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Innovative Medicine

Innovative Medicine
  • Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
  • Publisher :Unknown
  • Release Date :2015-10-13
  • Total pages :339
  • ISBN : 9784431556510
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Summary : This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Cell-Based Liver Regeneration

Cell-Based Liver Regeneration
  • Author : Hala Gabr,Wael Abo El-Kheir
  • Publisher :Unknown
  • Release Date :2021-10-01
  • Total pages :275
  • ISBN : 9780128223413
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Summary : Stem cell therapy is a fast-growing field of medicine with remarkable prospects in a broad spectrum of diseases. Cell-Based Liver Regeneration: Current Aspects and Future Approaches addresses the full spectrum of regenerative medicine in liver diseases. Coverage will include the basic science, current research and a comprehensive review of clinical trials conducted in the field. The book will discuss the various types of stem cells for liver regeneration, presenting the advantages and disadvantages of each type. A review of all aspects of implanting stem cell therapy for the liver, such as: choosing the cell type, the source, laboratory manipulation, dose, route and follow-up. The book concludes with a full discussion of the current clinical trials involving cellular therapy in liver regeneration. Cell-Based Liver Regeneration: Current Aspects and Future Approaches is written for stem cell biologists, liver biologists, hepatologists and graduate students by authors with extensive knowledge in basic, pre-clinical and clinical stem cell research. Introduces basic concepts of liver regeneration Discusses the various types of stem cells used in liver regeneration Explores published and ongoing clinical trials involving cellular therapy in liver regeneration

Regenerative Medicine, Stem Cells and the Liver

Regenerative Medicine, Stem Cells and the Liver
  • Author : David C. Hay
  • Publisher :Unknown
  • Release Date :2012-04-12
  • Total pages :200
  • ISBN : 9781578087396
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Summary : The regenerative capacity of the liver has been recognized for centuries, but when it is overwhelmed by insulting stimuli or is chronically damaged, its regenerative capability is substantially reduced or lost. Researchers have been working to find solutions to cure failing human liver function. Given the ability of stem cells to self- renew and differentiate into specialized cell liver types, they represent an attractive strategy to replace lost liver function. This book begins by outlining the complex nature of human liver disease and proceeds to examine the potential that stem cell-based approaches have to offer.

Stem Cell and Liver Regeneration

Stem Cell and Liver Regeneration
  • Author : K. Okita
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :87
  • ISBN : 4431401997
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Summary : Cellular therapy with liver stem cells and their progeny, including bone marrow cells, is a promising new approach that will contribute significantly to the treatment of liver diseases. The existence of the liver stem cell had long been debated, but it is now generally accepted that the liver contains cells with stem-like properties and that these cells can be activated to proliferate and differentiate into mature hepatocytes under certain conditions. There is also a substantial body of evidence to suggest that oval cells are involved in liver regeneration as they differentiate into hepatocytes and biliary cells. This book is a collection of work on stem cell and liver regeneration, initially delivered at the 14th Yamaguchi (Japan) Symposium on Liver Disease. Its nine chapters present the most recent data about basic and clinical research in hepatology in Japan and other countries, providing a valuable resource for researchers and practitioners alike.

Liver Regeneration

Liver Regeneration
  • Author : Dieter Häussinger
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :210
  • ISBN : 9783110250787
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Summary : Understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine.

Liver Regeneration

Liver Regeneration
  • Author : Udayan M. Apte
  • Publisher :Unknown
  • Release Date :2015-08-13
  • Total pages :326
  • ISBN : 9780128004319
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Summary : Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease. By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management. Hundreds of full-color, graphic photographs and illustrations underline key elements and show researchers and students important aspects of liver transplantation, immunofluorescence, and other techniques used in liver regeneration. Summarizes current liver regeneration studies and discussions on expected discoveries Provides an overview of standard scientific and cutting-edge technologies to study liver regeneration Presents details on the molecular mechanisms that affect liver regeneration Highly illustrated, with hundreds of full-color, graphic photographs and illustrations to enhance the learning process

Cardiac Regeneration

Cardiac Regeneration
  • Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
  • Publisher :Unknown
  • Release Date :2017-10-27
  • Total pages :274
  • ISBN : 9783319561066
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Summary : This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Principles of Regenerative Medicine

Principles of Regenerative Medicine
  • Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
  • Publisher :Unknown
  • Release Date :2010-12-16
  • Total pages :1202
  • ISBN : 0123814235
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Summary : Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Scientific Engineering of Distributed Java Applications.

Scientific Engineering of Distributed Java Applications.
  • Author : Nicoals Guelfi,Egidio Astesiano,Gianna Reggio
  • Publisher :Unknown
  • Release Date :2004-02-18
  • Total pages :154
  • ISBN : 3540210911
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Summary : This book constitutes the thoroughly refereed post-proceedings of the Third International Workshop on Scientific Engineering of Distributed Java Applications, FIDJI 2003, held in Luxembourg-Kirchberg, Luxembourg in November 2003. The 213 revised full papers presented together with abstracts of two invited contributions were carefully selected during two round of reviewing and revision from 29 submissions. Among the topics addressed are Java-enabled service gateways, mobility in distributed settings, XML, embedded Java software, interception services, mobile agents, error management, software model engineering, distributed composite objects, cooperative applications, distributed mobile applications, service-based software architectures, and distributed Java programs.

Stem Cells and Cancer in Hepatology

Stem Cells and Cancer in Hepatology
  • Author : Yun-Wen Zheng
  • Publisher :Unknown
  • Release Date :2018-05-18
  • Total pages :382
  • ISBN : 9780128123027
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Summary : Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge. Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation

Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation
  • Author : Giuseppe Orlando
  • Publisher :Unknown
  • Release Date :2013-10-11
  • Total pages :1050
  • ISBN : 9780123985200
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Summary : Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Liver, Lung and Heart Regeneration

Liver, Lung and Heart Regeneration
  • Author : Phuc Van Pham
  • Publisher :Unknown
  • Release Date :2016-12-10
  • Total pages :218
  • ISBN : 9783319466934
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Summary : This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Liver Cirrhosis

Liver Cirrhosis
  • Author : Georgios Tsoulfas
  • Publisher :Unknown
  • Release Date :2019-05-02
  • Total pages :178
  • ISBN : 9781789238853
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Summary : Liver cirrhosis and its complications affect millions of patients of all ages around the globe and present treating physicians with perplexing problems, given the variety of etiologies and the critical nature of hepatic physiology. This book is a collection of chapters offering the distilled knowledge of various worldwide experts in hepatic surgery and hepatic physiology. The various debates that are presented regarding the diagnosis and treatment of liver cirrhosis and its significant complications, in addition to the most up-to-date information regarding molecular aspects, provide the reader with the full spectrum of knowledge in this challenging and continuously evolving field.

Muse Cells

Muse Cells
  • Author : Mari Dezawa
  • Publisher :Unknown
  • Release Date :2018-11-27
  • Total pages :315
  • ISBN : 9784431568476
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Summary : This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

Adult Stem Cell Niches

Adult Stem Cell Niches
  • Author : Sabine Wislet
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :330
  • ISBN : 9789535117186
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Summary : Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Signaling Pathways in Liver Diseases

Signaling Pathways in Liver Diseases
  • Author : Jean-Francois Dufour,Pierre-Alain Clavien
  • Publisher :Unknown
  • Release Date :2015-08-24
  • Total pages :520
  • ISBN : 9781118663363
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Summary : Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Stem Cells – From Hype to Real Hope

Stem Cells – From Hype to Real Hope
  • Author : Khawaja Husnain Haider,Salim Aziz, MD
  • Publisher :Unknown
  • Release Date :2018-12-17
  • Total pages :220
  • ISBN : 9783110587043
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Summary : This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

Liver Regeneration and Carcinogenesis

Liver Regeneration and Carcinogenesis
  • Author : Randy L. Jirtle
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :402
  • ISBN : UOM:39015034937352
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Summary : Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field. * Logical organization of material in three detailed and comprehensive sections: liver regeneration, liver carcinogenesis, and liver tumor treatment * Contributors are pioneers and leaders in the field * There are currently no books on this subject on the market * Research focus is at the molecular level.

Hepatic Stem Cells

Hepatic Stem Cells
  • Author : Naoki Tanimizu
  • Publisher :Unknown
  • Release Date :2019-02-04
  • Total pages :248
  • ISBN : 149398960X
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Summary : This volume looks at the liver’s epithelial cells—hepatocytes and cholangiocytes—and their progenitors. This book is divided into five parts: isolation of progenitor cells; characterization of liver progenitors in vivo; generation of hepatocytes, cholangiocytes, and their progenitors; reconstitution of liver tissue structures; and liver injury models. The chapters in this book cover topics such as expansion of bipotential liver stem/progenitor cells (LPCs) from fetal and neonatal liver; identifying progenitor cells involved in liver regeneration in vivo; methods for generating hepatocytes and cholangiocytes from multiple cellular sources; 3D tissue structures ex vivo; and resolving hepatic fibrosis by bone marrow transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Hepatic Stem Cells: Methods and Protocols is a valuable resource to help researchers understand the current theories used to study hepatic stem/progenitor cells, and aid them in performing experiments related to liver biology and pathophysiology.

The Liver

The Liver
  • Author : Irwin M. Arias,Harvey J. Alter,James L. Boyer,David E. Cohen,David A. Shafritz,Snorri S. Thorgeirsson,Allan W. Wolkoff
  • Publisher :Unknown
  • Release Date :2020-01-22
  • Total pages :1144
  • ISBN : 9781119436836
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Summary : Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Translational Regenerative Medicine

Translational Regenerative Medicine
  • Author : Anthony Atala,Julie Allickson
  • Publisher :Unknown
  • Release Date :2014-12-01
  • Total pages :606
  • ISBN : 9780124104570
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Summary : Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine