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Genome Editing

Genome Editing
  • Author : Kursad Turksen
  • Publisher :Unknown
  • Release Date :2016-08-09
  • Total pages :166
  • ISBN : 9783319341484
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Summary : This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions. Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.

Genome Editing

Genome Editing
  • Author : Kiran Musunuru
  • Publisher :Unknown
  • Release Date :2021-06-15
  • Total pages :220
  • ISBN : 0128234849
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Summary : Genome Editing: A Practical Guide to Research and Clinical Applications is geared towards investigators interested in learning how to use CRISPR-Cas9-based technologies, with a focus on cardiovascular research and clinical applications. Covering a range of topics from the basics of genome editing to design considerations, to assessments and applications, this reference allows readers to get started and establish a full workflow from the beginning of the project to its full completion. With worked examples drawn from real-life experiments, as well as troubleshooting and pitfalls to avoid, the book serves as an essential reference for researchers and investigators in both cardiovascular and biomedical research. Help readers familiarise with the variety of genome-editing approaches that are being applied in cardiovascular research and medicine, i.e., both research applications and clinical applications Understand the use of genome editing through worked examples (based on real-life experiments) in which CRISPR-Cas9 is employed, online tools to design CRISPR-Cas9 reagents, methods to interpret data from genome-editing experiments, the downsides of genome-editing technology - both the scientific and ethical pitfalls to avoid Written in an easy-to-follow manner, guiding readers from the design of the project to its completion Includes unpublished and new methods

Cardiovascular Genomics

Cardiovascular Genomics
  • Author : Mohan K. Raizada,Julian F. R. Paton,Sergey Kasparov,Michael J. Katovich
  • Publisher :Unknown
  • Release Date :2005-01-06
  • Total pages :362
  • ISBN : 9781588294005
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Summary : Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Human Genome Editing

Human Genome Editing
  • Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
  • Publisher :Unknown
  • Release Date :2017-08-13
  • Total pages :328
  • ISBN : 9780309452885
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Summary : Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Establishment of the Human Cardiac Models Using Gene Editing and Reprogramming in Human Pluripotent Stem Cells to Understand the Putative Functions of the G-protein Coupled Receptor Kinase 5 Polymorphism (GRK5-L41).

Establishment of the Human Cardiac Models Using Gene Editing and Reprogramming in Human Pluripotent Stem Cells to Understand the Putative Functions of the G-protein Coupled Receptor Kinase 5 Polymorphism (GRK5-L41).
  • Author : Minh Duc Hoang
  • Publisher :Unknown
  • Release Date :2017
  • Total pages :229
  • ISBN : OCLC:1064678373
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Summary :

Genome Editing and Engineering

Genome Editing and Engineering
  • Author : Krishnarao Appasani
  • Publisher :Unknown
  • Release Date :2018-07-31
  • Total pages :586
  • ISBN : 9781107170377
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Summary : A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Genome Editing and Engineering

Genome Editing and Engineering
  • Author : Krishnarao Appasani
  • Publisher :Unknown
  • Release Date :2018-07-31
  • Total pages :586
  • ISBN : 9781107170377
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Summary : A complete guide to endonuclease-based genomic engineering, from basic science to application in disease biology and clinical treatment.

Congestive Heart Failure and Cardiac Transplantation

Congestive Heart Failure and Cardiac Transplantation
  • Author : Daniel J. Garry,Robert F. Wilson,Zeev Vlodaver
  • Publisher :Unknown
  • Release Date :2017-06-01
  • Total pages :572
  • ISBN : 9783319445779
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Summary : This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students.

Genome Engineering via CRISPR-Cas9 System

Genome Engineering via CRISPR-Cas9 System
  • Author : Vijai Singh,Pawan K. Dhar
  • Publisher :Unknown
  • Release Date :2020-02-18
  • Total pages :384
  • ISBN : 9780128181416
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Summary : Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

Encyclopedia of Cardiovascular Research and Medicine

Encyclopedia of Cardiovascular Research and Medicine
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2017-11-27
  • Total pages :2800
  • ISBN : 9780128051542
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Summary : Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.

Cardiovascular Diseases

Cardiovascular Diseases
  • Author : Nikolaos Papageorgiou
  • Publisher :Unknown
  • Release Date :2016-08-05
  • Total pages :252
  • ISBN : 9780128033135
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Summary : Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and Their Interaction covers the special heritability characteristics and identifying genetic and environmental contributions to cardiovascular health. This important reference provides an overview of the genetic basis of cardiovascular disease and its risk factors. Included are important topics, ranging from lifestyle choices, risk factors, and exposure, to pollutants and chemicals. Also covered are the influences of Mendelian traits and familial aggregation and the interactions and interrelationships between genetics and environmental factors which, when compared, provide a sound understanding of the interplay between inherited and acquired risk factors. The book provides a much needed reference for this rapidly growing field of study. By combining the latest research within the structured chapters of this reference, a better understanding of genetic and environmental contribution to cardiovascular disease is found, helping to substantiate further investigations in the field and design prevention and treatment strategies. Provides an overview of the genetic basis of cardiovascular disease and its risk factors Reviews several large population-based studies which indicate that exposure to several environmental factors may increase CVD morbidity and mortality, exploring the plausibility of this association by data from animal studies Reflects on future studies to help understanding the role of genes and environmental factors in the development and progression of cardiovascular disease

Pathophysiology and Pharmacotherapy of Cardiovascular Disease

Pathophysiology and Pharmacotherapy of Cardiovascular Disease
  • Author : Gowraganahalli Jagadeesh,Pitchai Balakumar,Khin Maung-U
  • Publisher :Unknown
  • Release Date :2015-05-06
  • Total pages :1342
  • ISBN : 9783319159614
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Summary : The present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease.

Advances in Genome Editing

Advances in Genome Editing
  • Author : Jennifer A. Doudna
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :229
  • ISBN : 1618962337
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Summary :

Translational Cardiometabolic Genomic Medicine

Translational Cardiometabolic Genomic Medicine
  • Author : Annabelle Rodriguez-Oquendo
  • Publisher :Unknown
  • Release Date :2015-09-07
  • Total pages :352
  • ISBN : 9780128004746
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Summary : Translational Cardiometabolic Genomic Medicine, edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases. This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis. It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets. Provides comprehensive research on translational genomic medicine Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome

Cardiovascular Engineering: A Protective Approach

Cardiovascular Engineering: A Protective Approach
  • Author : Shu Liu
  • Publisher :Unknown
  • Release Date :2020-06-12
  • Total pages :496
  • ISBN : 9781260457650
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Summary : Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Cardiovascular engineering principles and practices with a focus on disease prevention Aimed at advanced students taking cardiovascular, regenerative, and tissue engineering courses, Cardiovascular Engineering: A Protective Approach explores applications of protective engineering strategies and technologies to common cardiovascular disorders. A protective approach to cardiovascular engineering involves studying the naturally occurring mechanisms that protect molecules, cells, and organs from injury and dysfunction. The goal is to use this understanding to design and develop engineering-based therapeutic strategies and technologies that prevent cardiovascular injury and disease. Readers will learn the fundamental and applied aspects of cardiovascular engineering. Coverage includes: • Foundations of cardiovascular protective engineering • Development of the heart, blood vessels, and blood cells • Stem cells and regeneration • Structure and function of the heart and blood vessels • Cytokines and growth factors in cardiovascular disease • Mechanisms of disease • Systems protective mechanisms against injury • Protective engineering strategies • Systemic hypertension • Atherosclerosis and arterial aneurysms • Ischemic heart disease and ischemic stroke • Cardiomyopathies and congenital heart disease

Precision Medicine for Investigators, Practitioners and Providers

Precision Medicine for Investigators, Practitioners and Providers
  • Author : Joel Faintuch,Salomao Faintuch
  • Publisher :Unknown
  • Release Date :2019-11-16
  • Total pages :640
  • ISBN : 9780128191798
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Summary : Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Application of Genetics and Genomics in Poultry Science

Application of Genetics and Genomics in Poultry Science
  • Author : Xiaojun Liu
  • Publisher :Unknown
  • Release Date :2018-09-05
  • Total pages :184
  • ISBN : 9781789236309
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Summary : Genetics and genomics in poultry have been the most rapidly advancing subjects since the completion of the chicken genome sequence in 2004 and have been extensively used to understand the genetic determinants of complex traits. This book intends to provide readers with a comprehensive overview of the current progress in the application of genetic and genomic science in the poultry field. The contents cover genetic variation detection, selection methods for breeding, transgenesis and genome editing, genetic basis of disease resistance, control of gene expression and regulation, reproduction and meat quality, etc. The book should prove useful to researchers and students working in related fields.

Cardiovascular and Pulmonary Physical Therapy, Third Edition

Cardiovascular and Pulmonary Physical Therapy, Third Edition
  • Author : William DeTurk,Lawerence Cahalin
  • Publisher :Unknown
  • Release Date :2018-01-12
  • Total pages :800
  • ISBN : 9781259837968
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Summary : A comprehensive, up-to-date textbook spanning the entire scope of cardiovascular and pulmonary practice A Doody’s Core Title for 2019! Cardiovascular and Pulmonary Physical Therapy, Third Edition reflects the broadest possible spectrum of cardiovascular and pulmonary practice and draws upon the expertise of a carefully selected team of world-renowned contributors. This internationally acclaimed text reviews must-know background knowledge, thoroughly explains exercise principles, cites the best evidence, and integrates the American Physical Therapy Association’s approved practice patterns into the chapter content. Learn how to apply principles to practice in any setting with: • The Guide to Physical Therapy Practice integrated throughout, with an entire chapter devoted to its history and use • Preferred practice patterns for cardiovascular and pulmonary physical therapy form the core of eight chapters are used as springboards to describe interventions and outcomes • Case studies in practice pattern chapters allow you to experience the proper application of the practice patterns • The patient-client management model is used in the case studies with appropriate test, measures, and interventions selected from the practice patterns and applied to the patient • “International Perspectives” provide a way to gain insight into the global practice of physical therapy • Evidence-based and peer reviewed published material is included to help you develop specific intervention regimens • Online access to case-based exercises, video clips illustrating technical psychomotor skills, and demonstrations of cardiac and pulmonary physical exams

Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells

Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :229
  • ISBN : OCLC:1051396571
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Summary : Abstract: PRKAG2 cardiac syndrome is a distinct form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular pre-excitation and progressive cardiac conduction disorder. However, it remains unclear how mutations in the PRKAG2 gene give rise to such a complicated disease. To investigate the underlying molecular mechanisms, we generated disease-specific hiPSC-derived cardiomyocytes from two brothers both carrying a heterozygous missense mutation c.905G>A (R302Q) in the PRKAG2 gene and further corrected the R302Q mutation with CRISPR-Cas9 mediated genome editing. Disease-specific hiPSC-cardiomyocytes recapitulated many phenotypes of PRKAG2 cardiac syndrome including cellular enlargement, electrophysiological irregularities and glycogen storage. In addition, we found that the PRKAG2-R302Q mutation led to increased AMPK activities, resulting in extensive glycogen deposition and cardiomyocyte hypertrophy. Finally we confirmed that disrupted phenotypes of PRKAG2 cardiac syndrome caused by the specific PRKAG2-R302Q mutation can be alleviated by small molecules inhibiting AMPK activity and be rescued with CRISPR-Cas9 mediated genome correction. Our results showed that disease-specific hiPSC-CMs and genetically-corrected hiPSC-cardiomyocytes would be a very useful platform for understanding the pathogenesis of, and testing autologous cell-based therapies for, PRKAG2 cardiac syndrome. Abstract : Graphical abstract Highlights: Patient-specific hiPSC-CM model of PRKAG2 cardiac syndrome is successfully generated. Patient-specific hiPSC-CMs recapitulate critical properties of the PRKAG2 cardiac syndrome in vitro . PRKAG2-R302Q mutation increases AMPK activity, leading to extensive glycogen deposition in hiPSC-CMs. Patient-specific hiPSC-CMs provide a new way to study the pathogenesis of PRKAG2 cardiac syndrome. CRISPR-Cas9 mediated genome correction can rescue the phenotypes of PRKAG2 cardiac syndrome.

Pluripotent Stem Cells

Pluripotent Stem Cells
  • Author : Deepa Bhartiya,Nibedita Lenka
  • Publisher :Unknown
  • Release Date :2013-08-28
  • Total pages :640
  • ISBN : 9789535111924
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Summary : Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Handbook of Clinical Adult Genetics and Genomics

Handbook of Clinical Adult Genetics and Genomics
  • Author : Shweta Dhar,Sandesh Sreenath Chakravarthy Nagamani,Tanya Eble
  • Publisher :Unknown
  • Release Date :2020-04-10
  • Total pages :534
  • ISBN : 9780128173459
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Summary : Handbook of Clinical Adult Genetics and Genomics: A Practice-Based Approach provides a thorough overview of genetic disorders that are commonly encountered in adult populations and supports the full translation of adult genetic and genomic modalities into clinical practice. Expert chapter authors supplement foundational knowledge with case-based strategies for the evaluation and management of genetic disorders in each organ system and specialty area. Topics discussed include employing genetic testing technologies, reporting test results, genetic counseling for adult patients, medical genetics referrals, issues of complex inheritance, gene therapy, and diagnostic and treatment criteria for developmental, cardiovascular, gastrointestinal, neuropsychiatric, pulmonary issues, and much more. Employs clinical case studies to demonstrate how to evaluate, diagnosis and treat adult patients with genetic disorders Offers a practical framework for establishing an adult genetics clinic, addressing infrastructure, billing, counseling, and challenges unique to adult clinical genetics Features chapter contributions from authors at leading adult genetics institutions in the US and abroad