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Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
  • Author : Emmanuel C. Opara
  • Publisher :Unknown
  • Release Date :2020-02-28
  • Total pages :351
  • ISBN : 9780429582752
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Summary : This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Controlled Drug Delivery

Controlled Drug Delivery
  • Author : M A Mateescu,P Ispas-Szabo,E Assaad
  • Publisher :Unknown
  • Release Date :2014-12-09
  • Total pages :250
  • ISBN : 9781908818676
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Summary : In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this comprehensive book include: the concept of self-assembling; starch and derivatives as pharmaceutical excipients; and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Later chapters discuss polyelectrolyte complexes as excipients for oral administration; and natural semi-synthetic and synthetic materials. Closing chapters cover protein-protein associative interactions and their involvement in bioformulations; self-assembling materials, implants and xenografts; and provide conclusions and perspectives. Offers novel perspectives of a new concept: how minor alterations can induce major self-stabilization by cumulative forces exerted at short and long distances Gives guidance on how to approach modifications of biopolymers for drug delivery systems and materials for implants Describes structure-properties relationships in proposed excipients, drug delivery systems and biomedical materials

Polymers for Controlled Drug Delivery

Polymers for Controlled Drug Delivery
  • Author : Peter J. Tarcha
  • Publisher :Unknown
  • Release Date :1990-11-21
  • Total pages :296
  • ISBN : 0849356520
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Summary : Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
  • Author : Filippo Rossi,Giuseppe Perale,Maurizio Masi
  • Publisher :Unknown
  • Release Date :2016-01-19
  • Total pages :100
  • ISBN : 9783319022888
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Summary : This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.

Controlled Drug Delivery

Controlled Drug Delivery
  • Author : Stephen D. Bruck
  • Publisher :Unknown
  • Release Date :2019-06-04
  • Total pages :187
  • ISBN : 9780429557309
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Summary : Published in 1983: Volume 1 deals with basic pharmacological aspects of controlled drug delivery, transport of small molecules through polymers, biodegradation of polymers with or without enzymatic involvement, and drug carriers.

Oral Controlled Release Formulation Design and Drug Delivery

Oral Controlled Release Formulation Design and Drug Delivery
  • Author : Hong Wen,Kinam Park
  • Publisher :Unknown
  • Release Date :2011-01-14
  • Total pages :376
  • ISBN : 1118060326
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Summary : This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Focal Controlled Drug Delivery

Focal Controlled Drug Delivery
  • Author : Abraham J. Domb,Wahid Khan
  • Publisher :Unknown
  • Release Date :2014-02-17
  • Total pages :700
  • ISBN : 9781461494348
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Summary : The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Controlled Drug Release Of Oral Dosage Forms

Controlled Drug Release Of Oral Dosage Forms
  • Author : Jean-Maurice Vergnaud
  • Publisher :Unknown
  • Release Date :1993-07-31
  • Total pages :410
  • ISBN : 0131749544
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Summary : Numerical analysis of matter transfer is an area that pharmacists find difficult, but which is a technique frequently used in preparing controlled drug release and oral dosage forms. This book provides clear and straightforward information enabling the reader to carry out numerical analysis of matter transfer - a vital processs when looking at the formulation of oral dosage forms with controlled drug release. The drug is dispersed in a polymeric matrix either biodegradable or not, the basis of which is the transfer of the liquid and the drug through dosage form. Information on this diffusion is found either through mathematical treatment when the problem is simple, or through numerical analysis for more complex problems. Professor Vergnaud demonstrates and clarifies these, modelling the process of drug delivery by using numerical analysis and computerization. A simulation of the process is provided, together with a determination of the effects of all parameters, and the author uses both mathematical and numerical models to predict the preparation of new dosage forms able to fulfil specific conditions.

Design of Controlled Release Drug Delivery Systems

Design of Controlled Release Drug Delivery Systems
  • Author : Xiaoling Li
  • Publisher :Unknown
  • Release Date :2005-11-24
  • Total pages :435
  • ISBN : 9780071588836
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Summary : The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

Controlled Drug Delivery

Controlled Drug Delivery
  • Author : Kinam Park
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :629
  • ISBN : UOM:39015040351143
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Summary : This volume discusses the challenges of creating controlled release dosage forms that will deliver new therapeutic agents based on high-molecular-weight molecules. It examines strategies for delivering drugs through resistant biological barriers and surveys a variety of topics, including drug targeting, self-regulated drug delivery, protein drug delivery, biosensors, cell and tissue engineering, new biomaterials, modeling methods, pharmacokinetics, and U.S. federal regulations.

Colloidal Carriers for Controlled Drug Delivery and Targeting

Colloidal Carriers for Controlled Drug Delivery and Targeting
  • Author : Rainer H. Müller
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :379
  • ISBN : 3804710964
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Summary :

Treatise on Controlled Drug Delivery

Treatise on Controlled Drug Delivery
  • Author : Agis F. Kydonieus
  • Publisher :Unknown
  • Release Date :2017-10-02
  • Total pages :568
  • ISBN : 9781351406871
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Summary : An introductory but detailed treatise which includes some 1,000 references and solved examples and end-of-chapter problems, making it useful to both students and practitioners. The pharmokinetics, pharmacodynamics, and biological and biopharmaceutical parameters pertinent to each route of administra

Controlled Drug Delivery

Controlled Drug Delivery
  • Author : Joseph Robinson,Vincent H. L. Lee
  • Publisher :Unknown
  • Release Date :1987-01-30
  • Total pages :744
  • ISBN : 0824775880
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Summary : Drugs and the pharmaceutical sciences.

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery
  • Author : Juergen Siepmann,Ronald A. Siegel,Michael J. Rathbone
  • Publisher :Unknown
  • Release Date :2011-12-15
  • Total pages :594
  • ISBN : 9781461408819
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Summary : This book approaches the subject from a mechanistic perspective that pitches the language at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms. It provides a simple encapsulation of concepts and expands on them. In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material, exceptions to the general rule, examples, etc., is introduced and built up. Such material was generously supplemented with diagrams; conceptually elegant line diagrams in two or three colors. The artwork was well thought out and able to condense the scientific principles into a novel and visually exciting form. The diagrams encourage browsing or draw the reader to salient points. In addition, the technique of highlighting key concepts in a separate box is used throughout each chapter.

Functional Polymers for Controlled Drug Release

Functional Polymers for Controlled Drug Release
  • Author : Umile Gianfranco Spizzirri
  • Publisher :Unknown
  • Release Date :2020-03-19
  • Total pages :204
  • ISBN : 9783039284900
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Summary : This Special Issue focuses on the synthesis and characterization of hydrogels specifically used as carriers of biological molecules for pharmaceutical and biomedical employments. Pharmaceutical applications of hydrophilic materials has emerged as one of the most significant trends in the area of nanotechnology. To propose some of the latest findings in this field, each contribution involves an in-depth analysis including different starting materials and their physico-chemical and biological properties with the aim of synthetizing high-performing devices for specific use. In this context, intelligent polymeric devices able to be morphologically modified in response to an internal or external stimulus, such as pH or temperature, have been actively pursued. In general, hydrophilic polymeric materials lead to high in vitro and/or in vivo therapeutic efficacy, with programmed site-specific feature showing remarkable potential for targeted therapy. This Special Issue serves to highlight and capture the contemporary progress in this field. Relevant resources and people to approach - American Association Pharmaceutical Scientists (AAPS): web: www.aaps.org; email: (marketing division): [email protected]; (mmeting division): [email protected] - International Association for Pharmaceutical Technology (APV): web: apv-mainz.de; email (managing director): [email protected]; (congresses and trade fairs): [email protected] - International Society of Drug Delivery Sciences and Technology (APGI): web: http://www.apgi.org; email: [email protected]; - The Society of Chemical Industry (SCI): web: www.soci.org; email: [email protected] - Italian society of researchers in pharmaceutical technology (A.D.R.I.T.E.L.F.): web: www-3.unipv.it/adritelf/; email (head): [email protected]; - Italian Chemical Society (SCI): web: www.soc.chim.it; email: [email protected] - Associazione Farmaceutici Industria (AFI): web: http://www.afiweb.it; email:: [email protected] - Società Italiana di Chimica e Scienze Cosmetologiche (SICC): web: www.sicc.tv; mail: [email protected] - Society for biomaterials: web: www.biomaterials.org; email: [email protected] - European Society for Biomaterials (ESB): web: www.esbiomaterials.eu; email: - Società Italiana Biomateriali (SIB): web: www.biomateriali.org; email: [email protected] - Medical Device Manufactures Association (MDMA): web: www.medicaldevices.org; - European Polymer Federaton (EPF): web: www.europolyfed.org; email: [email protected] - Society of Plastics Engineers (SPE): web: www.4spe.org; email: [email protected] - Polymer Processing Society (PPS): web: www.poly-eng.uakron.edu/pps/; email: [email protected]; - American Chinese Pharmaceutical Association; web: www.acpa-rx.org; - Chinese Pharmaceutical Association: web: www.pharmachinaonline.com - Society of Polymer Science, Japan: web: www.spsj.or.jp; email: [email protected]

Drug Delivery

Drug Delivery
  • Author : Ashim K. Mitra,Chairman and Curator's Professor Pharmaceutical Sciences University of Missouri Kansas City Missouri Ashim K Mitra,Deep Kwatra,Aswani Dutt Vadlapudi
  • Publisher :Unknown
  • Release Date :2014-08-18
  • Total pages :400
  • ISBN : 9781449674267
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Summary : Drug Delivery is the latest and most up-to-date text on drug delivery and offers an excellent working foundation for students and clinicians in health professions and graduate students including nursing, pharmacy, medicine, dentistry, as well as researchers and scientists. Presenting this complex content in an organized and concise format, Drug Delivery allows students to gain a strong understanding of the key concepts of drug delivery.This text focuses on the basic concepts of drug delivery while thoroughly examining various topics such as: CNS delivery Gene delivery Ocular delivery World-wide research on drug delivery Recent advances in drug deliveryA significant advancement has been made in the field of drug delivery. This text provides a detailed overview of drug delivery systems, routes of drug administration and development of various formulations. The cutting edge research being carried out in this field will be compiled and a focus on worldwide research on drug delivery and targeting at the molecular, cellular, and organ levels will also be summarized.Each new print copy includes access to the Navigate Companion Website including: Chapter Quizzes, Interactive Glossary, Crossword Puzzles , Interactive Flashcards, and Matching Exercises

Controlled Release Veterinary Drug Delivery

Controlled Release Veterinary Drug Delivery
  • Author : M.J. Rathbone,R. Gurny
  • Publisher :Unknown
  • Release Date :2000-07-20
  • Total pages :392
  • ISBN : 0080529976
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Summary : Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months). The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field. Controlled Release Veterinary Drug Delivery comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems. The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

Handbook of Pharmaceutical Controlled Release Technology

Handbook of Pharmaceutical Controlled Release Technology
  • Author : Donald L. Wise
  • Publisher :Unknown
  • Release Date :2000-08-24
  • Total pages :902
  • ISBN : 0824703693
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Summary : The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology covers oral, transdermal, parenteral, and implantable delivery of drugs discusses modification methods to achieve desired release kinetics highlights constraints of system design for practical clinical application analyzes diffusion equations and mathematical modeling considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents evaluates polymers as drug delivery carriers describes peptide, protein, micro-, and nanoparticulate release systems examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices and more!

Designing Hydrogels for Controlled Drug Delivery

Designing Hydrogels for Controlled Drug Delivery
  • Author : Sonia Trombino,Roberta Cassano
  • Publisher :Unknown
  • Release Date :2020-02-14
  • Total pages :162
  • ISBN : 3039283561
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Summary : The aim of this book is to provide an analysis of the main characteristics and applications of hydrogels. Hydrogels are frequently used for manufacturing contact lenses, hygiene products, tissue engineering scaffolds, drug delivery systems, and wound dressings. These materials are useful in everyday life, so publicizing them in both academic and pharmaceutical fields is essential.

Rutgers'controlled Drug Delivery Research

Rutgers'controlled Drug Delivery Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :334
  • ISBN : OCLC:690797732
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Summary :

Plasticized Chitosan-based Xerogel Nanocomposite for Controlled Drug Delivery

Plasticized Chitosan-based Xerogel Nanocomposite for Controlled Drug Delivery
  • Author : Feiran Li
  • Publisher :Unknown
  • Release Date :2017
  • Total pages :80
  • ISBN : OCLC:1200648549
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Summary :