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Bioreactor Modeling

Bioreactor Modeling
  • Author : Jerome Morchain
  • Publisher :Unknown
  • Release Date :2017-10-06
  • Total pages :218
  • ISBN : 9780081011669
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Summary : Dynamic simulation of bioreactors is a challenge for both the industrial and academic worlds. Beyond the large number of physical and biological phenomena to be considered and the wide range of scales involved, the central difficulty lies in the need to account for the dynamic behavior of suspended microorganisms. In the case of chemical reactors, knowledge of the thermodynamic equilibrium laws at the interfaces makes it possible to produce macroscopic models by integrating local laws. Microorganisms, on the other hand, have the ability to modulate the rate of substrate assimilation. Moreover, the nature of the biochemical transformations results from a compromise between the needs of the cell and the available resources. This book revisits the modeling of bioreactors using a multi-scale approach. It addresses issues related to mixing, phase-to-phase transfers and the adaptation of microorganisms to variations in concentration, and explores the use of population balances for the simulation of bioreactors. By adopting a multidisciplinary perspective that draws on process engineering, fluid mechanics and microbiology, this book sheds new light on the particularity of bioprocesses in relation to physical and chemical phenomena. Presents a multiphase description of bioreactor modeling Includes a combination of concepts issued from different scientific fields to address a practical issue Provides a detailed description of the population balance concept as applied to biological systems Covers a set of illustrative examples of the interaction between hydrodynamics and biological response

Solid-State Fermentation Bioreactors

Solid-State Fermentation Bioreactors
  • Author : David A. Mitchell,Nadia Krieger,Marin Berovic
  • Publisher :Unknown
  • Release Date :2006-08-02
  • Total pages :448
  • ISBN : 9783540312864
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Summary : This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale up their processes. The authors survey bioreactor types in common use, and describe in depth how to plan a project, and model heat transfer phenomena. The book includes case studies, and a review of practical issues involved in bioreactor performance.

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer

An Introduction to Bioreactor Hydrodynamics and Gas-Liquid Mass Transfer
  • Author : Enes Kadic,Theodore J. Heindel
  • Publisher :Unknown
  • Release Date :2014-03-14
  • Total pages :328
  • ISBN : 9781118869833
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Summary : Reviews and compares the major types of bioreactors, defines their pros and cons, and identifies research needs and figures of merit that have yet to be addressed Describes common modes of operation in bioreactors Covers the three common bioreactor types, including stirred-tank bioreactors, bubble column bioreactors, and airlift bioreactors Details less common bioreactors types, including fixed bed bioreactors and novel bioreactor designs Discusses advantages and disadvantages of each bioreactor and provides a procedure for optimal bioreactor selection based on current process needs Reviews the problems of bioreactor selection globally while considering all bioreactor options rather than concentrating on one specific bioreactor type

DESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).

DESIGN, IMPLEMENTATION AND MODELING OF A TRANSTUBULAR BIOREACTOR FOR THE GROWTH OF MAMMALIAN CELLS (BIOREACTOR, HYBRIDOMA CELLS).
  • Author : CRAIG REED HALBERSTADT
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :123
  • ISBN : UOM:39015021908507
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Summary : antibody production. Whether the increase in antibody production is due to autocrine/paracrine factors, local pH concentrations, pulsatile delivery of growth factors or some other mechanism is unknown and requires further study.

Bioreactors

Bioreactors
  • Author : Lakhveer Singh,Abu Yousuf,Durga Madhab Mahapatra
  • Publisher :Unknown
  • Release Date :2020-04
  • Total pages :368
  • ISBN : 9780128212646
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Summary : Bioreactors: Sustainable Design and Industrial Applications in Mitigation of GHG Emissions presents and compares the foundational concepts, state-of-the-art design and fabrication of bioreactors. Solidly based on theoretical fundamentals, the book examines various aspects of the commercially available bioreactors, such as construction and fabrication, design, modeling and simulation, development, operation, maintenance, management and target applications for biofuels production and bio-waste management. Emerging issues in commercial feasibility are explored, constraints and pathways for upscaling, and techno-economic assessment are also covered. This book provides researchers and engineers in the biofuels and waste management sectors a clear, at-a-glance understanding of the actual potential of different advanced bioreactors for their requirements. It is a must-have reference for better-informed decisions when selecting the appropriate technology models for sustainable systems development and commercialization.

Modeling Analysis of and Human-human Hybridoma Culture in an Intercalated-spiral Alternate-dead-ended Hollow Fiber Bioreactor

Modeling Analysis of and Human-human Hybridoma Culture in an Intercalated-spiral Alternate-dead-ended Hollow Fiber Bioreactor
  • Author : John D. Brotherton
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :438
  • ISBN : UCSD:31822018737882
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Summary :

Bioreaction Engineering

Bioreaction Engineering
  • Author : K. Schügerl,K.-H. Bellgardt
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :604
  • ISBN : 9783642597350
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Summary : Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Bioreactors

Bioreactors
  • Author : Carl-Fredrik Mandenius
  • Publisher :Unknown
  • Release Date :2016-02-16
  • Total pages :520
  • ISBN : 9783527683376
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Summary : In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Development of a Multicompartmental, Multiple Cell Type Bioreactor and Corresponding Pharmacokinetic Model for Naphthalene

Development of a Multicompartmental, Multiple Cell Type Bioreactor and Corresponding Pharmacokinetic Model for Naphthalene
  • Author : Lisa Marie Sweeney
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :278
  • ISBN : CORNELL:31924072048055
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Summary :

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :229
  • ISBN : UIUC:30112042535077
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Summary :

A Model of a Split-flow Airlift Bioreactor for Attachment-dependent Baculovirus Infected Insect Cells

A Model of a Split-flow Airlift Bioreactor for Attachment-dependent Baculovirus Infected Insect Cells
  • Author : Arun Kumar
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :144
  • ISBN : CORNELL:31924073548517
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Summary :

Modeling and Simulation of Bioreactor Process Dynamics

Modeling and Simulation of Bioreactor Process Dynamics
  • Author : C. Kleinstreuer,T. Poweigha
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :56
  • ISBN : OCLC:301200203
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Summary :

Bioreactors

Bioreactors
  • Author : Goutam Saha,Alok Barua,Satyabroto Sinha
  • Publisher :Unknown
  • Release Date :2017-12-01
  • Total pages :136
  • ISBN : 9781498736015
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Summary : Bioreactors: Animal Cell Culture Control for Bioprocess Engineering presents the design, fabrication, and control of a new type of bioreactor meant especially for animal cell line culture. The new bioreactor, called the "see-saw bioreactor," is ideal for the growth of cells with a sensitive membrane. The see-saw bioreactor derives its name from its principle of operation in which liquid columns in either limb of the reactor alternately go up and down. The working volume of the reactor is small, to within 15 L. However, it can easily be scaled up for large production in volume of cell mass in the drug and pharmaceutical industries. The authors describe the principle of operation of the see-saw bioreactor and how to automatically control the bioprocess. They discuss different control strategies as well as the thorough experimental research they conducted on this prototype bioreactor in which they applied a time delay control for yield maximization. To give you a complete understanding of the design and development of the see-saw bioreactor, the authors cover the mathematical model they use to describe the kinetics of fermentation, the genetic algorithms used for deriving the optimal time trajectories of the bioprocess variables, and the corresponding control inputs for maximizing the product yield. One chapter is devoted to the application of time delay control. Following a description of the bioreactor’s working setup in the laboratory, the authors sum up their investigation and define the future scope of work in terms of design, control, and software sensors.

Recombinant DNA Technology and Applications

Recombinant DNA Technology and Applications
  • Author : Aleš Prokop,Rakesh K. Bajpai
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :619
  • ISBN : UCSD:31822003707874
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Summary :

Biomass Now

Biomass Now
  • Author : Miodrag Darko Matovic
  • Publisher :Unknown
  • Release Date :2013-04-30
  • Total pages :554
  • ISBN : 9789535111054
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Summary : This two-volume book on biomass is a reflection of the increase in biomass related research and applications, driven by overall higher interest in sustainable energy and food sources, by increased awareness of potentials and pitfalls of using biomass for energy, by the concerns for food supply and by multitude of potential biomass uses as a source material in organic chemistry, bringing in the concept of bio-refinery. It reflects the trend in broadening of biomass related research and an increased focus on second-generation bio-fuels. Its total of 40 chapters spans over diverse areas of biomass research, grouped into 9 themes.

Computational Modeling in Bioengineering and Bioinformatics

Computational Modeling in Bioengineering and Bioinformatics
  • Author : Nenad Filipovic
  • Publisher :Unknown
  • Release Date :2019-10-09
  • Total pages :442
  • ISBN : 9780128195840
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Summary : Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical image processing, analysis and visualization, high performance computing and sports bioengineering. The book's chapters are the result of many international projects in the area of bioengineering and bioinformatics done at the Research and Development Center for Bioengineering BioIRC and by the Faculty of Engineering at the University of Kragujevac, Serbia. Presents recent advances at the crossroads of biomedical engineering and bioinformatics, one of the hottest areas in biomedical and clinical research Discusses a wide range of leading-edge research topics, including biomechanics and bioimaging, biomedical decision support systems, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, amongst others Includes coverage of biomechanical, bioengineering and computational methods of treatment and diagnosis

Membrane Biological Reactors

Membrane Biological Reactors
  • Author : Faisal I. Hai,Kazuo Yamamoto,Chung-Hak Lee
  • Publisher :Unknown
  • Release Date :2013-11-01
  • Total pages :504
  • ISBN : 9781780400655
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Summary : In recent years the MBR market has experienced unprecedented growth. The best practice in the field is constantly changing and unique quality requirements and management issues are regularly emerging. Membrane Biological Reactors: Theory, Modeling, Design, Management and Applications to Wastewater Reuse comprehensively covers the salient features and emerging issues associated with the MBR technology. The book provides thorough coverage starting from biological aspects and fundamentals of membranes, via modeling and design concepts, to practitioners’ perspective and good application examples. Membrane Biological Reactors focuses on all the relevant emerging issues raised by including the latest research from renowned experts in the field. It is a valuable reference to the academic and professional community and suitable for undergraduate and postgraduate teaching in Environmental Engineering, Chemical Engineering and Biotechnology.

Fixed Bed Hybrid Bioreactor

Fixed Bed Hybrid Bioreactor
  • Author : Sushovan Sarkar
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9789813345461
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Summary :

Control in Bioprocessing

Control in Bioprocessing
  • Author : Pablo A. López Pérez,Ricardo Aguilar López,Ricardo Femat
  • Publisher :Unknown
  • Release Date :2020-03-03
  • Total pages :296
  • ISBN : 9781119296089
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Summary : Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

Ethanol Production in a Multimembrane Bioreactor

Ethanol Production in a Multimembrane Bioreactor
  • Author : David Ethan Steinmeyer
  • Publisher :Unknown
  • Release Date :1990
  • Total pages :552
  • ISBN : CORNELL:31924058503800
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Summary :

Industrial Biotechnology

Industrial Biotechnology
  • Author : Christoph Wittmann
  • Publisher :Unknown
  • Release Date :2017-03-06
  • Total pages :640
  • ISBN : 9783527341818
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Summary : The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.