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Biopharmaceutics and Pharmacokinetics Considerations

Biopharmaceutics and Pharmacokinetics Considerations
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021-07-15
  • Total pages :575
  • ISBN : 0128144254
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Summary : Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology

Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics
  • Author : Leon Shargel,Andrew B. C. Yu
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :625
  • ISBN : UOM:39015029461012
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Summary : The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Biopharmaceutics Applications in Drug Development

Biopharmaceutics Applications in Drug Development
  • Author : Rajesh Krishna,Lawrence Yu
  • Publisher :Unknown
  • Release Date :2007-09-20
  • Total pages :396
  • ISBN : 9780387723792
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Summary : The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics
  • Author : Leon Shargel,Andrew B. C. Yu
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :625
  • ISBN : UOM:39015029461012
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Summary : The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Applied Biopharmaceutics & Pharmacokinetics

Applied Biopharmaceutics & Pharmacokinetics
  • Author : Leon Shargel,Andrew B. C. Yu
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :768
  • ISBN : UOM:39015046909456
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Summary : This new edition emphasizes the application and understanding of basic theoretical principles of biopharmaceutics and pharmacokinetics. Now with a second highlight color, this book helps students gain skills in problem solving and includes examples and practice problems and solutions.

Applications of Pharmacokinetic Principles in Drug Development

Applications of Pharmacokinetic Principles in Drug Development
  • Author : Rajesh Krishna
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :550
  • ISBN : 0306477661
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Summary : This book presents a collection of articles that represent individual and expert perspectives in both preclinical and clinical development, including case studies on real-life examples of successful drugs that add value to the pharmacokinetic principles learned and applied. Unlike existing books that focus on pharmacokinetic theory, the current book emphasizes application of pharmacokinetic principles in new drug development.

Biopharmaceutics and clinical pharmacokinetics : an introduction

Biopharmaceutics and clinical pharmacokinetics : an introduction
  • Author : Robert E. Notari
  • Publisher :Unknown
  • Release Date :1977
  • Total pages :416
  • ISBN : UCAL:B5040156
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Summary :

Clinical Pharmacokinetics

Clinical Pharmacokinetics
  • Author : John E. Murphy
  • Publisher :Unknown
  • Release Date :2011-10-01
  • Total pages :434
  • ISBN : 1585283479
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Summary : In the complex field of pharmacokinetics, one reference guide has an identity all its own: Clinical Pharmacokinetics. Now the fully updated 5th edition brings to experienced practitioners and students alike the fresh information they need most: · Content organized for fast reference to specific drugs · The latest on dosing in obese and overweight patients · Dosing considerations for neonatal, pediatric and geriatric patients · A look at protein binding and its implications · Population values for a variety of drugs to initiate dosing · Drug dosing in renal disease and creatinine clearance estimation A Distinctively Straightforward Guide is Now Even Better The 5th Edition of Clinical Pharmacokinetics is completely revised and updated, making a handy clinical guide even easier to use than ever. · Reorganized content features two sections: Basic Concepts and Special Populations and Specific Drugs and Drug Classes · Sections on special populations, including Dosing in Overweight and Obese Patients, have been conveniently grouped together · Comprehensive introduction covers means, measurements and monitoring · Also conveniently placed up front” a glossary of pharmacokinetics basics and commonly used equations

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics
  • Author : Milo Gibaldi
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :406
  • ISBN : UOM:39015018883739
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Summary : This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.

Developing Solid Oral Dosage Forms

Developing Solid Oral Dosage Forms
  • Author : Yihong Qiu,Yisheng Chen,Geoff G.Z. Zhang,Lirong Liu,William Porter
  • Publisher :Unknown
  • Release Date :2009-03-10
  • Total pages :978
  • ISBN : 008093272X
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Summary : Developing Solid Oral Dosage Forms is intended for pharmaceutical professionals engaged in research and development of oral dosage forms. It covers essential principles of physical pharmacy, biopharmaceutics and industrial pharmacy as well as various aspects of state-of-the-art techniques and approaches in pharmaceutical sciences and technologies along with examples and/or case studies in product development. The objective of this book is to offer updated (or current) knowledge and skills required for rational oral product design and development. The specific goals are to provide readers with: Basics of modern theories of physical pharmacy, biopharmaceutics and industrial pharmacy and their applications throughout the entire process of research and development of oral dosage forms Tools and approaches of preformulation investigation, formulation/process design, characterization and scale-up in pharmaceutical sciences and technologies New developments, challenges, trends, opportunities, intellectual property issues and regulations in solid product development The first book (ever) that provides comprehensive and in-depth coverage of what's required for developing high quality pharmaceutical products to meet international standards It covers a broad scope of topics that encompass the entire spectrum of solid dosage form development for the global market, including the most updated science and technologies, practice, applications, regulation, intellectual property protection and new development trends with case studies in every chapter A strong team of more than 50 well-established authors/co-authors of diverse background, knowledge, skills and experience from industry, academia and regulatory agencies

Clinical Trials of Drugs and Biopharmaceuticals

Clinical Trials of Drugs and Biopharmaceuticals
  • Author : Chi-Jen Lee,Lucia H. Lee,Christopher L. Wu,Benjamin R. Lee,Mei-Ling Chen
  • Publisher :Unknown
  • Release Date :2005-09-19
  • Total pages :520
  • ISBN : 1420039148
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Summary : The pharmaceutical industry is on the verge of an exciting and challenging century. Advances in pharmaceutical sciences have dramatically changed the processes of discovery and development of new therapeutic drugs and, in turn, resulted in an extraordinary increase in the potential prophylactic and therapeutic interventions. In this atmosphere, an

Introduction to Biopharmaceutics

Introduction to Biopharmaceutics
  • Author : Milo Gibaldi
  • Publisher :Unknown
  • Release Date :1971
  • Total pages :80
  • ISBN : UOM:39015072267951
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Summary :

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :229
  • ISBN : UIUC:30112005411357
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Summary :

ADME Processes in Pharmaceutical Sciences

ADME Processes in Pharmaceutical Sciences
  • Author : Alan Talevi,Pablo A. M. Quiroga
  • Publisher :Unknown
  • Release Date :2018-11-30
  • Total pages :362
  • ISBN : 9783319995939
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Summary : Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.

Dosage Form Design Considerations

Dosage Form Design Considerations
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-07-28
  • Total pages :820
  • ISBN : 9780128144244
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Summary : Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries. Examines the history and recent developments in drug dosage forms for pharmaceutical sciences Focuses on physicochemical aspects, prefomulation solid state properties and polymorphism Contains extensive references for further discovery and learning that are appropriate for advanced undergraduates, graduate students and those interested in drug dosage design

Pharmacokinetics and Adverse Effects of Drugs

Pharmacokinetics and Adverse Effects of Drugs
  • Author : Ntambwe Malangu
  • Publisher :Unknown
  • Release Date :2018-05-23
  • Total pages :162
  • ISBN : 9781789231380
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Summary : This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Basic Pharmacokinetics and Pharmacodynamics

Basic Pharmacokinetics and Pharmacodynamics
  • Author : Sara E. Rosenbaum
  • Publisher :Unknown
  • Release Date :2016-11-28
  • Total pages :576
  • ISBN : 9781119143185
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Summary : Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out ... and also for use as a reference book ...." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD .... “ (British Toxicology Society Newsletter)

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics
  • Author : Lisa Plitnick,Danuta Herzyk
  • Publisher :Unknown
  • Release Date :2013-06-27
  • Total pages :432
  • ISBN : 9780123948236
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Summary : Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical Contains the most pertinent international regulatory guidance documents for nonclinical evaluation Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars" A multi-authored book with chapters written by qualified experts in their respective fields

Generic Drug Product Development

Generic Drug Product Development
  • Author : Leon Shargel,Isadore Kanfer
  • Publisher :Unknown
  • Release Date :2013-10-24
  • Total pages :397
  • ISBN : 9781420086362
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Summary : In this era of increased pharmaceutical industry competition, success for generic drug companies is dependent on their ability to manufacture therapeutic-equivalent drug products in an economical and timely manner, while also being cognizant of patent infringement and other legal and regulatory concerns.Generic Drug Product Development: Solid Oral

Preclinical Safety Evaluation of Biopharmaceuticals

Preclinical Safety Evaluation of Biopharmaceuticals
  • Author : Joy A. Cavagnaro
  • Publisher :Unknown
  • Release Date :2013-03-07
  • Total pages :1064
  • ISBN : 9781118679388
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Summary : "The goal is to provide a comprehensive reference book for thepreclinicaldiscovery and development scientist whoseresponsibilities span target identification, lead candidateselection, pharmacokinetics, pharmacology, and toxicology, and forregulatory scientists whose responsibilities include the evaluationof novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictivevalue, lessen the time and cost of launching newbiopharmaceuticals, and speed potentially lifesaving drugs tomarket. This guide covers topics ranging from lead candidateselection to establishing proof of concept and toxicity testing tothe selection of the first human doses. With chapters contributedby experts in their specific areas, Preclinical SafetyEvaluation of Biopharmaceuticals: A Science-Based Approach toFacilitating Clinical Trials: Includes an overview of biopharmaceuticals with information onregulation and methods of production Discusses the principles of ICH S6 and their implementation inthe U.S., Europe, and Japan Covers current practices in preclinical development andincludes a comparison of safety assessments for small moleculeswith those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process,including: the selection of relevant species; safety/toxicityendpoints; specific considerations based upon class; and practicalconsiderations in the design, implementation, and analysis ofbiopharmaceuticals Covers transitioning from preclinical development to clinicaltrials This is a hands-on, straightforward reference for professionalsinvolved in preclinical drug development, including scientists,toxicologists, project managers, consultants, and regulatorypersonnel.

NIH Publications List

NIH Publications List
  • Author : National Institutes of Health (U.S.). Editorial Operations Branch
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :229
  • ISBN : UCAL:B4631787
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Summary :