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Combination Therapy Against Multidrug Resistance

Combination Therapy Against Multidrug Resistance
  • Author : Mohmmad Younus Wani,Aijaz Ahmad
  • Publisher :Unknown
  • Release Date :2020-04-30
  • Total pages :268
  • ISBN : 0128205784
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Summary : Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to understand fully the ways to apply combined therapy to multidrug resistance Provides an overview of combination therapy, but also includes specific cases such as cancer, tuberculosis, HIV and malaria

Antibiotic Combination Therapy Against Multidrug-resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine

Antibiotic Combination Therapy Against Multidrug-resistant Staphylococcus Epidermidis Biofilms and Broadening Antibiotic Spectrum Using Polyethylenimine
  • Author : Anh Kim Lam
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :145
  • ISBN : 09876543XX
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Summary :

Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy

Pharmacokinetics and Pharmacodynamics of Antimalarial Drugs Used in Combination Therapy
  • Author : Qigui Li,Mark R. Hickman
  • Publisher :Unknown
  • Release Date :2015-06-04
  • Total pages :550
  • ISBN : 1681080540
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Summary : Malaria takes a great toll on human health and well-being, particularly in tropical regions including Sub-Saharan Africa, Southeast Asia, Oceania and parts of the Americas. In recent years, some Plasmodium strains have become increasingly resistant to all classes of conventional antimalarial drugs currently in use. Researchers have, therefore, stepped up efforts to revise atimalarial drug policies, develop new drugs, and implement new strategies to combat this disease. In order to prevent widespread resistance, antimalarial combination therapies (ACTs) have been deployed and a World Antimalarial Resistance Network has been established as a means of anitimalarial drug resistance surveillance. Artemisinin-based combination therapies have proven to be useful as a replacement for standard regimens. Currently, these ACTs successfully cure patients suffering from uncomplicated malaria with superior efficacy and lower toxicity, but there remains a huge challenge (high mortality rate) associated with treatment of severe malaria. Studies of drug disposition and drug efficacy (PK/PD evaluations) are essential to understanding why drugs work as antimalarials as they illustrate issues with drug resistance, drug safety and drug toxicity that are critical to finding the appropriate drug dose for patients. This eBook illustrates how currently available combination antimalarial drugs can be optimized for effective malaria treatment. Chapters in this book explain methods to select combination drugs based on PK/PD evaluations followed by methods o reduce drug toxicity based on these evaluations. The book also summarizes efforts that are being made by the research community to improve ACT. It is, therefore, a handy reference for medical professionals and pharmacologists working on antimalarial drugs.

Alternative Therapeutics Against Antimicrobial-Resistant Pathogens

Alternative Therapeutics Against Antimicrobial-Resistant Pathogens
  • Author : Rebecca Thombre,Kamlesh Jangid,Ravi Shukla,Noton Kumar Dutta
  • Publisher :Unknown
  • Release Date :2019-12-19
  • Total pages :229
  • ISBN : 2889632164
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Summary :

Management of Multiple Drug-Resistant Infections

Management of Multiple Drug-Resistant Infections
  • Author : Stephen H. Gillespie
  • Publisher :Unknown
  • Release Date :2004-01-12
  • Total pages :403
  • ISBN : 1592597386
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Summary : A comprehensive and cutting-edge review of how practicing physicians can best treat multiple drug resistance in bacterial, viral, protozoal, and helminthic infections. The authors focus on the major hospital and community-acquired pathogens, including S. aureus, S. pneumoniae, Enterococcus, Acinetobacter, and M. tuberculosis, and on the management of such common problems as multiple drug-resistant urinary tract infections and gonorrhea. Among the resistant tropical organisms covered are Salmonella typhi, malaria, and Burkholderia pseudomalei. Resistance to such important antiviral classes as antiretrovirals and anticytomegalovirals is also discussed, as are those measures necessary to prevent the spread of infections patients.

Combating Antimicrobial Resistance - A One Health Approach

Combating Antimicrobial Resistance - A One Health Approach
  • Author : Ghassan M. Matar,Antoine Andremont
  • Publisher :Unknown
  • Release Date :2020-02-14
  • Total pages :229
  • ISBN : 2889635155
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Summary :

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Kalpna D. Rakholiya,Mital J. Kaneria,Sumitra V. Chanda
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066822
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Summary : Antibiotics are antimicrobial agents that are used to treat infectious diseases. The outbreak of pathogenic antibiotic-resistant strains illustrates our urgent need to search for new alternative sources of treatment. Hence, an attempt has been made in this review to list some plant extracts, essential/volatile oils, and their antimicrobial activity against different microorganisms using different methods, as well as synergistic effects (plant extract-plant extract, plant extract-essential oils, plant extract-conventional antibiotics, phytochemical-antibiotics, and essential oil-essential oil). Plant products and their active constituents are useful in the treatment of infectious diseases caused by multidrug-resistant microbes, food borne diseases caused by food spoiling microbes, and oral pathogens. Products derived from plants have the potential to control microbial growth in diverse situations, and specifically in the treatment of disease. The various aspects of this review may be helpful for the food, cosmetic, and pharmaceutical industries.

Nosocomial and Ventilator-Associated Pneumonia

Nosocomial and Ventilator-Associated Pneumonia
  • Author : A. Torres,S. Ewig
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :169
  • ISBN : 1849840164
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Summary : Nosocomial and ventilator-associated pneumonia continue to be a major challenge in the management of intensive care patients. In particular, recent developments in microbial resistance are a cause of great concern. Internationally renowned experts provide comprehensive reviews on all the major topics within the field and, in particular, the recent insights into epidemiology, diagnosis and treatment surrounding this field. This Monograph is an essential reference book for both clinicians and researchers alike on this challenging subject.

Contemporary Topics of Pneumonia

Contemporary Topics of Pneumonia
  • Author : Zissis Chroneos
  • Publisher :Unknown
  • Release Date :2017-12-20
  • Total pages :222
  • ISBN : 9535137077
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Summary : Pneumonia is an inflammatory disease of the air sacs and surrounding interstitium caused by infectious agents or by endogenous inflammatory tissue disorder termed interstitial pneumonia. The present book covers contemporary topics of community, hospital, and health care-related bacterial and viral pneumonia in the setting of drug resistance, environmental exposures, climate change, hormonal influences, and gender. The topic of interstitial pneumonia is brought under the lens of an immune-related connective tissue disease.

Update in Sexually Transmitted Infections, an Issue of Infectious Disease Clinics,

Update in Sexually Transmitted Infections, an Issue of Infectious Disease Clinics,
  • Author : Jeanne Marrazzo
  • Publisher :Unknown
  • Release Date :2013-12-06
  • Total pages :153
  • ISBN : 0323261035
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Summary : This issue of the Infectious Disease Clinics is devoted to the treatment and prevention of the most common STDs – including syphilis, gonorrhea, herpes, and HPV. The articles will discuss the current research in the field such as antimicrobial resistance in treating gonorrhea and the development/trials of a genital herpes vaccine.

Antibiotic Resistance

Antibiotic Resistance
  • Author : Kateryna Kon,Mahendra Rai
  • Publisher :Unknown
  • Release Date :2016-06-14
  • Total pages :436
  • ISBN : 0128036680
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Summary : Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections. Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance. Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistance Provides information on modern methods used to fight antibiotic resistance Covers a wide range of alternative methods to fight bacterial resistance, offering the most complete information available Discusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developments Offers the most up-to-date information in fighting antibiotic resistance Includes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries

Antibiotics and Bacterial Resistance

Antibiotics and Bacterial Resistance
  • Author : Wiley
  • Publisher :Unknown
  • Release Date :2013-01-14
  • Total pages :146
  • ISBN : 1118580915
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Summary : The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and the antimicrobialagents used to combat infections with these organisms. Some newavenues that are being investigated for antibiotic development arealso discussed. Such developments include the discovery of agentsthat inhibit bacterial RNA degradation, the bacterial ribosome, andstructure-based approaches to antibiotic drug discovery. Two laboratory protocols are provided to illustrate differentstrategies for discovering new antibiotics. One is a bacterialgrowth inhibition assay to identify inhibitors of bacterial growththat specifically target conditionally essential enzymes in thepathway of interest. The other protocol is used to identifyinhibitors of bacterial cell-to-cell signaling. This e-book — a curated collection from eLS, WIREs, andCurrent Protocols — offers a fantastic introduction to thefield of antibiotics and antibiotic resistance for students orinterdisciplinary collaborators. Table of Contents: Introduction Antibiotics and the Evolution of Antibiotic Resistance eLS Jose L Martinez, Fernando Baquero Antimicrobials Against Streptococci, Pneumococci andEnterococci eLS Susan Donabedian, Adenike Shoyinka Techniques & Applications RNA decay: a novel therapeutic target in bacteria WIREs RNA Tess M. Eidem, Christelle M. Roux, Paul M. Dunman Antibiotics that target protein synthesis WIREs RNA Lisa S. McCoy, Yun Xie, Yitzhak Tor Methods High-Throughput Assessment of Bacterial Growth Inhibition byOptical Density Measurements Current Protocols Chemical Biology Jennifer Campbell Structure-Based Approaches to Antibiotic Drug Discovery Current Protocols Microbiology George Nicola, Ruben Abagyan Novel Approaches to Bacterial Infection Therapy by Interferingwith Cell-to-Cell Signaling Current Protocols Microbiology David A. Rasko, Vanessa Sperandio

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Kateryna Volodymyrivna Kon,Mahendra Kumar Rai
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066814
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Summary : High prevalence of multidrug-resistant microorganisms in the etiologic structure of different infectious processes significantly decreases the effectiveness of the treatment and enhances the probability of an unfavorable outcome from the infection. Combinations between antibiotics and other antimicrobial agents represent one of the most promising approaches for combating multidrug-resistant bacteria. A high therapeutic potential exists for combinations of antibiotics and natural antimicrobial substances with complex mechanisms of action and multiple healing properties, such as plant essential oils. The purpose of the present chapter is to review published studies on antibiotic-essential oil combinations and discuss the prospects for future studies. In general, many studies have shown the potential for essential oils to act synergistically with antibiotics in vitro. The main proposed mechanism of this beneficial effect is through inhibition of efflux pumps by some essential oils, which restores the activity of the antibiotic. Future efforts should be directed into further studies of antibiotic-essential oil combinations against multidrug-resistant bacteria, with an emphasis on understanding the mechanisms of the produced effect. Combinations of essential oils with different types of antimicrobial agents, such as bacteriophages, nanoparticles, and quorum-sensing inhibitors, require greater attention and are worthy of future investigations.

Infection Control

Infection Control
  • Author : Silpi Basak
  • Publisher :Unknown
  • Release Date :2013-05-29
  • Total pages :102
  • ISBN : 9535111450
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Summary : Health Care associated infection (HAI) is an emerging problem worldwide. HAI causes increased morbidity, mortality and average length of stay of the patient in the hospital. HAI also imposes economic burden on the patient, health care set up and also State and National Health care system. It has been estimated that 5 10 % of all hospital admission suffers from HAI even in developed countries. But 30% of HAI are preventable, if we follow the infection control practices properly especially hand hygiene while giving patient care. Hence, in this book importance has been given to Infection Control practices along with emerging trends of HAI due to Pseudomonas aeruginosa, Acinetobacter species etc.

Stenotrophomonas: Advances in Research and Treatment: 2011 Edition

Stenotrophomonas: Advances in Research and Treatment: 2011 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-01-09
  • Total pages :26
  • ISBN : 1464950369
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Summary : Stenotrophomonas: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Stenotrophomonas in a compact format. The editors have built Stenotrophomonas: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Stenotrophomonas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Stenotrophomonas: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria
  • Author : Natalia V. Kirienko,Laurence Rahme,You-Hee Cho
  • Publisher :Unknown
  • Release Date :2019-12-24
  • Total pages :229
  • ISBN : 2889632563
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Summary :

Advances in Cephaloridine Research and Application: 2013 Edition

Advances in Cephaloridine Research and Application: 2013 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2013-06-21
  • Total pages :30
  • ISBN : 1481669893
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Summary : Advances in Cephaloridine Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Advances in Cephaloridine Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Cephaloridine Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Emerging Respiratory Infections in the 21st Century, An Issue of Infectious Disease Clinics - E-Book

Emerging Respiratory Infections in the 21st Century, An Issue of Infectious Disease Clinics - E-Book
  • Author : Alimuddin Zumla,Wing-Wai Yew,David S.C. Hui
  • Publisher :Unknown
  • Release Date :2010-08-31
  • Total pages :320
  • ISBN : 145570038X
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Summary : Respiratory infections are among the most common causes of morbidity and mortality worldwide. These infections present a special challenge to physicians for several reasons, including of the recent disasters caused by severe acute respiratory syndrome (SARS) and bird and swine influenza, the increase in viral and bacterial resistance to currently available anti-microbial drugs, the increased frequency of new viral lung infections in clinical practice, and the worldwide emergence of deadly drug-resistant forms of TB. For these reasons, it is important for infectious disease specialists to have an overview of emerging respiratory infections.

Annals of the Academy of Medicine, Singapore

Annals of the Academy of Medicine, Singapore
  • Author : Academy of Medicine (Singapore)
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Antimalarial Chemotherapy

Antimalarial Chemotherapy
  • Author : Philip J. Rosenthal
  • Publisher :Unknown
  • Release Date :2001-04-01
  • Total pages :396
  • ISBN : 1592591116
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Summary : Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Antibiotic Policies: Fighting Resistance

Antibiotic Policies: Fighting Resistance
  • Author : Ian M. Gould,Jos W.M. van der Meer
  • Publisher :Unknown
  • Release Date :2007-09-12
  • Total pages :285
  • ISBN : 0387708405
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Summary : This volume examines many of the crucial issues of resistance in a clinical context, with an emphasis on MRSA; surely the greatest challenge to our antibiotic and infection control policies that modern health care systems have ever seen. Other chapters explore the psychology of prescribing, modern management techniques as an adjunct to antibiotic policies, and the less obvious downsides of antibiotic use.