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Chronic Pain and Brain Abnormalities

Chronic Pain and Brain Abnormalities
  • Author : Carl Y. Saab
  • Publisher :Unknown
  • Release Date :2013-06-28
  • Total pages :176
  • ISBN : 9780124058965
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Summary : It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes. Philosophical and social concepts of pain; testimonials of chronic-pain patients Clinical data from pain patients’ brains Advances in noninvasive brain imaging for pain patients Combining theoretical and empirical approaches to the analysis of pain-related brain function Manipulation of brain function in animal models Emerging neurotechnology principles for pain diagnostics and therapeutics

Translational Pain Research

Translational Pain Research
  • Author : Lawrence Kruger,Alan R Light
  • Publisher :Unknown
  • Release Date :2009-11-24
  • Total pages :432
  • ISBN : 9781439812105
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Summary : One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Fibromyalgia and Other Central Pain Syndromes

Fibromyalgia and Other Central Pain Syndromes
  • Author : Daniel Jeffrey Wallace,Daniel J. Clauw, M.D.
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :421
  • ISBN : 0781752612
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Summary : This volume is the first comprehensive text devoted to fibromyalgia and other centrally mediated chronic pain syndromes. Leading experts examine the latest research findings on these syndromes and present evidence-based reviews of current controversies. Chapters discuss the definition, epidemiology, and pathophysiology of chronic pain and fibromyalgia, the clinical presentations of fibromyalgia syndrome, and central sensitization syndromes associated with chronic neuromuscular pain. The contributors thoroughly examine various approaches to evaluation and management of patients with fibromyalgia and chronic pain. Other chapters focus on disability issues, prognosis, and future research directions. A critically reviewed listing of Websites and other resources is included.

Mental Health and Pain

Mental Health and Pain
  • Author : Serge Marchand,Djéa Saravane,Isabelle Gaumond
  • Publisher :Unknown
  • Release Date :2014-06-03
  • Total pages :307
  • ISBN : 9782817804149
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Summary : This book proposes a didactic approach to the different aspects of pain in mental health. The various chapters cover the myths, neurophysiology, perception, measurement and management of pain in mental health. The most common problems, including mood disorders, schizophrenia, anxiety, somatoform disorders and pervasive developmental disorders, are covered. Each chapter addresses the problem of pain by putting an emphasis on the characteristics of different populations of patients suffering from mental illness. The book helps specialists working in different areas of mental health to appreciate the importance of pain problems in mental health and also offers avenues for the measurement and treatment of pain in these patients. Mental health and pain are complex issues. They also share certain mutually influential neurophysiological mechanisms, which makes it even more difficult to identify their specific individual characteristics. This duality between the somatic and psychic components can become a pitfall for the specialist in mental health since it can be difficult to disentangle the evolution of a painful condition from the mental illness.

The Neurological Basis of Pain

The Neurological Basis of Pain
  • Author : Marco Pappagallo
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :673
  • ISBN : 0071440879
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Summary : Pappagallo (neurology, Albert Einstein College of Medicine; chronic pain, Beth Israel Medical Center) compiles the latest work from international contributors on the scientific basis of pain medicine, issues related to the pain physician, pain syndromes and disorders, and therapies. Some topics examined include opioid pharmacology, brain imaging of

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics

Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics
  • Author : Carl Faingold,Hal Blumenfeld
  • Publisher :Unknown
  • Release Date :2013-12-26
  • Total pages :512
  • ISBN : 9780124158641
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Summary : Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

100 Questions and Answers About Chronic Pain

100 Questions and Answers About Chronic Pain
  • Author : Jain
  • Publisher :Unknown
  • Release Date :2010-12-15
  • Total pages :165
  • ISBN : 9781449632823
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Summary : Empower Yourself! Millions of Americans suffer from chronic pain ranging from mild to excruciating. If you or a loved one experience chronic pain, 100 Questions and Answers About Chronic Pain offers essential and practical guidance. This easy-to-read guide provides authoritative answers to common questions asked by patients and their families about chronic pain. Topics include introduction to pain disorders, neurobiology of pain, treatments, and coping strategies for thriving despite pain. 100 Questions and Answers About Chronic Pain is an essential resource for anyone coping with the physical and emotional turmoil of this disorder.

The Genetics of Pain

The Genetics of Pain
  • Author : Jeffrey Steven Mogil
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :349
  • ISBN : UOM:39015059102452
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Summary : No field of biology has engendered so much interest, hope, and hype as genetics. Advances in molecular, statistical and behavioral methodologies have suddenly allowed genetic investigations of complex biological phenomena, including pain. Genetic studies of pain are already showing their power to identify new molecular targets for drug development and create new animal models of pain pathology. Alone among biological approaches, pain genetics can explain why we're not all alike with respect to pain - why some people hurt more, and receive less benefit from existing analgesics. The knowledge gained holds the promise of allowing truly individualized pain therapy.

Chronic Pain

Chronic Pain
  • Author : Gary W. Jay
  • Publisher :Unknown
  • Release Date :2007-06-20
  • Total pages :314
  • ISBN : 9780849330469
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Summary : Providing a general approach to the understanding and management of all forms of chronic pain, this book offers a clear and reader-friendly format that clarifies procedures in the diagnosis, assessment, and treatment of the most common chronic non-cancer pain entities. Describing various types of intractable non-cancer pain, including neuropathic, somatic, and visceral pain, this source discusses the many available types of treatments, including opioid and adjunctive pain medications, and the safe and proper use of narcotics for treating chronic pain.

HUB DISRUPTION IN PATIENTS WITH CHRONIC NECK PAIN: A GRAPH ANALYTICAL APPROACH

HUB DISRUPTION IN PATIENTS WITH CHRONIC NECK PAIN: A GRAPH ANALYTICAL APPROACH
  • Author : Mira Meeus
  • Publisher :Unknown
  • Release Date :2017
  • Total pages :229
  • ISBN : OCLC:1163855519
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Summary : Chronic pain is known to alter the brainu2019s network dynamics. These dynamics are often demonstrated by identifying alterations in the brain network topology. A common approach used for this purpose is graph theory. To date, little is known on how these potentially altered networks in chronic pain relate to the symptoms reported by these patients. Here, we applied a graph theoretical approach to identify network changes in patients suffering from chronic neck pain, a group that is often neglected in chronic pain research. Participants with chronic traumatic and non-traumatic neck pain were compared to healthy pain-free controls. They showed higher levels of self-reported symptoms of sensitization, higher levels of disability and impaired sensorimotor control. The brain suffering from chronic neck pain furthermore showed altered network properties in the posterior cingulate cortex, amygdala and pallidum compared to the healthy pain-free brain. These regions have been identified as brain hubs (i.e. regions that are responsible for orchestrating communication between other brain regions) and are therefore known to be more vulnerable in brain disorders including chronic pain. We were furthermore able to uncover associations between these altered brain network properties and the symptoms reported by patients. Our findings indicate that chronic neck pain patients reflect brain network alterations and that targeting the brain in patients might be of utmost importance.

The Autoimmune Brain

The Autoimmune Brain
  • Author : David S. Younger
  • Publisher :Unknown
  • Release Date :2019-11-10
  • Total pages :288
  • ISBN : 9781538117712
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Summary : There are millions of people who experience issues related to brain health--depression, attention issues, anxiety, forgetfulness, fatigue, and even chronic pain--yet can’t figure out what’s causing their problems and can’t find any relief. They may have seen a myriad of doctors, many of whom do not take their complaints seriously, or worse, turn to the easy, often inappropriate fix of antidepressants or antianxiety medications. Traditional medications, supplements, or other therapies haven’t worked. No matter what their age--from children to teens or seniors--people and their loved ones are frustrated, scared, and confused by their continued poor health. Countless others display severe psychiatric symptoms that seem to come out of nowhere, ranging from tics, obsessive-compulsive behaviors and anxiety, to depression, bipolar-like mood swings, and even borderline personality disorder and suicidal ideas. . Sometimes, the people affected are the only ones that notices a change to the way they think or feel, and they suffer in silence. Or, they reach out to try to get help, and are all too frequently misdiagnosed. Now, Dr. David Younger, a world-renowned physician, provides relief to these patients and their families. His diagnostic techniques and treatment protocols will help readers identify the true cause of their symptoms and put them on a clear path to healing so they no longer feel unbalanced, out of control, forgetful, and exhausted. THE AUTOIMMUNE BRAIN connects common brain health symptoms to the changes in the immune system, and particularly bacterial, viral, and parasitic infections. In this book, Dr. Younger explains his groundbreaking research and adds a new component: how traumatic stress (whether physical or emotional) and genetics affects this same triad as inextricable factors in initiating disease and brain health symptoms. In fact, a change in personality, behavior, coping style, and one’s emotional state may be the first clue that there is a health problem brewing somewhere else in the body. Readers will find new answers to troubling conditions, including: Alzheimer’s disease Anxiety Arthritis Autism Autonomic disturbances Bacterial and viral infections Bipolar Disorder Cancer Celiac disease and gluten intolerances Chronic Fatigue Syndrome (now referred to as Systemic Exertion Intolerance Disease) Chronic Pain Dementia Depression Endocrine Disorders Immune modulatory therapy using IVIg Lyme disease and co-infections Mast cell activation syndrome Medical cannabis Obsessive Compulsive Disorder Orthostatic hypotension Peripheral Neuropathy Porphyria Post-Traumatic Stress Disorder Postural orthostatic tachycardia

Clinical Neurotherapy

Clinical Neurotherapy
  • Author : Erbil Dursun,Nigar Dursun
  • Publisher :Unknown
  • Release Date :2013-10-18
  • Total pages :448
  • ISBN : 9780128061497
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Summary :

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
  • Author : Michael J. Zigmond,Joseph T. Coyle,Lewis P. Rowland
  • Publisher :Unknown
  • Release Date :2014-12-03
  • Total pages :824
  • ISBN : 9780123982803
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Summary : Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Pain Imaging

Pain Imaging
  • Author : Kenneth Lyman Casey,M. Catherine Bushnell
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :248
  • ISBN : UOM:39015053128370
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Summary :

Neuroimaging of Pain

Neuroimaging of Pain
  • Author : Luca Saba
  • Publisher :Unknown
  • Release Date :2017-06-08
  • Total pages :508
  • ISBN : 9783319480466
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Summary : Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.

Evaluation and Treatment of Chronic Pain

Evaluation and Treatment of Chronic Pain
  • Author : Gerald M. Aronoff
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :749
  • ISBN : UOM:39015046907302
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Summary :

Diagnosis and Treatment of Chronic Pain

Diagnosis and Treatment of Chronic Pain
  • Author : Nelson H. Hendler
  • Publisher :Unknown
  • Release Date :1982
  • Total pages :257
  • ISBN : UOM:39015007417044
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Summary :

Practical Pain Management

Practical Pain Management
  • Author : C. David Tollison,John R. Satterthwaite,Joseph W. Tollison
  • Publisher :Unknown
  • Release Date :2002-01
  • Total pages :829
  • ISBN : 0781731607
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Summary : Thoroughly revised to reflect contemporary diagnostics and treatment, this Third Edition is a comprehensive and practical reference on the assessment and management of acute and chronic pain. This edition features 14 new chapters and is filled with new information on invasive procedures...pharmacologic interventions...neuraxial pharmacotherapy...physical and occupational therapies...diagnostic techniques...pain in terminally ill patients...cancer pain...visceral pain...rheumatologic disorders...managed care...and medicolegal issues. Reorganized with two new sections focusing on diagnostics and cancer pain. A Brandon-Hill recommended title.

The Brain's Way of Healing

The Brain's Way of Healing
  • Author : Norman Doidge
  • Publisher :Unknown
  • Release Date :2015-01-27
  • Total pages :432
  • ISBN : 9780698191433
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Summary : NEW YORK TIMES BESTSELLER The New York Times–bestselling author of The Brain That Changes Itself presents astounding advances in the treatment of brain injury and illness. Now in an updated and expanded paperback edition. Winner of the 2015 Gold Nautilus Award in Science & Cosmology In his groundbreaking work The Brain That Changes Itself, Norman Doidge introduced readers to neuroplasticity—the brain’s ability to change its own structure and function in response to activity and mental experience. Now his revolutionary new book shows how the amazing process of neuroplastic healing really works. The Brain’s Way of Healing describes natural, noninvasive avenues into the brain provided by the energy around us—in light, sound, vibration, and movement—that can awaken the brain’s own healing capacities without producing unpleasant side effects. Doidge explores cases where patients alleviated chronic pain; recovered from debilitating strokes, brain injuries, and learning disorders; overcame attention deficit and learning disorders; and found relief from symptoms of autism, multiple sclerosis, Parkinson’s disease, and cerebral palsy. And we learn how to vastly reduce the risk of dementia, with simple approaches anyone can use. For centuries it was believed that the brain’s complexity prevented recovery from damage or disease. The Brain’s Way of Healing shows that this very sophistication is the source of a unique kind of healing. As he did so lucidly in The Brain That Changes Itself, Doidge uses stories to present cutting-edge science with practical real-world applications, and principles that everyone can apply to improve their brain’s performance and health.

Healing Back Pain

Healing Back Pain
  • Author : John E. Sarno
  • Publisher :Unknown
  • Release Date :2001-03-15
  • Total pages :208
  • ISBN : 0759520844
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Summary : Dr. John E. Sarno's groundbreaking research on TMS (Tension Myoneural Syndrome) reveals how stress and other psychological factors can cause back pain-and how you can be pain free without drugs, exercise, or surgery. Dr. Sarno's program has helped thousands of patients find relief from chronic back conditions. In this New York Times bestseller, Dr. Sarno teaches you how to identify stress and other psychological factors that cause back pain and demonstrates how to heal yourself--without drugs, surgery or exercise. Find out: Why self-motivated and successful people are prone to Tension Myoneural Syndrome (TMS) How anxiety and repressed anger trigger muscle spasms How people condition themselves to accept back pain as inevitable With case histories and the results of in-depth mind-body research, Dr. Sarno reveals how you can recognize the emotional roots of your TMS and sever the connections between mental and physical pain...and start recovering from back pain today.

Neurological Disorders

Neurological Disorders
  • Author : Thomas Brandt,Louis R. Caplan,Johannes Dichgans,Hans-Christoph Diener,Christopher Kennard
  • Publisher :Unknown
  • Release Date :2003-01-03
  • Total pages :1574
  • ISBN : 0121258319
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Summary : This single-volume reference covers the natural course, treatment, and management of all neurological diseases affecting the brain, spinal cord nerves and muscles. This comprehensive text reference seeks to assist physicians with treatment by providing an easy-to-use compendium covering the treatment and management of all neurological diseases along with details on the natural course of these diseases. Organized for ease of use and quick reference, each chapter presents a neurological disorder or key symptoms and systematically discusses the clinical syndrome and differential diagnosis, natural course, principles of therapy, and practical management of each. Key Features * Covers wide range of neurological conditions and potential treatments, including the evidence for and against each treatment * Describes the spontaneous course of neurological diseases along with discussion of the management of different stages and variants of a disorder * Presents special situations and exceptional cases in which alternative therapies should be considered