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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy
  • Author : Kasuya Hideki,Itzel Bustos Villalobos
  • Publisher :Unknown
  • Release Date :2021-01-15
  • Total pages :250
  • ISBN : 0128229144
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Summary : Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Immunotherapy discusses current treatment as well as treatment under investigation in pancreatic cancer. It brings information on how to combine current therapy with treatment under development and/or in clinical trials in order to be able to improve pancreatic cancer survival. Pancreatic cancer has a very low survival rate since it is discovered on late phase, when the patient already presents metastases and surgical options are limited. Currently, there are different modalities to treat pancreatic cancer, however its response has been poor and the toxicity of the treatment limits not only the survival rate, but also the patients that are able to get treated. This book reviews new modalities on basic research intending to reach the cure of pancreatic cancer, such as oncolytic viruses and Bi-specific T cell engager (BiTEs) as future clinical treatment, as well as discusses recent researches using those modalities as prospective combination therapy. The book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in learning more about new therapies to treat pancreatic cancer. Reviews current situation of pancreatic cancer before discussing new modalities, so the reader gets knowledge on what it is available and on problems faced on its treatment currently Discusses oncolytic virus in pancreatic cancer use, mainly herpes and adenoviruses, the results obtained on basic research as well as in clinical trials Encompasses knowledge on Bi-specific T cell engager (BiTEs) focusing on its function, development and use on pancreatic cancer Brings information on combination therapies recently developed that allow lower dose of treatment, which means less side effect

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
  • Author : Ganji Purnachandra Nagaraju
  • Publisher :Unknown
  • Release Date :2019-02-26
  • Total pages :223
  • ISBN : 9780128176627
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Summary : Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives
  • Author : Jorge Morales-Montor,Mariana Segovia-Mendoza
  • Publisher :Unknown
  • Release Date :2020-10-14
  • Total pages :286
  • ISBN : 9780128220290
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Summary : Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2019-10-04
  • Total pages :376
  • ISBN : 9780128178690
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Summary : Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
  • Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
  • Publisher :Unknown
  • Release Date :2019-08-19
  • Total pages :410
  • ISBN : 9780128194584
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Summary : Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Cancer Immunotherapy at the Crossroads

Cancer Immunotherapy at the Crossroads
  • Author : James H. Finke,Ronald M. Bukowski
  • Publisher :Unknown
  • Release Date :2003-11-24
  • Total pages :386
  • ISBN : 9781592597437
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Summary : Leading investigators and clinicians detail the different mechanisms used by tumors to escape and impair the immune system and then spell out possible clinical strategies to prevent or reverse tumor-induced immune dysfunction. The authors review the mechanisms of immune dysfunction and evasion mechanisms in histologically diverse human tumors, focusing on tumor-induced molecular defects in T cells and antigen-presenting cells (dendritic cells and tumors), that may serve as biomarkers for patient prognosis. They discuss the means by which these immune functions may be protected or restored in order to more effectively support the process of tumor rejection in situ. Cutting-edge techniques are outlined with the capacity to monitor the strength and quality of patients' immune responses using immunocytometry, MHC-peptide tetramers combined with apoptosis assay, ELISPOT assay, and detection of MHC-TAA peptide complexes on tumor cells.

Bibliography of Medical Reviews

Bibliography of Medical Reviews
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1976
  • Total pages :229
  • ISBN : OSU:32436000861995
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Summary :

Cancer and Autoimmunity

Cancer and Autoimmunity
  • Author : M.E. Gershwin,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :2000-03-27
  • Total pages :468
  • ISBN : 0080528457
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Summary : Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike. The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival. This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art. This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Special listing (International Cancer Research Data Bank). v. 334, 1980

Special listing (International Cancer Research Data Bank). v. 334, 1980
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1980
  • Total pages :229
  • ISBN : STANFORD:24501854122
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Summary :

Chemical Abstracts

Chemical Abstracts
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :229
  • ISBN : UOM:39015057321377
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Summary :

A Theranostic and Precision Medicine Approach for Female-Specific Cancers

A Theranostic and Precision Medicine Approach for Female-Specific Cancers
  • Author : Rama Rao Malla,Ganji Purnachandra Nagaraju
  • Publisher :Unknown
  • Release Date :2020-11-06
  • Total pages :318
  • ISBN : 9780128226926
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Summary : A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Role of Transcription Factors in Gastrointestinal Malignancies

Role of Transcription Factors in Gastrointestinal Malignancies
  • Author : Ganji Purnachandra Nagaraju,Pallaval Veera Bramhachari
  • Publisher :Unknown
  • Release Date :2018-03-27
  • Total pages :513
  • ISBN : 9789811067280
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Summary : This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Cancer Research

Cancer Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009-03
  • Total pages :229
  • ISBN : CORNELL:31924108287321
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Summary :

Transplantation Immunology

Transplantation Immunology
  • Author : Fritz H. Bach,Hugh Auchincloss
  • Publisher :Unknown
  • Release Date :1995-08-18
  • Total pages :409
  • ISBN : UOM:39015034864515
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Summary : Transplantation Immunology Edited by Fritz H. Bach, M.D., and Hugh Auchincloss, Jr., M.D. In recent years, transplantation immunology has evolved as a distinct field founded on the recognition that rejection of a transplanted organ or tissue is mediated by immune mechanisms in the host responding to antigens in the donor tissue. This book provides a comprehensive, up-to-date review of current knowledge regarding the specific immune mechanisms which can cause recipients to reject clinical transplants. The text is divided into four sections: Major and Minor Histocompatibility Antigens, Immunobiology of Graft Rejection, Clinical Transplantation, and Frontiers in Transplantation. The first two sections cover present-day understanding of the genetic controls of immunity as well as the two basic concerns of transplantation immunology, namely donor tissue antigens and the host cellular response. The third section deals with clinical aspects of transplantation, while the fourth looks toward future efforts of scientific research in this field—including advances in tolerance and xenotransplantation. A detailed appendix entitled "Molecular Biology for the Clinician" is included to help make the material accessible to readers of all backgrounds. Authored by a wide range of experts in both clinical and research fields, individual chapters cover such topics as: T cell immunity Antigen presentation Alloreactivity Pancreas and islet cell transplantation Allogeneic bone marrow transplantation Models of tolerance induction Xenotransplantation The swine leukocyte antigen (SLA) complex Transplantation Immunology is an ideal teaching text for the fundamental concepts, latest findings, and future directions in this increasingly important field. This volume will appeal to a wide range of clinicians including surgeons and primary-care physicians, as well as scientists in molecular biology and immunology.

Role of Tyrosine Kinases in Gastrointestinal Malignancies

Role of Tyrosine Kinases in Gastrointestinal Malignancies
  • Author : Ganji Purnachandra Nagaraju
  • Publisher :Unknown
  • Release Date :2018-09-27
  • Total pages :241
  • ISBN : 9789811314865
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Summary : The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.

Immunotherapy of Cancer

Immunotherapy of Cancer
  • Author : Yoshiyuki Yamaguchi
  • Publisher :Unknown
  • Release Date :2016-02-22
  • Total pages :358
  • ISBN : 9784431550310
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Summary : This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Anti-cancer Drugs

Anti-cancer Drugs
  • Author : Jasna Bankovic
  • Publisher :Unknown
  • Release Date :2016-12-07
  • Total pages :196
  • ISBN : 9789535128137
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Summary : We are in constant search for new therapeutic options to cure cancer. In this book, you can find out how scientists throughout the world deal with this problem. Readers will learn how to engage nature, chemical synthesis, and cell machinery to design new anticancer agents. Nature has already been very generous in providing us different compounds which are in widespread application. Starting from these resources, various synthetic processes are applied to create synthetic drugs which can be then obtained in large quantities. Also, the cell by itself provides different possibilities to meet the constantly increasing requirements for successful therapy. Explore the book and find out what are the new ways to fight cancer.

The Journal of Immunology

The Journal of Immunology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : UIUC:30112066647188
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Summary :

Critical Dietary Factors in Cancer Chemoprevention

Critical Dietary Factors in Cancer Chemoprevention
  • Author : Mohammad Fahad Ullah,Aamir Ahmad
  • Publisher :Unknown
  • Release Date :2015-10-06
  • Total pages :373
  • ISBN : 9783319214610
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Summary : This book focuses on the prophylactic potential of diet-derived factors in primary prevention of cancer. It is written by a group of highly reputed experts in the area of dietary agents and cancer chemoprevention. The translational potential of dietary factors from epidemiological, laboratory and clinical studies as prevention strategy in normal and risk populations is highlighted. The work presents options of routine inclusion of specific dietary regimens for prevention as well as therapeutic strategy for better management through adjuvant interventions in cancer treatment.

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy
  • Author : Benjamin Bonavida
  • Publisher :Unknown
  • Release Date :2013-07-04
  • Total pages :260
  • ISBN : 9781461470700
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Summary : ​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Essentials of Interventional Cancer Pain Management

Essentials of Interventional Cancer Pain Management
  • Author : Amitabh Gulati,Vinay Puttanniah,Brian M. Bruel,William S. Rosenberg,Joseph C. Hung
  • Publisher :Unknown
  • Release Date :2018-12-28
  • Total pages :530
  • ISBN : 9783319996844
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Summary : This text provides a comprehensive review and expertise on various interventional cancer pain procedures. The first part of the text addresses the lack of consistency seen in the literature regarding interventional treatment options for specific cancer pain syndromes. Initially, it discusses primary cancer and treatment-related cancer pain syndromes that physicians may encounter when managing cancer patients. The implementation of paradigms that can be used in treating specific groups of cancer such as breast cancer, follows. The remainder of the text delves into a more common approach to addressing interventional cancer pain medicine. After discussing interventional options that are commonly employed by physicians, the text investigates how surgeons may address some of the more severe pain syndromes, and covers the most important interventional available for our patients, intrathecal drug delivery. Chapters also cover radiologic options in targeted neurolysis and ablative techniques, specifically for bone metastasis, rehabilitation to address patients’ quality of life and function, and integrative and psychological therapies. Essentials of Interventional Cancer Pain Management globally assesses and addresses patients’ needs throughout the cancer journey. Written by experts in the field, and packed with copious tables, figures, and flow charts, this book is a must-have for pain physicians, residents, and fellows.