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Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher :Unknown
  • Release Date :2016-07-29
  • Total pages :272
  • ISBN : 9780128098998
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Summary : Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body
  • Author : Francesco Travascio
  • Publisher :Unknown
  • Release Date :2016-06-15
  • Total pages :374
  • ISBN : 9789535124153
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Summary : The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
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Summary :

Methods in Extracellular Matrix Biology

Methods in Extracellular Matrix Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-01-05
  • Total pages :468
  • ISBN : 9780128122983
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Summary : Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis of Matrix Degradation, Ultrastructural analysis of ECM, Versican and Large proteoglycans, and an ECM crosslink analysis. This series covers a wide array of topics about the extracellular matrix, including an understanding of crucial proteins and glycoproteins components of ECM. Contains contributions from experts in the field from across the world Covers a wide array of topics on the extracellular matrix, including an understanding crucial proteins and the glycoproteins components of ECM Includes analysis based topics, such as quantification of collagen and elastin, mulit-photon analysis of ECM and ECM crosslink analysis

The Extracellular Matrix Factsbook

The Extracellular Matrix Factsbook
  • Author : Shirley Ayad,Ray Boot-Handford,Martin Humphries,Karl Kadler,Adrian Shuttleworth
  • Publisher :Unknown
  • Release Date :1998-03-27
  • Total pages :301
  • ISBN : 9780080531519
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Summary : The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries being revised and updated * Includes new entries on proteinases involved in the deposition of the extracellular matrix * Presents 3D ribbon diagrams in cases where the protein structure is now known

Extracellular Matrix in Development and Disease

Extracellular Matrix in Development and Disease
  • Author : Julia Thom Oxford
  • Publisher :Unknown
  • Release Date :2019-02-21
  • Total pages :356
  • ISBN : 9783038975700
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Summary : This book is a printed edition of the Special Issue "Extracellular Matrix in Development and Disease" that was published in IJMS

Extracellular Matrix Genes

Extracellular Matrix Genes
  • Author : Linda Jo Sandell,Charles D. Boyd
  • Publisher :Unknown
  • Release Date :1990
  • Total pages :270
  • ISBN : UVA:X001832341
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Summary :

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher :Unknown
  • Release Date :2011-02-16
  • Total pages :426
  • ISBN : 3642165559
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Summary : Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Progress in Heritable Soft Connective Tissue Diseases

Progress in Heritable Soft Connective Tissue Diseases
  • Author : Jaroslava Halper
  • Publisher :Unknown
  • Release Date :2014-01-18
  • Total pages :245
  • ISBN : 9789400778931
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Summary : This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

Calcific Aortic Valve Disease

Calcific Aortic Valve Disease
  • Author : Elena Aikawa
  • Publisher :Unknown
  • Release Date :2013-06-12
  • Total pages :542
  • ISBN : 9789535111504
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Summary : Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Tissue Regeneration

Tissue Regeneration
  • Author : Hussein Abdelhay Essayed Kaoud
  • Publisher :Unknown
  • Release Date :2018-06-06
  • Total pages :206
  • ISBN : 9781789232608
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Summary : Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Decellularized Extracellular Matrix

Decellularized Extracellular Matrix
  • Author : Takashi Hoshiba,Tetsuji Yamaoka
  • Publisher :Unknown
  • Release Date :2019-12-05
  • Total pages :352
  • ISBN : 9781788014670
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Summary : Takashi Hoshiba and Tetsuji Yamaoka have brought together, for the first time, leading contributors to provide a fundamental guide to the decellularized extracelluar matrix. Focussing on the sources of dECM, preparation, characterization and applications of dECM in regenerative medicine and biological systems, this is a must-have resource for those working in regenerative medicine and tissue engineering.

Research in the Biomedical Sciences

Research in the Biomedical Sciences
  • Author : Michael Curtis,Michael Williams
  • Publisher :Unknown
  • Release Date :2017-06-01
  • Total pages :356
  • ISBN : 0128047259
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Summary : Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a "big picture" perspective that includes the scope of the replicability issue and covers initiatives that have the potential to act as effective solutions Offers real world research context for transparent, replicable experimental design and execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

Bones and Cartilage

Bones and Cartilage
  • Author : Brian K. Hall
  • Publisher :Unknown
  • Release Date :2014-12-23
  • Total pages :920
  • ISBN : 9780124166851
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Summary : Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research. Offers complete coverage of every aspect of bone and cartilage, with updated references and extensive illustrations Integrates development and evolution of the skeleton, as well a synthesis of differentiation, growth and patterning Treats all levels from molecular to clinical, embryos to evolution, and covers all vertebrates as well as invertebrate cartilages Includes new chapters on evolutionary skeletal biology that highlight normal variation and variability, and variation outside the norm (neomorphs, atavisms) Updates hypotheses on the origination of cartilage using new phylogenetic, cellular and genetic data Covers stem cells in embryos and adults, including mesenchymal stem cells and their use in genetic engineering of cartilage, and the concept of the stem cell niche

The Role of Matrix Metalloproteinase in Human Body Pathologies

The Role of Matrix Metalloproteinase in Human Body Pathologies
  • Author : Francesco Travascio
  • Publisher :Unknown
  • Release Date :2017-12-20
  • Total pages :200
  • ISBN : 9789535137177
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Summary : Matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes involved in physiological as well as in pathological processes in the human organism. MMPs play a key role in the remodeling of the extracellular matrix. Such a process may occur because of tissue homeostasis, morphogenesis, and tissue repair. However, remodeling could also be a part of many pathological states such as arthritis, cardiovascular diseases, neurodegenerative diseases, or impaired development in congenital anomalies. This book overviews the role of MMPs in different pathologies affecting the human body.

3D Cell Culture

3D Cell Culture
  • Author : Ranjna C. Dutta,Aroop K. Dutta
  • Publisher :Unknown
  • Release Date :2018-05-11
  • Total pages :212
  • ISBN : 9781351378512
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Summary : 3D cell culture is yet to be adopted and exploited to its full potential. It promises to upgrade and bring our understanding about human physiology to the highest level with the scope of applying the knowledge for better diagnosis as well as therapeutics. The focus of this book is on the direct impact of novel technologies and their evolution into viable products for the benefit of human race. It also describes the fundamentals of cell microenvironment to bring forth the relevance of 3D cell culture in tissue engineering and regenerative medicine. It discusses the extracellular matrix/microenvironment (ECM) and emphasizes its significance for growing cells in 3D to accomplish physiologically viable cell mass/tissue ex vivo. The book bridges the knowledge gaps between medical need and the technological applications through illustrations. It discusses the available models for 3D cell culture as well as the techniques to create substrates and scaffolds for achieving desired 3D microenvironment.

Structural Insufficiency Anomalies in Cardiac Valves

Structural Insufficiency Anomalies in Cardiac Valves
  • Author : Kaan Kirali
  • Publisher :Unknown
  • Release Date :2018-10-03
  • Total pages :162
  • ISBN : 9781789237665
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Summary :

Biochemistry

Biochemistry
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :229
  • ISBN : STANFORD:36105111673658
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Summary :

Physics of Cancer

Physics of Cancer
  • Author : Claudia Mierke
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :500
  • ISBN : 0750317515
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Summary : This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

Referral Guidelines for Funding Components of PHS

Referral Guidelines for Funding Components of PHS
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :229
  • ISBN : UOM:39015035690265
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Summary :

Muscle Cell and Tissue

Muscle Cell and Tissue
  • Author : Kunihiro Sakuma
  • Publisher :Unknown
  • Release Date :2015-09-02
  • Total pages :486
  • ISBN : 9789535121565
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Summary : In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.