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Biotechnology of Terpenoid Production from Microbial Cell Factories

Biotechnology of Terpenoid Production from Microbial Cell Factories
  • Author : Pratima Gupta,Suresh Phulara
  • Publisher :Unknown
  • Release Date :2021-04-30
  • Total pages :224
  • ISBN : 9780128231784
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Summary : Biotechnology of Terpenoid Production from Microbial Cell Factories is a unique reference to help researchers, scientists and scholars explore available strategies involved in the production of terpenoid-based, value-added compounds from GRAS status (Generally Recognized as Safe by FDA) microbes to address the associated challenges for the industry. The book covers the most up-to-date information about microbial terpenoid production, including culture condition modulation for the improved and high-specificity production of terpenoid and their in-situ extraction. Each class of terpenoid is explained in detail, including their nutritional and pharmaceutical information and their molecular aspects. Provides an in-depth look at both the natural and metabolic engineering aspects of microbial terpenoid production Includes production strategies and existing challenges for each class of terpenoid from microbial sources Presents broad application opportunities of terpenoids such as food additives, pharmaceuticals and fragrances Includes brief chapter summaries and a glossary for each chapter to simplify technical applications

Microbial Cell Factories Engineering for Production of Biomolecules

Microbial Cell Factories Engineering for Production of Biomolecules
  • Author : Vijai Singh
  • Publisher :Unknown
  • Release Date :2021-03-12
  • Total pages :490
  • ISBN : 9780128214770
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Summary : Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others. This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields. Offers basic understanding and a clear picture of various MCFs Explains several tools and technologies, including DNA synthesis, synthetic biology tools, genome editing, biosensors, computer-aided design, and OMICS tools, among others Harnesses the potential of engineered MCFs to produce a wide range of biomolecules for industrial, therapeutic, pharmaceutical, nutraceutical and biotechnological applications Highlights the advances, challenges, and future opportunities in designing MCFs

Engineering the Microbial Platform for the Production of Biologics and Small-Molecule Medicines

Engineering the Microbial Platform for the Production of Biologics and Small-Molecule Medicines
  • Author : Dipesh Dhakal,Eung-Soo Kim,Mattheos Koffas
  • Publisher :Unknown
  • Release Date :2019-12-23
  • Total pages :229
  • ISBN : 9782889632534
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Summary :

Microbial Cell Factories Engineering for Production of Biomolecules

Microbial Cell Factories Engineering for Production of Biomolecules
  • Author : Vijai Singh
  • Publisher :Unknown
  • Release Date :2021-02-26
  • Total pages :488
  • ISBN : 9780128214787
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Summary : Microbial Cell Factories Engineering for Production of Biomolecules presents a compilation of chapters written by eminent scientists worldwide. Sections cover major tools and technologies for DNA synthesis, design of biosynthetic pathways, synthetic biology tools, biosensors, cell-free systems, computer-aided design, OMICS tools, CRISPR/Cas systems, and many more. Although it is not easy to find relevant information collated in a single volume, the book covers the production of a wide range of biomolecules from several MCFs, including Escherichia coli, Bacillus subtilis, Pseudomonas putida, Streptomyces, Corynebacterium, Cyanobacteria, Saccharomyces cerevisiae, Pichia pastoris and Yarrowia lipolytica, and algae, among many others. This will be an excellent platform from which scientific knowledge can grow and widen in MCF engineering research for the production of biomolecules. Needless to say, the book is a valuable source of information not only for researchers designing cell factories, but also for students, metabolic engineers, synthetic biologists, genome engineers, industrialists, stakeholders and policymakers interested in harnessing the potential of MCFs in several fields. Offers basic understanding and a clear picture of various MCFs Explains several tools and technologies, including DNA synthesis, synthetic biology tools, genome editing, biosensors, computer-aided design, and OMICS tools, among others Harnesses the potential of engineered MCFs to produce a wide range of biomolecules for industrial, therapeutic, pharmaceutical, nutraceutical and biotechnological applications Highlights the advances, challenges, and future opportunities in designing MCFs

Systems and Synthetic Biotechnology for Production of Nutraceuticals

Systems and Synthetic Biotechnology for Production of Nutraceuticals
  • Author : Long Liu,Jian Chen
  • Publisher :Unknown
  • Release Date :2020-01-03
  • Total pages :208
  • ISBN : 9789811504464
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Summary : This book discusses systems and synthetic biotechnologies for the production of nutraceuticals, and summarizes recent advances in nutraceutical research in terms of the physiological effects on health, potential applications, drawbacks of traditional production processes, characteristics of production strains, and advances in microbial production based on systems and synthetic biotechnology. It also examines future directions in the microbial production of nutraceuticals using systems and synthetic biology. The book is intended for researchers and graduate students in the field of molecular biology and industrial biotechnology as well as staff working in the nutraceutical industry.

Bioprocessing for Biomolecules Production

Bioprocessing for Biomolecules Production
  • Author : Gustavo Molina,Vijai Kumar Gupta,Brahma N. Singh,Nicholas Gathergood
  • Publisher :Unknown
  • Release Date :2020-01-13
  • Total pages :536
  • ISBN : 9781119434320
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Summary : Presents the many recent innovations and advancements in the field of biotechnological processes This book tackles the challenges and potential of biotechnological processes for the production of new industrial ingredients, bioactive compounds, biopolymers, energy sources, and compounds with commercial/industrial and economic interest by performing an interface between the developments achieved in the recent worldwide research and its many challenges to the upscale process until the adoption of commercial as well as industrial scale. Bioprocessing for Biomolecules Production examines the current status of the use and limitation of biotechnology in different industrial sectors, prospects for development combined with advances in technology and investment, and intellectual and technical production around worldwide research. It also covers new regulatory bodies, laws and regulations, and more. Chapters look at biological and biotechnological processes in the food, pharmaceutical, and biofuel industries; research and production of microbial PUFAs; organic acids and their potential for industry; second and third generation biofuels; the fermentative production of beta-glucan; and extremophiles for hydrolytic enzymes productions. The book also looks at bioethanol production from fruit and vegetable wastes; bioprocessing of cassava stem to bioethanol using soaking in aqueous ammonia pretreatment; bioprospecting of microbes for bio-hydrogen production; and more. Provides up to date information about the advancements made on the production of important biotechnological ingredients Complete visualization of the general developments of world research around diverse products and ingredients of technological, economic, commercial and social importance Investigates the use and recovery of agro-industrial wastes in biotechnological processes Includes the latest updates from regulatory bodies for commercialization feasibility Offering new products and techniques for the industrial development and diversification of commercial products, Bioprocessing for Biomolecules Production is an important book for graduate students, professionals, and researchers involved in food technology, biotechnology; microbiology, bioengineering, biochemistry, and enzymology.

Systems Metabolic Engineering

Systems Metabolic Engineering
  • Author : Christoph Wittmann,Sang Yup Lee
  • Publisher :Unknown
  • Release Date :2012-06-15
  • Total pages :388
  • ISBN : 9789400745346
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Summary : Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.

Minimal Cells: Design, Construction, Biotechnological Applications

Minimal Cells: Design, Construction, Biotechnological Applications
  • Author : Alvaro R. Lara,Guillermo Gosset
  • Publisher :Unknown
  • Release Date :2019-12-04
  • Total pages :230
  • ISBN : 9783030318970
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Summary : This book provides a comprehensive overview of the design, generation and characterization of minimal cell systems. Written by leading experts, it presents an in-depth analysis of the current issues and challenges in the field, including recent advances in the generation and characterization of reduced-genome strains generated from model organisms with relevance in biotechnology, and basic research such as Escherichia coli, Corynebacterium glutamicum and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g. Bacillus subtilis. The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.

Biotechnology of Isoprenoids

Biotechnology of Isoprenoids
  • Author : Jens Schrader,Jörg Bohlmann
  • Publisher :Unknown
  • Release Date :2015-05-19
  • Total pages :475
  • ISBN : 9783319201078
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Summary : This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Synthetic Metabolic Pathways

Synthetic Metabolic Pathways
  • Author : Michael Krogh Jensen,Jay D. Keasling
  • Publisher :Unknown
  • Release Date :2017-11-24
  • Total pages :354
  • ISBN : 1493972944
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Summary : This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance. Chapters are divided into four sections focusing on the four steps of the iterative design-build-test-learn cycle related to modern cell factory engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Metabolic Pathways: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Industrial Biocatalysis

Industrial Biocatalysis
  • Author : Peter Grunwald
  • Publisher :Unknown
  • Release Date :2014-12-11
  • Total pages :1232
  • ISBN : 9789814463898
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Summary : Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

Synthetic Biology – Metabolic Engineering

Synthetic Biology – Metabolic Engineering
  • Author : Huimin Zhao,An-Ping Zeng
  • Publisher :Unknown
  • Release Date :2017-10-27
  • Total pages :322
  • ISBN : 9783319553184
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Summary : This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Mini Reviews in Medicinal Chemistry

Mini Reviews in Medicinal Chemistry
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :229
  • ISBN : UCSC:32106017986636
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Summary :

Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals

Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids: Production of Fuels and Chemicals
  • Author : Sang Yup Lee
  • Publisher :Unknown
  • Release Date :2018-03-04
  • Total pages :781
  • ISBN : 3319504355
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Summary : This book covers the current states of microbial and related technologies that have been developed for the efficient production of chemicals, fuels and materials by integrating strain and enzyme development, fermentation processes, and downstream processes. The book also covers how microbes and microbial products can be employed to facilitate petroleum recovery. Global consequences of bio-based production of chemicals, fuels and materials are also discussed with insights.

Bioactive Molecules in Plant Defense

Bioactive Molecules in Plant Defense
  • Author : Mostafa Abdelrahman,Sudisha Jogaiah
  • Publisher :Unknown
  • Release Date :2020-11-28
  • Total pages :101
  • ISBN : 9783030611491
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Summary : This book presents a broad perspective on saponins as important natural products with a key role in plant defense. The presence of saponins has been reported in several plant species, and many types of saponins have been found to exhibit significant antifungal activities. In addition to their role in plant defense, saponins are of increasing interest for drug research, as they are active ingredients in several traditional medicines and hold potentially valuable pharmacological properties. In this book, the authors briefly introduce readers to saponin accumulation in various plant organs, with a specific focus on their structure classification and diversity. Readers will find detailed information on the saponin structure-activity relationship and saponins’ vital role in sustainable agriculture as a chemical barrier to pathogen attack. The latest techniques for isolating, identifying, and quantifying saponins are also discussed. In the closing chapter, the authors outline the recent metabolic engineering strategies applied to improve saponin glycosides production and their potential applications in plant disease resistance. This book and the companion volume Bioactive Molecules in Plant Defense: Signaling in Growth and Stress offer vital resources for all researchers and students interested in plant pathology, mycology and sustainable agriculture.

Taxol

Taxol
  • Author : Matthew Suffness
  • Publisher :Unknown
  • Release Date :1995-05-25
  • Total pages :448
  • ISBN : 084938382X
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Summary : This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.

Industrial Biotechnology

Industrial Biotechnology
  • Author : Christoph Wittmann,James C. Liao,Sang Yup Lee,Jens Nielsen,Gregory Stephanopoulos
  • Publisher :Unknown
  • Release Date :2017-04-10
  • Total pages :792
  • ISBN : 9783527341795
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Summary : The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses. Of interest to biotechnologists and microbiologists, as well as those working in the biotechnological, chemical, food and pharmaceutical industries.

Microbial Production of Food Ingredients, Enzymes and Nutraceuticals

Microbial Production of Food Ingredients, Enzymes and Nutraceuticals
  • Author : Brian McNeil,David Archer,Ioannis Giavasis,Linda Harvey
  • Publisher :Unknown
  • Release Date :2013-03-21
  • Total pages :656
  • ISBN : 9780857093547
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Summary : Bacteria, yeast, fungi and microalgae can act as producers (or catalysts for the production) of food ingredients, enzymes and nutraceuticals. With the current trend towards the use of natural ingredients in foods, there is renewed interest in microbial flavours and colours, food bioprocessing using enzymes and food biopreservation using bacteriocins. Microbial production of substances such as organic acids and hydrocolloids also remains an important and fast-changing area of research. Microbial production of food ingredients, enzymes and nutraceuticals provides a comprehensive overview of microbial production of food ingredients, enzymes and nutraceuticals. Part one reviews developments in the metabolic engineering of industrial microorganisms and advances in fermentation technology in the production of fungi, yeasts, enzymes and nutraceuticals. Part two discusses the production and application in food processing of substances such as carotenoids, flavonoids and terponoids, enzymes, probiotics and prebiotics, bacteriocins, microbial polysaccharides, polyols and polyunsaturated fatty acids. Microbial production of food ingredients, enzymes and nutraceuticals is an invaluable guide for professionals in the fermentation industry as well as researchers and practitioners in the areas of biotechnology, microbiology, chemical engineering and food processing. Provides a comprehensive overview of microbial flavours and colours, food bioprocessing using enzymes and food biopreservation using bacteriocins Begins with a review of key areas of systems biology and metabolic engineering, including methods and developments for filamentous fungi Analyses the use of microorganisms for the production of natural molecules for use in foods, including microbial production of food flavours and carotenoids

Secondary Metabolites

Secondary Metabolites
  • Author : Ramasamy Vijayakumar,Suresh S.S. Raja
  • Publisher :Unknown
  • Release Date :2018-09-05
  • Total pages :148
  • ISBN : 9781789236422
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Summary : This book consists of an introductory overview of secondary metabolites, which are classified into four main sections: microbial secondary metabolites, plant secondary metabolites, secondary metabolites through tissue culture technique, and regulation of secondary metabolite production. This book provides a comprehensive account on the secondary metabolites of microorganisms, plants, and the production of secondary metabolites through biotechnological approach like the plant tissue culture method. The regulatory mechanisms of secondary metabolite production in plants and the pharmaceutical and other applications of various secondary metabolites are also highlighted. This book is considered as necessary reading for microbiologists, biotechnologists, biochemists, pharmacologists, and botanists who are doing research in secondary metabolites. It should also be useful to MSc students, MPhil and PhD scholars, scientists, and faculty members of various science disciplines.

Aroma Biotechnology

Aroma Biotechnology
  • Author : Ralf G. Berger
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :240
  • ISBN : 9783642793738
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Summary : Aroma biotechnology opens access to natural volatile flavors. Due to the attribute of "naturalness" these aromas are the most valuable ingredients for foods, cosmetics and related products. The author describes biocatalyzed reactions and biogenetic routes leading to aroma and flavor compounds and he depicts in detail their utilisation in industrial scale processes. All the important topics, including de-novo-synthesis, genetic engineering, in vitro rDNA methods, laboratory requirements and techniques, upscaling, product recovery, profitability, and legal aspects are covered. R.G. Berger contributes his own experimental experience to all except one chapter and leads the reader into state-of-the-art aroma biotechnology.

Synthetic Biology of Cyanobacteria

Synthetic Biology of Cyanobacteria
  • Author : Weiwen Zhang,Xinyu Song
  • Publisher :Unknown
  • Release Date :2018-08-08
  • Total pages :355
  • ISBN : 9789811308543
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Summary : This volume highlights recent breakthroughs in the interdisciplinary areas of synthetic biology, metabolic engineering and bioprocess engineering for the production of green chemicals. It also presents practical experimental and computational tools for the design, construction and manipulation of cyanobacteria cell factories. The respective contributions cover new technologies in the field, such as novel genetic transformation techniques and bioinformatics analysis methods and address various aspects of cyanobacterial synthetic biology, offering a valuable resource for students and researchers in the fields of industry microbiology and biomedical engineering.