Download Biological Chirality Book PDF

Download full Biological Chirality books PDF, EPUB, Tuebl, Textbook, Mobi or read online Biological Chirality anytime and anywhere on any device. Get free access to the library by create an account, fast download and ads free. We cannot guarantee that every book is in the library.

Biological Chirality

Biological Chirality
  • Author : Gyula Palyi
  • Publisher :Unknown
  • Release Date :2019-11-06
  • Total pages :268
  • ISBN : 9780128123386
GET BOOK HERE

Summary : Biological Chirality describes this occurrence, its history, and early research around the topic. The work covers analytical methods for observing the phenomenon, providing current techniques and practice and discussing the asymmetric morphology of certain living organisms, such as the position of the heart and liver in humans and the exceptions to biological homochirality seen in D-Amino Acids. In addition, it explores the requirement of enantioselectivity prepared pharmaceuticals to address enantioselectivities biomolecules, a major challenge in today's organic chemistry. Finally, the work considers the possible origin of biological homochirality, as well as the outlook for future research in this area. Describes the history of biological chirality research, its possible origins, and future exploration areas Discusses asymmetric exceptions in morphology and D-Amino Acids Explores the critical implications of enantioselective biomolecules for preparative organic chemistry with a goal of developing effective pharmaceuticals

Progress in Biological Chirality

Progress in Biological Chirality
  • Author : Gyula Palyi,Claudia Zucchi,Luciano Caglioti
  • Publisher :Unknown
  • Release Date :2004-12-13
  • Total pages :444
  • ISBN : 0080474039
GET BOOK HERE

Summary : Following on from Advances in BioChirality, Progress in Biological Chirality provides a unique summary and review of the most recent developments in the field of biochirality. Living organisms use only one enantiomer of chiral molecules in the majority of biologically important processes. The exact origin and mechanisms for this surprising selectivity are not yet known. This book discusses current research aimed at identifying the scientific reasons that may contribute to this phenomenon. Progress in Biological Chirality takes an interdisciplinary approach to this exciting field, covering a wide range of topics, such as, theory, palaeontology and food technology, to name but a few. This book presents findings via a broad spectrum of scientific approaches making it an excellent overview of Biological Chirality, suitable for postgraduate students, practitioners and researchers in the field of chemistry, biochemistry, biology, palaeontology, and food science with an interest in Chirality. This book contains 32 chapters written by Authors, who are leading authorities in the field Presents the most recent research taking place in this highly challenging field Contains both reference material for the specialist and provides an overview for those who are interested in the fundamental problems of biology and chemistry

Chirality and Biological Activity of Drugs

Chirality and Biological Activity of Drugs
  • Author : Roger J. Crossley
  • Publisher :Unknown
  • Release Date :1995-09-11
  • Total pages :208
  • ISBN : 0849391407
GET BOOK HERE

Summary : This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Advances in BioChirality

Advances in BioChirality
  • Author : C. Zucchi,L. Caglioti,Gyula Palyi
  • Publisher :Unknown
  • Release Date :1999-09-08
  • Total pages :407
  • ISBN : 0080526624
GET BOOK HERE

Summary : Chirality is a fundamental, persistent, but often overlooked feature of all living organisms on the molecular level as well as on the macroscopic scale. The high degree of preference for only one of two possible mirror image forms in Nature, often called biological homochirality is a puzzling, and not yet fully understood, phenomenon. This book covers biological homochirality from an interdisciplinary approach - contributions range from synthetic chemists, theoretical topologists and physicists, from palaeontologists and biologists to space scientists and representatives of the pharmaceutical and materials industries. Topics covered include - theory of biochirality, origins of biochirality, autocatalysis with amplification of chirality, macroscopic (present) biochirality, fossil records of chiral organisms - paleochirality, extraterrestrial origin of chirality, exceptions to the rule of biological homochirality, D-amino acids, chemical transfer of chirality, PV effects, and polarised radiation chemistry.

Asymmetry in Biological Homochirality

Asymmetry in Biological Homochirality
  • Author : David Hochberg
  • Publisher :Unknown
  • Release Date :2021-06-04
  • Total pages :102
  • ISBN : 9783036504421
GET BOOK HERE

Summary : Chirality, or handedness, is a fundamental physical characteristic, which spans the length scales ranging from elementary particles to the chiral asymmetry of spiral galaxies. The way in which chirality in chemistry, or molecular handedness, may have emerged in a primitive terrestrial environment, and how it can be triggered, amplified, and transferred, are deeply challenging problems rooted in both fundamental scientific interests and the technological potentials for science and society. Chirality constitutes a unifying feature of the living world and is a prime driving force for molecular selection and genetic evolution in biology. In this book, we offer a selection of five distinct approaches to this problem by leading experts in the field. The selected topics range from protein chirality and its relevance to protein ageing, protein aggregation and neurodegeneration, entropy production associated with chiral symmetry breaking in closed systems, chiral oscillations in polymerization models involving higher-order oligomers, the mirror symmetry breaking in liquids and its implications for the development of homochirality in abiogenesis, the role of chirality in the chemical sciences, and some philosophical implications of chirality.

Chirality in Biological Nanospaces

Chirality in Biological Nanospaces
  • Author : Nilashis Nandi
  • Publisher :Unknown
  • Release Date :2011-07-27
  • Total pages :209
  • ISBN : 9781439840023
GET BOOK HERE

Summary : Chirality is widely studied and omnipresent in biological molecules. However, how the retention of enantiomeric forms persists in many life processes without racemization is still unclear, and the molecular understanding of the stringent chiral specificity in enzymatic reactions is sparse. An overview of the influence of chirality in driving reactions within enzymatic cavities, Chirality in Biological Nanospaces: Reactions in Active Sites covers: Influences of molecular chirality on the structure of the active site and network of interactions to drive reactions with improved speed, accuracy, and efficiency The conserved features of the organization of the active site structures of enzymes The intricate interplay of electrostatic, hydrophobic, and van der Waals interactions Interactions between the active site residues and the substrate molecules Despite being time-consuming and expensive, trial-and-error is often the primary method used to develop synthetic enzymes. This book describes methods that combine crystallographic studies with electronic structure-based computational analysis. These methods may lead to future elucidation of new drugs that can target biological active sites with better efficacy and can be used to design custom-made novel biocytes with improved efficiency.

Chiral Drugs

Chiral Drugs
  • Author : Guo-Qiang Lin,Qi-Dong You,Jie-Fei Cheng
  • Publisher :Unknown
  • Release Date :2011-08-08
  • Total pages :472
  • ISBN : 1118075633
GET BOOK HERE

Summary : An integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.

Studies of Chirality, Supramolecular Structure, Order and Reactivity in and from Biological Systems

Studies of Chirality, Supramolecular Structure, Order and Reactivity in and from Biological Systems
  • Author : Jie Song
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :332
  • ISBN : MSU:31293020611723
GET BOOK HERE

Summary :

Second International Symposium on Biological Chirality

Second International Symposium on Biological Chirality
  • Author : International Symposium on Biological Chirality
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :133
  • ISBN : OCLC:48052898
GET BOOK HERE

Summary :

Chirality and Biological Activity

Chirality and Biological Activity
  • Author : Hartmut Frank,Bo Holmstedt,Bernard Testa
  • Publisher :Unknown
  • Release Date :1990
  • Total pages :283
  • ISBN : UCAL:B4494559
GET BOOK HERE

Summary : Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY (POLARIZED POSITRONS, POSITRONIUM, SLOW).

BETA DECAY AND THE ORIGINS OF BIOLOGICAL CHIRALITY (POLARIZED POSITRONS, POSITRONIUM, SLOW).
  • Author : JAMES CHRISTOPHER VAN HOUSE
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :169
  • ISBN : OCLC:68295394
GET BOOK HERE

Summary : an asymmetry in the rate of orthopositronium formation, Ap(,s), when low energy positron beams with a net helicity form positronium in optically active molecules, and quantitatively connect Ap(,s) to asymmetric radiolysis.

Current Topics in Chirality

Current Topics in Chirality
  • Author : Takashiro Akitsu
  • Publisher :Unknown
  • Release Date :2021-09-01
  • Total pages :196
  • ISBN : 9781839689536
GET BOOK HERE

Summary : Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Bioflavour ’87

Bioflavour ’87
  • Author : Peter Schreier
  • Publisher :Unknown
  • Release Date :2019-11-18
  • Total pages :596
  • ISBN : 9783110867121
GET BOOK HERE

Summary :

Comprehensive Chirality

Comprehensive Chirality
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :5648
  • ISBN : 9780080951683
GET BOOK HERE

Summary : Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Biochirality

Biochirality
  • Author : Pedro Cintas
  • Publisher :Unknown
  • Release Date :2014-07-08
  • Total pages :316
  • ISBN : 9783642376269
GET BOOK HERE

Summary : Early History of the Recognition of Molecular Biochirality, by Joseph Gal, Pedro Cintas Synthesis and Chirality of Amino Acids Under Interstellar Conditions, by Chaitanya Giri, Fred Goesmann, Cornelia Meinert, Amanda C. Evans, Uwe J. Meierhenrich Chemical and Physical Models for the Emergence of Biological Homochirality, by son E. Hein, Dragos Gherase, Donna G. Blackmond Biomolecules at Interfaces: Chiral, Naturally, by Arántzazu González-Campo and David B. Amabilino Stochastic Mirror Symmetry Breaking: Theoretical Models and Simulation of Experiments, by Celia Blanco, David Hochberg Self-Assembly of Dendritic Dipeptides as a Model of Chiral Selection in Primitive Biological Systems, by Brad M. Rosen, Cécile Roche, Virgil Percec Chirality and Protein Biosynthesis, by Sindrila Dutta Banik, Nilashis Nandi

The Origin of Chirality in the Molecules of Life

The Origin of Chirality in the Molecules of Life
  • Author : Albert Guijarro,Miguel Yus
  • Publisher :Unknown
  • Release Date :2008-01-01
  • Total pages :150
  • ISBN : 9780854041565
GET BOOK HERE

Summary : Few times an unsolved issue in science has dealt with a larger number of approaches or theories intending to shed light on it and few times this has been done from so different, often orthogonal perspectives. This book covers a hot topic, one of the unsolved problems not just in chemistry, but in science.

Advances in Asymmetric Autocatalysis and Related Topics

Advances in Asymmetric Autocatalysis and Related Topics
  • Author : Gyula Palyi,Robert Kurdi,Claudia Zucchi
  • Publisher :Unknown
  • Release Date :2017-05-18
  • Total pages :408
  • ISBN : 9780128128251
GET BOOK HERE

Summary : Advances in Asymmetric Autocatalysis and Related Topics provides various viewpoints on the important developments in asymmetric autocatalysis that have occurred in the past few years, also including brand new information in the field. Asymmetric autocatalysis is a chemical reaction which leads from achiral starting materials to chiral products, and in which the product accelerates its own formation reaction (conventional catalysis) and promotes the prevalence of its own chiral configuration (asymmetric induction). The combination of these two effects in the same reaction was unprecedented before 1995 when it was first described by Kenso SOAI at the Tokyo University of Science. Since then, several new combinations of this effect have been found, most intriguingly the possibility of absolute asymmetric synthesis, which is the spontaneous formation of the excess of one of the enantiomers of the product, a dream of organic chemists for more than a century. The book contains expert-contributed chapters that describe the most exciting recent developments in the field of the Soai reaction and in related topics, ranging from mechanistic studies and theoretical research, to very practical problems in chiral syntheses and products. Features contributions from global experts, including several chapters from Kenso Soai and expert colleagues Focuses on recent developments in the field of asymmetric autocatalysis and newly reported findings Explores the Soai reaction, new developments, and the light it sheds on homochirality in certain biomolecules

On Chirality and the Universal Asymmetry

On Chirality and the Universal Asymmetry
  • Author : Georges H. Wagnière
  • Publisher :Unknown
  • Release Date :2008-09-26
  • Total pages :256
  • ISBN : 9783906390604
GET BOOK HERE

Summary : Until half a century ago, it was assumed that the forces of nature were symmetric and that they did not distinguish between right and left, between image and mirror image. The discovery of the violation of parity in 1956 was more than a sensation, for some it was a shock. It implied that the universe displays handedness, or chirality, and that it is fundamentally asymmetric. Remarkably, a most striking asymmetry is encountered in the realm of biology. Living organisms contain proteins built almost exclusively from L-amino acids, and nucleic acids derived from D-sugars only. Yet a mirror-image biochemistry, based on D-amino acids and L-sugars is, from a purely chemical standpoint, entirely conceivable. Where, then, does this extraordinary natural selectivity come from? Is it directly, or indirectly, connected to the universal violation of parity? This book is meant as a brief review of the various manifestations of handedness, or chirality, in the universe. It does not attempt to present a solution to basic questions which perhaps will never be unambiguously and conclusively answered. Rather, it is an excursion through nature, to observe and recognize how the chirality manifests itself at different structural levels. The excursion starts in the chemistry and physics laboratory. Then a journey into outer space and back in time is undertaken. After a return to our planet Earth, the focus is on the development of living organisms. The text should be accessible to anyone having the equivalent of a first-year university instruction in physics and chemistry. It is also hoped that a layperson with a more modest scientific formation may gain a general impression of the basic asymmetry in nature and of the fundamental significance of chirality. Mathematical expressions, wherever they occur, may then be overlooked. Some more difficult sections may be skipped. A Glossary preceding the Subject Index should be helpful.

Possible Scenarios for Homochirality on Earth

Possible Scenarios for Homochirality on Earth
  • Author : Michiya Fujiki
  • Publisher :Unknown
  • Release Date :2019-11-14
  • Total pages :318
  • ISBN : 9783039217229
GET BOOK HERE

Summary : In 1978, Fred Hoyle proposed that interstellar comets carrying several viruses landed on Earth as part of the panspermia hypotheses. With respect to life, the origin of homochirality on Earth has been the greatest mystery because life cannot exist without molecular asymmetry. Many scientists have proposed several possible hypotheses to answer this long-standing L-D question. Previously, Martin Gardner raised the question about mirror symmetry and broken mirror symmetry in terms of the homochirality question in his monographs (1964 and 1990). Possible scenarios for the L-D issue can be categorized into (i) Earth and exoterrestrial origins, (ii) by-chance and necessity mechanisms, and (iii) mirror-symmetrical and non-mirror-symmetrical forces as physical and chemical origins. These scenarios should involve further great amplification mechanisms, enabling a pure L- or D-world.

Chirality and Molecular Interactions

Chirality and Molecular Interactions
  • Author : Thirumoorthy Krishnan
  • Publisher :Unknown
  • Release Date :2010-10
  • Total pages :248
  • ISBN : 3843356866
GET BOOK HERE

Summary : This book discusses the influence of chirality and intermolecular interactions in biomimetic (amphiphilic and peptide systems) and biological (amino acids and model biological reactions involving amino acids and peptides) systems using computational chemical methods. Generation and retention of homochirality are fundamentally important in biology. The difference in intermolecular interactions between enantiomeric and racemic pairs (homochiral and heterochiral interactions) and their interactions with the surrounding molecular structures leading to chiral discrimination, which could be responsible for homochiral preference, is also discussed. The nature of intermolecular energy surfaces as a function of molecular mutual orientations dictates the chiral discrimination in biology. The knowledge gained in the biomimetic systems is employed to understand more complex biological reactions like synthesis of amino acids by transamination reaction, synthesis of aminoacyl-tRNA in the aminoacylation process and synthesis of peptides in ribosome. The molecular recognition process in biomimetic amphiphiles and peptides are correlated with the nature of the intermolecular energy surfaces.

Organometallic Chirality

Organometallic Chirality
  • Author : Gyula Pályi,Claudia Zucchi,Luciano Caglioti
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :276
  • ISBN : 9788870004915
GET BOOK HERE

Summary :