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Clinical Diagnosis and Management of Alzheimer's Disease, Third Edition

Clinical Diagnosis and Management of Alzheimer's Disease, Third Edition
  • Author : Serge Gauthier
  • Publisher :Unknown
  • Release Date :2006-11-22
  • Total pages :392
  • ISBN : 0203931718
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Summary : The third edition of this successful textbook has been completely updated throughout and includes new chapters on electrophysiological tests, biological markers, global staging measures, and management of neuropsychiatric symptoms. There has been steady progress in our understanding of the natural history, prognostic factors and treatments for Alzheimer’s disease since the previous edition of this textbook was published in 1999. The chapters deal with the full spectrum of populations at risk, persons in prodromal stages, and patients from mild to severe and even terminal stages. The contributors are opinion leaders from North America and Europe, which gives the book an internationally balanced outlook. This new edition will be essential reading for a wide range of clinical neuroscientists who manage patients with this challenging disease.

The Healthy Brain Toolbox

The Healthy Brain Toolbox
  • Author : Ken Sharlin
  • Publisher :Unknown
  • Release Date :2018-06-11
  • Total pages :214
  • ISBN : 1732077010
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Summary : At last, neurologist-proven strategies to improve your memory and protect yourself against age-related diseases of the brain! The science and the "art" of functional medicine for the brain are laid out in this book. Dr. Ken Sharlin shows us how the individual pieces of the puzzle are integrated and nurtured along in a stepwise, achievable fashion, while recognizing the uniqueness of each individual who makes this approach their own. Here's what you will find inside: FORWARD by Terry Wahls, MD, IFMCP PART 1 - THE SCIENCE CHAPTER 1 Houston, We Have a Problem! How to Think Outside the Box to Solve a Global Health Crisis CHAPTER 2 I am a Product of My Generation: The Truth About How I Got Here CHAPTER 3 The Apple Can Land Far from the Tree, If You Give it a Push: How A Conventionally-Trained Doctor Turned into a Functional Medicine Fanatic CHAPTER 4 Inflammation and Oxidative Stress: Unearthing the Root Causes of Chronic Disease CHAPTER 5 The Seven Biological Systems: Imbalances in Functional Systems Affect One Another and Spark the Fire of Illness CHAPTER 6 The Clues are in the History: How Your Story Can Help You Learn What You Need to Do to Protect Your Brain CHAPTER 7 Getting Around the Parts of the Brain: How Structure Relates to Function, When it Comes to Preventing Memory Loss PART 2 - THE STRATEGIES CHAPTER 8 Brain Tune Up! In the Office: How a Functional Medicine Practice Can Work for You CHAPTER 9 Sleep Is More Than A Time Of Rest: Get Your Zzzs to Protect Your Brain! CHAPTER 10 Movement and Exercise: How Physical Activity Prevents Memory Loss and Protects Your Brain by Amy Gordin, PT CHAPTER 11 Nutrition to Tune Up Your Brain: How Food Provides the Building Blocks to Brain Health by Angela Jenkins, RD, LD CHAPTER 12 To Om and Beyond: An Emotional and Spiritual Stress Resilience Practice Can Improve Your Memory and Grow Your Brain by Chuck Renner, OTR, CHT CHAPTER 13 Eureka! How to Use Supplements, Herbal Brain Enhancers, and Technology to Prevent Memory Loss and Protect Your Aging Brain EPILOGUE: The Road Back

The End of Alzheimer's Program

The End of Alzheimer's Program
  • Author : Dale Bredesen
  • Publisher :Unknown
  • Release Date :2020-08-18
  • Total pages :352
  • ISBN : 9780525538509
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Summary : The instant New York Times bestseller The New York Times Best Selling author of The End of Alzheimer's lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower. In The End of Alzheimer's Dale Bredesen laid out the science behind his revolutionary new program that is the first to both prevent and reverse symptoms of Alzheimer's disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed, it can be tailored to anyone's needs and will enhance cognitive ability at any age. What we call Alzheimer's disease is actually a protective response to a wide variety of insults to the brain: inflammation, insulin resistance, toxins, infections, and inadequate levels of nutrients, hormones, and growth factors. Bredesen starts by having us figure out which of these insults we need to address and continues by laying out a personalized lifestyle plan. Focusing on the Ketoflex 12/3 Diet, which triggers ketosis and lets the brain restore itself with a minimum 12-hour fast, Dr. Bredesen drills down on restorative sleep, targeted supplementation, exercise, and brain training. He also examines the tricky question of toxic exposure and provides workarounds for many difficult problems. The takeaway is that we do not need to do the program perfectly but will see tremendous results if we can do it well enough. With inspiring stories from patients who have reversed cognitive decline and are now thriving, this book shifts the treatment paradigm and offers a new and effective way to enhance cognition as well as unprecedented hope to sufferers of this now no longer deadly disease.

Disease Control Priorities, Third Edition (Volume 4)

Disease Control Priorities, Third Edition (Volume 4)
  • Author : Vikram Patel,Dan Chisholm,Tarun Dua,Ramanan Laxminarayan,Mari'a Lena Medina-Mora,Theo Vos
  • Publisher :Unknown
  • Release Date :2016-03-10
  • Total pages :304
  • ISBN : 9781464804281
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Summary : Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.

Alzheimer’s Disease

Alzheimer’s Disease
  • Author : Ralph W. Richter,Brigitte Zoeller Richter
  • Publisher :Unknown
  • Release Date :2003-10-10
  • Total pages :479
  • ISBN : 9781592596614
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Summary : Alzheimer’s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic. Alzheimer’s Disease: A Physician’s Guide to Practical Management was written by selected clinicians and scientists who represent some of the world’s leading centers of excellence in AD research. The editors are proud and grateful for their profound contributions. This book is particularly designed to assist physicians and other health-care professionals in the evaluation, assessment, and treatment of individuals with AD. At the same time, by illuminating the basic scientific background, we hope to provide state-of-the art information about the disease and possible future therapeutic strategies. The recent psychiatric treatment aspects of AD are also clearly presented. Because the early diagnosis of the dementia process is now considered of increasing importance, we focus particularly in several chapters on early changes and preclinical conditions, such as mild cognitive impairment and predementia AD.

Marijuana As Medicine?

Marijuana As Medicine?
  • Author : Institute of Medicine,Janet Joy,Alison Mack
  • Publisher :Unknown
  • Release Date :2000-12-30
  • Total pages :216
  • ISBN : 9780309065313
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Summary : Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patients--as well as the people who care for them--with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and students--in short, anyone who wants to learn more about this important issue.

Memory Loss, Alzheimer's Disease, and Dementia E-Book

Memory Loss, Alzheimer's Disease, and Dementia E-Book
  • Author : Andrew E. Budson,Paul R. Solomon
  • Publisher :Unknown
  • Release Date :2015-05-20
  • Total pages :276
  • ISBN : 9780323316101
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Summary : Now presented in full color, this updated edition of Memory Loss, Alzheimer's Disease, and Dementia is designed as a practical guide for clinicians that delivers the latest treatment approaches and research findings for dementia and related illnesses. Drs. Budson and Solomon — both key leaders in the field — cover the essentials of physical and cognitive examinations and laboratory and imaging studies, giving you the tools you need to consistently make accurate diagnoses in this rapidly growing area. Access in-depth coverage of clinically useful diagnostic tests and the latest treatment approaches. Detailed case studies facilitate the management of both common and uncommon conditions. Comprehensive coverage of hot topics such as chronic traumatic encephalopathy, in addition to new criteria on vascular dementia and vascular cognitive impairment. Includes new National Institute on Aging–Alzheimer's Association and DSM-5 criteria for Alzheimer’s Disease and Mild Cognitive Impairment. Learn how to use new diagnostic tests, such as the amyloid imaging scans florbetapir (Amyvid), flutemetamol (Vizamyl), and florbetaben (Neuraceq), which can display amyloid plaques in the living brains of patients. Updated case studies, many complete with videos illustrating common tests, clinical signs, and diagnostic features, are now incorporated into the main text as clinical vignettes for all major disorders. Brand-new chapters on how to approach the differential diagnosis and on primary progressive aphasia. Medicine eBook is accessible on a variety of devices.

Neurochemical Aspects of Alzheimer's Disease

Neurochemical Aspects of Alzheimer's Disease
  • Author : Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2017-05-25
  • Total pages :414
  • ISBN : 9780128099384
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Summary : Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease

The Spectrum of Hope

The Spectrum of Hope
  • Author : Gayatri Devi
  • Publisher :Unknown
  • Release Date :2017-10-31
  • Total pages :256
  • ISBN : 9781523500581
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Summary : Imagine finding a glimmer of good news in a diagnosis of Alzheimer’s. And imagine how that would change the outlook of the 5 million Americans who suffer from Alzheimer’s disease and other dementias, not to mention their families, loved ones, and caretakers. A neurologist who’s been specializing in dementia and memory loss for more than 20 years, Dr. Gayatri Devi rewrites the story of Alzheimer’s by defining it as a spectrum disorder—like autism, Alzheimer’s is a disease that affects different people differently. She encourages people who are worried about memory impairment to seek a diagnosis, because early treatment will enable doctors and caregivers to manage the disease more effectively through drugs and other therapies. Told through the stories of Dr. Devi’s patients, The Spectrum of Hope is the kind of narrative medical writing that grips the reader, humanizes the science, and offers equal parts practical advice and wisdom with skillful ease. But beyond the pleasures of great reading, it’s a book that offers real hope. Here are chapters on how to maintain independence and dignity; how to fight depression, anxiety, and apathy; how to communicate effectively with a person suffering from dementia. Plus chapters on sexuality, genetics, going public with the diagnosis, even putting together a bucket list—because through her practice, Dr. Devi knows that the majority of Alzheimer’s patients continue to live and work in their communities. They babysit their grandkids, drive to the store (or own the store), serve their clients, or otherwise live fulfilling lives. That’s news that 5 million people are waiting to hear.

The Omentum

The Omentum
  • Author : Harry S. Goldsmith
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :252
  • ISBN : 9781461234364
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Summary : The Omentum explores and assesses the comparatively new approach of using omental attachment in the treatment of a variety of neurologic diseases. Topics discussed include historical images and ideas connected with the greater omentum; angiogenesis and the greater omentum; implications for central nervous system injury of vasoactive chemicals in the omentum; effects of omental-derived lipid fractions on osseous vascularization and bone formation; cerebral revascularization by omental graft for moyamoya disease; omental transposition for treating the sequelae of viral encephalitis; experimental and clinical use of omental transposition for spinal cord pathology; and lumbo-omental shunt for treatment of communicating hydrocephalus. The effect of omentum transposition to the brain on regional cerebral blood flow in stroke patients and on delivery of chemotherapeutic agents to malignant brain tumors is also considered.

The Alzheimer's Disease Challenge

The Alzheimer's Disease Challenge
  • Author : Athanasios Alexiou,Mohammad A. Kamal,Ghulam Md Ashraf
  • Publisher :Unknown
  • Release Date :2019-12-04
  • Total pages :229
  • ISBN : 9782889631285
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Summary : Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

A Paradigm Shift to Prevent and Treat Alzheimer's Disease

A Paradigm Shift to Prevent and Treat Alzheimer's Disease
  • Author : Howard Friel,Sally A. Frautschy
  • Publisher :Unknown
  • Release Date :2017-07-18
  • Total pages :290
  • ISBN : 9780128122792
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Summary : A Paradigm Shift to Prevent and Treat Alzheimer’s Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols is the first book to systematically exhibit the powerful pleiotropic pharmacological effects on Alzheimer’s disease of plant-based compounds from ancient foods that humans have been consuming safely with substantial health benefits for thousands of years. These plant-based compounds include curcuminoids from turmeric, resveratrol from red wine and grape seed extract from other grape products, epigallocatechin-gallate (EGCG) from green tea, and oleocanthal and oleuropein from olive oil, in addition to a special extract, EGb 761, from the leaves of Ginkgo biloba, the oldest living species of tree on earth. This book also presents a new analytical framework that convincingly favors a multi-targeting ("pleiotropic") approach to the prevention and treatment of complex chronic diseases, in contrast to the mono-targeting of the pharmaceutical model. A Paradigm Shift to Prevent and Treat Alzheimer’s Disease is a unique and exciting resource for pharmaceutical scientists, pharmacologists, neurologists, general practitioners, research scientists in various medical and life sciences, healthcare professionals in clinical and executive positions, conventional medical schools, schools of naturopathic medicine, healthcare and medical journalists, executives in both national public healthcare systems and private insurers, and informed general readers. Presents carefully compiled evidence supporting the need to shift from pharmaceutical-based mono-targeting to plant polyphenol-based pleiotropic targeting for the prevention and treatment of Alzheimer’s disease Includes valuable tables that aggregate pleiotropic pharmacological effects of the plant polyphenols on Alzheimer’s disease-related pathogenic hallmarks Highlights regulatory aspects and discusses the challenges and potential solutions with respect to bioavailability of certain plant polyphenols

Neurological Disorders

Neurological Disorders
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :218
  • ISBN : 9789241563369
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Summary : Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
  • Author : Adeboye Adejare
  • Publisher :Unknown
  • Release Date :2016-09-20
  • Total pages :316
  • ISBN : 9780128028117
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Summary : Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Deep Brain Stimulation for Parkinson's Disease

Deep Brain Stimulation for Parkinson's Disease
  • Author : Gordon H. Baltuch,Matthew B. Stern
  • Publisher :Unknown
  • Release Date :2007-03-19
  • Total pages :372
  • ISBN : 1420019759
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Summary : Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's

Oversight on Treatment of Alzheimer's Disease, 1983

Oversight on Treatment of Alzheimer's Disease, 1983
  • Author : United States. Congress. Senate. Committee on Labor and Human Resources. Subcommittee on Aging
  • Publisher :Unknown
  • Release Date :1983
  • Total pages :262
  • ISBN : STANFORD:36105045504987
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Summary :

The End of Alzheimer's

The End of Alzheimer's
  • Author : Dale Bredesen
  • Publisher :Unknown
  • Release Date :2017-08-22
  • Total pages :320
  • ISBN : 9780735216228
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Summary : The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher :Unknown
  • Release Date :2016-09-28
  • Total pages :558
  • ISBN : 9789535126546
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Summary : The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Principles of Drug Therapy in Neurology

Principles of Drug Therapy in Neurology
  • Author : Michael V. Johnston,Robert Gross
  • Publisher :Unknown
  • Release Date :2008-05
  • Total pages :558
  • ISBN : UOM:39015076178212
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Summary : Since the first edition of this book was published in 1992, the number of pharmacological therapies available for treating neurological disorders has grown exponentialy. This new edition brings the book fully up-to-date, and features PET scans to illustrate brain action, and new chapters on practical therapeutics and clinical trials.

The Dementias: Hope Through Research (Revised December 2017)

The Dementias: Hope Through Research (Revised December 2017)
  • Author : U.S. Department of Health and Human Services
  • Publisher :Unknown
  • Release Date :2019-04-13
  • Total pages :40
  • ISBN : 9780359588299
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Summary : Dementia is the loss of cognitive functioning?the ability to think, remember, or reason?to such an extent that it interferes with a person's daily life and activities. These functions include memory, language skills, visual perception, problem solving, self-management, and the ability to focus and pay attention. Some people with dementia cannot control their emotions, and their personalities may change. Dementia ranges in severity from the mildest stage, when it is just beginning to affect a person's functioning, to the most severe stage, when the person must depend completely on others for basic activities of daily living. Age is the primary risk factor for developing dementia. For that reason, the number of people living with dementia could double in the next 40 years as the number of Americans age 65 and older increases from 48 million today to more than 88 million in 2050. Regardless of the form of dementia, the personal, economic, and societal demands can be devastating.

Alzheimer's Disease Diagnosis and Treatments

Alzheimer's Disease Diagnosis and Treatments
  • Author : Marisa R. Boyd
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :298
  • ISBN : 1611220645
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Summary : Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's Disease (AD), which involves the parts of the brain that control thought, memory, and language. Age is the most important known risk factor for AD. The course the disease takes and the speed at which changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years. This book presents research in the study of Alzheimer's Disease, including diagnosis, testing and treatment of this condition.