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• Author : Patrizio Lancellotti,Jose L Zamorano,Maurizio Galderisi
• Publisher :Unknown
• Release Date :2016-11-11
• Total pages :470
• ISBN : 9780128026472

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Summary : Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients Written by world-leading experts in the field of cardiotoxicity Includes high-quality images, case studies, and test questions Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment

• Author : Patrizio Lancellotti,Jose L. Zamorano,Maurizio Galderisi
• Publisher :Unknown
• Release Date :2016-06-01
• Total pages :300
• ISBN : 0128025093

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Summary :

• Author : Wenyong Tan
• Publisher :Unknown
• Release Date :2018-11-14
• Total pages :162
• ISBN : 9781789842371

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Summary : Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.

• Author : Sotiris Missailidis
• Publisher :Unknown
• Release Date :2008-10-13
• Total pages :424
• ISBN : 9780470697030

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Summary : Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

• Author : Roberta A. Gottlieb,Puja K Mehta
• Publisher :Unknown
• Release Date :2016-11-26
• Total pages :356
• ISBN : 9780128035535

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Summary : Cardio-Oncology: Principles, Prevention and Management is a clinical volume that focuses on the basic science of cardio-oncology, addresses cardiotoxicity as a consequence of cancer therapy, and discusses prevention, diagnosis and management of cardiovascular disease in patients with cancer. This comprehensive volume presents unique perspectives ranging from basic science to clinical medicine in the field of cardio-oncology. It would be a valuable resource for cardiologists, oncologists, internists, and pediatricians caring for patients with cancer who have cardiovascular risk factors, as well as for cardio-oncology researchers. Covers basic science of cardio-oncology to provide readers with the necessary background Addresses cardiotoxicity related to current cancer therapeutic modalities Discusses diagnostic and management approaches of patients with underlying cardiac risk factors as well as otherwise healthy cancer patients

• Author : Gretchen G. Kimmick,Daniel J. Lenihan,Douglas B. Sawyer,Erica L. Mayer,Dawn L. Hershman
• Publisher :Unknown
• Release Date :2017-04-11
• Total pages :319
• ISBN : 9783319430966

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Summary : Co-edited and written by an interdisciplinary team of experts in oncology and cardiology, this book is a clinically useful resource on these overlapping topics: • Cardiac complications in patients receiving cancer therapy • The treatment of cancer in patients with cardiovascular disease • The treatment of cardiovascular disease in patients with cancer When relevant to medical practice, epidemiology and basic science are also included in the discussion and each chapter is written by an oncologist and a cardiologist. Additionally, the chapters follow a similar format to make the book truly interdisciplinary, user-friendly, and clinically applicable to specialists and non-specialists who care for patients with both cancer and cardiovascular disease.

• Author : Michael S. Ewer,Edward T. H. Yeh, M.D.
• Publisher :Unknown
• Release Date :2013
• Total pages :492
• ISBN : 1607950405

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Summary : The book begins with the basic science behind the medical applications of the knowledge: cardiovascular biology, pathways, and their relationship to cancer treatment and principles of chemotherapy and immunotherapy. The second section consists of an overview and classification of anti-cancer drugs and a look at their cardiotoxicity. The third section looks at cardiac imaging in the cancer patient, including cardiac ultrasound, Doppler imaging, nuclear imaging, magnetic resonance imaging, and computed tomography in the cancer patient. In section four, management of cardiac disease in the cancer patient is discussed, including cardiac rhythm disturbances and heart failure. Cardiac emergencies and interventions are described as is preoperative assessment of the cancer patient for non- cardiovascular surgery. The final section includes a range of topics such as the pericardium, cardiovascular effects of endocrine treatments, primary cardiac tumors and malignancies of the myocardium and pericardium. Cardiac monitoring during clinical trials and pulmonary concerns are also addressed, as are psychosocial, social, economic, and legal issues of the cancer patient with heart disease.

• Author : Antonio Russo,Giuseppina Novo,Patrizio Lancellotti,Antonio Giordano,Fausto J. Pinto
• Publisher :Unknown
• Release Date :2018-10-04
• Total pages :224
• ISBN : 9783319934020

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Summary : This proposed text is designed to provide a useful and comprehensive resource and state-of-the-art overview to readers about vascular damage potentially induced by antineoplastic drugs. Thanks to more and more effective antineoplastic treatments the survival of cancer patients is enormously increasing, but at the same time it is increasing the burden of related cardiovascular complications that affect morbidity and mortality. On this basis a new branch of cardiology has been developed, that is Cardio-Oncology. The aim is to prevent cardiovascular complications related to cancer therapy and to facilitate and avoid interruption of antineoplastic drugs due to the occurrence of cardiovascular damage. An increasing attention has been given to cardiac damage, while, until today, vascular complications have been poorly evaluated. The aim of this book is to focus on vascular complications related to cancer treatment, to guide the clinician at facing, during his every day practice, cardiovascular toxicity in cancer and hematologic patients. The proposed sections of the book have been structured to review the molecular mechanisms underlying vascular damage induced by new and old treatments, to describe the various manifestations of vascular disease that may range from artery to venous disease (including coronary artery disease, peripheral arterial disease, venous thromboembolism and pulmonary hypertension), and to provide advice to monitor patients undergoing onco-hematologic treatments in order to prevent and eventually manage vascular damage.This book will address resident and fellow physicians, medical oncologists, cardiologists, general practitioners and all those who take care of these patients.All invited authors will be recognized experts in their field, and leading international researchers on these topics. The editor has worked with these expert colleagues on a variety of other projects. The authors will provide their manuscript according to current literature and clinical research studies. The book does not seek to duplicate or replace other current resources. Rather, it will create a comprehensive yet concise resource on this emerging topic that is not adequately covered by any current literature.

• Author : Karen Wonders,Brittany Stout
• Publisher :Unknown
• Release Date :2017-06-07
• Total pages :114
• ISBN : 9789535132196

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Summary : Pediatric cancer develops in 1 to 500 children. Typically, the type of cancers that develop in children is different than those that develop in adults, in that they are often the result of a DNA mutation rather than environmental or lifestyle risk factors. Leukemia, brain and central nervous system tumors, and neuroblastomas are the most common cancer types in child populations. Children tend to respond better to anticancer treatments, including chemotherapy and radiation. However, long-term side effects are common in children, often requiring follow-up care and lifestyle intervention for the rest of their lives. The percentage of 5-year survivors was over 50% for the most common cancers. This suggests that a majority of cancers in this population are highly survivable. As such, research should focus on aspects of survivorship for these individuals. This book will explore issues related to pediatric cancer and their associated treatments.

• Author : Anecita P. Fadol
• Publisher :Unknown
• Release Date :2013-01-01
• Total pages :305
• ISBN : 1935864246

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Summary : Cardiac complications of anticancer therapy represent an emerging clinical issue in both established chemotherapeutics as well as novel molecular therapies. As a result, healthcare providers are under greater pressure to be vigilant in evaluating patients with cancer for acute and chronic or late physical effects of cancer therapy some of which could be life-threatening. Cardiac Complications of Cancer Therapy, edited by Anecita P. Fadol, PhD, RN, FNP-BC, FAANP, provides you with the essentials of clinical management of the most common cardiac complications of cancer therapy. While you can find a multitude of literature on the management of cardiac problems, including both texts and journal articles, no other clinical reference book on the current market is written for nurses and midlevel providers and examines both the complexity of cardiac problems in conjunction with a cancer diagnosis. Describing the assessment and management of common cardiac problems, chapters in this quick-reference guide examine issues such as cardiovascular anatomy, the development of cardiotoxicity and the management of cardiomyopathy in patients with cancer, targeted therapies and cardiomyopathy, acute coronary syndromes in patients with cancer, cardiac inflammatory conditions and cardiac tamponade in patients with cancer, hypertension in patients with cancer, heart failure in patients with cancer, screening and management of cardiovascular risk factors in cancer survivors, and much more.

• Author : Susan F. Dent
• Publisher :Unknown
• Release Date :2019-08-30
• Total pages :244
• ISBN : 9781351583565

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Summary : This book takes a holistic view of the treatment of cardio-oncology patients, from evaluating those at high risk of developing cardio-toxicity, guidance for monitoring and managing patients during therapy to cardiac care of cancer survivors. Throughout, this book utilizes the latest research and guidance to offer advice on treatment strategy as well as practical elements of such as training, cardio-oncology nursing, patient education and how to establish a cardio-oncology unit. This book focuses on the practical knowledge and skills key to successful collaboration between cardiologists and oncologists to achieve the optimum cardiac care for cancer patients. Key Features Focuses on the practical elements of cardio-oncology care Outlines the importance and process of setting up a cardio-oncology unit and cardio-oncology fellowships Provides advice and guidance on the set up and common pit falls of coordinating care for cardio-oncology patients Outlines current guidelines and potential future directions for the field of cardio-oncology

• Author : Letícia Rangel
• Publisher :Unknown
• Release Date :2013-05-09
• Total pages :630
• ISBN : 9789535110989

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Summary : Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.

• Author : Anonim
• Publisher :Unknown
• Release Date :1986
• Total pages :229
• ISBN : PSU:000068853907

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Summary :

• Author : James F. Holland
• Publisher :Unknown
• Release Date :1997
• Total pages :3467
• ISBN : 0683040952

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Summary :

• Author : Eylem Taskin,Celal Guven,Yusuf Sevgiler
• Publisher :Unknown
• Release Date :2018-08-29
• Total pages :496
• ISBN : 9781789236743

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Summary : Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

• Author : United States. Congress. Senate. Committee on Labor and Human Resources
• Publisher :Unknown
• Release Date :1984
• Total pages :117
• ISBN : PURD:32754076781784

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Summary :

• Author : Ana Cristina Andreazza,Gustavo Scola
• Publisher :Unknown
• Release Date :2015-07-08
• Total pages :244
• ISBN : 9789535121404

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Summary : The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed. Since the bioactivation of many toxins and toxicants and its consequences on human health are not clearly known, this book offers a quick overview of cellular toxicology through the cell, drug and environmental toxicity. This book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. The book is divided into three main sections,; the first one discusses the role of mitochondrial dysfunction, oxidative stress and mitochondrial drug development. The second and third sections bring light to forensic toxicology and drug poisoning followed by environmental toxicity.

• Author : Sivakumar Joghi Thatha Gowder
• Publisher :Unknown
• Release Date :2014-07-02
• Total pages :358
• ISBN : 9789535116202

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Summary : The book "Pharmacology and Therapeutics" targets every aspect of the mechanisms for the chemical actions of both traditional and novel drugs. This book covers six sections: Molecular Modeling and Bio-molecular Pharmacology, Immunopharmacology, Environmental Pharmacology and Toxicology, Nanotechnology and Chemotherapy, Drugs and Drug Delivery System and Addiction Pharmacology. Each of these sections is interwoven with the theoretical aspects and experimental techniques of physiology, biochemistry, nutrition, cellular and molecular biology, microbiology, immunology, genetics, and pathology. This book will be a significant source to scientists, physicians, health care professionals and students who are interested to explore the effect of chemical agents on human life.

• Author : Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
• Publisher :Unknown
• Release Date :2019-11-06
• Total pages :596
• ISBN : 9789811382734

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Summary : This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

• Author : Dan Simionescu,Agneta Simionescu
• Publisher :Unknown
• Release Date :2017-04-05
• Total pages :464
• ISBN : 9789535130239

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Summary : The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

• Author : Amar S. Kapoor
• Publisher :Unknown
• Release Date :2012-12-06
• Total pages :316
• ISBN : 9781461248989

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Summary : Within the broad field of oncology is a relatively small but important area of cardiac oncology. The scope of cardiac oncology will increase as we con tinue to develop expertise in the detection and management of cardiac prob we intensify efforts to improve survival in patients who at an lems and as earlier time might have succumbed to advanced disease and a fragile cardio vascular system. With our aging population and the developing complexity of treatment modalities, we now recognize that the cardiovascular system is a target of the adverse effects of chemotherapy, radiotherapy, and cancer itself. The goal of this book is to present the scope of modern cardiac oncology as a growing discipline with sophisticated diagnostic testing and treatment modalities. The views of different specialists from different subspecialities are integrated to provide a multidisciplinary approach to the diagnosis, man agement, and complications of cancer of the heart and related conditions. The rapidly growing interest in cardiac oncology has largely been advanced through the ready availability of two-dimensional echocardiography, nuclear magnetic resonance imaging, angiocardiography, and other imaging tech niques. This book is divided into four parts. The first appraises cardiac tumors in detail and describes the distribution, pathology, noninvasive and invasive methods for testing, diagnosis, and treatment. The surgical approach to cardiac tumors has been included. It is a major advance that was essentially nonexistent a decade or so ago. Novel surgical approaches have now been successful in many instances.