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• Author : Andrew J Ruys
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780857098887

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Summary : A significant proportion of modern medical technology has been developed through biomimetics, which is biologically inspired by studying pre-existing functioning systems in nature. Typical biomimetically inspired biomaterials include nano-biomaterials, smart biomaterials, hybrid biomaterials, nano-biocomposites, hierarchically porous biomaterials and tissue scaffolds. This important book summarises key research in this important field. The book is divided into two parts: Part one is devoted to the biomimetics of biomaterials themselves while part two provides overviews and case studies of tissue engineering applications from a biomimetics' perspective. The book has a strong focus on cutting edge biomimetically inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings. Since many scaffolds for skin tissue engineering are biomimetically inspired, the book also has a strong focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs. With its distinguished editor and international team of contributors, Biomimetic biomaterials is a standard reference for both the biomaterials research community and clinicians involved in such areas as bone regeneration, skin tissue and wound repair. Places strong focus on cutting edge biomimetically-inspired biomaterials including chitin, hydrogels, calcium phosphates, biopolymers and anti-thrombotic coatings Provides overviews and case studies of tissue engineering applications from a biomimetics perspective Also places focus on the biomimetics of tissue engineering in the repair of bone, skin, cartilage, soft tissue and specific organs

• Author : S. Sprio,M. Sandri,M. Iafisco,S. Panseri,C. Cunha,A. Ruffini,N. Zini,R. Toni,A. Tampieri
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088081

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Summary : Scientific research on tissue regeneration is increasingly becoming the most promising response to a number of disabling pathologies with huge impact on the progressively growing and ageing world population. The biomimicry of scaffolds with the target tissue is now universally considered to be a key requirement to properly instruct cells towards the restoration of physiological functioning. In this respect, the present chapter presents an overview of recent findings on biomimetic materials and devices addressed to bone and osteochondral tissues as well as soft organ regeneration. Particular focus is given to new apatite phases, including the newly discovered superparamagnetic apatite and processes to develop ceramic, polymeric and hybrid regenerative scaffolds.

• Author : H. Ehrlich
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088098

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Summary : Chitin is an evolutionarily ancient and fundamental template in biomineralization, commonly found in invertebrate species and biological systems across the globe. The chapter first discusses structural peculiarities of chitin from sponges (Porifera) with regards to its role in both calcification and silicification. It then describes strategies for applications of this unique chitin towards biomedical and technical goals.

• Author : R. Rabiei,A.K. Dastjerdi,M. Mirkhalaf,F. Barthelat
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088104

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Summary : This chapter investigates the concept of hierarchy widely found in biological materials. First, natural hierarchical materials are explored in terms of their high order structures formed from universal building blocks. Hierarchical arrangement is claimed to give rise to remarkable mechanical properties of biological structures. Therefore at the next step, the significance of hierarchical structuring on mechanical properties is investigated through available analytical models. Finally, fabrication methods which could potentially lead to artificial hierarchical structures are briefly reviewed in the domain of biomimetics.

• Author : Joao F. Mano
• Publisher :Unknown
• Release Date :2013-02-08
• Total pages :606
• ISBN : 9783527652297

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Summary : Biomimetics, in general terms, aims at understanding biological principles and applying them for the development of man-made tools and technologies. This approach is particularly important for the purposeful design of passive as well as functional biomaterials that mimic physicochemical, mechanical and biological properties of natural materials, making them suitable, for example, for biomedical devices or as scaffolds for tissue regeneration. The book comprehensively covers biomimetic approaches to the development of biomaterials, including: an overview of naturally occurring or nature inspired biomaterials; an in-depth treatment of the surface aspects pivotal for the functionality; synthesis and self-assembly methods to prepare devices to be used in mineralized tissues such as bone and teeth; and preparation of biomaterials for the controlled/ sustained release of bioactive agents. The last part reviews the applications of bioinspired materials and principles of design in regenerative medicine such as in-situ grown bone or cartilage as well as the biomimetic techniques for soft tissue engineering. The comprehensive scope of this book makes it a must-have addition to the bookshelf of everyone in the fields of Materials Science/Engineering, Nanotechnologies / Nanosciences, Medical Sciences, Biochemistry, Polymer Chemistry, and Biomedical Engineering.

• Author : P. Boughton,G. Roger,R. Rohanizadeh,R.S. Mason,A. Ruys
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088128

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Summary : Naturally occurring gradients have been identified in the natural spinal disk joint. Emulating these gradients within a total joint arthroplasty may allow the motion-moderating function of the disk to be more closely replicated. Biomimetic functionally gradient materials have been developed for providing rigid bone-engaging caudal and coronal bioactive surfaces that transition to a flexible fibrocartilage-like portion. Methods are detailed for forming thermoplastic elastomers, bioactive reinforcement, radially aligned anisotropic composites and functionally graded materials with axial and radial gradients. Employing these methods to the vertebral-interlocking spinal disk design provides a biomimetic approach to reduce risk of hypermobility, stress concentration and implant migration.

• Author : D. Campbell
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088173

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Summary : This chapter discusses recent developments of injectable biomimetic hydrogel systems found in soft tissue repair applications. It begins by introducing how biomimesis and biomaterials are related, and how tissue repair systems can be considered biomimetic. We introduce hydrogels by discussing their classification, synthesis and applications, then discuss how injectable biomimetic hydrogels have been investigated for use in soft tissue repair. Different approaches to the use of biomimetic hydrogels for soft tissue repair are covered, focusing on synthetic, non-biodegrable polymers. We include so-called conventional polymers and more biomimetic polymers. The chapter concludes with the likely future trends and highlights further reading materials.

• Author : E. Mázl Chánová,F. Rypáček
• Publisher :Unknown
• Release Date :2013-09-30
• Total pages :344
• ISBN : 9780128088111

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Summary : This chapter outlines the role of surface modifications for biomaterials used in tissue engineering, and reviews approaches to creating biomimetic coatings on several types of biomaterial. In the first section, the principles used in preparing non-fouling surfaces with minimized non-specific interactions with proteins are discussed, followed by the creation of biomimetic structures which promote controlled cell-surface interactions. The following sections go on to provide examples of key methods used in relation to specific materials, including polymers, metals and ceramics. Finally, methods for the characterization of coating efficiency are reviewed.

• Author : Insup Noh
• Publisher :Unknown
• Release Date :2018-11-23
• Total pages :399
• ISBN : 9789811304453

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Summary : This volume outlines the current status in the field of biomimetic medical materials and illustrates research into their applications in tissue engineering. The book is divided into six parts, focusing on nano biomaterials, stem cells, tissue engineering, 3D printing, immune responses and intellectual property. Each chapter has its own introduction and outlines current research trends in a variety of applications of biomimetic medical materials. The biomimetic medical materials that are covered include functional hydrogels, nanoparticles for drug delivery and medicine, the 3D bioprinting of biomaterials, sensor materials, stem cell interactions with biomaterials, immune responses to biomaterials, biodegradable hard scaffolds for tissue engineering, as well as other important topics, like intellectual property. Each chapter is written by a team of experts. This volume attempts to introduce the biomimetic properties of biomedical materials within the context of our current understanding of the nanotechnology of nanoparticles and fibres and the macroscopic aspects of 3D bioprinting.

• Author : Matteo Santin,Gary J. Phillips
• Publisher :Unknown
• Release Date :2012-04-10
• Total pages :248
• ISBN : 9780470056714

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Summary : The accessible introduction to biomaterials and their applications in tissue replacement, medical devices, and more Molecular and cell biology is being increasingly integrated into the search for high-performance biomaterials and biomedical devices, transforming a formerly engineering- and materials science–based field into a truly interdisciplinary area of investigation. Biomimetic, Bioresponsive, and Bioactive Materials presents a comprehensive introduction to biomaterials, discussing how they are selected, designed, and modified for integration with living tissue and how they can be utilized in the development of medical devices, orthopedics, and other related areas. Examining the physico chemical properties of widely used biomaterials and their uses in different clinical fields, the book explores applications including soft and hard tissue replacement; biointeractive metals, polymers, and ceramics; and in vitro, in vivo, and ex vivo biocompatibility tests and clinical trials. The book critically assesses the clinical level of research in the field, not only presenting proven research, but also positing new avenues of exploration. Biomimetic, Bioresponsive, and Bioactive Materials contains everything needed to get a firm grasp on materials science, fast. Written in an accessible style and including practice questions that test comprehension of the material covered in each chapter, the book is an invaluable tool for students as well as professionals new to the field.

• Author : Angela Dillow,Anthony Lowman
• Publisher :Unknown
• Release Date :2002-08-28
• Total pages :696
• ISBN : 020390897X

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Summary : Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

• Author : Trans Tech Publications, Limited
• Publisher :Unknown
• Release Date :2012-10-08
• Total pages :104
• ISBN : 9783038268345

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Summary : This volume of the "Journal of Biomimetics, Biomaterials and Biomedical Engineering" covers topical issue of biomimetic approach to the development of modern means of a wide range of industrial applications, the new solutions in the field of biomedical engineering and of pharmacological practice and also illuminates the results of the latest solutions in the field of development of biomaterials and their application.

• Author : Trans Tech Publications, Limited
• Publisher :Unknown
• Release Date :2014-06-06
• Total pages :96
• ISBN : 9783038268390

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Summary : This volume of the "Journal of Biomimetics, Biomaterials and Biomedical Engineering" covers topical issue of biomimetic approach to the development of modern means of a wide range of industrial applications, the new solutions in the field of biomedical engineering and of pharmacological practice and also illuminates the results of the latest solutions in the field of development of biomaterials and their application.

• Author : Sooraj Hussain Nandyala
• Publisher :Unknown
• Release Date :2020-05-26
• Total pages :78
• ISBN : 9783035733891

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Summary : The 45th volume of the "Journal of Biomimetics, Biomaterials and Biomedical Engineering" presents the latest research results in the field of biomechanics and design of foot pressure sensors, and biomimetic foot analyzes, biomechanical analysis of the influence of different surfaces on long-distance running. Also, there is data about biocomposite with glycerol as the dura mater and the study on a novel method to extract hydroxyapatite from the bovine bone without producing hazardous residue. It depicts developing an AI-based computer-aided diagnosis tool using a chest X-ray. This volume will be interesting for researchers in sport science, prothesis and biomaterials.

• Author : Heung Jae Chun,Rui L. Reis,Antonella Motta,Gilson Khang
• Publisher :Unknown
• Release Date :2020-06-29
• Total pages :198
• ISBN : 9789811532627

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Summary : This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

• Author : Zhenhai Xia
• Publisher :Unknown
• Release Date :2016-08-29
• Total pages :320
• ISBN : 9781118533079

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Summary : This book explores the structure-property-process relationship of biomaterials from engineering and biomedical perspectives, and the potential of bio-inspired materials and their applications. A large variety of natural materials with outstanding physical and mechanical properties have appeared in the course of evolution. From a bio-inspired viewpoint, materials design requires a novel and highly cross disciplinary approach. Considerable benefits can be gained by providing an integrated approach using bio-inspiration with materials science and engineering. The book is divided into three parts; Part One focuses on mechanical aspects, dealing with conventional material properties: strength, toughness, hardness, wear resistance, impact resistance, self-healing, adhesion, and adaptation and morphing. Part Two focuses on functional materials with unique capabilities, such as self-cleaning, stimuli-response, structural color, anti-reflective materials, catalytic materials for clean energy conversion and storage, and other related topics. Part Three describes how to mimic natural materials processes to synthesize materials with low cost, efficient and environmentally friendly approaches.For each chapter, the approach is to describe situations in nature first and then biomimetic materials, fulfilling the need for an interdisciplinary approach which overlaps both engineering and materials science.

• Author : Roger Narayan,P. N. Kumta,W. R. Wagner
• Publisher :Unknown
• Release Date :2009-08-19
• Total pages :204
• ISBN : 0470538341

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Summary : A collection of articles from the Advances in Biomedical and Biomimetic Materials symposium give insight into advances in biomedical and biomimetic materials. These selected articles cover such topics as scaffolds for tissue engineering, bioceramics, biomimetic materials, nanoparticles for medical diagnosis and treatment, and novel materials for drug delivery and biosensing.

• Author : Hyun Jung Kim
• Publisher :Unknown
• Release Date :2020-02-05
• Total pages :380
• ISBN : 9781000725803

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Summary : This book will examine the relevant biological subjects involved in biomimetic microengineering as well as the design and implementation methods of such engineered microdevices. Physiological topics covered include regeneration of complex responses of our body on a cellular, tissue, organ, and inter-organ level. Technological concepts in cell and tissue engineering, stem cell biology, microbiology, biomechanics, materials science, micro- and nanotechnology, and synthetic biology are highlighted to increase understanding of the transdisciplinary methods used to create the more complex, robust biomimetic engineered models. The effectiveness of the new bioinspired microphysiological systems as replacements for existing in vitro or in vivo models is explained through sections that include the protocols to reconstitute three-dimensional (3D) structures, recapitulate physiological functions, and emulate the pathophysiology of human diseases. This book will also discuss how researchers can discover bridge technologies for disease modeling and personalized precision medicine. Features Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner. Incorporates research on reverse engineering of comples microenvironmental factors in human diseases. Highlights technologies related to patient-specific personalized medicine and their potential uses. Written by chapter authors who are highly respected researchers in science and engineering. Includes extensive references at the end of each chapter to enhance further study. Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving hois Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancers at UT Austin. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement in pharmaceutical and clinical fields. • Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner. • Incorporates research on reverse engineering of complex microenvironmental factors in human diseases. • Highlights technologies related to patient-specific personalized medicine and their potential uses. • Written by chapter authors who are highly respected researchers in science and engineering. • Includes extensive references at the end of each chapter to enhance further study. Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving his Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdoctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancer at UT Austin. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement in pharmaceutical and clinical fields.

• Author : Murugan Ramalingam,Xiumei Wang,Guoping Chen,Peter Ma,Fu-Zhai Cui
• Publisher :Unknown
• Release Date :2013-08-01
• Total pages :384
• ISBN : 9781118810392

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Summary : This book compiles all aspects of biomimetics from fundamentalprinciples to current technological advances and their futuretrends in the development of nanoscale biomaterials and tissueengineering. The scope of this book is principally confined tobiologically-inspired design of materials and systems for thedevelopment of next generation nanobiomaterials and tissueengineering. The book addresses the state-of-the-art of researchprogress in the applications of the principles, processes, andtechniques of biomimetics. The prospective outcomes of currentadvancements and challenges in biomimetic approaches are alsopresented.

• Author : Darryl Knight Knight
• Publisher :Unknown
• Release Date :2013
• Total pages :468
• ISBN : OCLC:1067161323

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Summary : The focus of this research was to develop a biomimetic, degradable vascular scaffold that could be considered as part of a tissue-engineered vascular graft strategy. A family of degradable poly(ester amide)s (PEAs) derived from naturally occurring -amino acids, aliphatic diols and diacids were synthesized to yield PEAs with glass transition temperatures below physiologic temperature ensuring their pliability. Tri-functional amino acids l-lysine or l-aspartic acid were incorporated into the polymer backbone yielding complementary functional handles for subsequent conjugation of growth factors. Higher molecular weight PEAs were obtained using an interfacial polycondensation technique compared with a solution polymerization approach. Human coronary artery smooth muscle cells (HCASMCs) attached and proliferated on all two-dimensional (2D) PEA films. Well-spread cells were observed on the non-functional and aspartic acid functionalized PEAs up to 7 days, more so than on the corresponding lysine containing PEAs. The HCASMCs formed focal adhesions on all 2D PEA surfaces as illustrated by vinculin immunofluorescence, yet smooth muscle -actin (SMA) expression was not abundant, suggesting that the HCASMCs had adopted a synthetic phenotype. Uniform, nano-scale, fibrous PEA mats ranging in average fiber diameter from 130 to 294 nm were prepared by electrospinning. The increased surface charge attributed to the pendant carboxylic acid groups decreased the average fiber diameter. HCASMCs seeded on the three-dimensional fibrous mat revealed excellent cell attachment and spreading, but limited cell infiltration. In the aspartic acid containing functional PEA, the fibrous structure was lost post-processing due to a plasticizing effect facilitated by the aspartic acid monomer. The dual effect of topography and TGF-1 on HCASMC phenotype was investigated by Western blot analysis. While a modest increase in the expression of both smooth SMA and calponin was observed on all 2D films at four days culture, the 3D topography alone increased both SMA and calponin expression suggesting the cellular microenvironment can modulate SMC phenotype. Finally, X-ray photoelectron spectroscopy and immunofluorescence demonstrated the successful conjugation of TGF-1 to the pendant carboxylic acid groups suggesting that functional PEAs can be used to generate degradable, biomimetic biomaterials for vascular tissue engineering.

• Author : Anastasia Mardilovich
• Publisher :Unknown
• Release Date :2006
• Total pages :278
• ISBN : MINN:31951P01026040H

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Summary :