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Asthma and COPD

Asthma and COPD
  • Author : Peter J. Barnes,Jeffrey M. Drazen,Stephen I. Rennard,Neil C. Thomson
  • Publisher :Unknown
  • Release Date :2009-03-19
  • Total pages :896
  • ISBN : 9780080920603
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Summary : The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

Asthma, COPD, and Overlap

Asthma, COPD, and Overlap
  • Author : Jonathan A. Bernstein,Louis-Philippe Boulet,Michael E. Wechsler, MD,MMSc
  • Publisher :Unknown
  • Release Date :2018-03-22
  • Total pages :290
  • ISBN : 9780429765186
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Summary : Using illustrative case examples, this book thoroughly reviews similarities and differences between asthma, chronic obstructive pulmonary disease (COPD) and the overlap syndrome. It is important to highlight the distinctions because these commonly encountered conditions in respiratory and primary care share many similarities but have important differences often mistaken for each other. This can have serious implications for treatment, particularly as new treatments are targeted at specific phenotypes of the diseases. This practical guide shows how to distinguish between the diseases on a pathological and clinical basis so that appropriate management and treatment may be pursued.

COPD Clinical Perspectives

COPD Clinical Perspectives
  • Author : Ralph J. Panos
  • Publisher :Unknown
  • Release Date :2014-07-16
  • Total pages :208
  • ISBN : 9789535116240
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Summary : Chronic Obstructive Pulmonary Disease (COPD) is an increasingly recognized cause of morbidity and mortality. Over the next 10 years, deaths due to COPD are expected to increase by 30% and, by 2030, COPD is estimated to be the third leading cause of death worldwide. Research into the pathophysiology and management of COPD over the past decade has progressed immensely with greater understanding of the global burden of COPD, its pathophysiology, better understanding of the multisystemic manifestations of COPD, and, most importantly, novel and more effective therapeutic strategies. This volume brings together an international group of experts in COPD to provide in depth reviews of clinical perspectives into COPD. Topics range from the diagnosis of airflow limitation by spirometry; distinguishing COPD from another common obstructive lung disease, asthma; alpha-1-antitrypsin deficiency and opportunities to diagnose this most common hereditary cause of COPD and as a paradigm for the development of novel therapeutics; the overlap syndrome - the concurrence of two epidemic disorders: COPD and obstructive sleep apnea; and pulmonary rehabilitation, one of the most effective treatments for COPD.

New Drugs and Targets for Asthma and COPD

New Drugs and Targets for Asthma and COPD
  • Author : T.T. Hansel,P.J. Barnes
  • Publisher :Unknown
  • Release Date :2010-08-31
  • Total pages :324
  • ISBN : 9783805595674
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Summary : Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.

New Drugs for Asthma, Allergy and COPD

New Drugs for Asthma, Allergy and COPD
  • Author : Trevor T. Hansel,Peter J. Barnes
  • Publisher :Unknown
  • Release Date :2001-01-01
  • Total pages :389
  • ISBN : 9783805568623
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Summary : This book provides a state-of-the-art account by academic respiratory physicians and senior pharmaceutical industry personnel on the development of new drugs for asthma, allergy and COPD. It contains 80 chapters of highly condensed information, presented in an attractive, reader-friendly format with much use of tables, figures and diagrams. In addition to summarizing the diverse range of current approaches, this handbook also looks into the future, considering many topics that are promising, but have only emerged in the last few years. Developments within established drug categories such as beta-2-agonists, steroids and leukotriene antagonists are also reviewed. Never before has a single book brought together so many pharmaceutical drug developers sharing their experience on such a wide range of respiratory topics!

Pharmacology and Therapeutics of Asthma and COPD

Pharmacology and Therapeutics of Asthma and COPD
  • Author : Clive P. Page,Peter J. Barnes
  • Publisher :Unknown
  • Release Date :2004-01-07
  • Total pages :378
  • ISBN : 3540004645
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Summary : The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology.

Advances in Combination Therapy for Asthma and COPD

Advances in Combination Therapy for Asthma and COPD
  • Author : Jan Lotvall
  • Publisher :Unknown
  • Release Date :2011-11-28
  • Total pages :352
  • ISBN : 9781119978466
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Summary : Aimed at specialists in respiratory medicine, this new book comprehensively reviews the variety of agents currently available for treatment of asthma, COPD, and other airway diseases and covers practical guidelines as well as challenges and complications in their use. Advances in Combination Therapy for Asthma and COPD is the first book to address the complexity of multi-agent therapy and deal with management issues in an integrated fashion. A review of currently available agents and their applications, as well as new therapies soon to become available are outlined. Advantages of combined therapies and additional considerations that arise from multi-agent programs are highlighted.

Pharmacology of Asthma

Pharmacology of Asthma
  • Author : Clive P. Page,Peter J. Barnes
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :320
  • ISBN : 9783642758553
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Summary : This volume forms part of a prestigious series and covers the latest advances in our understanding of the pathophysiology and treatment of asthma. Our understanding of asthma has changed dramatically in recent years, and much of this new information is brought together in this volume written by inter nationally recognised authorities. The aim of the book is to review in depth the changing concepts of inflammatory processes in asthma and to discuss the implications for research of this common chronic disease. Many of the advances in and future therapy our understanding of asthma have originated from a pharmacological approach, and this volume highlights the promising new options for pharma cological intervention. It is hoped this book will be invaluable for research scientists and clinic ians involved in asthma research and will be a major reference resource for chest physicians and those involved in the development of novel pharmaceu tical entities. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this growing area. c.P. PAGE P.l. BARNES Contents CHAPTER 1 The Pathology of Asthma: An Overview L.A. LAmNEN and A. LAmNEN. With 10 Figures ...................... 1 A. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . . . . . . . . . . B. Methods to Investigate the Pathology of Human Asthma ............ 1 C. Bronchial Epithelium and Inflammatory Cells in Asthmatic Patients Between Attacks ........................... 2 I. Mast Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . 4 . . . . . . . . . . . . . . II. Eosinophils ............................................... 7 III. Neutrophils.............................................. 10 D. Bronchial Epithelial Inflammation During an Asthma Attack. . . . . .. . 10 E. Epithelial Regeneration .... . . . . . . . . . . . . . . . . . . . . . . .. . . 12 . . . . . . . . .

Asthma-COPD Overlap Syndrome (ACOS): Single Disease Entity Or Not? Could Exhaled Nitric Oxide be a Useful Biomarker for the Differentiation of ACOS, Asthma and COPD?.

Asthma-COPD Overlap Syndrome (ACOS): Single Disease Entity Or Not? Could Exhaled Nitric Oxide be a Useful Biomarker for the Differentiation of ACOS, Asthma and COPD?.
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :229
  • ISBN : OCLC:1052059219
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Summary : Abstract: Asthma and chronic obstructive pulmonary disease (COPD) represent two major public health problems. However, there is a significant proportion of patients with a mixed asthma-COPD phenotype. This condition is defined as asthma-COPD overlap syndrome (ACOS). Since there are no internationally accepted criteria for the diagnosis of that syndrome, its management remains difficult. Given the fact that patients with ACOS have an increased risk of exacerbation and hospitalization, there is a pressing need for a more targeted approach and better management. We propose that fractional exhaled nitric oxide (FeNO), a marker of eosinophilic inflammation, could help clinicians differentiate ACOS from asthma and COPD. We evaluate this hypothesis, using data derived from the existing literature.

Asthma

Asthma
  • Author : Celso Pereira
  • Publisher :Unknown
  • Release Date :2016-07-06
  • Total pages :254
  • ISBN : 9789535124412
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Summary : The clinical specificities developed in this book, particularly from those reported in the pediatric population to those reported in complex shapes at ACOS patients, emphasize the importance of identifying not only biomarkers but also critical aspects regarding the variability in pharmacogenomics responsible for the individual response to the different drugs on the therapeutic plan. The contribution of several well-known specialists with their profound knowledge inherent to this issue into different age groups and socio geographical contexts has resulted in this interesting book with relevant key contents in asthma.

Current Review of Asthma

Current Review of Asthma
  • Author : Michael A. Kaliner
  • Publisher :Unknown
  • Release Date :2013-11-11
  • Total pages :245
  • ISBN : 9781461310952
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Summary : This comprehensive source of up-to-date information on asthma diagnosis and treatment offers concise discussions on concomitant diseases and treatment choices. Coverage includes epidemiology, pathology, airway remodeling, and pathophysiology. Each chapter offers a topic overview, followed by an analysis of current understanding, supplemented by charts, tables, and graphs. Dr. Michael A. Kaliner, the editor, contributes a chapter, "The Pathogenesis of Bronchial Asthma," drawing on his 30 years of clinical experience.

Airway Remodeling

Airway Remodeling
  • Author : Peter H. Howarth,John William Wilson,Jean Bousquet,Sabina Rak,Romain Pauwels
  • Publisher :Unknown
  • Release Date :2001-01-16
  • Total pages :328
  • ISBN : 0824704487
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Summary : This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias! Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodeling describes the contribution of inflammatory cells in the development of airway structural changes examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling reviews the action of cytokines and growth factors on ASM signaling outlines novel approaches to regulating smooth muscle growth clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation and more! Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.

Bronchial Vascular Remodeling in Asthma and COPD

Bronchial Vascular Remodeling in Asthma and COPD
  • Author : Aili Lazaar
  • Publisher :Unknown
  • Release Date :2006-08-04
  • Total pages :233
  • ISBN : 1420018450
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Summary : Responding to the growth of research in the field over the past decade, this book brings together leading investigators with expertise in pulmonology, pathology, and developmental biology to clarify the mechanisms that regulate the development of bronchial vascular remodeling in asthma and COPD, as well as explore the pathophysiological processes that may impact the formulation of new therapeutic strategies for these conditions.

Lung Function

Lung Function
  • Author : John E. Cotes,Robert L. Maynard,Sarah J. Pearce,Benoit B. Nemery,Peter D. Wagner,Brendan G. Cooper
  • Publisher :Unknown
  • Release Date :2020-03-13
  • Total pages :808
  • ISBN : 9781118597323
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Summary : The seventh edition of the most authoritative and comprehensive book published on lung function, now completely revised and restructured Lung function assessment is the central pillar of respiratory diagnosis. Most hospitals have lung function laboratories where patients are tested with a variety of physiological methods. The tests and techniques used are specialized and utilize the expertise of respiratory physicians, physiologists, and technicians. This new edition of the classic text on lung function is a theoretical textbook and practical manual in one that gives a comprehensive account of lung function and its assessment in healthy persons and those with all types of respiratory disorder, against a background of respiratory, exercise, and environmental physiology. It incorporates the technical and methodological recommendations for lung function testing of the American Thoracic Society and European Respiratory Society. Cotes' Lung Function, 7th Edition is filled with chapters covering respiratory surveys, respiratory muscles, neonatal assessment, exercise, sleep, high altitude, hyperbaria, the effects of cold and heat, respirable dusts, fumes and vapors, anesthesia, surgery, and respiratory rehabilitation. It also offers a compendium of lung function in selected individual diseases and is filled with more diagrams and illustrative cases than previous editions. The only text to cover lung function assessment from first principles including methodology, reference values, and interpretation Completely re-written in a contemporary style—includes user-friendly equations and more diagrams Covers the latest advances in the treatment of lung function, including a stronger clinical and practical bias and more on new techniques and equipment Keeps mathematical treatments to a minimum Cotes' Lung Function is an ideal guide for respiratory physicians and surgeons, staff of lung function laboratories, and others who have a professional interest in the function of the lungs at rest or on exercise and how it may be assessed. Physiologists, anthropologists, pediatricians, anesthetists, occupational physicians, explorers, epidemiologists, and respiratory nurses should also find the book useful.

Chronic Obstructive Pulmonary Disease Exacerbations

Chronic Obstructive Pulmonary Disease Exacerbations
  • Author : Jadwiga A. Wedzicha,Fernando J. Martinez
  • Publisher :Unknown
  • Release Date :2008-09-22
  • Total pages :456
  • ISBN : 9781420070873
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Summary : Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat

Controversies in COPD

Controversies in COPD
  • Author : Antonio Anzueto,Yvonne Heijdra,John R. Hurst
  • Publisher :Unknown
  • Release Date :2015-09-01
  • Total pages :336
  • ISBN : 9781849840644
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Summary : Edited by Antonio Anzueto, Yvonne Heijdra and John R. Hurst COPD is one of the most common diseases worldwide and is projected to be the third leading cause of death by 2020. But that does not mean it is easy to understand or manage. In everyday practice, pulmonologists face areas of controversy in COPD, for which evidence-based medicine is often unavailable. This ERS Monograph considers where the current controversies in COPD lie, discussing areas such as screening, premature birth, asthma–COPD overlap syndrome, treatment, rehabilitation and palliative care. This book will be of great interest to both clinicians and scientists, and aims to stimulate further discussion about this diverse and fascinating disease. "...contains a vast amount of information on the disease, its prevalence, signs and symptoms, diagnositc tests and treatment options. The book's format makes it quick and simple to find out what you need to know, and its size would make it easy to take to work for use in practice [...] invaluable for anyone working with patients with the disease." Emma Vincent, Nursing Standard

Asthma and COPD

Asthma and COPD
  • Author : David Price
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :143
  • ISBN : UOM:39015058245971
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Summary : The In Clinical Practice series aims to provide expert information 'at your fingertips' - concise handbooks organized in a straightforward manner. The series is designed to meet the needs of the busy primary care providers by delivering authoritative and accessible information from clinical experts to assist with treatment decisions. Jointly written by specialists and GPs to provide cutting edge information tailored perfectly for the primary care setting Include management algorithms to provide quick reference treatment pathways Credible evidence-based sources - when possible, evidence base for best practice by reference to primary research or international guidelines Bullet lists and short tables for clear presentation of key information

A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases

A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases
  • Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases
  • Publisher :Unknown
  • Release Date :2011-08-26
  • Total pages :200
  • ISBN : 9780309212199
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Summary : Chronic diseases are common and costly, yet they are also among the most preventable health problems. Comprehensive and accurate disease surveillance systems are needed to implement successful efforts which will reduce the burden of chronic diseases on the U.S. population. A number of sources of surveillance data--including population surveys, cohort studies, disease registries, administrative health data, and vital statistics--contribute critical information about chronic disease. But no central surveillance system provides the information needed to analyze how chronic disease impacts the U.S. population, to identify public health priorities, or to track the progress of preventive efforts. A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases outlines a conceptual framework for building a national chronic disease surveillance system focused primarily on cardiovascular and chronic lung diseases. This system should be capable of providing data on disparities in incidence and prevalence of the diseases by race, ethnicity, socioeconomic status, and geographic region, along with data on disease risk factors, clinical care delivery, and functional health outcomes. This coordinated surveillance system is needed to integrate and expand existing information across the multiple levels of decision making in order to generate actionable, timely knowledge for a range of stakeholders at the local, state or regional, and national levels. The recommendations presented in A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases focus on data collection, resource allocation, monitoring activities, and implementation. The report also recommends that systems evolve along with new knowledge about emerging risk factors, advancing technologies, and new understanding of the basis for disease. This report will inform decision-making among federal health agencies, especially the Department of Health and Human Services; public health and clinical practitioners; non-governmental organizations; and policy makers, among others.

Models of Exacerbations in Asthma and COPD

Models of Exacerbations in Asthma and COPD
  • Author : Ulf Sjöbring,Dr. John D. Taylor
  • Publisher :Unknown
  • Release Date :2007-01-01
  • Total pages :145
  • ISBN : 9783805583329
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Summary : This volume provides an overview of exacerbation models of asthma and chronic obstructive pulmonary disease (COPD). Within this wide field the book focuses on experimental systems that mimic pathobiological processes likely to be critical in exacerbations of these conditions. To generate insight into the mechanisms of exacerbation of pulmonary disease and to promote the discovery of future treatments, both animal models and human experimental models are described. For this update some of the most eminent scientists within the area of pulmonology could be recruited to share their knowledge of this evolving field of human medicine. Models of Exacerbations in Asthma and COPD will be of great interest to pulmonologists, allergologists, specialists in internal medicine and critical care, as well as to microbiologists, infectiologists and pharmacologists studying the response to respiratory infections.

The Nose and Sinuses in Respiratory Disorders

The Nose and Sinuses in Respiratory Disorders
  • Author : Claus Bachert,Arnaud Bourdin,Pascal Chanez
  • Publisher :Unknown
  • Release Date :2017-06-01
  • Total pages :224
  • ISBN : 9781849840866
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Summary :

Pocket Guide to COPD Diagnosis, Management and Prevention

Pocket Guide to COPD Diagnosis, Management and Prevention
  • Author : Global Initiative for Chronic Obstructive Lung Disease
  • Publisher :Unknown
  • Release Date :2017-11-15
  • Total pages :50
  • ISBN : 1986342220
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Summary : Chronic Obstructive Pulmonary Disease (COPD) represents an important public health challenge and is a major cause of chronic morbidity and mortality throughout the world. COPD is currently the fourth leading cause of death in the world1 but is projected to be the 3rd leading cause of death by 2020. More than 3 million people died of COPD in 2012 accounting for 6% of all deaths globally. Globally, the COPD burden is projected to increase in coming decades because of continued exposure to COPD risk factors and aging of the population.2 This Pocket Guide has been developed from the Global Strategy for the Diagnosis, Management, and Prevention of COPD (2018 Report), which aims to provide a non-biased review of the current evidence for the assessment, diagnosis and treatment of patients with COPD that can aid the clinician. Discussions of COPD and COPD management, evidence levels, and specific citations from the scientific literature are included in that source document, which is available from www.goldcopd.org. The tables and figures in this Pocket Guide follow the numbering of the 2018 Global Strategy Report for reference consistency.