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Comparative Toxicogenomics

Comparative Toxicogenomics
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008-07-11
  • Total pages :352
  • ISBN : 0080560024
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Summary : Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. * Reviews some of the first really fruitful studies made in this area * Covers different organisms ranging from humans to model species and environmental sentinels * Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Environmental Health Perspectives

Environmental Health Perspectives
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :229
  • ISBN : NYPL:33433082968292
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Summary :

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005
  • Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : MINN:31951D02570187S
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Summary :

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations

Departments of Labor, and Health and Human Services, Education, and Related Agencies Appropriations
  • Author : United States. Congress. Senate. Committee on Appropriations
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :229
  • ISBN : PSU:000055819718
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Summary :

Design, Management, and Quality Control of Toxicogenomic Experiments

Design, Management, and Quality Control of Toxicogenomic Experiments
  • Author : Lyle David Burgoon
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :338
  • ISBN : MSU:31293027364276
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Summary :

Bulletin of the Mount Desert Island Biological Laboratory

Bulletin of the Mount Desert Island Biological Laboratory
  • Author : Mount Desert Island Biological Laboratory
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :229
  • ISBN : UOM:39015072701066
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Summary :

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment
  • Author : Darrell R. Boverhof,B. Bhaskar Gollapudi
  • Publisher :Unknown
  • Release Date :2011-10-11
  • Total pages :392
  • ISBN : 1118008987
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Summary : This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Genomic Approaches for Cross-Species Extrapolation in Toxicology

Genomic Approaches for Cross-Species Extrapolation in Toxicology
  • Author : William H. Benson,Richard T. Di Giulio
  • Publisher :Unknown
  • Release Date :2006-12-13
  • Total pages :216
  • ISBN : 1420043641
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Summary : The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

In Vivo Examination of the Inhibitory Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on Estrogen-mediated Gene Expression Responses

In Vivo Examination of the Inhibitory Effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on Estrogen-mediated Gene Expression Responses
  • Author : Darrell Ralph Boverhof
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :476
  • ISBN : MSU:31293027368863
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Summary :

Development and Validation of the Daphnia CDNA Microarray as a Method for Predicting Contamination in Aquatic Environments

Development and Validation of the Daphnia CDNA Microarray as a Method for Predicting Contamination in Aquatic Environments
  • Author : Helen Catherine Poynton
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :346
  • ISBN : UCAL:C3511221
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Summary :

An Introduction to Toxicogenomics

An Introduction to Toxicogenomics
  • Author : Michael E. Burczynski
  • Publisher :Unknown
  • Release Date :2003-03-26
  • Total pages :348
  • ISBN : 020350481X
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Summary : Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Clinical Genetics in Nursing Practice

Clinical Genetics in Nursing Practice
  • Author : Felissa R. Lashley, PhD, RN, FABMGG
  • Publisher :Unknown
  • Release Date :2005-04-15
  • Total pages :584
  • ISBN : 0826123678
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Summary : Designated a Doody's Core Title! The third edition of this award-winning text provides new and updated knowledge about genetics issues relevant to nursing practice. Read in sequence or used as a reference, this is a comprehensive overview of how genetics affetcs the care that nurses provide. In addition to a summary of basic human genetics and discussion of the Human Genome Project, this new edition includes the latest research findings and implications about inheritance, major genetic disorders (cytogenetics or chromosomal, inherited biochemical, and congenital anomalies), and genetics in twin studies. A consideration of the ethical impact of genetics on society and future generations, as well as information on assisted reproduction round out the overview. Includes over 100 illustrations and photos of specific genetic disorders; tables and figures on the distribution of disease; and an extensive appendix listing associations, organizations, and websites relevant to genetics.

Encyclopedia of Ecology

Encyclopedia of Ecology
  • Author : Sven Erik Jørgensen,Brian D. Fath
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :4122
  • ISBN : 0080454003
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Summary : The Encyclopedia of Ecology contains contributions from international experts on a diverse array of topics related to ecology. It provides current and comprehensive information on many themes, including behavioral ecology, ecological processes, ecological modeling, ecological engineering, ecological indicators, ecological informatics, ecosystems, ecotoxicology, evolutionary ecology, general ecology, global ecology, human ecology, and systems ecology. The online version includes extensive internal cross-referencing and dynamic linking to journal articles and abstract databases.

Bisphenol A

Bisphenol A
  • Author : Pinar Erkekoglu,Belma Koçer-Gümüşel
  • Publisher :Unknown
  • Release Date :2017-06-07
  • Total pages :164
  • ISBN : 9789535132172
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Summary : Bisphenol A (BPA) is a synthetic compound for hardening and clearing polycarbonate plastics. BPA is mainly classified as an estrogen-like endocrine-disrupting chemical. In the last decade, attention has arisen in scientific communities that it is not safe to use this chemical in mainly polycarbonate plastics. Exposure to BPA starts in prenatal period, which is the critical period for its toxic effects on different organs. Throughout this book, the readers will obtain information on the effects of BPA on different systems. They will also get information on the prenatal and postnatal effects of BPA. We believe that readers will get qualified scientific knowledge and a general overview of the toxic effects of BPA exposure and its consequences from this book.

An Introduction to Toxicogenomics

An Introduction to Toxicogenomics
  • Author : Michael E. Burczynski
  • Publisher :Unknown
  • Release Date :2003-03-26
  • Total pages :348
  • ISBN : 020350481X
GET BOOK HERE

Summary : Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Biological Data Mining in Protein Interaction Networks

Biological Data Mining in Protein Interaction Networks
  • Author : Li, Xiao-Li,Ng, See-Kiong
  • Publisher :Unknown
  • Release Date :2009-05-31
  • Total pages :450
  • ISBN : 9781605663999
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Summary : "The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.

Annual Review of Nursing Research, Volume 29

Annual Review of Nursing Research, Volume 29
  • Author : Ginette A. Pepper, PhD, RN, FAAN,Kenneth J. Wysocki, PhD, RN, FNP-BC, FAANP
  • Publisher :Unknown
  • Release Date :2012-05-29
  • Total pages :400
  • ISBN : 9780826157553
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Summary : This landmark annual review has provided three decades of knowledge, insight, and research on topics critical to the continued advancement of the nursing profession. This latest edition is a compilation of the most significant nursing research in genetics and genomics. Articles have been carefully selected by the editors, highly respected scholars and researchers in the field of genetics, to bring together current research that has particular relevance for translation into a clinical setting or expansion into other research areas. The review provides authoritative information of the highest caliber not only to researchers, but also to clinicians and undergraduate and graduate nursing students. Key Topics: The current status of genomic molecular science Ethical, legal, and social issues in genomics Genetics of diseases and symptoms Genomics across the lifespan

Cross-species Comparison of Estrogenic Endocrine Disruptor-induced, Uterotrophic Gene Expression in the Rodent

Cross-species Comparison of Estrogenic Endocrine Disruptor-induced, Uterotrophic Gene Expression in the Rodent
  • Author : Joshua Caleb Kwekel
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :334
  • ISBN : MSU:31293030624369
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Summary :

Antitargets and Drug Safety

Antitargets and Drug Safety
  • Author : Laszlo Urban,Vinod Patel,Roy J. Vaz
  • Publisher :Unknown
  • Release Date :2015-02-23
  • Total pages :528
  • ISBN : 9783527673667
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Summary : With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.

Smart Health

Smart Health
  • Author : Andreas Holzinger,Carsten Röcker,Martina Ziefle
  • Publisher :Unknown
  • Release Date :2015-02-24
  • Total pages :275
  • ISBN : 9783319162263
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Summary : Prolonged life expectancy along with the increasing complexity of medicine and health services raises health costs worldwide dramatically. Whilst the smart health concept has much potential to support the concept of the emerging P4-medicine (preventive, participatory, predictive, and personalized), such high-tech medicine produces large amounts of high-dimensional, weakly-structured data sets and massive amounts of unstructured information. All these technological approaches along with “big data” are turning the medical sciences into a data-intensive science. To keep pace with the growing amounts of complex data, smart hospital approaches are a commandment of the future, necessitating context aware computing along with advanced interaction paradigms in new physical-digital ecosystems. The very successful synergistic combination of methodologies and approaches from Human-Computer Interaction (HCI) and Knowledge Discovery and Data Mining (KDD) offers ideal conditions for the vision to support human intelligence with machine learning. The papers selected for this volume focus on hot topics in smart health; they discuss open problems and future challenges in order to provide a research agenda to stimulate further research and progress.

Nonalcoholic Fatty Liver Disease, An Issue of Clinics in Liver Disease - E-Book

Nonalcoholic Fatty Liver Disease, An Issue of Clinics in Liver Disease - E-Book
  • Author : Arun J. Sanyal
  • Publisher :Unknown
  • Release Date :2012-08-12
  • Total pages :240
  • ISBN : 9781455747368
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Summary : Dr. Sanyal's expertise as Chairman of the Division of Hepatology at Virginia Commonwealth University and the breadth of his published articles in hepatology make him the perfect person to compile state-of-the-art reviews on the topic of NASH/fatty liver. The articles in this issue address the following topics: The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease; Relevance of Liver Histology to Predict Clinically Meaningful Outcomes in NASH; Mechanisms of Simple Hepatic Steatosis; Cellular and Molecular Basis for Phenotype of Steatohepatitis; Mechanisms of Disease Progression in NASH: New Paradigms; Can NASH Be Diagnosed, Graded and Staged Non-Invasively?; Is NAFLD in Children the Same Disease as in Adults?; The Cardiovascular Link to NAFLD: A Critical Analysis; Impact of Behavioral Disturbances and Their Treatment on Obesity and NAFLD; and Management of NASH.