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Bioassays

Bioassays
  • Author : Donat Hader,Gilmar Erzinger
  • Publisher :Unknown
  • Release Date :2017-10-27
  • Total pages :464
  • ISBN : 9780128118900
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Summary : Bioassays: Advanced Methods and Applications provides a thorough understanding of the applications of bioassays in monitoring toxicity in aquatic ecosystems. It reviews the newest tests and applications in discovering compounds and toxins in the environment, covering all suitable organisms, from bacteria, to microorganisms, to higher plants, including invertebrates and vertebrates. By learning about newer tests, water pollution control testing can be less time and labor consuming, and less expensive. This book will be helpful for anyone working in aquatic environments or those who need an introduction to ecotoxicology or bioassays, from investigators, to technicians and students. Features chapters written by internationally renowned researchers in the field, all actively involved in the development and application of bioassays Gives the reader an understanding of the advantages and deficiencies of available tests Addresses the problem of understanding the impact of toxins in an aquatic environment and how to assess them

Behavioral Bioassays

Behavioral Bioassays
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1974
  • Total pages :308
  • ISBN : UCSD:31822012269999
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Summary :

Algal Bioassays with Leachates and Distillates from Western Coal

Algal Bioassays with Leachates and Distillates from Western Coal
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1980
  • Total pages :69
  • ISBN : UCR:31210012934053
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Summary :

Role of Acute Toxicity Bioassays in the Remedial Action Process at Hazardous Waste Sites

Role of Acute Toxicity Bioassays in the Remedial Action Process at Hazardous Waste Sites
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1987
  • Total pages :229
  • ISBN : UIUC:30112112943417
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Summary :

Pharmaceutical Bioassays

Pharmaceutical Bioassays
  • Author : Shiqi Peng,Ming Zhao
  • Publisher :Unknown
  • Release Date :2009-12-09
  • Total pages :480
  • ISBN : 0470522194
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Summary : The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer's, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications

Bioassays of Entomopathogenic Microbes and Nematodes

Bioassays of Entomopathogenic Microbes and Nematodes
  • Author : Amos Navon,K. R. S. Ascher
  • Publisher :Unknown
  • Release Date :2000-01-01
  • Total pages :324
  • ISBN : 0851999204
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Summary : This volume provides background theory and practical protocols for bioassays of bacteria, viruses, fungi and nematodes that can be used as biological control agents against insect pests of agricultural and medical importance.

Bioassays with Arthropods

Bioassays with Arthropods
  • Author : Jacqueline L. Robertson,Moneen Marie Jones,Efren Olguin,Brad Alberts
  • Publisher :Unknown
  • Release Date :2017-06-26
  • Total pages :194
  • ISBN : 9781482217094
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Summary : Imagine a statistics book for bioassays written by a statistician. Next, imagine a statistics book for bioassays written for a layman. Bioassays with Arthropods, Third Edition offers the best of both worlds by translating the terse, precise language of the statistician into language used by the laboratory scientist. The book explains the statistical basis and analysis for each kind of quantal response bioassay in just the right amount of detail. The first two editions were a great reference for designing, conducting, and interpreting bioassays: this completely revised and updated third edition will also train the laboratory scientist to be an expert in estimation of dose response curves. New in the Third Edition: Introduces four new Windows and Apple-based computer programs (PoloJR, OptiDose, PoloMixture and PoloMulti) for the analyses of binary and multiple response analyses, respectively Replaces out-of-date GLIM examples with R program samples Includes a new chapter, Population Toxicology, and takes a systems approach to bioassays Expands the coverage of invasive species and quarantine statistics Building on the foundation set by the much-cited first two editions, the authors clearly delineate applications and ideas that are exceptionally challenging for those not already familiar with their use. They lead you through the methods with such ease and organization, that you suddenly find yourself readily able to apply concepts that you never thought you would understand. To order the PoloSuite computer software described in Bioassays with Arthropods, Third Edition, use the order form found at www.leora-software.com or contact the LeOra Software Company at [email protected]

Chemistry and in Vitro Bioassay of Smoke from Experimental Filter Cigarettes

Chemistry and in Vitro Bioassay of Smoke from Experimental Filter Cigarettes
  • Author : Smoking and Health Program (U.S.)
  • Publisher :Unknown
  • Release Date :1976
  • Total pages :42
  • ISBN : PURD:32754081249207
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Summary :

Dilution-field Bioassays for Local Effects Monitoring of Wastewater Discharges Into San Francisco Bay

Dilution-field Bioassays for Local Effects Monitoring of Wastewater Discharges Into San Francisco Bay
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :76
  • ISBN : UCBK:C037781411
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Summary :

Analytical Electrogenerated Chemiluminescence

Analytical Electrogenerated Chemiluminescence
  • Author : Neso Sojic
  • Publisher :Unknown
  • Release Date :2019-11-19
  • Total pages :501
  • ISBN : 9781788014144
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Summary : Electrogenerated chemiluminescence (ECL) is a powerful and versatile analytical technique, which is widely applied for biosensing and successfully commercialized in the healthcare diagnostic market. After introducing the fundamental concepts, this book will highlight the recent analytical applications with a special focus on immunoassays, genotoxicity, imaging, DNA and enzymatic assays. The topic is clearly at the frontier between several scientific domains involving analytical chemistry, electrochemistry, photochemistry, materials science, nanoscience and biology. This book is ideal for graduate students, academics and researchers in industry looking for a comprehensive guide to the different aspects of electrogenerated chemiluminescence.

Principles for the Selection of Doses in Chronic Rodent Bioassays

Principles for the Selection of Doses in Chronic Rodent Bioassays
  • Author : Jeffery A. Foran
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :128
  • ISBN : CORNELL:31924073240040
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Summary :

Skin Painting Techniques and in Vivo Carcinogenesis Bioassays

Skin Painting Techniques and in Vivo Carcinogenesis Bioassays
  • Author : Freddy Homburger
  • Publisher :Unknown
  • Release Date :1983
  • Total pages :312
  • ISBN : 3805535562
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Summary :

Bioassay Techniques for Drug Development

Bioassay Techniques for Drug Development
  • Author : Atta-ur-Rahman,M. Iqbal Choudhary,William J. Thomsen
  • Publisher :Unknown
  • Release Date :2001-10-04
  • Total pages :240
  • ISBN : 9781135287221
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Summary : The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassa

The Use of Multiple Parameter Flume Bioassays to Assess the Impact of Effluent Loadings of the Aufwuch Community of a Sub-alpine River (the Truckee River, California-Nevada).

The Use of Multiple Parameter Flume Bioassays to Assess the Impact of Effluent Loadings of the Aufwuch Community of a Sub-alpine River (the Truckee River, California-Nevada).
  • Author : Roderick Wylie Hoffman
  • Publisher :Unknown
  • Release Date :1978
  • Total pages :270
  • ISBN : UCAL:X14167
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Summary :

Statistical Issues in Rodent Bioassays

Statistical Issues in Rodent Bioassays
  • Author : Tony Hai Lin
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :90
  • ISBN : UCAL:C3386495
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Summary :

Bioassays with Arthropods

Bioassays with Arthropods
  • Author : Jacqueline L. Robertson,N. E. Savin,Haiganoush K. Preisler
  • Publisher :Unknown
  • Release Date :2007-06-14
  • Total pages :224
  • ISBN : 1420004042
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Summary : Providing clear examples of the use of state-of-the-art computer programs for analyses of bioassay data, Bioassays with Arthropods, Second Edition explains the statistical basis and analysis for each kind of quantal response bioassay. The first edition was a must-have reference for designing, conducting, and interpreting bioassays: this comp

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures, V

Short-Term Bioassays in the Analysis of Complex Environmental Mixtures, V
  • Author : Shahbeg S. Sandhu
  • Publisher :Unknown
  • Release Date :1987
  • Total pages :409
  • ISBN : UCAL:B4499798
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Summary :

Merperidine in I̲ṉ V̲i̲ṯṟo̲ Bioassays

Merperidine in I̲ṉ V̲i̲ṯṟo̲ Bioassays
  • Author : Carol Elizabeth Glasgow
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :276
  • ISBN : UCAL:X49777
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Summary :

MONITORING GUIDELINES FOR THE CONDUCT OF CARCINOGEN BIOASSAYS

MONITORING GUIDELINES FOR THE CONDUCT OF CARCINOGEN BIOASSAYS
  • Author : DEPARTMENT OF HEALTH AND HUMAN SERVICES
  • Publisher :Unknown
  • Release Date :1981
  • Total pages :229
  • ISBN : STANFORD:24500173418
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Summary :

Rational Hydrogel Design for Point-of-care Bioassays

Rational Hydrogel Design for Point-of-care Bioassays
  • Author : Sarah Jane Shapiro
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :146
  • ISBN : OCLC:1196087455
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Summary : As the global disease burden shifts increasingly towards chronic diseases, there is a need for improved diagnosis and monitoring so that patients can get the care they need. This is particularly evident in the developing world, where many people live far from diagnostic laboratories. Point-of-care diagnostics are tests that can be run in doctor's offices, clinics, and in patient homes. These tests must be rapid, so that they can be run quickly while the patient waits for results. Established point-of-care technologies are largely centered on lateral flow assays. Hydrogel microparticles have been used extensively for bioassays due to their nonfouling nature and ability to be functionalized with different types of biomolecules. Here, we use polyethylene glycol hydrogel particles to develop point-of-care bioassays. We focus on two different biomarkers: proteins and microRNA. Proteins are well established clinical biomarkers that are regularly tested to diagnose a number of different diseases. miRNA are emerging biomarkers that were discovered within the past thirty years and have dysregulation patterns that are implicated in a wide variety of diseases. The aim of this thesis is to enable hydrogel-based point-of-care detection of miRNA and proteins by developing and applying theory to aid in rational design of the bioassay. First, we establish a theoretical framework to investigate the key factors that influence bioassay signal for hydrogel-based rapid bioassays. By developing scaling arguments for the flux of target into the hydrogel, we find that the key factors that influence bioassay signal are the reaction rate constant, the diffusion coefficient of the target in the gel, the probe concentration, the target concentration, the assay time, and the shape of the hydrogel. By changing the hydrogel particle shape, we are able to decrease the limit of detection of a protein assay by a factor of six. We then apply the theory we developed for hydrogel signal to an assay for microRNA. Using the theory, we are able to design the hydrogels to enable muultiplexed detection of miRNA directly from serum in a 40-minute assay, with a clinically-relevant limit of detection. This assay only requires minimal preprocessing of the serum, making it useful for point-of-care applications. Leveraging our theoretical knowledge, we also develop a new assay format by incorporating hydrogels into fibrous substrates such as nitrocellulose, glass fiber membranes, and silk fabric and demonstrating their utility for bioassays. We demonstrate that these constructs can be used for detection of both miRNA and proteins. This work combines the fields of flexible fibrous materials and lithographic patterning to directly pattern hydrogels of varying shape and function within fibrous substrates. The work presented in this thesis demonstrates the utility of hydrogels for point-of-care applications. We believe that this work can be leveraged in the future to develop tests for additional biomarkers and can be combined with advances in fluorescence imaging and portable heating to create point-of-care devices that can quickly and reliably quantify proteins and miRNA from complex samples, in order to enable earlier diagnosis of disease.

Herbicide

Herbicide
  • Author : Jens C. Streibig,Per Kudsk
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :270
  • ISBN : UCSC:32106010181722
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Summary :