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Biomarkers in Toxicology

Biomarkers in Toxicology
  • Author : Ramesh C. Gupta
  • Publisher :Unknown
  • Release Date :2019-02-13
  • Total pages :1246
  • ISBN : 9780128146569
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Summary : Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Molecular, Clinical and Environmental Toxicology

Molecular, Clinical and Environmental Toxicology
  • Author : Andreas Luch
  • Publisher :Unknown
  • Release Date :2012-06-07
  • Total pages :574
  • ISBN : 9783764383404
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Summary : Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Drug Discovery Toxicology

Drug Discovery Toxicology
  • Author : Yvonne Will,J. Eric McDuffie,Andrew J. Olaharski,Brandon D. Jeffy
  • Publisher :Unknown
  • Release Date :2016-04-18
  • Total pages :584
  • ISBN : 9781119053330
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Summary : As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Toxicologic Biomarkers

Toxicologic Biomarkers
  • Author : Anthony P. DeCaprio
  • Publisher :Unknown
  • Release Date :2006-04-18
  • Total pages :312
  • ISBN : 1420014919
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Summary : Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical s

Ecological Biomarkers

Ecological Biomarkers
  • Author : Claude Amiard-Triquet,Jean-Claude Amiard,Philip S. Rainbow
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :464
  • ISBN : 9781439880531
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Summary : Does a change, which affects a few biological macro-molecules, some cells, or a few individuals within a population, have any ecological significance that would allow the prediction of deleterious effects at higher levels of biological organization, namely the population, community, and ultimately the ecosystem? With contributions from experts in the field, Ecological Biomarkers: Indicators of Ecotoxicological Effects explores how biomarkers can be used to predict effects farther down the chain. It presents a synthesis of the state of the art in the methodology of biomarkers and its contribution to ecological risk assessment. This book describes the core biomarkers currently used in environmental research concerned with biological monitoring, biomarkers which correspond to the defences developed by living organisms in response to contaminants in their environment, and biomarkers that reveal biological damage resulting from contaminant stressors. It examines the efficacy of lysosomal biomarkers, immunotoxicity effects, behavioral disturbances, energy metabolism impairments, endocrine disruption measures, and genotoxicity as all indicative of probable toxic effects at higher biological levels. It is time to revisit the biological responses most ecologically relevant in the diagnosis of the health status of an aquatic environment well before it becomes unmanageable. Biomarkers provide a real possibility of delivering an easily measured marker at a simple level of biological organization that is predictably linked to a potentially ecologically significant effect at higher levels of biological organization. The text explores the latest knowledge and thinking on how to use biomarkers as tools for the assessment of environmental health and management.

Biomarkers of Environmental Contamination

Biomarkers of Environmental Contamination
  • Author : 0 McCarthy
  • Publisher :Unknown
  • Release Date :2018-01-18
  • Total pages :467
  • ISBN : 9781351087162
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Summary : How can biological markers help assess and predict human health risks? Find out the answers to this question and others in this timely new book examining the use of biological markers in animals and plants for evaluating the ecological and health effects of environmental contamination. The book explains the concept of environmental sentinels, presents example of field studies and discusses the utility of biomarkers within a risk analysis paradigm. Anyone who needs to know how to assess and predict environmental contamination should consider this book essential reading.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development
  • Author : Ali S. Faqi
  • Publisher :Unknown
  • Release Date :2016-11-03
  • Total pages :986
  • ISBN : 9780128036211
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Summary : A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Hair in Toxicology

Hair in Toxicology
  • Author : Desmond John Tobin
  • Publisher :Unknown
  • Release Date :2007-10-31
  • Total pages :378
  • ISBN : 9781847552518
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Summary : Hair in Toxicology: An Important Biomonitor is the first book of its kind devoted exclusively to in-depth analysis of the hair shaft as an important tool for a diverse range of scientific investigations. This authoritative book combines contributions from experts in academic, governmental and industrial environments, to provide a unique, comprehensive look at: - Why hair can serve as an invaluable bio-resource in toxicology, with up-to-date reviews on hair growth, hair fibre formation and hair pigmentation - Information (including regulatory details) on the exposure of hair (and by extension the body) to drug and non-drug chemicals and pollutants - Toxicological issues relevant to the use of hair products (including colourants, shampoos and depilatories) - The ability of hair to capture information on personal identity, chemical exposure, and environmental interactions - How hair can provide an understanding of human life from archaeological and historical perspectives - Future direction in the use of hair in toxicology Hair in Toxicology: An Important Biomonitor is ideal as a reference and guide to investigations in the biomedical, biochemical and pharmaceutical sciences at the graduate and post graduate level.

Technical Aspects of Toxicological Immunohistochemistry

Technical Aspects of Toxicological Immunohistochemistry
  • Author : Syed A. Aziz,Rekha Mehta
  • Publisher :Unknown
  • Release Date :2015-12-23
  • Total pages :231
  • ISBN : 9781493915163
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Summary : This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

The Toxicology of Fishes

The Toxicology of Fishes
  • Author : Richard T. Di Giulio,David E. Hinton
  • Publisher :Unknown
  • Release Date :2008-02-25
  • Total pages :1096
  • ISBN : 0203647297
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Summary : When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on these organisms has been widely available, until now. Filling this void, The Toxicology of Fishes, written by recognized experts, covers toxic responses ranging from reduced reproduction and/or abnormal development, growth, and differentiation. General Principles — Discusses fundamental topics such as the bioavailability of chemicals present in the aquatic environment to fishes, processes governing chemical distribution within these organisms, how fish metabolize organic chemicals, and fundamental mechanisms of chemical toxicity Key Target Systems and Organismal Effects — Describes key target organ systems for chemical impacts in fish, how chemicals produce cancer in these animals, and how fishes can develop resistance to chemical toxicity Methodologies and Applications — Dovers methods for the assessment of chemical effects on fish such as toxicity tests, biomarkers, simulated ecosystems, and modeling approaches and the use of data from such studies in ecological risk assessments Case Studies — Provides examples of how the principles and approaches presented in earlier units are actually deployed in studies Illustrated by case studies of actual, large-scale field investigations, the book reviews the tools used to assess unwanted effects in laboratory model- and wild fish in detail. With 238 illustrations, 70 tables, and 50 equations, this comprehensive monograph presents detailed information on the boiavailability of chemical pollutants, their distribution, metabolism, and excretion in the host fish and mechanisms and sites of toxic responses.

Animal Biomarkers as Pollution Indicators

Animal Biomarkers as Pollution Indicators
  • Author : David B. Peakall
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :291
  • ISBN : 9789401123464
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Summary : Ecotoxicology is a relatively new scientific discipline. Indeed, it might be argued that it is only during the last 5-10 years that it has come to merit being regarded as a true science, rather than a collection of procedures for protecting the environment through management and monitoring of pollutant discharges into the environment. The term 'ecotoxicology' was first coined in the late sixties by Prof. Truhaut, a toxicologist who had the vision to recognize the importance of investigating the fate and effects of chemicals in ecosystems. At that time, ecotoxicology was considered a sub-discipline of medical toxicology. Subsequently, several attempts have been made to portray ecotoxicology in a more realistic light. Notably, both F. Moriarty (1988) and F. Ramade (1987) emphasized in their books the broad basis of ecotoxicology, encompassing chemical and radiation effects on all components of ecosystems. In doing so, they and others have shifted concern from direct chemical toxicity to man, to the far more subtle effects that pollutant chemicals exert on natural biota. Such effects potentially threaten the existence of all life on Earth. Although I have identified the sixties as the era when ecotoxicology was first conceived as a coherent subject area, it is important to acknowledge that studies that would now be regarded as ecotoxicological are much older. Wherever people's ingenuity has led them to change the face of nature significantly, it has not escaped them that a number of biological con sequences, often unfavourable, ensue.

Nondestructive Biomarkers in Vertebrates

Nondestructive Biomarkers in Vertebrates
  • Author : Cristina Fossi,Claudio Leonzio
  • Publisher :Unknown
  • Release Date :2020-01-29
  • Total pages :368
  • ISBN : 9781000724301
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Summary : Nondestructive Biomarkers in Vertebrates presents an innovative approach for hazard assessment in vertebrates based on nondestructive rather than destructive methods. The book reviews the state of the art and defines the development and validation procedure of this new strategy. Biological materials, such as blood samples, epithelial tissue, eggs, feathers, and feces that can be obtained without stress or damage to the animal are suggested. Certain traditional studies (blood esterases, blood chemistry, mixed function oxidases, porphyrins, DNA damage, and cytological changes) can be performed on these specimens, along with new tests requiring only very small samples. This approach is developed to benefit protected, threatened species whose existence cannot be further jeopardized by the use of destructive methods. This volume will be particularly useful to ecotoxicologists, wildlife protection personnel, environmental consultants, and conservationist organizations.

Biochemical Ecotoxicology

Biochemical Ecotoxicology
  • Author : Francois Gagne
  • Publisher :Unknown
  • Release Date :2014-07-07
  • Total pages :282
  • ISBN : 9780124116238
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Summary : Biochemical Ecotoxicology: Principles and Methods presents practical approaches to biochemical ecotoxicology experiments for environmental protection and conservation. With its methodical, stepped approach this essential reference introduces readers to current techniques for toxicity endpoint testing, suitable for laboratories of any size and budget. Each chapter presents a state-of-the-art principle, a quick and inexpensive procedure (including appropriate reagents), case studies, and demonstrations on how to analyze your results. Generic techniques are covered, suitable for a variety of organisms, as well as high-throughput techniques like quantitative polymerase chain reactions and enzyme-linked immunoassays. Cutting-edge approaches, including gPCR arrays and lipidomic techniques, are also included, making this is an essential reference for anyone who needs to assess environmental toxicity. Practical, cost-effective approaches to assess environmental toxicity endpoints for all types of organism Presents theory, methods, case studies and information on how to analyze results State-of-the-art techniques, such as ‘omics’ approaches to toxicology

Biologic Markers in Immunotoxicology

Biologic Markers in Immunotoxicology
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
  • Publisher :Unknown
  • Release Date :1992-02-01
  • Total pages :224
  • ISBN : 9780309043892
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Summary : Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markers--sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.

Environmental Toxicology and Risk Assessment

Environmental Toxicology and Risk Assessment
  • Author : Diane S. Henshel
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :476
  • ISBN : 0803120311
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Summary : Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Encyclopedia of Aquatic Ecotoxicology

Encyclopedia of Aquatic Ecotoxicology
  • Author : Jean-Francois Férard,Christian Blaise
  • Publisher :Unknown
  • Release Date :2013-06-14
  • Total pages :1221
  • ISBN : 9400750404
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Summary : With its 104 chapters, this Encyclopedia of aquatic ecotoxicology reveals the diversity of issues, problems and challenges that have faced, and are facing today, receiving environments. It also indicates ways by which tools, strategies and future investigations can contribute to correct, minimize, solve and prevent water quality degradation. Structured homogeneously, the chapters convey salient information on historical background, features, characteristics, uses and/or applications of treated topics, often complemented by illustrations and case studies, as well as by conclusions and prospects. This work is most suitable for teaching purposes. Academics, for example, could literally deliver comprehensive lectures to students simply based on chapter outlines and contents. Meet the Authors of the Encyclopedia! Check out 'Meet the Authors' under ADDITIONAL INFORMATION (Right menu).

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
  • Author : José Luis García-Giménez
  • Publisher :Unknown
  • Release Date :2015-12-07
  • Total pages :696
  • ISBN : 9780128019214
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Summary : Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Biomarkers as Targeted Herbal Drug Discovery

Biomarkers as Targeted Herbal Drug Discovery
  • Author : Mahfoozur Rahman,Sarwar Beg,Mazin A. Zamzami,Hani Choudhry,Aftab Ahmad,Khalid S. Alharbi
  • Publisher :Unknown
  • Release Date :2021-07-05
  • Total pages :362
  • ISBN : 9781000067514
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Summary : This new volume looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Biomarkers as Targeted Herbal Drug Discovery: A Pharmacological Approach to Nanomedicines discusses phytoconstituent-based nanotherapeutics with applications for some specific health issues, such as arthritis, leishmanicidal, cardiovascular diseases, cancer, ocular disorders, etc.

Toxicity Testing in the 21st Century

Toxicity Testing in the 21st Century
  • Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
  • Publisher :Unknown
  • Release Date :2007-11-05
  • Total pages :216
  • ISBN : 9780309151733
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Summary : Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Introduction to Toxicology, Third Edition

Introduction to Toxicology, Third Edition
  • Author : John Timbrell
  • Publisher :Unknown
  • Release Date :2001-11-15
  • Total pages :215
  • ISBN : 0415247632
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Summary : Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing. This third edition caters for this need in a clear and easy-to-read style, featuring: * Up-to-the-minute information * Relevant toxicological examples that reinforce principles * End-of-chapter essay questions * New and redrawn illustrations * Glossary of terms * Extensively revised bibliography The fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.

Critical Issues in Alcohol and Drugs of Abuse Testing

Critical Issues in Alcohol and Drugs of Abuse Testing
  • Author : Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2019-01-10
  • Total pages :560
  • ISBN : 9780128156087
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Summary : Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians