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Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics
  • Author : Allan Matte
  • Publisher :Unknown
  • Release Date :2020-09-07
  • Total pages :222
  • ISBN : 9780081030196
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Summary : Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :229
  • ISBN : UIUC:30112065974724
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Summary :

Process Scale Purification of Antibodies

Process Scale Purification of Antibodies
  • Author : Uwe Gottschalk
  • Publisher :Unknown
  • Release Date :2017-04-03
  • Total pages :752
  • ISBN : 9781119126911
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Summary : Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing

Science

Science
  • Author : John Michels
  • Publisher :Unknown
  • Release Date :2001-09
  • Total pages :229
  • ISBN : UIUC:30112037736953
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Summary :

Monoclonal Antibodies

Monoclonal Antibodies
  • Author : Philip Shepherd,Christopher J. Dean
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :479
  • ISBN : 0199637229
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Summary : Monoclonal Antibodies: A Practical Approach covers the preparation, testing, derivation, and applications of monoclonal antibodies. New immunological techniques incorporating tried and tested methodologies are described, making the book of interest to established and inexperienced immunologists. Both the standard somatic hybridization technique and recombinant techniques, including the use of phage libraries, for the preparation of rodent and human monoclonal antibodies are described. Protocols for both the small and large scale production are detailed, as well as purification and labelling (with both radioisotopes and non-radioisotopes) methods. The applications of monoclonal antibodies in immunoblotting, enzyme linked immunoassays, immunofluorescence, and FACS analysis are all covered in detail. Finally protocols are given for the use of monoclonal antibodies in rheumatoid arthritis, tissue typing, detecting DNA modified during chemotherapy, and in the clinical analysis of transplantation samples for malignancy. This book will therefore be an invaluable laboratory companion to anyone using monoclonal antibodies in their research.

Purification and Analysis of Recombinant Proteins

Purification and Analysis of Recombinant Proteins
  • Author : SEETHARAM
  • Publisher :Unknown
  • Release Date :1991-01-07
  • Total pages :344
  • ISBN : 0824782771
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Summary : Covering both new and traditional topics in the purification and analysis of recombinant proteins, this volume demonstrates how to overcome problems in protein research and presents practical methods used in protein work, explaining their theoretical bases. The collection also explores innovative co

Index Medicus

Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :229
  • ISBN : OSU:32436011091202
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Summary :

Research Awards Index

Research Awards Index
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1977
  • Total pages :229
  • ISBN : MINN:31951D03401933J
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Summary :

Federation Proceedings

Federation Proceedings
  • Author : Federation of American Societies for Experimental Biology
  • Publisher :Unknown
  • Release Date :1987
  • Total pages :229
  • ISBN : UOM:39015010280215
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Summary : Vols. for 1942- include proceedings of the American Physiological Society.

Therapeutic Proteins

Therapeutic Proteins
  • Author : Vladimir Voynov,Justin A. Caravella
  • Publisher :Unknown
  • Release Date :2016-05-01
  • Total pages :516
  • ISBN : 1493959492
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Summary : Emphasizing the newest developments in the field, this volume presents detailed methodswith added emphasison therapeutic protein discovery. It features key tips and valuable implementation advice to ensure successful results."

Therapeutic Proteins

Therapeutic Proteins
  • Author : C. Mark Smales,David Cameron James
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :482
  • ISBN : 9781592599226
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Summary : This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, formulation and viral inactivation who cover all aspects of protein drug production downstream of the discovery stage. Protocols for the production of therapeutic proteins using a variety of sources are covered. including bacterial and yeast expression systems, insect and mammalian cells. Therapeutic Proteins: Methods and Protocols will prove an invaluable resourse to all those working in the field of therapeutic protein production.

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher :Unknown
  • Release Date :2018-02-21
  • Total pages :312
  • ISBN : 9789535138259
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Summary : Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display methods, humanization by chain shuffling, affinity maturation techniques, de novo synthesis of antibody genes, colony assays for library screening, construction of scFvs from hybridomas, and purification of monoclonal antibodies by exclusion chromatography. In addition, other topics that are discussed in this book are application and mechanism of single domain antibodies, structural diversity of antibodies, immune-mediated skin reactions induced by TNF-alpha recombinant antibodies, and bioinformatic approaches to select pathogen-derived peptide sequences for antibody targets.

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability

State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability
  • Author : Anthony R. Mire-Sluis
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :213
  • ISBN : UOM:39015062415834
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Summary : With the latest advances in analytical technologies, most biological products can now be extensively characterized in terms of their identity, heterogeneity and impurity profile. The currently available analytical methods (both physicochemical and biological) can characterize the primary, secondary and to some extent, the higher order structure of proteins. The sensitivity and selectivity of these methods allow for the identification and characterization not only of the desired protein component, but also many product-related substances and impurities as well as process-related impurities present in the drug preparations. Using an appropriate selection of analytical tools, it may be possible to demonstrate physicochemical and functional comparability between protein products manufactured before and after a manufacturing change or during product development. However, the extent of demonstrable comparability depends on the tests used, on the nature of the product and on the basic understanding of structure-function relationships. Assessment of immunogenicity is also a critical component of product characterization and is highly dependent on the types of assays used.

Modern HPLC for Practicing Scientists

Modern HPLC for Practicing Scientists
  • Author : Michael W. Dong
  • Publisher :Unknown
  • Release Date :2016-04-06
  • Total pages :304
  • ISBN : 9781119293606
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Summary : A comprehesive yet concise guide to Modern HPLC Written for practitioners by a practitioner, Modern HPLC for Practicing Scientists is a concise text which presents the most important High-Performance Liquid Chromatography (HPLC) fundamentals, applications, and developments. It describes basic theory and terminology for the novice, and reviews relevant concepts, best practices, and modern trends for the experienced practitioner. Moreover, the book serves well as an updated reference guide for busy laboratory analysts and researchers. Topics covered include: HPLC operation Method development Maintenance and troubleshooting Modern trends in HPLC such as quick-turnaround and "greener" methods Regulatory aspects While broad in scope, this book focuses particularly on reversed-phase HPLC, the most common separation mode, and on applications for the pharmaceutical industry, the largest user segment. Accessible to both novice and intermedate HPLC users, information is delivered in a straightforward manner illustrated with an abundance of diagrams, chromatograms, tables, and case studies, and supported with selected key references and Web resources. With intuitive explanations and clear figures, Modern HPLC for Practicing Scientists is an essential resource for practitioners of all levels who need to understand and utilize this versatile analytical technology.

Scientific Report

Scientific Report
  • Author : Ohio State University. Comprehensive Cancer Center
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :229
  • ISBN : OSU:32435027704311
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Summary :

Genetic Engineering News

Genetic Engineering News
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :229
  • ISBN : STANFORD:36105113164730
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Summary :

State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization

State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization
  • Author : Oleg Borisov
  • Publisher :Unknown
  • Release Date :2014
  • Total pages :229
  • ISBN : 0841230269
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Summary :

Basic Methods in Antibody Production and Characterization

Basic Methods in Antibody Production and Characterization
  • Author : Gary C. Howard,Delia R. Bethell
  • Publisher :Unknown
  • Release Date :2000-09-21
  • Total pages :288
  • ISBN : 142003653X
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Summary : Written for researchers and professionals in the fields of biomedical research, immunology, biochemistry, molecular biology, pathology, and biotechnology, Basic Methods in Antibody Production and Characterization uses a cookbook approach to presenting the methods for the production, characterization, and use of antibodies. Antibodies described include polyclonal and monoclonal and those made by the phage display. Basic Methods in Antibody Production and Characterization focuses on specific aspects of antibodies and takes readers on a step-by-step process from antigen preparation to immunizations, adjuvants, screening, purification, storage, and applications. Introductory material accompanies each chapter, giving readers a better understanding of the methods and applications. Ample references arm researchers with many applications pertaining to the particular technology.

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
  • Author : Zhiqiang An
  • Publisher :Unknown
  • Release Date :2011-09-20
  • Total pages :896
  • ISBN : 9781118210260
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Summary : 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Current Research on Pre-clinical Aspects of Cancer Therapy

Current Research on Pre-clinical Aspects of Cancer Therapy
  • Author : Current Cancer Research Project Analysis Center (U.S.)
  • Publisher :Unknown
  • Release Date :1975
  • Total pages :271
  • ISBN : STANFORD:36105219431199
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Summary :

Development of Antibody-Based Therapeutics

Development of Antibody-Based Therapeutics
  • Author : Mohammad A. Tabrizi,Gadi G. Bornstein,Scott L. Klakamp
  • Publisher :Unknown
  • Release Date :2018-09-11
  • Total pages :248
  • ISBN : 9789811304965
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Summary : With a key focus on recent developments and advances in the field, this book provides in-depth coverage of topics fundamental to the development of targeted therapeutics. The expansion of targeted modalities in rapidly evolving therapeutic areas, such as immune-oncology, and developments with respect to combination therapies, novel technologies, and the therapeutic application of antibody-drug conjugates, are presented. Additionally, the book builds upon topics discussed in the first edition (2012) where recent innovations warrant elaboration. This, the second edition of Development of Antibody-Based Therapeutics: Translational Considerations, represents a comprehensive evaluation of progress in the field, which sits alongside the first edition to inform, in detail, professional and academic researchers, as well as graduate students.