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Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis
  • Author : P. Perlmutter
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :394
  • ISBN : 9781483293783
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Summary : This book provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organised in terms of the major classes of conjugate acceptors. Within each of these classes, the chemistry and applications of conjugate additions with several different categories of nucleophiles have been examined. Where several different nucleophiles achieve the same synthetic transformation, they are cross-referenced within the book and qualitative comparisons offered where appropriate. Examples of the use of conjugate additions in total synthesis of important molecules are included, with a special emphasis throughout the book on stereoselectivity. This will be a useful main text for graduate and postgraduate courses on conjugate addition reactions or the Michael reaction. It could also serve as a supplementary text for courses on topics such as the chemistry of organocopper reagents, enamines and carbanion chemistry.

Conjugate Addition Reactions in Organic Synthesis

Conjugate Addition Reactions in Organic Synthesis
  • Author : Patrick Perlmutter
  • Publisher :Unknown
  • Release Date :2020-12-29
  • Total pages :512
  • ISBN : 0128186283
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Summary : Conjugate Addition Reactions in Organic Synthesis, second edition, provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organized according to class of acceptor rather than the class of nucleophile, which makes for easier synthetic problem solving. All aspects of conjugate addition reactions are covered, including theory, mechanism, catalysis, and total synthesis. Asymmetric processes are featured heavily, and there is emphasis on catalysis, given its importance in all aspects of organic synthesis today. Extensive examples in total synthesis illustrate how particular synthetic challenges are addressed and resolved with conjugate addition chemistry. The second edition features new coverage of acceptors and nucleophiles, as well as organocatalysis, gold catalysis, peptide catalysis, arene additions, and emerging areas such as biocatalytic methods and advances in mechanism theory. This book is an ideal reference for advanced undergraduates, post-graduates, researchers, and academics working in medicinal, pharmaceutical, polymer and industrial chemistry. Features a unique structure for this subject which enables readers to readily access information based on specific classes of conjugate acceptor Provides a thorough account of the latest thinking of the mechanistic basis of conjugate addition reactions and all the latest - and best - methods for achieving the highest selectivity in conjugate addition reactions Includes over 200 examples of total synthesis illustrating how particular synthetic challenges are addressed and resolved with conjugate addition chemistry Covers an up to date treatment of the latest aspects of conjugate addition reactions including inter alia, cascade reactions, organocatalysis and flow chemistry

Organocatalytic Enantioselective Conjugate Addition Reactions

Organocatalytic Enantioselective Conjugate Addition Reactions
  • Author : Jose L. Vicario
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :354
  • ISBN : 9781849730242
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Summary : This book, unique in its field, is a comprehensive description of all the methodologies reported for carrying out conjugate addition reactions in a stereoselective way, using small chiral organic molecules as catalysts (organocatalysts). In the last 3-4 years, this has been a rapidly growing field in organic chemistry, and many papers have appeared reporting excellent protocols for carrying out these highly efficient transformations that compete well with other classical approachse using transition metal catalysts. A particularly attractive feature of this transformation relies upon the fact that the conjugate addition (Michael and Hetero-Michael reactions) is an extraoridinarily effective means to initiate cascade processes which result in the formation of complex molecules from very small and simple starting blocks. The book, written by noted experts, covers all recent advances in this not topic, and provides a good state-of-the-art review for organic chemists working in this field and all those who wish to start projects in this area. The Series is intended to provide an accessible reference for postgraduates and industrialists working in the field of catalysis and its applications. Books will be produced either as monographs or reference handbooks. The Series will cover research developments and applications of catalysis, in both academia and industry.

Modern Methods of Organic Synthesis

Modern Methods of Organic Synthesis
  • Author : J. E. Carruthers,W. Carruthers,Iain Coldham
  • Publisher :Unknown
  • Release Date :2004-10-14
  • Total pages :493
  • ISBN : 0521778301
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Summary : Textbook on modern methods of organic synthesis.

Asymmetric Conjugate Addition Reactions

Asymmetric Conjugate Addition Reactions
  • Author : Scott Bentley
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :229
  • ISBN : OCLC:827258922
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Summary : This thesis is concerned with the asymmetric conjugate addition reactions of a range of chiral nucloeophiles. Chapter 1 introduces the conjugate addition reaction as a valuable carbon-carbon and carbon-heteroatom bond forming reaction in organic chemistry, and explores the asymmet- ric conjugate addition of a range of chiral and achiral carbon and nitrogen nucleophiles to a range of acceptors. Chapter 2 explores the use of the N-benzyl-N-([alpha]-methylbenzyl)amino group as a chi- ral auxiliary, by employing the attempted conjugate additions of both N-benzyl-N-([alpha]- methylbenzyl)hydrazine and N -benzyl-N -([alpha]-methylbenzyl)hydroxylamine as chiral ammo- nia and water equivalents respectively. Chapter 3 describes the asymmetric and stereoselective preparation of a range of 4,4- disubstituted isoxazolidin-5-ones from the conjugate addition of lithium (S)-N-tert-butyl- dimethylsilyloxy-N -([alpha]-methylbenzyl)amide. The isoxazolidin-5-ones are then globally de- protected via hydrogenolysis, giving rise to the corresponding [beta]2,2,3-amino acids. Chapter 4 focuses on the development of a protocol to effect the conjugate addition of a chiral aniline equivalent. The scope of the reaction is delineated by varying both the nu- cleophile and the [alpha],[beta]-unsaturated ester. Finally, cyclisation of the [beta]-N-arylamino esters to the corresponding tetrahydroquinolines is explored, and an application to the synthesis of the natural product (-)-angustureine is presented. Chapter 5 contains full experimental procedures and characterisation data for all com- pounds synthesised in Chapters 2, 3 and 4.

Basic Principles of Organic Chemistry

Basic Principles of Organic Chemistry
  • Author : John D. Roberts,Marjorie C. Caserio
  • Publisher :Unknown
  • Release Date :1977
  • Total pages :1596
  • ISBN : 0805383212
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Summary : Introduction what is organic chemistry all about?; Structural organic chemistry the shapes of molecules functional groups; Organic nomenclature; Alkanes; Stereoisomerism of organic molecules; Bonding in organic molecules atomic-orbital models; More on nomenclature compounds other than hydrocarbons; Nucleophilic substitution and elimination reactions; Separation and purification identification of organic compounds by spectroscopic techniques; Alkenes and alkynes. Ionic and radical addition reactions; Alkenes and alkynes; Oxidation and reduction reactions; Acidity or alkynes.

The Chemistry of Organocopper Compounds

The Chemistry of Organocopper Compounds
  • Author : Zvi Rappoport,Ilan Marek
  • Publisher :Unknown
  • Release Date :2010-01-07
  • Total pages :1178
  • ISBN : 9780470772966
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Summary : Copper in organic synthesis has seen a tremendous development over the past ten years. This text represents the most comprehensive survey on the use of Copper and Cuprates in organic synthesis. The first time that the Patai Series touches on Copper compounds, it contains contributions by leading experts, and delivers the quality expected from the Patai Series.

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
  • Publisher :Unknown
  • Release Date :2006-12-13
  • Total pages :631
  • ISBN : 9783527608683
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Summary : Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Organic Chemistry

Organic Chemistry
  • Author : G. Marc Loudon
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :1259
  • ISBN : UOM:39015018902935
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Summary :

Catalysis in Asymmetric Synthesis

Catalysis in Asymmetric Synthesis
  • Author : Vittorio Caprio,Jonathan Williams
  • Publisher :Unknown
  • Release Date :2009-03-09
  • Total pages :393
  • ISBN : 9781405190916
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Summary : Written from a synthetic organic chemistry perspective, this is a highly practical and relevant text for undergraduates, postgraduates and industrial organic chemists.

Carbanions in Organic Synthesis

Carbanions in Organic Synthesis
  • Author : John Charles Stowell
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :247
  • ISBN : UOM:39015049485959
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Summary :

An Introduction to Synthesis Using Organocopper Reagents

An Introduction to Synthesis Using Organocopper Reagents
  • Author : Gary H. Posner
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :140
  • ISBN : CORNELL:31924052552266
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Summary :

My Favorite Organic Synthesis

My Favorite Organic Synthesis
  • Author : 有機合成化学協会
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :253
  • ISBN : STANFORD:36105112213959
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Summary :

Organic Reactions

Organic Reactions
  • Author : Scott E. Denmark
  • Publisher :Unknown
  • Release Date :2016-06-20
  • Total pages :952
  • ISBN : 9781119281443
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Summary : The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.

Organic Synthesis, Today and Tomorrow

Organic Synthesis, Today and Tomorrow
  • Author : International Union of Pure and Applied Chemistry
  • Publisher :Unknown
  • Release Date :1981
  • Total pages :354
  • ISBN : UCSD:31822010225282
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Summary : Organic Synthesis: Today and Tomorrow covers the proceedings of the Third International Union of Pure and Applied Chemistry (IUPAC) Symposium on Organic Synthesis. The book covers topics that tackle relevant issues about organic chemistry. Comprised of 27 chapters, the book covers lectures that tackle topics pertaining organic chemistry. These topics include useful synthetic methods for general application; development of chemistry concepts for use in construction of molecular sub-assemblies; and interplay of synthetic methodology and the total synthesis of organic compounds. The book will be ...

I) Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-appended Enones. II) Synthetic Developments Toward the Aplykurodin Family

I) Enantioselective Conjugate Addition of Alkenylboronic Acids to Indole-appended Enones. II) Synthetic Developments Toward the Aplykurodin Family
  • Author : Brian Jeffrey Lundy
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :229
  • ISBN : OCLC:930365763
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Summary : This dissertation presents two different projects, the first being the use of boronic acids in conjugate addition reactions on different substituted indoles, and the second discusses the strategies toward the synthesis of the natural product, aplykurodinone 1. Conjugate addition reactions are very valuable reactions in forming carbon-carbon bonds and have been studied quite a bit over the years. However, the use of conjugate addition reactions have not been shown to be plausible with unprotected indoles enantioselectively. The previous methods used to do these types of reactions on indoles suffer from limited scope and also require protecting the indole nitrogen. What will be discussed is a very general reaction that tolerates different functional groups such as electron donating and electron withdrawing, as well as tolerating unprotected indoles making it a very useful and powerful method for organic synthesis. The second project I will discuss is efforts toward the total synthesis of the natural product aplykurodinone 1. Aplykurodinone 1 is part of the aplykurodin family of natural products that was found to have potential cytotoxic activity against cancer cell lines. This potential biological activity combined with the interesting steroidal type structure of the natural product piqued our interest and desire to focus efforts to make it synthetically.

Organic Chemistry

Organic Chemistry
  • Author : Joe Karty
  • Publisher :Unknown
  • Release Date :2014-01-01
  • Total pages :1488
  • ISBN : 9780393937121
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Summary : Joel Karty has dedicated nearly a decade developing a teaching approach and textbook that is organized by mechanism, promotes learning by doing, and provides students with the background and support they need to be successful in organic chemistry as well as pre-professional placement exams like the MCAT. Karty’s organization, conversational writing style, and interactive pedagogy facilitate understanding rather than memorization and place the emphasis back on mechanisms.

Bifunctional Compounds

Bifunctional Compounds
  • Author : Robert S. Ward,Robert S.. Ward
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :90
  • ISBN : UOM:39015048548682
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Summary : This concise text outlines some of the methods used to prepare bifunctional compounds and then surveys the chemistry of some of the more important classes. Problems - with solutions - and suggestions for further reading are provided.

Comprehensive Organic Synthesis

Comprehensive Organic Synthesis
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2014-02-14
  • Total pages :9806
  • ISBN : 9780080977430
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Summary : The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively

Organic Chemistry

Organic Chemistry
  • Author : Jonathan Clayden,Nick Greeves,Stuart Warren
  • Publisher :Unknown
  • Release Date :2012-03-15
  • Total pages :1234
  • ISBN : 9780199270293
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Summary : Rev. ed. of: Organic chemistry / Jonathan Clayden ... [et al.].

Synthesis of Optically Active [alpha]-amino Acids

Synthesis of Optically Active [alpha]-amino Acids
  • Author : Robert Michael Williams,Robert Moore Williams
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :410
  • ISBN : UOM:39015016106539
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Summary : The purpose of this book is to review and critically evaluate the best new methods to synthesize alpha-amino acids in optically active form. There is so much new literature on amino acid synthesis that the experimentalist will undoubtedly have difficulty in selecting the most appropriate methodology for constructing the amino acid of immediate interest. This book is a guide for steering the scientist through the maze of existing reports on the subject and contains the most up-to-date critical reviews of methods of asymmetric synthesis of amino acids. In areas that are relatively new conceptually and less studied experimentally, an effort has been made to review the most salient works with an eye towards future development. Over 330 schemes and figures are presented with references for rapid visual retrieval of information. The book will be of great value to academic and industrial organic research chemists, especially those concerned with medicinal and agricultural chemistry, as well as to graduate and post graduate students, biochemists and biologists.