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Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring
  • Author : William Clarke,Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2016-07-21
  • Total pages :376
  • ISBN : 9780128020524
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Summary : Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring
  • Author : William Clarke, PhD, MBA,Amitava Dasgupta, PhD, DABCC
  • Publisher :Unknown
  • Release Date :2016-05-31
  • Total pages :376
  • ISBN : 0128020253
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Summary : Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
  • Author : Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2012-06-07
  • Total pages :468
  • ISBN : 9780123854681
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Summary : Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (1996)

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology (1996)
  • Author : Steven H.Y. Wong,Irving Sunshine
  • Publisher :Unknown
  • Release Date :2017-11-22
  • Total pages :366
  • ISBN : 9781351364270
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Summary : Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
  • Author : Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2007-10-23
  • Total pages :445
  • ISBN : 9781588297808
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Summary : In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Individualized Drug Therapy for Patients

Individualized Drug Therapy for Patients
  • Author : Roger W Jelliffe,Michael Neely
  • Publisher :Unknown
  • Release Date :2016-11-15
  • Total pages :434
  • ISBN : 9780128033494
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Summary : Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Personalized Immunosuppression in Transplantation

Personalized Immunosuppression in Transplantation
  • Author : Michael Oellerich,Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2015-08-08
  • Total pages :316
  • ISBN : 9780128011331
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Summary : Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Accurate Results in the Clinical Laboratory

Accurate Results in the Clinical Laboratory
  • Author : Amitava Dasgupta,Jorge L. Sepulveda
  • Publisher :Unknown
  • Release Date :2019-07-20
  • Total pages :510
  • ISBN : 9780128137772
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Summary : Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors. Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing Includes new case studies that highlight clinical relevance and errors to avoid Highlights the best titles published within a variety of medical specialties Reviewed by medical librarians and content specialists, with key selections compiled in their annual list

Clinical Chemistry, Immunology and Laboratory Quality Control

Clinical Chemistry, Immunology and Laboratory Quality Control
  • Author : Amitava Dasgupta,Amer Wahed
  • Publisher :Unknown
  • Release Date :2013-12-02
  • Total pages :504
  • ISBN : 9780124079359
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Summary : All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. Clinical Chemistry, Immunology and Laboratory Quality Control meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry knowledge to everyday patient care. This basic primer offers practical examples of how things function in the pathology clinic as well as useful lists, sample questions, and a bullet-point format ideal for quick pre-Board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this may be too much information for students, residents, and clinicians. This book is designed to educate senior medical students, residents, and fellows, and to "refresh" the knowledge base of practicing clinicians on how tests are performed in their laboratories (i.e., method principles, interferences, and limitations). Takes a practical and easy-to-read approach to understanding clinical chemistry and toxicology Covers all important clinical information found in larger textbooks in a more succinct and easy-to-understand manner Covers essential concepts in instrumentation and statistics in such a way that fellows and clinicians understand the methods without having to become specialists in the field Includes chapters on drug-herb interaction and pharmacogenomics, topics not covered by textbooks in the field of clinical chemistry or laboratory medicine

Applied Clinical Pharmacokinetics

Applied Clinical Pharmacokinetics
  • Author : Larry A. Bauer
  • Publisher :Unknown
  • Release Date :2007-09-22
  • Total pages :840
  • ISBN : 0071593721
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Summary : New sections on dosing strategies in all chapters. New chapter on sirolimus under the Immunosuppressants section. Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure. 30% of chapters extensively revised, others lightly updated

Critical Issues in Alcohol and Drugs of Abuse Testing

Critical Issues in Alcohol and Drugs of Abuse Testing
  • Author : Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2019-01-10
  • Total pages :560
  • ISBN : 9780128156087
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Summary : Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians

Casebook in Clinical Pharmacokinetics and Drug Dosing

Casebook in Clinical Pharmacokinetics and Drug Dosing
  • Author : Henry Cohen
  • Publisher :Unknown
  • Release Date :2014-10-06
  • Total pages :304
  • ISBN : 9780071832762
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Summary : A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.

Adverse Reactions to Biologics

Adverse Reactions to Biologics
  • Author : L. Puig,W. Gulliver
  • Publisher :Unknown
  • Release Date :2017-11-07
  • Total pages :108
  • ISBN : 9783318061017
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Summary : In many areas of medicine physicians still face the great challenge of finding therapies that will meet the patients’ needs. In dermatology the challenge has arisen on multiple fronts through advances in the understanding of the immunopathogenesis of many inflammatory and malignant cutaneous disorders. Breakthroughs, combined with significant developments in targeted immunotherapy, have resulted in improved outcomes as these newer therapies are being used for both approved indications and as off-label therapies for various chronic inflammatory skin disorders and many forms of skin cancer. In the expectation that by truly understanding the safety profile of these targeted therapies patients’ outcomes will be significantly improved, this book offers insights into topics such as adverse reactions, infectious complications and the perioperative use of biologics in psoriasis, immunogenicity of biologic therapies, paradoxical reactions, safety of biologics used to treat autoimmune bullous diseases and primary cutaneous lymphomas, adverse reactions and skin manifestations of therapies targeting melanoma and non-melanoma skin cancer and other neoplastic diseases. Eminent researchers with extensive clinical experience have contributed to this publication, providing an in-depth overview of the latest knowledge in this field.

The ESC Handbook on Cardiovascular Pharmacotherapy

The ESC Handbook on Cardiovascular Pharmacotherapy
  • Author : Juan Carlos Kaski,Keld Per Kjeldsen
  • Publisher :Unknown
  • Release Date :2019-05-23
  • Total pages :960
  • ISBN : 9780198759935
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Summary : The ESC Handbook on Cardiovascular Pharmacotherapy, based on the most recent guidelines in cardiovascular pharmacology, and containing a comprehensive A-Z formulary of common and less commonly used cardiac drugs and drug groups, provides practical and accessible guidance on all areas of drugprescribing.Previously published as Drugs in Cardiology, this new edition has been developed by the ESC Working Group on Cardiovascular Pharmacology. Pharmacology is an integral aspect in almost all disciplines within cardiology and all cardiologists use cardiovascular drugs.Completely updated and aligned with the ESC Clinical Practice Guidelines for prescribing, this handbook is essential reading for consultants, registrars in training, general practitioners, specialist cardiac nurses and cardiovascular pharmacologists.

Clinical Pharmacy Education, Practice and Research

Clinical Pharmacy Education, Practice and Research
  • Author : Dixon Thomas
  • Publisher :Unknown
  • Release Date :2018-11-23
  • Total pages :540
  • ISBN : 9780128142776
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Summary : Clinical Pharmacy Education, Practice and Research offers readers a solid foundation in clinical pharmacy and related sciences through contributions by 83 leading experts in the field from 25 countries. This book stresses educational approaches that empower pharmacists with patient care and research competencies. The learning objectives and writing style of the book focus on clarifying the concepts comprehensively for a pharmacist, from regular patient counseling to pharmacogenomics practice. It covers all interesting topics a pharmacist should know. This book serves as a basis to standardize and coordinate learning to practice, explaining basics and using self-learning strategies through online resources or other advanced texts. With an educational approach, it guides pharmacy students and pharmacists to learn quickly and apply. Clinical Pharmacy Education, Practice and Research provides an essential foundation for pharmacy students and pharmacists globally. Covers the core information needed for pharmacy practice courses Includes multiple case studies and practical situations with 70% focused on practical clinical pharmacology knowledge Designed for educational settings, but also useful as a refresher for advanced students and researchers

Cardio-Oncology

Cardio-Oncology
  • Author : Gretchen G. Kimmick,Daniel J. Lenihan,Douglas B. Sawyer,Erica L. Mayer,Dawn L. Hershman
  • Publisher :Unknown
  • Release Date :2017-04-11
  • Total pages :319
  • ISBN : 9783319430966
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Summary : Co-edited and written by an interdisciplinary team of experts in oncology and cardiology, this book is a clinically useful resource on these overlapping topics: • Cardiac complications in patients receiving cancer therapy • The treatment of cancer in patients with cardiovascular disease • The treatment of cardiovascular disease in patients with cancer When relevant to medical practice, epidemiology and basic science are also included in the discussion and each chapter is written by an oncologist and a cardiologist. Additionally, the chapters follow a similar format to make the book truly interdisciplinary, user-friendly, and clinically applicable to specialists and non-specialists who care for patients with both cancer and cardiovascular disease.

Biomarkers in Psychiatry

Biomarkers in Psychiatry
  • Author : Judith Pratt,Jeremy Hall
  • Publisher :Unknown
  • Release Date :2019-01-05
  • Total pages :437
  • ISBN : 9783319996424
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Summary : This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.

CURRENT Medical Diagnosis and Treatment 2021

CURRENT Medical Diagnosis and Treatment 2021
  • Author : Maxine A. Papadakis,Stephen J. McPhee,Michael W. Rabow
  • Publisher :Unknown
  • Release Date :2020-09-09
  • Total pages :1920
  • ISBN : 9781260469875
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Summary : The 60th anniversary edition of the most popular, relied-upon guide to internal medicine For 60 years, CURRENT Medical Diagnosis and Treatment—the flagship volume of the renowned Lange medical series—has been delivering the authoritative information students, residents, and clinicians need to build their medical knowledge, expertise, and confidence. Covering the latest clinical developments in all facets of medicine and fully focused on bedside clinical issues, this new edition provides completely the latest guidelines, reference, drug prices, approved drugs, and evidence-based coverage of more than 1,000 diseases and disorders—all formatted to enable you to find the answers you need quickly and effortlessly. This landmark guide covers inpatient and outpatient care, focusing on the diagnostic tools relevant to daily practice, and reviews all primary care topics, including gynecology/obstetrics, dermatology, ophthalmology, geriatrics, preventive medicine, psychiatry, and neurology. Now includes a “year in review” feature highlighting what’s new in CMDT! Includes essentials of diagnosis for most diseases/disorders Hundreds of quick-access drug treatment tables with indexed trade names Diagnostic and treatment algorithms present important information in an at-a-glance style Up-to-date references provide peer-reviewed, evidence-based information Seven bonus chapters available online to all book purchasers, featuring expanded content and annual review of advances in HIV treatment and critical information on emerging viral infections

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders
  • Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
  • Publisher :Unknown
  • Release Date :2014-02-06
  • Total pages :118
  • ISBN : 9780309292498
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Summary : Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics
  • Author : Leon Shargel,Andrew B. C. Yu
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :625
  • ISBN : UOM:39015029461012
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Summary : The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Drug Interactions in Infectious Diseases

Drug Interactions in Infectious Diseases
  • Author : Stephen C. Piscitelli,Keith Rodvold
  • Publisher :Unknown
  • Release Date :2007-10-28
  • Total pages :534
  • ISBN : 9781592599240
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Summary : Over the past 25 years, the world’s population has witnessed an explosion in kno- edge about infectious diseases. The global population is coming to the realization that diseases long recognized to cause substantial suffering, such as malaria, tuberculosis, schistosomiasis, and hepatitis, can be diagnosed and treated, and that transmission can be prevented using tools that are available, and which may be becoming increasingly affordable. The global population is recognizing that few infections are local: the travel of humans, other animals, insects, and food transport pathogens around the world, often with astonishing rapidity. New pathogens are appearing, either newly recognized or newly developing, such as severe acute respiratory syndrome (SARS), avian inf- enza, metapneumovirus, or hepatitis C, which are causing human morbidity and m- tality. Finally, there is growing fear that dangerous pathogens may be intentionally introduced into human populations by deranged individuals or terrorist organizations. The potential to use drugs or biologic agents to treat and prevent infectious diseases has increased dramatically over the past quarter century as we have learned more about the biology of many of these agents, and as we have developed techniques to discover new agents by high throughput screening programs and by sophisticated drug design and synthesis.