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Clinical Bioenergetics

Clinical Bioenergetics
  • Author : Sergej M. Ostojic
  • Publisher :Unknown
  • Release Date :2020-11-12
  • Total pages :716
  • ISBN : 9780128227725
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Summary : Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Bioenergetics

Bioenergetics
  • Author : David G. Nicholls
  • Publisher :Unknown
  • Release Date :2013-05-20
  • Total pages :434
  • ISBN : 9780123884312
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Summary : Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. BMA Medical Book Awards 2014-Highly Commended, Basic and Clinical Sciences,2014,British Medical Association Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins. Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging. Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :229
  • ISBN : MINN:31951P002070717
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Summary :

Research Awards Index

Research Awards Index
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :229
  • ISBN : MINN:30000008789194
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Summary :

The Charnoly Body

The Charnoly Body
  • Author : Sushil Sharma
  • Publisher :Unknown
  • Release Date :2019-01-31
  • Total pages :388
  • ISBN : 9781351366700
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Summary : Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.

Bioenergetics

Bioenergetics
  • Author : Chong H. Kim,Takayuki Ozawa
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :484
  • ISBN : 9781468458350
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Summary : The emergence of the Biochemical Sciences is underlined by the FAOB symposium in Seoul and highlighted by this Satellite meeting on the "New Bioenergetics. " Classical mitochondrial electron transfer and energy coupling is now complemented by the emerging molecular biology of the respiratory chain which is studied hand in hand with the recognition of mitochondrial disease as a major and emerging study in the basic and clinical medical sciences. Thus, this symposium has achieved an important balance of the fundamental and applied aspects of bioenergetics in the modern setting of molecular biology and mitochondrial disease. At the same time, the symposium takes note not only of the emerging excellence of Biochemical Studies in the Orient and indeed in Korea itself, but also retrospectively enjoys the history of electron transport and energy conservation as represented by the triumvirate ofYagi, King and Slater. Many thanks are due Drs. Kim and Ozawa for their elegant organization of this meeting and its juxtaposition to the FAOB Congress. Britton Chance April 2, 1990 v PREFACE This book contains the contributed papers presented at the "International Symposium on Bioenergetics: Molecular Biology, Biochemistry and Pathology", held in Seoul, Korea, August 18-21, 1989, sponsored by International Union of Biochemistry (as ruB Symposium No. 191) and Ewha Womans University, Seoul, Korea. The symposium was held in honor of Professor Kunio Yagi to commemorate his 70th birthday.

A Personal History of Nuclear Medicine

A Personal History of Nuclear Medicine
  • Author : Henry N. Wagner
  • Publisher :Unknown
  • Release Date :2007-12-23
  • Total pages :299
  • ISBN : 9781846280726
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Summary : A Personal History of Nuclear Medicine is an account of how nuclear medicine developed, and its basic philosophy in the past, present and future. The book outlines the history of the development of nuclear medicine as experienced by the author and describes the hurdles that nuclear medicine has had to face, in view of the perception of risk of radiation. It also explains how nuclear medicine solves medical problems in clinical practice and how it has contributed to a new definition of disease. The book concludes with future projections of the likely developments in this area in the next 50 years. Target market: nuclear medicine professionals as well non-nuclear medicine physicians and the public

Bioenergetics 2

Bioenergetics 2
  • Author : David G. Nicholls,Stuart J. Ferguson
  • Publisher :Unknown
  • Release Date :2014-06-28
  • Total pages :272
  • ISBN : 9781483214207
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Summary : Bioenergetics 2 aims to clarify topics such as the thermodynamics of bioenergetic processes and the stoichiometries of energy coupling reactions. The book discusses chemiosmotic energy transduction; ion transport across energy-conserving membranes; and quantitative bioenergenetics as the measurement of driving forces. The text also describes the chemiosmotic proton circuit; the respiratory chain; the photosynthetic generators of protonmotive force; and the ATP synthase. The secondary transport of products across the membrane, as well as the structures of the bacterial photosynthetic reaction center and bacteriorhodopsin are also considered. Biochemists will find the book invaluable.

Clinical Handbook of Depression

Clinical Handbook of Depression
  • Author : Janice Wood Wetzel
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :386
  • ISBN : UOM:39015015287629
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Summary :

Bioenergetics Primer for Exercise Science

Bioenergetics Primer for Exercise Science
  • Author : Jie Kang
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :209
  • ISBN : 0736062416
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Summary : "More in-depth than cursory discussions found in exercise physiology texts and more practical and accessible than dedicated bioenergetics texts, Bioenergetics Primer for Exercise Science encompasses all the up-to-date research and information regarding human bioenergetics and energy metabolism. It offers both students and professionals a depth of knowledge that will inform their further study, research, and profession."--Page [4 de la couv.].

Bioenergetics of the Cell: Quantitative Aspects

Bioenergetics of the Cell: Quantitative Aspects
  • Author : Valdur A. Saks,Renée Ventura-Clapier,Xavier Leverve,André Rossi,Michel Rigoulet
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :460
  • ISBN : 9781461556534
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Summary : This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation.

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes
  • Author : Beatrice Morio,Luc Penicaud,Michel Rigoulet
  • Publisher :Unknown
  • Release Date :2019-04-15
  • Total pages :736
  • ISBN : 9780128117521
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Summary : Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Diagnostic Nuclear Medicine

Diagnostic Nuclear Medicine
  • Author : Christiaan Schiepers
  • Publisher :Unknown
  • Release Date :2006-01-30
  • Total pages :356
  • ISBN : 9783540300052
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Summary : 2nd edition - totally updated and revised. Provides the latest update on procedures in nuclear medicine. Documents the role of PET in oncology and introduces dual modality imaging with PET/CT. Includes sections on molecular imaging and future prospects. Represents an adjunct to standard knowledge of diagnostic nuclear medicine.

Biomedical and Clinical Aspects of Coenzyme Q

Biomedical and Clinical Aspects of Coenzyme Q
  • Author : Yūichi Yamamura
  • Publisher :Unknown
  • Release Date :1981
  • Total pages :414
  • ISBN : NWU:35558000630125
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Summary :

Harper's Illustrated Biochemistry Thirty-First Edition

Harper's Illustrated Biochemistry Thirty-First Edition
  • Author : Victor W. Rodwell,David Bender,Kathleen M. Botham,Peter J. Kennelly,P. Anthony Weil
  • Publisher :Unknown
  • Release Date :2018-06-22
  • Total pages :800
  • ISBN : 9781259837944
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Summary : Gain a full understanding of the principles of biochemistry as it relates to clinical medicine A Doody’s Core Title for 2020! The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-color presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school. All 58 chapters help you understand the medical relevance of biochemistry: • Full-color presentation includes more than 600 illustrations • Case studies emphasize the clinical relevance of biochemistry • NEW CHAPTER on Biochemistry of Transition Metals addresses the importance and overall pervasiveness of transition metals • Review Questions follow each of the eleven sections • Boxed Objectives define the goals of each chapter • Tables encapsulate important information • Every chapter includes a section on the biomedical importance of a given topic NEW TO THIS EDITION: • Emphasis throughout on the integral relationship between biochemistry and disease, diagnostic pathology, and medical practice • Hundreds of references to disease states throughout • New chapter addressing the biochemical roles of transition metals • Many updated review questions • Frequent tables summarizing key links to disease states • New text on cryo-electron microscopy (cryo-EM) • Cover picture of the protein structure of the Zika virus, solved by cryo-EM Applauded by medical students and online reviewers for its currency and engaging style, Harper’s Illustrated Biochemistry is essential for USMLE® review and the single-best reference for learning the clinical relevance of any biochemistry topic.

Biomedical and Clinical Aspects of Coenzyme Q

Biomedical and Clinical Aspects of Coenzyme Q
  • Author : Karl August Folkers,Yūichi Yamamura
  • Publisher :Unknown
  • Release Date :1986
  • Total pages :410
  • ISBN : NWU:35558001088737
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Summary :

Which Degree in Britain

Which Degree in Britain
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : UCAL:$B337544
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Summary : A comprehensive guide to full-time degree courses, institutions and towns in Britain.

Biomedical and Clinical Aspects of Coenzyme Q

Biomedical and Clinical Aspects of Coenzyme Q
  • Author : Karl Folkers,Yūichi Yamamura
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :432
  • ISBN : UOM:39015010182999
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Summary :

Clinical Nephrology

Clinical Nephrology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : NWU:35558003970023
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Summary :

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2020-09-01
  • Total pages :322
  • ISBN : 9780128231227
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Summary : Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.

Molecular System Bioenergetics

Molecular System Bioenergetics
  • Author : Valdur Saks
  • Publisher :Unknown
  • Release Date :2008-01-08
  • Total pages :633
  • ISBN : 9783527621101
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Summary : In this first integrated view, practically each of the world's leading experts has contributed to this one and only authoritative resource on the topic. Bringing systems biology to cellular energetics, they address in detail such novel concepts as metabolite channeling and medical aspects of metabolic syndrome and cancer.