :549
  • ISBN : 9781522552383
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Summary : Enzymes have interesting applications in our biological system and act as valuable biocatalysts. Their various functions allow enzymes to develop new drugs, detoxifications, and pharmaceutical chemistry. Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology provides emerging research on biosynthesis, enzymatic treatments, and bioengineering of medicinal waste. While highlighting issues such as structural implications for drug development and food applications, this publication explores information on various applications of enzymes in pharmaceutical, nutritional, and industrial aspects. This book is a valuable resource for medical professionals, pharmacists, pharmaceutical companies, researchers, academics, and upper-level students seeking current information on developing scientific ideas for new drugs and other enzymatic advancements.

Pharmaceutical Executive

Pharmaceutical Executive
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :229
  • ISBN : UCLA:L0061674727
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Innovation in Pharmacy: Advances and Perspectives. September 2018

Innovation in Pharmacy: Advances and Perspectives. September 2018
  • Author : Organizer Committee IPAP18 – Salamanca
  • Publisher :Unknown
  • Release Date :2018-09-21
  • Total pages :358
  • ISBN : 9788490129760
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Summary : This book contains the summaries of the "Innovation in Pharmacy: Advances and Perspectives" that took place in Salamanca (Spain) in September 2018. The early science of chemistry and microbiology were the source of most drugs until the revolution of genetic engineering in the mid 1970s. Then biotechnology made available novel protein agents such as interferons, blood factors and monoclonal antibodies that have changed the modern pharmacy. Over the past year, a new pharmacy of oligonucleotides has emerged from the science of gene expression such as RNA splicing and RNA interference. The ability to design therapeutic agents from genomic sequences will transform treatment for many diseases. The science that created this advance and its future promise will be discussed. Phillip Allen Sharp is an American geneticist and molecular biologist who co-discovered RNA splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for “the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence. He works in Institute Professor Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, US. Este libro recoge los resúmenes de la «Innovation in Pharmacy: Advances and Perspectives» que tuvo lugar en Salamanca (España) en septiembre de 2018. La ciencia primitiva de la química y la microbiología fue la fuente de la mayoría de las drogas hasta la revolución de la ingeniería genética a mediados de la década de 1970. Luego, la biotecnología puso a disposición agentes proteínicos novedosos como interferones, factores sanguíneos y anticuerpos monoclonales que han cambiado la farmacia moderna. Durante el año pasado, surgió una nueva farmacia de oligonucleótidos a partir de la ciencia de la expresión génica, como el empalme de ARN y la interferencia de ARN. La capacidad de diseñar agentes terapéuticos a partir de secuencias genómicas transformará el tratamiento de muchas enfermedades. La ciencia que creó este avance y su promesa futura será discutida. Phillip Allen Sharp es un genetista y biólogo molecular estadounidense que co-descubrió el empalme de ARN. Compartió el Premio Nobel de 1993 en Fisiología o Medicina con Richard J. Roberts por "el descubrimiento de que los genes en eucariotas no son cadenas contiguas, sino que contienen intrones, y que el empalme del ARN mensajero para eliminar esos intrones puede ocurrir de diferentes maneras, produciendo diferentes proteínas de la misma secuencia de ADN. Trabaja en el Instituto Profesor Koch Institute for Integrative Cancer Research, Instituto Tecnológico de Massachusetts (MIT), Cambridge, MA, EE. UU.

Advances in QSAR Modeling

Advances in QSAR Modeling
  • Author : Kunal Roy
  • Publisher :Unknown
  • Release Date :2017-05-22
  • Total pages :555
  • ISBN : 9783319568508
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Summary : The book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR). Written by an international group of recognized researchers, this edited volume discusses applications of QSAR in multiple disciplines such as chemistry, pharmacy, environmental and agricultural sciences addressing data gaps and modern regulatory requirements. Additionally, the applications of QSAR in food science and nanoscience have been included – two areas which have only recently been able to exploit this versatile tool. This timely addition to the series is aimed at graduate students, academics and industrial scientists interested in the latest advances and applications of QSAR.

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes
  • Author : Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer
  • Publisher :Unknown
  • Release Date :2017-05-23
  • Total pages :552
  • ISBN : 9780128097182
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Summary : Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

AAAS Bulletin

AAAS Bulletin
  • Author : American Association for the Advancement of Science
  • Publisher :Unknown
  • Release Date :1964-11
  • Total pages :229
  • ISBN : UVA:X002233196
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Summary :

Continuous Pharmaceutical Processing

Continuous Pharmaceutical Processing
  • Author : Zoltan K Nagy,Arwa El Hagrasy,Jim Litster
  • Publisher :Unknown
  • Release Date :2020-06-10
  • Total pages :541
  • ISBN : 9783030415242
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Summary : Continuous pharmaceutical manufacturing is currently receiving much interest from industry and regulatory authorities, with the joint aim of allowing rapid access of novel therapeutics and existing medications to the public, without compromising high quality. Research groups from different academic institutions have significantly contributed to this field with an immense amount of published research addressing a variety of topics related to continuous processing. The book is structured to have individual chapters on the different continuous unit operations involved in drug substance and drug product manufacturing. A wide spectrum of topics are covered, including basic principles of continuous manufacturing, applications of continuous flow chemistry in drug synthesis, continuous crystallization, continuous drying, feeders and blenders, roll compaction and continuous wet granulation.The underlying theme for each of these chapters is to present to the reader the recent advances in modeling, experimental investigations and equipment design as they pertain to each individual unit operation. The book also includes chapters on quality by design (QbD) and process analytical technology (PAT) for continuous processing, process control strategies including new concepts of quality-by-control (QbC), real-time process management and plant optimization, business and supply chain considerations related to continuous manufacturing as well as safety guidelines related to continuous chemistry. A separate chapter is dedicated to discussing regulatory aspects of continuous manufacturing, with description of current regulatory environment quality/GMP aspects, as well as regulatory gaps and challenges. Our aim from publishing this book is to make it a valuable reference for readers interested in this topic, with a desire to gain a fundamental understanding of engineering principles and mechanistic studies utilized in understanding and developing continuous processes. In addition, our advanced readers and practitioners in this field will find that the technical content of Continuous Pharmaceutical Processing is at the forefront of recent technological advances, with coverage of future prospects and challenges for this technology.

Modern Pharmaceutics: Applications and advances

Modern Pharmaceutics: Applications and advances
  • Author : Alexander Taylor Florence,Jürgen Siepmann
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :537
  • ISBN : 1420065645
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Summary :

Modern Applications of Plant Biotechnology in Pharmaceutical Sciences

Modern Applications of Plant Biotechnology in Pharmaceutical Sciences
  • Author : Saurabh Bhatia,Kiran Sharma,Randhir Dahiya,Tanmoy Bera
  • Publisher :Unknown
  • Release Date :2015-07-22
  • Total pages :452
  • ISBN : 9780128024980
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Summary : Modern Applications of Plant Biotechnology in Pharmaceutical Sciences explores advanced techniques in plant biotechnology, their applications to pharmaceutical sciences, and how these methods can lead to more effective, safe, and affordable drugs. The book covers modern approaches in a practical, step-by-step manner, and includes illustrations, examples, and case studies to enhance understanding. Key topics include plant-made pharmaceuticals, classical and non-classical techniques for secondary metabolite production in plant cell culture and their relevance to pharmaceutical science, edible vaccines, novel delivery systems for plant-based products, international industry regulatory guidelines, and more. Readers will find the book to be a comprehensive and valuable resource for the study of modern plant biotechnology approaches and their pharmaceutical applications. Builds upon the basic concepts of cell and plant tissue culture and recombinant DNA technology to better illustrate the modern and potential applications of plant biotechnology to the pharmaceutical sciences Provides detailed yet practical coverage of complex techniques, such as micropropogation, gene transfer, and biosynthesis Examines critical issues of international importance and offers real-life examples and potential solutions