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Anticancer Treatments and Cardiotoxicity

Anticancer Treatments and Cardiotoxicity
  • Author : Patrizio Lancellotti,Jose L Zamorano,Maurizio Galderisi
  • Publisher :Unknown
  • Release Date :2016-11-11
  • Total pages :470
  • ISBN : 0128026472
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Summary : Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients Written by world-leading experts in the field of cardiotoxicity Includes high-quality images, case studies, and test questions Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment

Anti-Cancer Treatments and Cardiotoxicity

Anti-Cancer Treatments and Cardiotoxicity
  • Author : Patrizio Lancellotti,Jose L. Zamorano,Maurizio Galderisi
  • Publisher :Unknown
  • Release Date :2016-06-01
  • Total pages :300
  • ISBN : 9780128025093
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Summary :

Cardiotoxicity

Cardiotoxicity
  • Author : Wenyong Tan
  • Publisher :Unknown
  • Release Date :2018-11-14
  • Total pages :162
  • ISBN : 1789842379
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Summary : Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.

Cardio-Oncology

Cardio-Oncology
  • Author : Roberta A. Gottlieb,Puja K Mehta
  • Publisher :Unknown
  • Release Date :2016-11-26
  • Total pages :356
  • ISBN : 0128035536
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Summary : Cardio-Oncology: Principles, Prevention and Management is a clinical volume that focuses on the basic science of cardio-oncology, addresses cardiotoxicity as a consequence of cancer therapy, and discusses prevention, diagnosis and management of cardiovascular disease in patients with cancer. This comprehensive volume presents unique perspectives ranging from basic science to clinical medicine in the field of cardio-oncology. It would be a valuable resource for cardiologists, oncologists, internists, and pediatricians caring for patients with cancer who have cardiovascular risk factors, as well as for cardio-oncology researchers. Covers basic science of cardio-oncology to provide readers with the necessary background Addresses cardiotoxicity related to current cancer therapeutic modalities Discusses diagnostic and management approaches of patients with underlying cardiac risk factors as well as otherwise healthy cancer patients

Cardio-Oncology

Cardio-Oncology
  • Author : Gretchen G. Kimmick,Daniel J. Lenihan,Douglas B. Sawyer,Erica L. Mayer,Dawn L. Hershman
  • Publisher :Unknown
  • Release Date :2017-04-11
  • Total pages :319
  • ISBN : 3319430963
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Summary : Co-edited and written by an interdisciplinary team of experts in oncology and cardiology, this book is a clinically useful resource on these overlapping topics: • Cardiac complications in patients receiving cancer therapy • The treatment of cancer in patients with cardiovascular disease • The treatment of cardiovascular disease in patients with cancer When relevant to medical practice, epidemiology and basic science are also included in the discussion and each chapter is written by an oncologist and a cardiologist. Additionally, the chapters follow a similar format to make the book truly interdisciplinary, user-friendly, and clinically applicable to specialists and non-specialists who care for patients with both cancer and cardiovascular disease.

Cancer and the Heart

Cancer and the Heart
  • Author : Michael S. Ewer,Edward T. H. Yeh, M.D.
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :492
  • ISBN : 9781607950400
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Summary : The book begins with the basic science behind the medical applications of the knowledge: cardiovascular biology, pathways, and their relationship to cancer treatment and principles of chemotherapy and immunotherapy. The second section consists of an overview and classification of anti-cancer drugs and a look at their cardiotoxicity. The third section looks at cardiac imaging in the cancer patient, including cardiac ultrasound, Doppler imaging, nuclear imaging, magnetic resonance imaging, and computed tomography in the cancer patient. In section four, management of cardiac disease in the cancer patient is discussed, including cardiac rhythm disturbances and heart failure. Cardiac emergencies and interventions are described as is preoperative assessment of the cancer patient for non- cardiovascular surgery. The final section includes a range of topics such as the pericardium, cardiovascular effects of endocrine treatments, primary cardiac tumors and malignancies of the myocardium and pericardium. Cardiac monitoring during clinical trials and pulmonary concerns are also addressed, as are psychosocial, social, economic, and legal issues of the cancer patient with heart disease.

Cardiac Complications of Cancer Therapy

Cardiac Complications of Cancer Therapy
  • Author : Anecita P. Fadol
  • Publisher :Unknown
  • Release Date :2013-01-01
  • Total pages :305
  • ISBN : 9781935864240
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Summary : Cardiac complications of anticancer therapy represent an emerging clinical issue in both established chemotherapeutics as well as novel molecular therapies. As a result, healthcare providers are under greater pressure to be vigilant in evaluating patients with cancer for acute and chronic or late physical effects of cancer therapy some of which could be life-threatening. Cardiac Complications of Cancer Therapy, edited by Anecita P. Fadol, PhD, RN, FNP-BC, FAANP, provides you with the essentials of clinical management of the most common cardiac complications of cancer therapy. While you can find a multitude of literature on the management of cardiac problems, including both texts and journal articles, no other clinical reference book on the current market is written for nurses and midlevel providers and examines both the complexity of cardiac problems in conjunction with a cancer diagnosis. Describing the assessment and management of common cardiac problems, chapters in this quick-reference guide examine issues such as cardiovascular anatomy, the development of cardiotoxicity and the management of cardiomyopathy in patients with cancer, targeted therapies and cardiomyopathy, acute coronary syndromes in patients with cancer, cardiac inflammatory conditions and cardiac tamponade in patients with cancer, hypertension in patients with cancer, heart failure in patients with cancer, screening and management of cardiovascular risk factors in cancer survivors, and much more.

Manual of Cardio-oncology

Manual of Cardio-oncology
  • Author : Chiara Lestuzzi,Stefano Oliva,Francesco Ferraù
  • Publisher :Unknown
  • Release Date :2017-10-13
  • Total pages :473
  • ISBN : 3319402366
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Summary : This concise and handy manual provides straightforward, up-to-date guidance for cardiologists and other practitioners on the management of cancer patients with cardiac problems, whether they be due to the cancer itself or to antineoplastic treatment. Detailed attention is devoted to the various forms of cardiotoxicity associated with chemotherapy and radiotherapy. The drugs commonly responsible for each toxicity are identified and clear advice is offered on monitoring techniques and treatment approaches. In addition, the issue of cardiotoxicity due to cancer treatment in particular patient groups – children, the elderly, and those with pre-existing cardiac disease – is addressed separately, with guidance on when and how antineoplastic (and/or cardiological) treatments should be modified. Further sections describe the correct responses to cardiac problems secondary to the cancer itself, including thromboembolic disorders and electrolyte imbalances, and the diagnosis, treatment, and follow-up of cardiac tumors. A closing section considers how to improve cooperation between oncologists, cardiologists, and general practitioners to ensure that cancer patients’ cardiovascular needs are met in a multidisciplinary approach.

Cardiovascular Toxicities of Breast Cancer Treatment: Emerging Issues in Cardio-Oncology

Cardiovascular Toxicities of Breast Cancer Treatment: Emerging Issues in Cardio-Oncology
  • Author : Sharad Goyal,Bruce George Haffty
  • Publisher :Unknown
  • Release Date :2016-05-20
  • Total pages :229
  • ISBN : 2889195694
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Summary : Cancer and cardiovascular disease (CVD) are the two most common causes of mortality and morbidity worldwide. The incidence of both cancer and cardiovascular disease increases with age. With increased life expectancy, the burden of both these diseases will increase substantially in coming years. Patients with CVD share multiple common risk factors and lifestyle behaviors in addition to frequently suffering from multiple comorbid conditions. Tobacco use, hypertension, high cholesterol, diabetes, physical inactivity, and poor nutrition are all established risk factors of heart disease. Patients with diseases such as breast cancer may develop CVD from treatment, such as use of chemotherapy and RT. Effects on the heart are a potentially significant and serious clinical problem in radiation therapy treatment of breast cancer. Over the course of the past 50 years, there have been great advances in the delivery of RT due to the development of new techniques, beam energy, improvement in imaging modalities, and development of image registration strategies. It is hypothesized that cardiac damage from RT is correlated to the dose absorbed by the heart and differs between left- and right-breast radiotherapy. The damage to cardiac micro- and macro-vasculature is the pathophysiological cause of RT-related heart disease. Given the growing clinical relevance of cardio-oncology, this Frontiers in Oncology Research Topic provides a venue for disseminating focused reviews and cutting edge research in this quickly growing field. We encourage submission of original papers and reviews dealing with cardiac toxicity after breast cancer treatment, motion management to reduce cardiac exposure, imaging to evaluate potential cardiac toxicities and primary prevention of cardiac disease in the breast cancer patient.

Cancer Treatment

Cancer Treatment
  • Author : Letícia Rangel
  • Publisher :Unknown
  • Release Date :2013-05-09
  • Total pages :630
  • ISBN : 9535110985
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Summary : Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.

ALERT • Adverse Late Effects of Cancer Treatment

ALERT • Adverse Late Effects of Cancer Treatment
  • Author : Philip Rubin,Louis S. Constine,Lawrence B. Marks
  • Publisher :Unknown
  • Release Date :2013-12-12
  • Total pages :700
  • ISBN : 3540758631
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Summary : The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of "ALERT – Adverse Late Effects of Cancer Treatment" is to offer a coherent multidisciplinary approach to the care of cancer survivors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables. It is anticipated that this textbook will become the gold standard in providing information on the late effects of cancer treatment and that, in its digitized form, it will be referenced in cancer survivorship guidelines.

Pediatric Cancer Survivors

Pediatric Cancer Survivors
  • Author : Karen Wonders,Brittany Stout
  • Publisher :Unknown
  • Release Date :2017-06-07
  • Total pages :114
  • ISBN : 9535132199
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Summary : Pediatric cancer develops in 1 to 500 children. Typically, the type of cancers that develop in children is different than those that develop in adults, in that they are often the result of a DNA mutation rather than environmental or lifestyle risk factors. Leukemia, brain and central nervous system tumors, and neuroblastomas are the most common cancer types in child populations. Children tend to respond better to anticancer treatments, including chemotherapy and radiation. However, long-term side effects are common in children, often requiring follow-up care and lifestyle intervention for the rest of their lives. The percentage of 5-year survivors was over 50% for the most common cancers. This suggests that a majority of cancers in this population are highly survivable. As such, research should focus on aspects of survivorship for these individuals. This book will explore issues related to pediatric cancer and their associated treatments.

Cardio-Oncology: From Bench to Bedside

Cardio-Oncology: From Bench to Bedside
  • Author : Jun-ichi Abe,Anil K. Sood,James Martin
  • Publisher :Unknown
  • Release Date :2019-05-17
  • Total pages :113
  • ISBN : 288945875X
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Summary : Cardio-oncology is a medical subspecialty concerned with the diagnosis and treatment of cardiovascular disease (CVD) and organ failure mediated by micro- to macro-circulation defects in cancer patients and survivors. The risk of CVD in cancer survivors is eight times higher than the general population, and the relative risk of coronary artery disease and heart failure (HF) is 10 times and 15 times higher, respectively, compared to their siblings without cancer. It is important to note that cancer treatments including chemotherapy and radiation can lead to both short- (< 1 year) and long-term (> 5 years) cardiovascular complications. Previously, Dr. Edward T.H. Yeh initiated the MD Anderson Practice (MAP) project, and published 16 MAPs to provide the current best practice we considered at UT MD Anderson. As shown in these MAPs, one of the key issues of cardio-oncology practice and science is how we can allow cancer patients to receive maximum and uninterrupted treatments for cancer while protecting them from cancer therapy-mediated cardiovascular complications. Therefore, it is crucial to understand not only pathophysiology of CVD, but also mechanistic insights of how each cancer treatment can control cancer growth and metastasis. Without having the profound knowledge in the pathophysiological, clinical and epidemiologic aspects of cardiovascular complications of existing cancer therapy, it is impossible to establish the strong evidence-based strategies and approaches for both short- and long-term cardiovascular complications after cancer treatment. In addition, we believe that cardio-oncology science should not be restricted to deal with the side effects of each specific cancer drug, because many common cardiovascular phenotypes among the different cancer treatments are also observed. This Research Topic provides a comprehensive overview from both of the current research and practice, and a platform for obtaining the logical and up-to-date treatment and prevention of CVD in cancer patients and survivors.

Mechanical Ventilation in Critically Ill Cancer Patients

Mechanical Ventilation in Critically Ill Cancer Patients
  • Author : Antonio M. Esquinas,S. Egbert Pravinkumar,Ayman O. Soubani
  • Publisher :Unknown
  • Release Date :2018-02-07
  • Total pages :368
  • ISBN : 331949256X
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Summary : This book aims to equip the reader to make optimal decisions on the use of mechanical ventilatory support in critically ill cancer patients with acute respiratory failure (ARF) and to implement the different strategies effectively. Detailed information is provided on the rationale for invasive and non-invasive ventilation, the different modes of ventilation, indications and contraindications, prognostic factors, and outcomes. The role of postoperative mechanical ventilation following various forms of surgery is extensively addressed, and key aspects of withdrawal from ventilatory support are discussed. Attention is also devoted to mechanical ventilation in the palliative care context. The concluding part of the book focuses on healthcare resource utilization and organizational support in cancer critical care. ARF is the most common reason for hospital and intensive care admission among oncological patients, and there is growing evidence that outcome following mechanical ventilation is improving. Readers will find this book to be an invaluable aid when selecting and executing a strategy for management of ARF in individual cancer patients.

The Chemotherapy Source Book

The Chemotherapy Source Book
  • Author : Michael Clinton Perry
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :779
  • ISBN : 9780781773287
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Summary : The Chemotherapy Source Book, Fourth Edition pulls together all the current information on the chemotherapeutic management of cancer patients, including choice of chemotherapeutic agents, use of combinations, and toxicity of individual drugs. Organized by disease site, the book brings together pharmacologic and patient management information in one source that clinicians can consult for any question encountered in the delivery of chemotherapy. This updated Fourth Edition includes new drugs as well as new indications for older drugs. Content has been streamlined to provide essential information more quickly for the busy practitioner. Plus, this edition is softcover for greater portability and convenience.

Toxicology Studies

Toxicology Studies
  • Author : Ana Cristina Andreazza,Gustavo Scola
  • Publisher :Unknown
  • Release Date :2015-07-08
  • Total pages :244
  • ISBN : 9535121405
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Summary : The increased exposure to toxins, toxicants and novel drugs has promoted toxicology to become one of the most important areas of research with emerging innovative toxicity testing protocols, techniques, and regulation being placed. Since the bioactivation of many toxins and toxicants and its consequences on human health are not clearly known, this book offers a quick overview of cellular toxicology through the cell, drug and environmental toxicity. This book does not strive to be comprehensive but instead offers a quick overview of principle aspects of toxins and toxicants in order to familiarize the key principles of toxicology. The book is divided into three main sections,; the first one discusses the role of mitochondrial dysfunction, oxidative stress and mitochondrial drug development. The second and third sections bring light to forensic toxicology and drug poisoning followed by environmental toxicity.

Practical Cardio-Oncology

Practical Cardio-Oncology
  • Author : Susan F. Dent
  • Publisher :Unknown
  • Release Date :2019-08-30
  • Total pages :244
  • ISBN : 1351583565
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Summary : This book takes a holistic view of the treatment of cardio-oncology patients, from evaluating those at high risk of developing cardio-toxicity, guidance for monitoring and managing patients during therapy to cardiac care of cancer survivors. Throughout, this book utilizes the latest research and guidance to offer advice on treatment strategy as well as practical elements of such as training, cardio-oncology nursing, patient education and how to establish a cardio-oncology unit. This book focuses on the practical knowledge and skills key to successful collaboration between cardiologists and oncologists to achieve the optimum cardiac care for cancer patients. Key Features Focuses on the practical elements of cardio-oncology care Outlines the importance and process of setting up a cardio-oncology unit and cardio-oncology fellowships Provides advice and guidance on the set up and common pit falls of coordinating care for cardio-oncology patients Outlines current guidelines and potential future directions for the field of cardio-oncology

Cardio-Oncology, An Issue of Cardiology Clinics E-Book

Cardio-Oncology, An Issue of Cardiology Clinics E-Book
  • Author : Monika Jacquelin Leja
  • Publisher :Unknown
  • Release Date :2019-10-11
  • Total pages :229
  • ISBN : 0323711871
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Summary : This issue of Cardiology Clinics, guest edited by Dr. Monika Jacquelina Leja, will focus on Cardio-Oncology. Topics include, but are not limited to, Anthracycline Cardiomyopathy in Cancer Patients, Common Vascular Toxicities of Cancer Therapies, Cardiotoxicity of Immune Therapy, 5 FU Related Cardiotoxicity, Trastuzumab Induced Cardiotoxicity, Echocardiography Imaging of Cardiotoxicity, MRI Imaging of Cardiotoxicity, Cardiomyopathy Prevention in Cancer Patients, Radiation Related Cardiovascular Disease, Electrophysiology in Cardio-Oncology, Cardiac Interventional Procedures in Cardio-Oncology Patients, Diagnosis and Treatment of Amyloid Related to Myeloid Dyscrasias, Carcinoid Heart Disease, Cardiac Tumors, Cardiovascular Toxicities in Pediatric Cancer Survivors, and Developing a Cardio-Oncology Practice Nuts and Bolts: Coding and Billing.

Cancer and Aging

Cancer and Aging
  • Author : M. Extermann
  • Publisher :Unknown
  • Release Date :2013-01-18
  • Total pages :178
  • ISBN : 3318023078
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Summary : Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.

Pharmacology and Therapeutics

Pharmacology and Therapeutics
  • Author : Sivakumar Joghi Thatha Gowder
  • Publisher :Unknown
  • Release Date :2014-07-02
  • Total pages :358
  • ISBN : 9535116207
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Summary : The book "Pharmacology and Therapeutics" targets every aspect of the mechanisms for the chemical actions of both traditional and novel drugs. This book covers six sections: Molecular Modeling and Bio-molecular Pharmacology, Immunopharmacology, Environmental Pharmacology and Toxicology, Nanotechnology and Chemotherapy, Drugs and Drug Delivery System and Addiction Pharmacology. Each of these sections is interwoven with the theoretical aspects and experimental techniques of physiology, biochemistry, nutrition, cellular and molecular biology, microbiology, immunology, genetics, and pathology. This book will be a significant source to scientists, physicians, health care professionals and students who are interested to explore the effect of chemical agents on human life.

Breast Cancer

Breast Cancer
  • Author : Phuc Van Pham
  • Publisher :Unknown
  • Release Date :2017-04-05
  • Total pages :568
  • ISBN : 9535129996
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Summary : Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.