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Cell Instructive Materials to Control and Guide Cell Function

Cell Instructive Materials to Control and Guide Cell Function
  • Author : Paolo Netti,Maurizio Ventre
  • Publisher :Unknown
  • Release Date :2020-11-26
  • Total pages :258
  • ISBN : 9780081029381
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Summary : Cell Instructive Materials to Control and Guide Cell Function: Programmable Bioactive Interfaces looks at the key determinants of the dynamic interface between cell and materials and how this can be applied in developing new, bioactive biomaterials surfaces. The interface between cell and synthetic materials has attracted considerable scientific and technological interest, leading to the awareness that functional interfaces can actively guide and control specific adhesion and recognitions events. Introduces readers to the fundamentals of complex cell-material interface dynamics Provides valuable tools for the control of the interfacial dynamics to instruct and control cells or tissues functions Covers the prospect of encoding specific cell instructions on, or within, a biomaterial by micro- and nano-patterning materials features

Bioinspired Approaches for Human-Centric Technologies

Bioinspired Approaches for Human-Centric Technologies
  • Author : Roberto Cingolani
  • Publisher :Unknown
  • Release Date :2014-06-04
  • Total pages :334
  • ISBN : 9783319049243
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Summary : The present book discusses topics related to research and development of materials and devices at nanoscale size and their respective application in medicine and biomedicine. The individual chapters give a detailed state of the art overview to the distinct topic. Apparently disconnected fields - life sciences, biomedicine, chemistry, physics, medicine and engineering - will be bridged with a highly interdisciplinary view onto each subject.

Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation
  • Author : Giuseppe Orlando
  • Publisher :Unknown
  • Release Date :2013-10-11
  • Total pages :1050
  • ISBN : 9780123985200
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Summary : Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Hydrogels in Tissue Engineering

Hydrogels in Tissue Engineering
  • Author : Esmaiel Jabbari
  • Publisher :Unknown
  • Release Date :2018-08-24
  • Total pages :158
  • ISBN : 9783038971214
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Summary : This book is a printed edition of the Special Issue " Hydrogels in Tissue Engineering" that was published in Gels

Regenerative Engineering

Regenerative Engineering
  • Author : Yusuf Khan,Cato T. Laurencin
  • Publisher :Unknown
  • Release Date :2018-04-19
  • Total pages :154
  • ISBN : 9781498738255
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Summary : This book focuses on advances made in both materials science and scaffold development techniques, paying close attention to the latest and state-of-the-art research. Chapters delve into a sweeping variety of specific materials categories, from composite materials to bioactive ceramics, exploring how these materials are specifically designed for regenerative engineering applications. Also included are unique chapters on biologically-derived scaffolding, along with 3D printing technology for regenerative engineering. Features: Covers the latest developments in advanced materials for regenerative engineering and medicine. Each chapter is written by world class researchers in various aspects of this medical technology. Provides unique coverage of biologically derived scaffolding. Includes separate chapter on how 3D printing technology is related to regenerative engineering. Includes extensive references at the end of each chapter to enhance further study.

Bio-inspired Materials for Biomedical Engineering

Bio-inspired Materials for Biomedical Engineering
  • Author : Anthony B. Brennan,Chelsea M. Kirschner
  • Publisher :Unknown
  • Release Date :2014-04-14
  • Total pages :400
  • ISBN : 9781118369364
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Summary : This book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine. Scientists, engineers and physicians are working together to replicate the sophisticated hierarchical organization and adaptability found in nature and selected by evolution to recapitulate the cellular microenvironment. This book demonstrates the dramatic clinical breakthroughs that have been made in engineering all four of the major tissue types and modulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments) covers Bio-inspired Presentation of Chemical Cues, Bio-inspired Presentation of Physical Cues, and Bio-inspired Integration of Natural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissue engineering in epithelial tissue, muscle tissue, connective tissue, and the immune system.

Biomolecularly and Mechanically Instructive Materials for Guiding Cell-substrate Interactions

Biomolecularly and Mechanically Instructive Materials for Guiding Cell-substrate Interactions
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2015
  • Total pages :229
  • ISBN : OCLC:931702394
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Summary :

Nanotechnologies in Preventive and Regenerative Medicine

Nanotechnologies in Preventive and Regenerative Medicine
  • Author : Vuk Uskokovic
  • Publisher :Unknown
  • Release Date :2017-11-22
  • Total pages :616
  • ISBN : 9780323480642
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Summary : Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage Explains how nanomaterials can be manipulated to create more effective drug treatments Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments

Functional 3D Tissue Engineering Scaffolds

Functional 3D Tissue Engineering Scaffolds
  • Author : Ying Deng,Jordan Kuiper
  • Publisher :Unknown
  • Release Date :2017-10-17
  • Total pages :482
  • ISBN : 9780081009802
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Summary : In order to grow replacement tissues, 3D scaffolds are widely used as a template for tissue engineering and regeneration. These scaffolds, which are typically ‘seeded’ with cells, support the growth of new tissues. However, in order to achieve successful tissue growth, the scaffold must meet specific requirements and are often ‘functionalized’ to accentuate particular properties. Functional 3D tissue engineering scaffolds: materials, technologies, and applications, is a comprehensive review of functional 3D scaffolds, providing information on the fundamentals, technologies, and applications. Part 1 focuses on the fundamentals of 3D tissue scaffolds, examining information on materials, properties, and trends. Part 2 discusses a wide range of conventional technologies for engineering functional 3D scaffolds, leading the way to a discussion on CAD and advanced technologies for functional 3D scaffold engineering. Chapters in part 3 study methods for functionalizing scaffolds to support a variety of in vivo functions whilst the final set of chapters provides an important review of the most significant applications of functional 3D scaffolds within tissue engineering. This book is a valuable resource for biomaterial scientists and biomedical engineers in academia and industry, with interests in tissue engineering and regenerative medicine. Provides a self-contained work for the field of biomaterials and tissue engineering Discusses all the requirements a scaffold must meet and a wide range of strategies to create them Highlights significant and successful applications of functional 3D scaffolds

Combinatorial Approach to Synthetic Extracellular Environments to Control the Growth of Human Embryonic Stem Cells

Combinatorial Approach to Synthetic Extracellular Environments to Control the Growth of Human Embryonic Stem Cells
  • Author : Ratmir Derda
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :271
  • ISBN : WISC:89099670598
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Summary :

Advances in the Application of Lasers in Materials Science

Advances in the Application of Lasers in Materials Science
  • Author : Paolo M. Ossi
  • Publisher :Unknown
  • Release Date :2018-10-01
  • Total pages :395
  • ISBN : 9783319968452
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Summary : The book covers recent advances and progress in understanding both the fundamental science of lasers interactions in materials science, as well as a special emphasis on emerging applications enabled by the irradiation of materials by pulsed laser systems. The different chapters illustrate how, by careful control of the processing conditions, laser irradiation can result in efficient material synthesis, characterization, and fabrication at various length scales from atomically-thin 2D materials to microstructured periodic surface structures. This book serves as an excellent resource for all who employ lasers in materials science, spanning such different disciplines as photonics, photovoltaics, and sensing, to biomedical applications.

Smart Polymers and Their Applications

Smart Polymers and Their Applications
  • Author : Maria Rosa Aguilar,Julio San Román
  • Publisher :Unknown
  • Release Date :2019-02-15
  • Total pages :650
  • ISBN : 9780081024171
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Summary : Smart Polymers and Their Applications, Second Edition presents an up-to-date resource of information on the synthesis and properties of different types of smart polymers, including temperature, pH, electro, magnetic and photo-responsive polymers, amongst others. It is an ideal introduction to this field, as well as a review of the latest research in this area. Shape memory polymers, smart polymer hydrogels, and self-healing polymer systems are also explored. In addition, a very strong focus on applications of smart polymers is included for tissue engineering, smart polymer nanocarriers for drug delivery, and the use of smart polymers in medical devices. Additionally, the book covers the use of smart polymers for textile applications, packaging, energy storage, optical data storage, environmental protection, and more. This book is an ideal, technical resource for chemists, chemical engineers, materials scientists, mechanical engineers and other professionals in a range of industries. Includes a significant number of new chapters on smart polymer materials development, as well as new applications development in energy storage, sensors and devices, and environmental protection Provides a multidisciplinary approach to the development of responsive polymers, approaching the subject by the different types of polymer (e.g. temperature-responsive) and its range of applications

Comprehensive Biomaterials II

Comprehensive Biomaterials II
  • Author : Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
  • Publisher :Unknown
  • Release Date :2017-05-18
  • Total pages :4858
  • ISBN : 9780081006924
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Summary : Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

Current Advances in Oral and Craniofacial Tissue Engineering

Current Advances in Oral and Craniofacial Tissue Engineering
  • Author : Vincenzo Guarino,Marco Antonio Alverez-Perez
  • Publisher :Unknown
  • Release Date :2020-11-12
  • Total pages :230
  • ISBN : 9780429750830
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Summary : Oral tissue engineering involves the study of current approaches for in vitro regeneration of soft and hard tissues located into the oral cavity. In this context, recent approaches involves the use of innovative biomaterials to replace the lost or damaged human oral tissues. Recent discoveries in materials science and nanotechnology are drastically changing the traditional approach to dentistry by the design of innovative devices able more efficiently supporting the natural regeneration process. The objective of this book is to highlight current progress in tissue engineering for various dental hard/soft tissues including enamel, dentin, pulp, alveolar bone, periodontium, gum and oral mucosa, by emphasizing the role of materials and their specific applications.

Biomaterials Science

Biomaterials Science
  • Author : Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :1573
  • ISBN : 9780080877808
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Summary : The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank

Tissue and Organ Regeneration

Tissue and Organ Regeneration
  • Author : Lijie Grace Zhang,Ali Khademhosseini,Thomas Webster
  • Publisher :Unknown
  • Release Date :2014-05-15
  • Total pages :822
  • ISBN : 9789814411677
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Summary : Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell–based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.

Principles of Tissue Engineering

Principles of Tissue Engineering
  • Author : Robert Lanza,Robert Langer,Joseph P. Vacanti,Anthony Atala
  • Publisher :Unknown
  • Release Date :2020-03-26
  • Total pages :1678
  • ISBN : 9780128214015
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Summary : Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field. Organized into twenty-three parts, covering the basics of tissue growth and development, approaches to tissue and organ design, and a summary of current knowledge by organ system Introduces a new section and chapters on emerging technologies in the field Full-color presentation throughout

Dysfunction and Repair of Neural Circuits for Motor Control

Dysfunction and Repair of Neural Circuits for Motor Control
  • Author : John Martin,George Mentis,Andrew Paul Tosolini
  • Publisher :Unknown
  • Release Date :2021-04-21
  • Total pages :229
  • ISBN : 9782889667055
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Stem Cell Regulators

Stem Cell Regulators
  • Author : Gerald Litwack
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :490
  • ISBN : 9780123860156
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Summary : First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on stem cell regulators. Longest running series published by Academic Press Contributions by leading international authorities

Andrological Evaluation of Male Infertility

Andrological Evaluation of Male Infertility
  • Author : Ashok Agarwal,Sajal Gupta,Rakesh Sharma
  • Publisher :Unknown
  • Release Date :2016-07-26
  • Total pages :215
  • ISBN : 9783319267975
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Summary : This state-of-the-art laboratory manual includes 20 clinical protocols used daily for the investigation of the infertile male, presented with easy to understand, step-by-step methodology. The protocols are arranged from routine to advanced laboratory procedures common to clinical practice, including computer-assisted semen analysis, sperm preparation for IUI by density gradient and swim-up, sperm cryopreservation, and sperm DNA fragmentation test by TUNEL method, among others. The methodology in each protocol follows best practice guidelines made clearer by professionally hand-drawn illustrations covering most of the important steps and equipment. The authors, hailing from the world-renowned Andrology Center at Cleveland Clinic, have over 50 years of combined first-hand experience in managing very busy diagnostic and research facilities in male infertility and andrology. The book will be an indispensable resource for thousands of laboratory technologists, clinicians and reproductive professionals (andrologists, embryologist, etc.) engaged in the diagnosis and management of infertile men around the world.

Discovery, Integration, and Interrogation of Biotic/abiotic Materials and Systems

Discovery, Integration, and Interrogation of Biotic/abiotic Materials and Systems
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :178
  • ISBN : OCLC:873872276
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Summary : Immobilization of individual cells and collections of cells in well-defined, reproducible, nano-to-microscale structures that allow structural and functional manipulation and interrogation is important for developing new classes of biotic/abiotic materials, for establishing the relationship between genotype and phenotype, and for elucidating responses to disease, injury/stress, or therapy - primary goals of biomedical research. Although there has been considerable recent progress in investigating the response of cells to chemical or topological patterns defined lithographically on 2D surfaces, it is time to advance from two-dimensional adhesion on dishes/fluidic devices to three-dimensional architectures that better represent the nanoporous, 3-D extracellular matrix (ECM). 3D immobilization in nanostructured hosts enables cells to be surrounded by other cells, maintains fluidic connectivity/accessibility, and allows development of 3-D molecular or chemical gradients that provide an instructive background to guide cellular behavior. Although 3-D cell immobilization in polymers, hydrogels, and inorganic gels has been practiced for decades, these approaches do not provide for bio/nano interfaces with 3D spatial control of topology and composition important to both the maintenance of natural cellular behavior patterns and the development of new non-native behaviors and functions. This LDRD project exploited our discovery of the ability of living cells to organize extended nanostructures and nano-objects in a manner that creates a unique, highly biocompatible bio/nano interface, mimicking the ECM, and maintaining cell viability, accessibility, and functionality (Baca et al. Science, 2006). Briefly, we found that, using short chain phospholipids to direct the formation of thin film silica mesophases during evaporation-induced self-assembly (EISA, Lu, Brinker et al. Nature 1997), the introduction of cells (yeast, Gram negative and positive bacteria, and several mammalian cells) alters profoundly the inorganic self-assembly pathway. Cells actively organize around themselves an ordered, multilayered lipid-membrane that interfaces coherently with a lipid-templated silica nanostructure. This bio/nano interface is unique in that it withstands drying (even evacuation) without cracking or the development of tensile stresses - yet it maintains accessibility to molecules, proteins/antibodies, plasmids, etc - introduced into the 3D silica host. Additionally cell viability is preserved for weeks to months in the absence of buffer or a fluidic architecture, making these constructs useful as standalone cell-based sensors. (On this basis, our sensors were launched to the space station for viability studies after exposure to vacuum and UV). The bio/nano interfaces we describe do not form 'passively' - rather they are a consequence of the cell's ability to sense and actively respond to external stimuli. During EISA, solvent evaporation concentrates the extracellular environment in osmolytes. In response to this hyperosmotic stress, the cells release water, creating a gradient in pH (and presumably other molecular components), which is maintained within the adjoining nanostructured host and serves to localize lipids, proteins, plasmids, lipidized nanocrystals, and a variety of other components at the cellular surface. This active organization of the bio/nano interface, which we refer to as cell directed assembly (CDA) can be accomplished during ink-jet printing or selective wetting - processes allowing patterning of cellular arrays - what's more we find that cells printed onto preformed, fluid lipid/silica mesophases integrate themselves within the silica nanostructure, creating a 3D environment essentially indistinguishable from that in CDA. We refer to this latterprocess as cell-directed integration (CDI). The synthetic constructs we have developed have allowed us to explore several fundamental questions concerning the mechanisms by which cells actively control nanostructure formation and function and conversely the mechanisms by which nanostructured interfaces, matrices, and patterns can control cellular behavior.