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• Author : Gabor Forgacs,Wei Sun
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9781455730049

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Summary : Biofabrication is a practical guide to the novel, inherently cross-disciplinary scientific field that focuses on biomanufacturing processes and a related range of emerging technologies. These processes and technologies ultimately further the development of products that may involve living (cells and/or tissues) and nonliving (bio-supportive proteins, scaffolds) components. The book introduces readers to cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips as a coherent micro-/nano-fabrication toolkit. Real-world examples illustrate how to apply biofabrication techniques in areas such as regenerative medicine, pharmaceuticals and tissue engineering. In addition to being a vital reference for scientists, engineers and technicians seeking to apply biofabrication techniques, this book also provides an insight into future developments in the field, and potential new applications. Discover the multi-disciplinary toolkit provided by biofabrication and apply it to develop new products, techniques and therapies Covers a range of important emerging technologies in a coherent manner: cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips... Readers develop the ability to apply biofabrication technologies through practical examples

• Author : Joydip Kundu,Falguni Pati,Young Hun Jeong,Dong-Woo Cho
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090497

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Summary : Biomaterials have advanced from merely interacting with the body to controlling biological processes toward the goal of tissue regeneration. In order to reconstitute a new tissue or repair a damaged/diseased tissue, three components are critical for regenerative medicine or tissue engineering: cells, biomaterials as scaffold substrates, and growth factors. Thus, the design and selection of materials and the methods used for scaffold fabrication play a very important role in tissue engineering and regenerative medicine. Recent developments in biofabrication strategies have created enormous possibilities for the construction of biomimetic 3D scaffolds, where well-defined architectures can be generated with suitable surface chemistry using appropriate materials. This chapter summarizes the materials used for the fabrication of scaffolds, the different types of scaffold manufacturing processes, and the basics of the various tissue-specific scaffolds used in regenerative medicine.

• Author : Bertrand Guillotin,Muhammad Ali,Alexandre Ducom,Sylvain Catros,Virginie Keriquel,Agnès Souquet,Murielle Remy,Jean-Christophe Fricain,Fabien Guillemot
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090534

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Summary : Laser-assisted bioprinting (LAB) is an emerging technology in the field of tissue engineering. Its physical mechanism makes it possible to print cells and liquid materials with a cell-level resolution. By giving tissue engineers control over cell density and organization of 3D tissue constructs, LAB holds much promise for fabricating living tissues with physiological functionality. After introducing the rationale of applying LAB to tissue engineering, we present exhaustively the physical parameters related to the laser-induced forward transfer technique (LIFT), which is implemented in LAB. These parameters are critical to controlling the cell printing process and must work together to print viable cell patterns with respect to cell-level histological organization and to high-throughput manufacturing. After describing the experimental requirements that should be considered to fabricate 3D tissues by LAB, we present some of the main breakthroughs, including multicomponent printing, 3D printing approaches, and bioprinting in vivo that may serve in tissue engineering and regenerative medicine.

• Author : Antonietta Messina,Loredana De Bartolo
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090527

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Summary : In tissue engineering the formation of organized and functional tissues is a very complex task: the cellular environment requires suitable physiological conditions that, presently, can be achieved and maintained by using properly designed biomaterials that can support the viability and all specific functions of cells. The creation of the biomimetic environment can be realized by using polymeric membranes with specific physico-chemical, morphological, and transport properties on the basis of the targeted tissue or organ. Membrane can act as an instructive extracellular matrix (ECM) for cells, especially for stem cells or progenitor cells, whose differentiation is desired for their therapeutic potential and usefulness in the toxicological testing. Similar to the ECM, membrane exhibits from microscale to nanoscale of chemistry and topography and is able to provide physical, chemical, and mechanical signals to the cells, which are important for guiding their differentiation. In this chapter, the authors report on tailor-made membrane systems designed and operated according to well-defined engineering criteria and their potential use in the biofabrication of tissues and organs. Membrane surface and transport properties play a pivotal role in the proliferation and differentiation process governing mass transfer and providing instructive signals to the cells. Furthermore, membrane bioreactors, through the fluid dynamics modulation, may simulate the in vivo complex physiological environment, ensuring an adequate mass transfer of nutrients and metabolites and the molecular and mechanical regulatory signals.

• Author : Koichi Nakayama
• Publisher :Unknown
• Release Date :2021-01-22
• Total pages :184
• ISBN : 9783030586881

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Summary : This is the first book about the “Kenzan” method for scaffold-free biofabrication, which does not rely on biomaterials as scaffolds to ensure correct multicellular spheroid positioning for building three dimensional construct only made from cells. The book explains the basic principles and concepts of the microneedle-based (“Kenzan”) method of building surgically-implantable tissue constructs using robotic cell spheroid-based three-dimensional bioprinting, a novel technology that opens up unique opportunities for the bioengineering of tissues and organs. First book on the novel Kenzan method of tissue engineering; Explains basic concepts and applications for organ regeneration modeling; Introduces a unique robotic system for scaffold-free cell construction.

• Author : Anthony Atala,James J Yoo
• Publisher :Unknown
• Release Date :2015-07-17
• Total pages :440
• ISBN : 9780128010150

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Summary : Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

• Author : Gulden Camci-Unal,Pinar Zorlutuna,Ali Khademhosseini
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090510

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Summary : Microscale hydrogels are potentially useful materials for controlling cellular behavior to mimic native microenvironments for tissue engineering applications. In this chapter, various fabrication techniques to generate microscale hydrogels and their applications in tissue engineering have been outlined. In addition, we provide examples of microscale hydrogels with different physical and chemical properties for generation of tissue constructs. Finally, we discuss potential future directions in fabrication of hydrogels to address challenges in tissue engineering. It is expected that these techniques will enable engineering of three-dimensional (3D) structures with controlled features for the formation of functional tissues and organs.

• Author : Shiv Sanjeevi
• Publisher :Unknown
• Release Date :2019-11
• Total pages :290
• ISBN : 1774073439

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Summary : Biofabrication discusses about the basic concept of regenerating tissues, the approaches to the concept of Biofabrication. This book provides information about the construction of tissues and includes more examples as well as case studies in the fabricating tissues. The introduction of the three-dimensional bioprinting has been mentioned in this book which includes possibilities, challenges and future aspects of bioprinting. This book discusses functional skin grafts and the biodegradable scaffold for bone tissue engineering including the design, materials and mechanobiology. There is a strategy for tissue engineering and medical devices which refers to the fabrication of the polymeric biomaterials which have been mentioned in the book. This book provides readers with the insights on bioprinting of vascularized tissue scaffolds and the complex particulate biomaterials which are immunostimulant-delivery platforms.

• Author : Koichi Nakayama
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090480

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Summary : In vitro fabrication of tissues and the regeneration of internal organs are no longer regarded as science fiction but as potential remedies for individuals suffering from chronic degenerative diseases. Tissue engineering has generated much interest from researchers in many fields, including cell and molecular biology, biomedical engineering, transplant medicine, and organic chemistry. Attempts to build tissues or organs in vitro have utilized both scaffold and scaffold-free approaches. Despite considerable progress, fabrication of three-dimensional tissue constructs in vitro remains a challenge. In this chapter, we introduce and discus current concepts of tissue engineering with particular focus on future clinical application.

• Author : Dong-Woo Cho
• Publisher :Unknown
• Release Date :2019-01-02
• Total pages :352
• ISBN : 9781788016643

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Summary : 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

• Author : Mohit P. Chhaya,Ferry P.W. Melchels,Paul S. Wiggenhauser,Jan T. Schantz,Dietmar W. Hutmacher
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090572

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Summary : Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.

• Author : Yi Cheng,Yi Liu,Benjamin D. Liba,Reza Ghodssi,Gary W. Rubloff,William E. Bentley,Gregory F. Payne
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090596

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Summary : Integrated circuits transformed our lives, and the potential for integrating biology with devices promises even greater transformations. A key question is how to effectively interface biological and microfabricated systems. Our approach is to “biofabricate” the biology-device interface using biological materials and mechanisms. Here, we review recent progress on three biofabrication approaches: the use of stimuli-responsive materials to recognize device-imposed electrical inputs to direct the assembly (i.e., to electrodeposit) of hydrogels; the use of enzymes to build structure by conjugating and crosslinking macromolecules; and the use of genetic techniques to engineer proteins for assembly. We further illustrate how these biofabrication approaches enable the biofunctionalization of previously fabricated microfluidic devices and suggest the potential for lab-on-chip analysis and the creation of experimental devices to study complex biological systems. We anticipate that the complementarity between biological and technological fabrication paradigms will provide broad opportunities to build structures that couple the power of electronics to the versatility of biology.

• Author : Andrew M. Blakely,Jacquelyn Y. Schell,Adam P. Rago,Peter R. Chai,Anthony P. Napolitano,Jeffrey R. Morgan
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090558

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Summary : Scaffold-free tissue engineering approaches take advantage of cell–cell interactions, specifically the phenomena of self-assembly and self-sorting. By using micro-molded nonadhesive hydrogels, mono-dispersed cells can be seeded and directed to form spheroids as well as more complex shapes. These complex structures, including toroids, honeycombs, and loop-ended dogbones, bypass the critical diffusion distance required to maintain cell viability in culture over time. In addition, the formed microtissues are amenable to assays that analyze the self-assembly dynamics, the sorting of two different cell types, the fusion of two individual tissues, and the power produced by cell aggregates as they contract around molded gel pegs. The biofabrication of multiple microtissues into a larger macrotissue with a patent network of lumens for perfusion is an active area of research for eventual translation of tissue engineering products to the operating room.

• Author : Ritu Raman
• Publisher :Unknown
• Release Date :2021-09-14
• Total pages :168
• ISBN : 026254296X

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Summary : "This book will discuss the principles and ethics of biofabrication, a growing field in which biological tissue is fabricated in for medical, research, technological, and even food applications"--

• Author : Dong-Woo Cho
• Publisher :Unknown
• Release Date :2019-01-02
• Total pages :369
• ISBN : 9781788011983

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Summary : 3D tissue modelling is an emerging field used for the investigation of disease mechanisms and drug development. The two key drivers of this upsurge in research lie in its potential to offer a way to reduce animal testing with respect to biotoxicity analysis, preferably on physiology recapitulated human tissues and, additionally, it provides an alternative approach to regenerative medicine. Integrating physics, chemistry, materials science, and stem cell and biomedical engineering, this book provides a complete foundation to this exciting, and interdisciplinary field. Beginning with the basic principles of 3D tissue modelling, the reader will find expert reviews on key fabrication technologies and processes, including microfluidics, microfabrication technology such as 3D bioprinting, and programming approaches to emulating human tissue complexity. The next stage introduces the reader to a range of materials used for 3D tissue modelling, from synthetic to natural materials, as well as the emerging field of tissue derived decellularized extracellular matrix (dECM). A whole host of critical applications are covered, with several chapters dedicated to hard and soft tissues, as well as focused reviews on the respiratory and central nervous system. Finally, the development of in vitro tissue models to screen drugs and study progression and etiologies of diseases, with particular attention paid to cancer, can be found.

• Author : Ayesha Ahmad
• Publisher :Unknown
• Release Date :2020-12-07
• Total pages :172
• ISBN : 1636765106

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Summary : Have you ever imagined being able to wear a piece of clothing that was grown for you? In Ayesha Ahmad's Fashion's Biofabrication Revolution, she shares how that's not only possible, but the future of fashion. In this book, you will discover how this industry has evolved and why we're now at the crossroads between buying the next big thing and needing to make choices that will protect the environment. In this eye-opening work, you will learn: What fast fashion has done to our environment and why we need to alter our relationship with the clothing we wear. How biofabrication is changing the fashion industry and what designers and scientists have already accomplished. Why bacteria is referred to as nature's perfected tool and the incredible uses we have for it. Exploring the past, present, and future, you'll see how America's fashion industry has progressed and how biofabrication will change it for the better.

• Author : Ema C. Ciucurel,M. Dean Chamberlain,Michael V. Sefton
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090541

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Summary : Modular tissue engineering was initially introduced as a method of building intrinsically vascularized tissue engineered constructs by mixing together smaller building blocks (“modules”), with each module designed to include both vascular cells as well as functional cells. This approach has several advantages: it includes a built-in vascular component, it is scalable, it enables uniform cell distribution within the construct, it enables mixing of multiple cell types in controlled ratios, and it is minimally invasive because modules can be simply injected through a needle. The modular approach has also been used as a means of building larger tissues with controlled architecture from the bottom up, with or without a vascular component, and using different techniques to direct the assembly of the modules. The goal in this case is to recreate the native tissue architecture by directing the assembly of the building blocks. Both natural and synthetic materials have been used to fabricate the modules.

• Author : Paulo Rui Fernandes,Paulo Jorge Bartolo
• Publisher :Unknown
• Release Date :2013-07-31
• Total pages :178
• ISBN : 9789400770737

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Summary : This book describes the state of the art on computational modeling and fabrication in Tissue Engineering. It is inspired by the ECCOMAS thematic conference, the European Committee on Computational Methods in Applied Sciences, on Tissue Engineering, held in Lisbon, Portugal, June 2-4, 2011. Tissue Engineering is a multidisciplinary field involving scientists from different fields. The development of mathematical methods is quite relevant to understand cell biology and human tissues as well to model, design and fabricate optimized and smart scaffolds. Emphasis is put on mathematical and computational modeling for scaffold design and fabrication. This particular area of tissue engineering, whose goal is to obtain substitutes for hard tissues such as bone and cartilage, is growing in importance.

• Author : Pranav Soman,Shaochen Chen
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090503

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Summary : Natural tissues have complex structural hierarchy and biological heterogeneity. Tissue engineering utilizes biomaterial scaffolds to mimic various natural properties in order to augment regeneration therapies. Current tissue engineering techniques typically incorporate imprecise scaffold geometries with random cell placement. As a result, little can be known about the specific influences of controlled changes in 3D scaffold properties on cell behavior and therefore making the results less predictive of how cell behaves in a 3D environment. Digital micromirror-assisted projection printing (DMD-PP) technology has become a promising tool to develop user-defined precise 3D microenvironments using complex biological components such as cells and native extracellular matrix (ECM). DMD-PP technology has been used in a variety of applications ranging from tissue engineering to cancer cell migration to neural stem cell culture, with the potential of patterning multiple cells in precise 3D locations. This chapter describes the novel use of DMD-PP technology in developing biomaterial scaffolds with tunable Poisson’s ratio, a fundamental aspect of mechanical property of all biomaterials.

• Author : Aleksandr Ovsianikov,James Yoo,Vladimir Mironov
• Publisher :Unknown
• Release Date :2017-10-23
• Total pages :229
• ISBN : 3319454439

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Summary : This volume provides an in-depth introduction to 3D printing and biofabrication and covers the recent advances in additive manufacturing for tissue engineering. The book is divided into two parts, the first part on 3D printing discusses conventional approaches in additive manufacturing aimed at fabrication of structures, which are seeded with cells in a subsequent step. The second part on biofabrication presents processes which integrate living cells into the fabrication process.

• Author : Qudus Hamid,Chengyang Wang,Jessica Snyder,Yu Zhao,Wei Sun
• Publisher :Unknown
• Release Date :2013-03-18
• Total pages :288
• ISBN : 9780128090565

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Summary : Micro-electro-mechanical systems (MEMS) have revolutionized computation power due to their capabilities to develop advanced micro-architectures. MEMS technologies illustrate the potential for many applications in the field of tissue engineering, regenerative medicine, and life sciences. The fabrication of tissue models integrates the multidisciplinary field of life sciences and engineering. Presently, monolayer cell cultures are frequently used to investigate potential anticancer agents. These monolayer cultures give limited feedback on the effects of the microenvironment on chemotherapeutic and the heterogeneity of the tumor. A microenvironment, which mimics that of the cancerous tissue, will eliminate the limitations of the traditional mainstays of cancer research. The fabrication of such microenvironments requires a thorough investigation of the actual target organ, tissue, and/or tumor. Conventional MEMS technologies are developed for the fabrication of integrated circuits (ICs) on silicone wafers. Conventional MEMS technologies are very expensive and are not developed for biological applications. The digital micro-mirroring microfabrication (DMM) system eliminates the need for an expensive chrome mask by incorporating a dynamic maskless fabrication technique. The DMM is designed to utilize its digital micro-mirrors to fabricate biological devices. This digital microfabrication-based system provides a platform for the fabrication of economic biological models that are specifically designed to mimic the in vivo conditions of the tissue of interest.