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Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease

Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease
  • Author : Ronald Ross Watson,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2014-09-11
  • Total pages :528
  • ISBN : 9780124115293
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Summary : Nutritional supplement research concerning brain health and neurological disease is becoming an important focus. While nutritional supplements are very popular for general health and well being, the effectiveness of common supplements and their impact on general brain health and for the treatment or prevention of neurological disease is not clearly understood. This comprehensive introduction to bioactive nutraceuticals for brain and neurological provides a foundation review for research neuroscientists, clinical neurologists, pharmacology researchers and nutrition scientists on what we know now about these supplements and the brain and where focused research is still necessary. Foundational review content covering nutrition and brain and neurological health Reviews known nutritional supplements and impact on brain and neurological health Comprehensive coverage ideal for research scientists and clinical practitioners

Nutraceuticals in Brain Health and Beyond

Nutraceuticals in Brain Health and Beyond
  • Author : Dr. Dilip Ghosh
  • Publisher :Unknown
  • Release Date :2020-11-12
  • Total pages :476
  • ISBN : 9780128206102
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Summary : Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer’s, Parkinson’s, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health. Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. • Addresses nutritional psychiatry and cognitive health at all stages of the lifespan • Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients • Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders • Explores the role of genomics and epigenetics, including discussion of the gut–brain axis

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases

Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2017-10-24
  • Total pages :484
  • ISBN : 9780128119600
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Summary : Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases
  • Author : Colin R. Martin,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2020-06-12
  • Total pages :444
  • ISBN : 9780128177815
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Summary : Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases
  • Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
  • Publisher :Unknown
  • Release Date :2016-09-20
  • Total pages :496
  • ISBN : 9783319283838
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Summary : Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Neuroscience of Alcohol

Neuroscience of Alcohol
  • Author : Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2019-03-19
  • Total pages :736
  • ISBN : 9780128131268
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Summary : Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects

Neuroprotective Effects of Phytochemicals in Neurological Disorders

Neuroprotective Effects of Phytochemicals in Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2017-03-20
  • Total pages :648
  • ISBN : 9781119155140
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Summary : Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Nutrition in Neurologic Disorders

Nutrition in Neurologic Disorders
  • Author : Ethem Murat Arsava
  • Publisher :Unknown
  • Release Date :2017-06-01
  • Total pages :206
  • ISBN : 9783319531717
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Summary : This book offers focused and concise coverage of all issues relating to malnutrition in the field of neurology, and in particular addresses practical aspects of nutritional support from a neurology perspective. In addition to providing basic knowledge on important nutritional concepts (body metabolism, assessment and diagnosis of malnutrition, epidemiology, enteral/parenteral nutrition), detailed information is presented on nutritional support for various neurologic disorders handled in a variety of settings, including the neurointensive care unit. Much consideration is also given to the diagnosis and management of dysphagia, which is a common and highly critical cause of malnutrition in these patients. Finally, the newly developing concept of neuronutrition (or brain foods) – the use of certain nutrients for treatment of neurologic disorders – is discussed. By providing practical solutions to commonly encountered challenges in the nutritional management of neurologic patients, this book will prove a valuable resource for practicing neurologists in a wide variety of fields. It will also be very useful for medical personnel from other specialties such as clinical nutrition, critical care, and geriatric medicine.

Anti-inflammatory Nutraceuticals and Chronic Diseases

Anti-inflammatory Nutraceuticals and Chronic Diseases
  • Author : Subash Chandra Gupta,Sahdeo Prasad,Bharat B. Aggarwal
  • Publisher :Unknown
  • Release Date :2016-09-26
  • Total pages :482
  • ISBN : 9783319413341
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Summary : This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.

Gerontology

Gerontology
  • Author : Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco
  • Publisher :Unknown
  • Release Date :2018-07-04
  • Total pages :276
  • ISBN : 9781789232523
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Summary : Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.

Nutraceuticals

Nutraceuticals
  • Author : Ramesh C. Gupta
  • Publisher :Unknown
  • Release Date :2016-01-28
  • Total pages :1040
  • ISBN : 9780128021651
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Summary : Nutraceuticals: Efficacy, Safety and Toxicity brings together all current knowledge regarding nutraceuticals and their potential toxic effects as written by the scientists at the forefront of their study. Users will find an introduction to nutraceuticals, herbal medicines, ayurvedic medicines, prebiotics, probiotics, and adaptogens, along with their use and specific applications. This essential reference then discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and their interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered, providing a comprehensive overview of the most effective tools for the evaluation, safety, and toxicity of nutraceuticals, prebiotics, probiotics, and alternative medicines. Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effects Provides effective tools to evaluate the potential toxicity of any nutraceutical Includes details of regulatory issues as written by international experts

Nutrigenomics and Proteomics in Health and Disease

Nutrigenomics and Proteomics in Health and Disease
  • Author : Martin Kussmann,Patrick J. Stover
  • Publisher :Unknown
  • Release Date :2017-05-08
  • Total pages :344
  • ISBN : 9781119098836
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Summary : "This volume brings together leading experts in the areas of nutrition, nutrigenomics, metabolic programming, food-based bioactive dietary components and the gut microbiome, as well as those expert in the application of innovative tools and methods for statistical and biological network analysis, which are now at the forefront of nutritional and biomedical sciences. The articles provide a roadmap for the integration of normative science methods and approaches with more comprehensive systems biology-based investigations that deploy a multitude of omic platforms. This integration is essential to escape the bottleneck in knowledge generation by applying decades of knowledge of nutrients and their function to comprehensive omics and clinical data acquisition, processing, visualization, and interpretation. Achieving a systems-level understanding of nutrient function in health and disease will usher in an age of precision nutrition in support of maximizing human health and potential"--

Neuroscience of Nicotine

Neuroscience of Nicotine
  • Author : Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2019-03-20
  • Total pages :566
  • ISBN : 9780128130360
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Summary : Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse. With an estimated one billion individuals worldwide classified as tobacco users—and tobacco use often being synonymous with nicotine addiction—nicotine is one of the world’s most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects

Functional Foods and Nutraceuticals

Functional Foods and Nutraceuticals
  • Author : Chukwuebuka Egbuna,Genevieve Dable Tupas
  • Publisher :Unknown
  • Release Date :2020-08-24
  • Total pages :642
  • ISBN : 9783030423193
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Summary : Functional foods and nutraceuticals are food products that naturally offer or have been modified to offer additional health benefits beyond basic nutrition. As such products have surged in popularity in recent years, it is crucial that researchers and manufacturers understand the concepts underpinning functional foods and the opportunity they represent to improve human health, reduce healthcare costs, and support economic development worldwide. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations presents a guide to functional foods from experienced professionals in key institutions around the world. The text provides background information on the health benefits, bioavailability, and safety measurements of functional foods and nutraceuticals. Subsequent chapters detail the bioactive components in functional foods responsible for these health benefits, as well as the different formulations of these products and recent innovations spurred by consumer demands. Authors emphasize product development for increased marketability, taking into account safety issues associated with functional food adulteration and solutions to be found in GMP adherence. Various food preservation methods aimed at enhancing the quality and shelf life of functional food are also highlighted. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations is the first of its kind, designed to be useful to students, teachers, nutritionists, food scientists, food technologists and public health regulators alike.

Nutraceuticals and the Skin: Roles in Health and Disease

Nutraceuticals and the Skin: Roles in Health and Disease
  • Author : Jean Christopher Chamcheu,Deeba Nadeem Syed,G. Kerr Whitfield
  • Publisher :Unknown
  • Release Date :2018-10-08
  • Total pages :224
  • ISBN : 9783038971924
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Summary : This book is a printed edition of the Special Issue "Nutraceuticals and the Skin: Roles in Health and Disease" that was published in Nutrients

Omega-3 Fatty Acids in Brain and Neurological Health

Omega-3 Fatty Acids in Brain and Neurological Health
  • Author : Ronald Ross Watson,Fabien De Meester
  • Publisher :Unknown
  • Release Date :2014-06-25
  • Total pages :496
  • ISBN : 9780124105478
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Summary : Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health. The first book-length collection of original research on the connection between omega-3 fatty acids and the brain Provides a comprehensive introduction to the state of research on omega-3 fatty acids and the brain and directions for future research A foundational collection for neuroscience, neurology, and nutrition research

Functional Foods, Ageing and Degenerative Disease

Functional Foods, Ageing and Degenerative Disease
  • Author : C Remacle,B Reusens
  • Publisher :Unknown
  • Release Date :2004-06-09
  • Total pages :792
  • ISBN : 9781855739017
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Summary : Degenerative diseases linked to ageing populations are a growing problem for the developed world. Edited by two authorities, this important collection reviews the role of functional foods in helping to prevent a number of such degenerative conditions, from osteoporosis and obesity to immune system disorders and cancer. The book begins with a number of introductory chapters which discuss the regulation of functional foods in the EU, the role of diet generally in preventing degenerative disease. Part one then examines bone and oral health with chapters on the use of diet to control osteoporosis, the use of functional ingredients to improve bone strength, and ways of maintaining dental health. Part two discusses how obesity can be controlled, whilst part three looks at gut health and maintaining the immune function using functional ingredients such as probiotics and prebiotics. The final part of the book reviews research on functional foods and cancer with chapters on synbiotics, anti-angiogenic functional foods, glucosinolates, dietary fibre and phytoestrogens. Functional foods, ageing and degenerative disease is a standard reference for all those concerned with the role of functional foods in the prevention and control of degenerative disease. Explores diet strategies for preventing diseases including osteoporosis Summarises key management techniques for obesity, irritable bowel syndrome and oral health Presents the role of functional foods in promoting good health

Oxidative Stress and Chronic Degenerative Diseases

Oxidative Stress and Chronic Degenerative Diseases
  • Author : Jose Antonio Morales-Gonzalez
  • Publisher :Unknown
  • Release Date :2013-05-22
  • Total pages :514
  • ISBN : 9789535111238
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Summary : This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Nutraceutical and Functional Food Regulations in the United States and Around the World

Nutraceutical and Functional Food Regulations in the United States and Around the World
  • Author : Debasis Bagchi
  • Publisher :Unknown
  • Release Date :2014-02-25
  • Total pages :592
  • ISBN : 9780124059122
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Summary : This fully revised and updated edition begins with insights into the scope, importance and continuing growth opportunities in the nutraceutical and functional food industries and explores the latest regulatory changes and their impacts. The book demonstrates the global scenario of the acceptance and demand for these products and explores the regulatory hurdles and claim substantiation of these foods and dietary supplements, as well as addressing the intricate aspects of manufacturing procedures. As the public gains confidence in the quality of these products based on sophisticated quality control, a broad spectrum of safety studies and GRAS, peer-reviewed publications and cutting-edge human clinical studies have emerged. An increasing number of additional populations around-the-world now recognize the efficacy and functions of nutraceuticals and functional foods as established by those scientific research studies. As a result, a number of structurally and functionally active novel nutraceuticals and several new functional beverages have been introduced into the marketplace around the world. Features fully revised and updated information with current regulations from around the world, including GRAS status and DSHEA regulators Offers 45% new content including three new chapters –NSF: Ensuring the Public Health and Safety Aspects of Nutraceuticals and Functional Foods; Role of the United States Pharmacoepia in the Establishment of Nutraceuticals and Functional Food Safety; An Overview on the New Dietary Ingredient (NDI) and Generally Recognized as Safe (GRAS) Status, and the addition of cGMP regulations for dietary supplements Includes insight into working with regulatory agencies, processes and procedures Provides a link to the contact information for most regulatory bodies for readers wishing to gain further knowledge

Functional Foods, Nutraceuticals, and Degenerative Disease Prevention

Functional Foods, Nutraceuticals, and Degenerative Disease Prevention
  • Author : Gopinadhan Paliyath,Marica Bakovic,Kalidas Shetty
  • Publisher :Unknown
  • Release Date :2011-08-15
  • Total pages :424
  • ISBN : 9780470960820
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Summary : Functional Foods, Nutraceuticals and Degenerative Disease Prevention is a compilation of different segments of functional foods and nutraceuticals focusing on their mechanism of action in the human body leading to disease prevention. Numerous chapters deal with different functional foods in terms of their efficacy, highlighting the mechanism of action of their ingredients. The book focuses on the biochemistry and molecular biology of the disease prevention process rather than simply compiling the benefits of functional foods and nutraceuticals. Aimed primarily at an audience comprised of researchers, industry professionals, food scientists, medical professionals and graduate level students, Functional Foods, Nutraceuticals and Degenerative Disease Prevention offers a mechanism-based interpretation for the effect of nutraceuticals within the human body. Ultimately, the discussion of the biological effects of a variety of functional foods will provide a wholesome approach to the maintenance of health through judicious choice of functional foods.

Nutraceuticals and Human Health

Nutraceuticals and Human Health
  • Author : Paul A Spagnuolo
  • Publisher :Unknown
  • Release Date :2020-03-25
  • Total pages :238
  • ISBN : 9781788014168
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Summary : Nutraceuticals is a broad umbrella term used to describe any product derived from food sources with extra health benefits in addition to the basic nutritional value found in foods. This book is a comprehensive look at two themes in the area: technical and biological considerations. Technical considerations include an in-depth look at the process of bioactive identification and extraction and factors controlling bioactive concentrations in food. It also includes details of how these products are regulated and the steps necessary to utilize these products in human populations. Biological considerations include looking at how these products can be used in the prevention and treatment of chronic diseases, and a discussion on the process of formulations and how these influence bioavailability. This will be the first book to comprehensively examine the entire process of nutraceutical development from food to supplement creation and all the important considerations in between. This serves as an excellent and up-to-date reference for food scientists, food chemists, researchers in nutraceuticals and human nutrition.