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• Author : Siddhartha Roy,Tapas K. Kundu
• Publisher :Unknown
• Release Date :2020-11-01
• Total pages :384
• ISBN : 9780128176450

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Summary : Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics Highlights innovative pathways and molecular targets for new disease study and drug discovery

• Author : Ted Lister
• Publisher :Unknown
• Release Date :2002
• Total pages :46
• ISBN : 0854043969

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Summary : This resource aims to show the chemical science behind the discovery for post-16 students of chemistry and biology, and places it in the context of science in the 21st century.

• Author : Stefan Jurga,Jan Barciszewski
• Publisher :Unknown
• Release Date :2020-10-01
• Total pages :545
• ISBN : 9783030447434

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Summary : This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

• Author : Tadhg P. Begley,John Wiley & Sons
• Publisher :Unknown
• Release Date :2009
• Total pages :229
• ISBN : 0471754773

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• Author : Tadhg P. Begley
• Publisher :Unknown
• Release Date :2009-02-03
• Total pages :828
• ISBN : 0470470194

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Summary : The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

• Author : Haian Fu
• Publisher :Unknown
• Release Date :2012-02-13
• Total pages :345
• ISBN : 9780521889483

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Summary : This text covers new techniques and applications in chemical genomics for researchers, professionals and graduates in biology, biomedicine and chemistry.

• Author : David Van Vranken,Gregory A. Weiss
• Publisher :Unknown
• Release Date :2018-10-08
• Total pages :504
• ISBN : 9781135054823

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Summary : Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

• Author : Nancy Lynn Craig,Rachel Green,Orna Cohen-Fix,Carol W. Greider,Gisela Storz,Cynthia Wolberger
• Publisher :Unknown
• Release Date :2014
• Total pages :912
• ISBN : 9780198705970

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Summary : Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many intriguing questions remain to be answered. Itis written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline;- An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences betweenthe three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity;- An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separatedtopicsAt heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge ofintroducing the experimental evidence in a way that students can readily comprehend.Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating difference aspects of molecular biology. Each panel iscarefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book.Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggestedfurther readings grouped by topic; and an extensive glossary of key terms.Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimatelyfascinating discipline.

• Author : Anonim
• Publisher :Unknown
• Release Date :2017-06-20
• Total pages :478
• ISBN : 9780128118474

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Summary : DNA Repair Enzymes, Part A, Volume 591 is the latest volume in the Methods in Enzymology series and the first part of a thematic that focuses on DNA repair enzymes. Topics in this new release include chapters on the Optimization of Native and Formaldehyde iPOND Techniques for Use in Suspension Cells, the Proteomic Analyses of the Eukaryotic Replication Machinery, DNA Fiber Analysis: Mind the Gap!, Comet-FISH for Ultrasensitive Strand-Specific Detection of DNA Damage in Single Cells, Examining DNA Double-Strand Break Repair in a Cell Cycle-Dependent Manner, Base Excision Repair Variants in Cancer, and Fluorescence-Based Reporters for Detection of Mutagenesis in E. coli. Includes contributions from leading authorities working in enzymology Focuses on DNA repair enzymes Informs and updates on all the latest developments in the field of enzymology

• Author : Anonim
• Publisher :Unknown
• Release Date :2005
• Total pages :298
• ISBN : STANFORD:36105123859816

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Summary :

• Author : Tadhg P. Begley
• Publisher :Unknown
• Release Date :2009-02-03
• Total pages :812
• ISBN : WISC:89101786226

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Summary : The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

• Author : Sheng Ding
• Publisher :Unknown
• Release Date :2008-02-08
• Total pages :272
• ISBN : 9780470199121

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Summary : Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.

• Author : Jordanka Zlatanova,Kensal van Holde
• Publisher :Unknown
• Release Date :2015-11-23
• Total pages :648
• ISBN : 9781317633228

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Summary : Recipient of the CHOICE Outstanding Academic Title (OAT) Award.Molecular Biology: Structure and Dynamics of Genomes and Proteomes illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins.This textbook emphasizes the experimental basis of discovery and the most recent a

• Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
• Publisher :Unknown
• Release Date :1988-01-01
• Total pages :128
• ISBN : 9780309038409

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Summary : There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

• Author : Yanyan Li,Séverine Zirah,Sylvie Rebuffat
• Publisher :Unknown
• Release Date :2014-10-21
• Total pages :103
• ISBN : 9781493910106

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Summary : Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.

• Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
• Publisher :Unknown
• Release Date :2017-09-22
• Total pages :622
• ISBN : 9781351643283

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Summary : Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

• Author : Elizabeth Anne Blackson Emmert
• Publisher :Unknown
• Release Date :1999
• Total pages :192
• ISBN : WISC:89071215347

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• Author : Anonim
• Publisher :Unknown
• Release Date :2007
• Total pages :229
• ISBN : STANFORD:36105123095759

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• Author : Bruce Alberts
• Publisher :Unknown
• Release Date :2004
• Total pages :229
• ISBN : 0815332181

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• Author : Charles R. Cantor,Cassandra L. Smith
• Publisher :Unknown
• Release Date :2004-01-06
• Total pages :596
• ISBN : 9780471461869

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Summary : A unique exploration of the principles and methods underlying theHuman Genome Project and modern molecular genetics andbiotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the HumanGenome Project, and Cassandra L. Smith give the first integraloverview of the strategies and technologies behind the Human GenomeProject and the field of molecular genetics and biotechnology.Written with a range of readers in mind-from chemists andbiologists to computer scientists and engineers-the book beginswith a review of the basic properties of DNA and the chromosomesthat package it in cells. The authors describe the three maintechniques used in DNA analysis-hybridization, polymerase chainreaction, and electrophoresis-and present a complete exploration ofDNA mapping in its many different forms. By explaining both thetheoretical principles and practical foundations of modernmolecular genetics to a wide audience, the book brings thescientific community closer to the ultimate goal of understandingthe biological function of DNA. Genomics features: Topical organization within chapters for easy reference A discussion of the developing methods of sequencing, such assequencing by hybridization (SBH) in which data is read throughwords instead of letters Detailed explanations and critical evaluations of the manydifferent types of DNA maps that can be generated-includingcytogenic and restriction maps as well as interspecies cellhybrids Informed predictions for the future of DNA sequencing

• Author : Anonim
• Publisher :Unknown
• Release Date :2005
• Total pages :1368
• ISBN : UCSD:31822034385112

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Summary :