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• Author : Andrew J Ruys
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780857098887

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Summary : A significant proportion of modern medical technology has been developed through biomimetics, which is biologically inspired by studying pre-existing functioning systems in nature. Typical biomimetically inspired biomaterials include nano-biomaterials, smart biomaterials, hybrid biomaterials, nano-biocomposites, hierarchically porous biomaterials and tissue scaffolds. This important book summarises key research in this important field. The book is divided into two parts: Part one is devoted to the biomimetics of biomaterials themselves while part two provides overviews and case studies of tissue engineering applications from a biomimetics' perspective. The book has a strong focus on cutting edge biomimetically inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings. Since many scaffolds for skin tissue engineering are biomimetically inspired, the book also has a strong focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs. With its distinguished editor and international team of contributors, Biomimetic biomaterials is a standard reference for both the biomaterials research community and clinicians involved in such areas as bone regeneration, skin tissue and wound repair. Places strong focus on cutting edge biomimetically-inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings Provides overviews and case studies of tissue engineering applications from a biomimetics perspective Also places focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs

• Author : D. Campbell
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088173

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Summary : This chapter discusses recent developments of injectable biomimetic hydrogel systems found in soft tissue repair applications. It begins by introducing how biomimesis and biomaterials are related, and how tissue repair systems can be considered biomimetic. We introduce hydrogels by discussing their classification, synthesis and applications, then discuss how injectable biomimetic hydrogels have been investigated for use in soft tissue repair. Different approaches to the use of biomimetic hydrogels for soft tissue repair are covered, focusing on synthetic, non-biodegrable polymers. We include so-called conventional polymers and more biomimetic polymers. The chapter concludes with the likely future trends and highlights further reading materials.

• Author : H. Ehrlich
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088098

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Summary : Chitin is an evolutionarily ancient and fundamental template in biomineralization, commonly found in invertebrate species and biological systems across the globe. The chapter first discusses structural peculiarities of chitin from sponges (Porifera) with regards to its role in both calcification and silicification. It then describes strategies for applications of this unique chitin towards biomedical and technical goals.

• Author : E. Mázl Chánová,F. Rypáček
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088111

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Summary : This chapter outlines the role of surface modifications for biomaterials used in tissue engineering, and reviews approaches to creating biomimetic coatings on several types of biomaterial. In the first section, the principles used in preparing non-fouling surfaces with minimized non-specific interactions with proteins are discussed, followed by the creation of biomimetic structures which promote controlled cell-surface interactions. The following sections go on to provide examples of key methods used in relation to specific materials, including polymers, metals and ceramics. Finally, methods for the characterization of coating efficiency are reviewed.

• Author : R. Rabiei,A.K. Dastjerdi,M. Mirkhalaf,F. Barthelat
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088104

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Summary : This chapter investigates the concept of hierarchy widely found in biological materials. First, natural hierarchical materials are explored in terms of their high order structures formed from universal building blocks. Hierarchical arrangement is claimed to give rise to remarkable mechanical properties of biological structures. Therefore at the next step, the significance of hierarchical structuring on mechanical properties is investigated through available analytical models. Finally, fabrication methods which could potentially lead to artificial hierarchical structures are briefly reviewed in the domain of biomimetics.

• Author : P. Boughton,G. Roger,R. Rohanizadeh,R.S. Mason,A. Ruys
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088128

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Summary : Naturally occurring gradients have been identified in the natural spinal disk joint. Emulating these gradients within a total joint arthroplasty may allow the motion-moderating function of the disk to be more closely replicated. Biomimetic functionally gradient materials have been developed for providing rigid bone-engaging caudal and coronal bioactive surfaces that transition to a flexible fibrocartilage-like portion. Methods are detailed for forming thermoplastic elastomers, bioactive reinforcement, radially aligned anisotropic composites and functionally graded materials with axial and radial gradients. Employing these methods to the vertebral-interlocking spinal disk design provides a biomimetic approach to reduce risk of hypermobility, stress concentration and implant migration.

• Author : S. Sprio,M. Sandri,M. Iafisco,S. Panseri,C. Cunha,A. Ruffini,N. Zini,R. Toni,A. Tampieri
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088081

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Summary : Scientific research on tissue regeneration is increasingly becoming the most promising response to a number of disabling pathologies with huge impact on the progressively growing and ageing world population. The biomimicry of scaffolds with the target tissue is now universally considered to be a key requirement to properly instruct cells towards the restoration of physiological functioning. In this respect, the present chapter presents an overview of recent findings on biomimetic materials and devices addressed to bone and osteochondral tissues as well as soft organ regeneration. Particular focus is given to new apatite phases, including the newly discovered superparamagnetic apatite and processes to develop ceramic, polymeric and hybrid regenerative scaffolds.

• Author : T.L.B. Ha
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088142

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Summary : Recent advances in stem cell biology and tissue engineering have paved the way for new therapies for incurable diseases and replacement of tissues and/or organs. These therapies rely on biomaterial mimicking involving niches to control the fate of stem cells and produce stem cell-based tissues. The niches or biomimetic scaffolds can be used for long-term maintenance and lineage-specific differentiation of stem cells. This chapter introduces a method for creation of biomimetic scaffolds. Acellular scaffolds were obtained by removing the cellular components of natural tissues. Then, human stem cells were isolated and cultured on these scaffolds.

• Author : E. Boughton,S.V. Mclennan
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088135

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Summary : Scaffolds are increasingly being used to repair skin lesions, in particular in acute conditions such as burns. Their use in the repair of chronic wounds is less well established, but they offer a potential solution to this debilitating condition. The biomimetic approach of mimicking the structure and function of the dermis via design of scaffolds for soft tissue repair marks a shift from the traditional approach of simple replacement of tissue and has potential to improve healing in chronic wounds. This chapter will focus on a review of the scaffolds currently used for skin repair and examine their utility for repair of chronic wounds.

• Author : K.A. Hing
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088159

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Summary : This chapter reviews basic bone biology and bone graft technology to give an insight into the increasingly biomimetic approach being pursued in this field. Many current synthetic bone graft substitute materials have calcium phosphate chemistries reflecting the composition of bone mineral, and hierarchical pore structures similar to cancellous bone. Significant research effort has been devoted to understanding how slight variations in chemistry and pore structure impact a graft material’s ability to support or stimulate bone healing. It appears that the best results are obtained when a graft chemistry or structure is designed to mimic the natural tissue.

• Author : J. Zhu,J. Hu,R.E. Marchant
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088166

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Summary : Hydrogels are widely used in biomedical applications, especially tissue engineering. This chapter discusses recent progress in design and synthesis of biomimetic hydrogels as scaffolds for tissue engineering. An overview is given of the extracellular matrix (ECM) as a natural model for biomimetic modification of synthetic hydrogels, then bioactive molecules and approaches for preparing biomimetic hydrogels are described, followed by highlighting applications in bioengineering of various tissues. Finally, conclusions and perspectives are provided regarding biomimetic modification of hydrogels and challenges in developing biomimetic hydrogels as tissue-engineering scaffolds.

• Author : Joao F. Mano
• Publisher :Unknown
• Release Date :2013-02-08
• Total pages :606
• ISBN : 9783527652297

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Summary : Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration. The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering. The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.

• Author : Md Nurunnabi
• Publisher :Unknown
• Release Date :2021-07-30
• Total pages :336
• ISBN : 9780128219492

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Summary : Bioinspired and Biomimetic Materials for Drug Delivery delves into the potential of bioinspired materials in drug delivery, detailing each material type and its latest developments. In the last decade, biomimetic and bioinspired materials and technology has garnered increased attention in drug delivery research. Various material types including polymer, small molecular, protein, peptide, cholesterol, polysaccharide, nano-crystal and hybrid materials are widely considered in drug delivery research. However, biomimetic and bioinspired materials and technology have shown promising results for use in therapeutics, due to their high biocompatibility and reduced immunogenicity. Such materials include dopamine, extracellular exosome, bile acids, ionic liquids, and red blood cell. This book covers each of these materials in detail, reviewing their potential and usage in drug delivery. As such, this book will be a great source of information for biomaterials scientists, biomedical engineers and those working in pharmaceutical research. Explores latest developments for a broad range of bioinspired and biomimetic materials for drug delivery applications Helps researchers overcome the challenges of biocompatibility and immunogenicity in drug development Provides both theoretical and practical knowledge in regards to materials characterization and use in a range of drugs

• Author : Insup Noh
• Publisher :Unknown
• Release Date :2018-11-23
• Total pages :399
• ISBN : 9789811304453

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Summary : This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

• Author : Mamoni Dash
• Publisher :Unknown
• Release Date :2021-11-26
• Total pages :229
• ISBN : 9811645655

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Summary : This book illustrates the influence of biomimetics in the field of tissue engineering and drug delivery. These two distinct fields of regenerative medicine have greatly benefited from the concept of biomimetics, which focuses on using or imitating nature to develop materials for improving human lives. The book begins by highlighting the relevance and recent advances in biomimetic biomaterials. An updated and innovative content has been presented in terms of biomimetic systems that are being utilized in controlled delivery and stem cell therapy. Further, the book reviews the role of these materials in enhanced capacity for drug loading, cellular uptake, and controlled release within the target cells. The book includes advanced techniques for characterizing biomimetic biomaterials and highlights their pivotal role in providing three-dimensional templates and synthetic extracellular matrices.

• Author : Trans Tech Publications, Limited
• Publisher :Unknown
• Release Date :2014-06-06
• Total pages :96
• ISBN : 9783038268390

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Summary : This volume of the "Journal of Biomimetics, Biomaterials and Biomedical Engineering" covers topical issue of biomimetic approach to the development of modern means of a wide range of industrial applications, the new solutions in the field of biomedical engineering and of pharmacological practice and also illuminates the results of the latest solutions in the field of development of biomaterials and their application.

• Author : Heung Jae Chun,Rui L. Reis,Antonella Motta,Gilson Khang
• Publisher :Unknown
• Release Date :2020-06-29
• Total pages :198
• ISBN : 9789811532627

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Summary : This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

• Author : Matteo Santin,Gary J. Phillips
• Publisher :Unknown
• Release Date :2012-03-07
• Total pages :248
• ISBN : 9781118129890

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Summary : The accessible introduction to biomaterials and their applications in tissue replacement, medical devices, and more Molecular and cell biology is being increasingly integrated into the search for high-performance biomaterials and biomedical devices, transforming a formerly engineering- and materials science–based field into a truly interdisciplinary area of investigation. Biomimetic, Bioresponsive, and Bioactive Materials presents a comprehensive introduction to biomaterials, discussing how they are selected, designed, and modified for integration with living tissue and how they can be utilized in the development of medical devices, orthopedics, and other related areas. Examining the physico chemical properties of widely used biomaterials and their uses in different clinical fields, the book explores applications including soft and hard tissue replacement; biointeractive metals, polymers, and ceramics; and in vitro, in vivo, and ex vivo biocompatibility tests and clinical trials. The book critically assesses the clinical level of research in the field, not only presenting proven research, but also positing new avenues of exploration. Biomimetic, Bioresponsive, and Bioactive Materials contains everything needed to get a firm grasp on materials science, fast. Written in an accessible style and including practice questions that test comprehension of the material covered in each chapter, the book is an invaluable tool for students as well as professionals new to the field.

• Author : Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
• Publisher :Unknown
• Release Date :2015-08-28
• Total pages :3672
• ISBN : 9780080552941

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Summary : Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

• Author : Angela Dillow,Anthony Lowman
• Publisher :Unknown
• Release Date :2002-08-28
• Total pages :696
• ISBN : 9780824743802

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Summary : Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

• Author : Anastasia Mardilovich
• Publisher :Unknown
• Release Date :2006
• Total pages :278
• ISBN : MINN:31951P01026040H

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Summary :