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Computer-Aided Vaccine Design

Computer-Aided Vaccine Design
  • Author : Joo Chuan Tong,Shoba Ranganathan
  • Publisher :Unknown
  • Release Date :2013-07-31
  • Total pages :164
  • ISBN : 9781908818416
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Summary : Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign

Computer-Aided Drug Design

Computer-Aided Drug Design
  • Author : Dev Bukhsh Singh
  • Publisher :Unknown
  • Release Date :2020-10-09
  • Total pages :306
  • ISBN : 9789811568152
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Summary : This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

Scientific Modeling and Simulations

Scientific Modeling and Simulations
  • Author : Sidney Yip,Tomas Diaz Rubia
  • Publisher :Unknown
  • Release Date :2010-04-07
  • Total pages :402
  • ISBN : 9781402097416
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Summary : Although computational modeling and simulation of material deformation was initiated with the study of structurally simple materials and inert environments, there is an increasing demand for predictive simulation of more realistic material structure and physical conditions. In particular, it is recognized that applied mechanical force can plausibly alter chemical reactions inside materials or at material interfaces, though the fundamental reasons for this chemomechanical coupling are studied in a material-speci c manner. Atomistic-level s- ulations can provide insight into the unit processes that facilitate kinetic reactions within complex materials, but the typical nanosecond timescales of such simulations are in contrast to the second-scale to hour-scale timescales of experimentally accessible or technologically relevant timescales. Further, in complex materials these key unit processes are “rare events” due to the high energy barriers associated with those processes. Examples of such rare events include unbinding between two proteins that tether biological cells to extracellular materials [1], unfolding of complex polymers, stiffness and bond breaking in amorphous glass bers and gels [2], and diffusive hops of point defects within crystalline alloys [3].

Vaccines

Vaccines
  • Author : Farhat Afrin,Hassan Hemeg,Hani Ozbak
  • Publisher :Unknown
  • Release Date :2017-09-06
  • Total pages :192
  • ISBN : 9789535134756
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Summary : Microbes that elude host's defenses and have developed resistance to the existing antibiotic arsenal continuously invade the human body. Cure for such diseases is inevitable as it may result in high morbidity and mortality, if not properly treated. Vaccination represents the most cost-effective way for disease prevention. Vaccines activate sentinels of the immune system including macrophages and T, B, and dendritic cells to release a battery of effector molecules and cytokines and ward off infection. For long-lasting protection, the memory cells also need to be evoked. This book encompasses biotechnological vaccines in clinical use, cocooning, disease resurgence postvaccination and other vaccine adverse effects, prospects of therapeutic versus prophylactic vaccines, and design of effective vaccines using bioinformatic tools and engineering molecular pattern interactions.

Molecular Docking for Computer-Aided Drug Design

Molecular Docking for Computer-Aided Drug Design
  • Author : Mohane S. Coumar
  • Publisher :Unknown
  • Release Date :2021-03-01
  • Total pages :520
  • ISBN : 9780128223130
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Summary : Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. Covers the latest information and state-of-the-art trends in structure-based drug design methodologies Includes case studies that complement learning Consolidates fundamental concepts and current practice of molecular docking into one convenient resource

Vaccine Design

Vaccine Design
  • Author : Rino Rappuoli,Fabio Bagnoli
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :380
  • ISBN : 1904455743
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Summary : In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

Post-Genomic Approaches in Drug and Vaccine Development

Post-Genomic Approaches in Drug and Vaccine Development
  • Author : Kishore R. Sakharkar,Meena K. Sakharkar ,Ramesh Chandra
  • Publisher :Unknown
  • Release Date :2015-04-11
  • Total pages :450
  • ISBN : 9788793102842
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Summary : Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. This book focuses on some key advances in the field. Technical topics discussed in the book include: Drug discoveryTarget identification and prioritizationHypothesis driven multi-target drug designGenomics in vaccine developmentGene regulatory networks Vaccine design and developmentPrediction of drug side effects in silico

Comprehensive Medicinal Chemistry II

Comprehensive Medicinal Chemistry II
  • Author : David J Triggle,John B Taylor
  • Publisher :Unknown
  • Release Date :2006-12-29
  • Total pages :7200
  • ISBN : 9780080445137
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Summary : The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Process Selection

Process Selection
  • Author : K. G. Swift,J. D. Booker
  • Publisher :Unknown
  • Release Date :2003-06-02
  • Total pages :336
  • ISBN : 0080474004
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Summary : The definitive practical guide to choosing the optimum manufacturing process, written for students and engineers. Process Selection provides engineers with the essential technological and economic data to guide the selection of manufacturing processes. This fully revised second edition covers a wide range of important manufacturing processes and will ensure design decisions are made to achieve optimal cost and quality objectives. Expanded and updated to include contemporary manufacturing, fabrication and assembly technologies, the book puts process selection and costing into the context of modern product development and manufacturing, based on parameters such as materials requirements, design considerations, quality and economic factors. Key features of the book include: manufacturing process information maps (PRIMAs) provide detailed information on the characteristics and capabilities of 65 processes and their variants in a standard format; process capability charts detailing the processing tolerance ranges for key material types; strategies to facilitate process selection; detailed methods for estimating costs, both at the component and assemby level. The approach enables an engineer to understand the consequences of design decisions on the technological and economic aspects of component manufacturing, fabrication and assembly. This comprehensive book provides both a definitive guide to the subject for students and an invaluable source of reference for practising engineers. * manufacturing process information maps (PRIMAs) provide detailed information on the characteristics and capabilities of 65 processes in a standard format * process capability charts detail the processing tolerance ranges for key material types * detailed methods for estimating costs, both at the component and assembly level

Computational Immunology

Computational Immunology
  • Author : Shyamasree Ghosh
  • Publisher :Unknown
  • Release Date :2020-01-31
  • Total pages :172
  • ISBN : 9781351023498
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Summary : Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

Chemical Process Design and Simulation: Aspen Plus and Aspen Hysys Applications

Chemical Process Design and Simulation: Aspen Plus and Aspen Hysys Applications
  • Author : Juma Haydary
  • Publisher :Unknown
  • Release Date :2019-01-03
  • Total pages :448
  • ISBN : 9781119311430
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Summary : A comprehensive and example oriented text for the study of chemical process design and simulation Chemical Process Design and Simulation is an accessible guide that offers information on the most important principles of chemical engineering design and includes illustrative examples of their application that uses simulation software. A comprehensive and practical resource, the text uses both Aspen Plus and Aspen Hysys simulation software. The author describes the basic methodologies for computer aided design and offers a description of the basic steps of process simulation in Aspen Plus and Aspen Hysys. The text reviews the design and simulation of individual simple unit operations that includes a mathematical model of each unit operation such as reactors, separators, and heat exchangers. The author also explores the design of new plants and simulation of existing plants where conventional chemicals and material mixtures with measurable compositions are used. In addition, to aid in comprehension, solutions to examples of real problems are included. The final section covers plant design and simulation of processes using nonconventional components. This important resource: Includes information on the application of both the Aspen Plus and Aspen Hysys software that enables a comparison of the two software systems Combines the basic theoretical principles of chemical process and design with real-world examples Covers both processes with conventional organic chemicals and processes with more complex materials such as solids, oil blends, polymers and electrolytes Presents examples that are solved using a new version of Aspen software, ASPEN One 9 Written for students and academics in the field of process design, Chemical Process Design and Simulation is a practical and accessible guide to the chemical process design and simulation using proven software.

Zika Virus Surveillance, Vaccinology, and Anti-Zika Drug Discovery

Zika Virus Surveillance, Vaccinology, and Anti-Zika Drug Discovery
  • Author : Subhash C. Basak,Ashesh Nandy
  • Publisher :Unknown
  • Release Date :2019-03-15
  • Total pages :176
  • ISBN : 1536149705
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Summary : The bubonic plague, smallpox, HIV/AIDS, malaria, and influenza are some of the worst epidemics/pandemics that afflicted human beings from antiquity to modern times, killing millions of people. The mosquito-borne human-infecting viruses, rotavirus, and the seasonal influenza regularly affect lives across continents in the millions. Currently, we are facing various disease-inducing organisms of the Flavivirus family the Yellow fever virus (YFV), West Nile virus (WNV), Japanese encephalitis virus (JEV), Tick-borne encephalitis virus (TBEV), Dengue virus (DENV) and Zika virus (ZIKV). Zika virus was first isolated from a febrile rhesus monkey in the Zika forest of Uganda in 1947. It drew out heightened attention following the large number of microcephaly in newborn babies in Latin America in 2015. On 1 February 2016, WHO declared that the association of Zika infection with clusters of microcephaly and other neurological disorders constituted a Public Health Emergency of International Concern. Although the severity and number of ZIKV afflicted cases have gone down lately, the public health community worldwide is keeping a watchful eye on it. ZIKV is an enveloped virus with a positive-sense RNA genome that translates into a single polypeptide, which then gets cleaved into three structural and seven nonstructural viral proteins. As compared to the earlier centuries, we have an expanding repertoire of diverse and fast acting technologies available at our hand to manage and mitigate emerging diseases. Completion of the Human Genome Project has given rise to sequencing methods which can quickly determine the genetic sequence of an alarming pathogen. Following Moores law, the power of computers, essential for data analysis and visualization, has grown substantially with time. The combination of genomic data of pathogens, computational modeling methods, and data driven methodologies can lead to a generic approach of surveillance, mitigation, vaccine design as well as new drug discovery for emerging pathogens. The four pillars of this may consist of: a) Epidemiological approaches for the characterization of carriers of next possible emerging pathogens; b) Fast computational sequence comparison methods for the characterization of emerging pathogens to understand how novel or severe they could be; c) Once the sequences of the pathogen have been determined, computer-aided vaccine design (CAVD) methods can be used to suggest a set of probable vaccine candidates for quick synthesis and testing in the laboratory; and d) Computer-assisted design of novel therapeutics and their laboratory testing as well as repurposing of already existing FDA-approved drugs. A combination of different classes of methods in vivo, in vitro and in silico will be needed to tackle suddenly emerging viruses like the Zika virus. As in many other fields of biomedical research, high throughput and low cost in silico technologies may provide the first line of defense against such emerging pathogens providing decision support systems for the judicious applications of medium throughput in vitro methods and low throughput as well as costly in vivo techniques. An emerging trend in many scientific disciplines is a strong tendency of being transformed into some form of information science. The editors of this book sincerely hope that the four-pronged computer-assisted approach described in this book will help in managing and mitigating emerging infectious diseases like Zika.

Computer-Aided Applications in Pharmaceutical Technology

Computer-Aided Applications in Pharmaceutical Technology
  • Author : Jelena Djuris
  • Publisher :Unknown
  • Release Date :2013-04-10
  • Total pages :300
  • ISBN : 9781908818324
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Summary : Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

Annual Report

Annual Report
  • Author : India. Department of Scientific & Industrial Research
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :229
  • ISBN : UOM:39015066160477
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Summary :

Precarious Life

Precarious Life
  • Author : Judith Butler
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :168
  • ISBN : 1844675440
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Summary : An appraisal of post-September 11 America presents the U.S. government's decision to attack Afghanistan and Iraq as a response to loss and grief, arguing that the vulnerability being experienced in the western world is posing an opportunity to imagine a global political community without violence. Reprint.

Computer-aided Molecular Design

Computer-aided Molecular Design
  • Author : William Graham Richards
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :266
  • ISBN : UOM:39015054001550
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Summary :

Leaky Bodies and Boundaries

Leaky Bodies and Boundaries
  • Author : Margrit Shildrick
  • Publisher :Unknown
  • Release Date :2015-12-22
  • Total pages :264
  • ISBN : 9781136184628
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Summary : Drawing on postmodernist analyses, Leaky Bodies and Boundaries presents a feminist investigation into the marginalization of women within western discourse that denies female moral agency and embodiment. With reference to contemporary and historical issues in biomedicine, the book argues that the boundaries of both the subject and the body are no longer secure. The aim is both to valorise women and to suggest that 'leakiness' may be the very ground for a postmodern feminist ethic. The contribution made by Leaky Bodies and Boundaries is to go beyond modernist feminisms to radically displace the mechanisms by which women are devalued. The anxiety that postmodernism cannot yield an ethics, nor advance feminist concerns is addressed. This book will provide invaluable reading for those studying feminist philosophy, cultural studies and sociology.

Annual Report - Council of Scientific and Industrial Research

Annual Report - Council of Scientific and Industrial Research
  • Author : Council of Scientific & Industrial Research (India)
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : UIUC:30112075347127
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Summary :

Citrus

Citrus
  • Author : Pierre Laszlo
  • Publisher :Unknown
  • Release Date :2008-10
  • Total pages :252
  • ISBN : 9780226470283
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Summary : Laszlo traces the spectacular rise and spread of citrus across the globe, from southeast Asia in 4000 BC to modern Spain and Portugal, whose explorers inroduced the fruit to the Americas. This book explores the numerous roles that citrus has played in agriculture, horticulture, cooking, nutrition, religion, and art.

Seeking Spatial Justice

Seeking Spatial Justice
  • Author : Edward W. Soja
  • Publisher :Unknown
  • Release Date :2013-11-30
  • Total pages :280
  • ISBN : 1452915288
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Summary : In 1996, the Los Angeles Bus Riders Union, a grassroots advocacy organization, won a historic legal victory against the city’s Metropolitan Transit Authority. The resulting consent decree forced the MTA for a period of ten years to essentially reorient the mass transit system to better serve the city’s poorest residents. A stunning reversal of conventional governance and planning in urban America, which almost always favors wealthier residents, this decision is also, for renowned urban theorist Edward W. Soja, a concrete example of spatial justice in action. In Seeking Spatial Justice, Soja argues that justice has a geography and that the equitable distribution of resources, services, and access is a basic human right. Building on current concerns in critical geography and the new spatial consciousness, Soja interweaves theory and practice, offering new ways of understanding and changing the unjust geographies in which we live. After tracing the evolution of spatial justice and the closely related notion of the right to the city in the influential work of Henri Lefebvre, David Harvey, and others, he demonstrates how these ideas are now being applied through a series of case studies in Los Angeles, the city at the forefront of this movement. Soja focuses on such innovative labor–community coalitions as Justice for Janitors, the Los Angeles Alliance for a New Economy, and the Right to the City Alliance; on struggles for rent control and environmental justice; and on the role that faculty and students in the UCLA Department of Urban Planning have played in both developing the theory of spatial justice and putting it into practice. Effectively locating spatial justice as a theoretical concept, a mode of empirical analysis, and a strategy for social and political action, this book makes a significant contribution to the contemporary debates about justice, space, and the city.

Bioinformatics for Vaccinology

Bioinformatics for Vaccinology
  • Author : Darren R. Flower
  • Publisher :Unknown
  • Release Date :2008-10-13
  • Total pages :302
  • ISBN : 9780470699829
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Summary : “... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.