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Translational and Experimental Clinical Research

Translational and Experimental Clinical Research
  • Author : Daniel P. Schuster,William J. Powers (MD.)
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :490
  • ISBN : 0781755654
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Summary : This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Translational Medicine: Tools And Techniques

Translational Medicine: Tools And Techniques
  • Author : Aamir Shahzad
  • Publisher :Unknown
  • Release Date :2015-11-24
  • Total pages :196
  • ISBN : 9780128034941
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Summary : Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine. Includes detailed and standardized information about the techniques and tools used in translational medicine Provides specific industry case scenarios Explains how to use translational medicine tools and techniques to plan and improve infrastructures and capabilities while reducing cost and optimizing resources

Evaluating and Conducting Research in Audiology

Evaluating and Conducting Research in Audiology
  • Author : Vinaya Manchaiah, Eldré Beukes, Ross J. Roeser
  • Publisher :Unknown
  • Release Date :2021-02-04
  • Total pages :400
  • ISBN : 9781635502015
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Summary : Evaluating and Conducting Research in Audiology is the first research methods textbook that is specific to the field of audiology and designed to serve as an academic textbook for audiology graduate students. This text can also be accessible for audiology practitioners who are interested in clinical and applied research. The comprehensive coverage includes materials for multiple courses within audiology degree programs, including research methods, analysis of professional literature, evidence-based practice, and capstone research projects. Classroom tested, and written by authors who have extensive backgrounds in publishing and editing, this text provides knowledge that is required in evaluating, conducting, and disseminating research. The book is separated into three sections: (a) research methods; (b) evidence-based practice; and (c) conducting and disseminating research. Together, these sections provide a detailed coverage of the research methods that are relevant to conducting research, particularly in the field of Audiology. Key Features: * Learning outcomes at the beginning of each chapter * End of chapter reviews including key points and study questions * Audiology-specific examples, research methods, and study designs * “Golden Nugget” boxes throughout the book containing valuable information related to the critical concepts * In-depth discussion of qualitative research methods, survey research methods, and systematic reviews to motivate students and early career researchers to consider these methodologies in their research

Translational Medicine

Translational Medicine
  • Author : James Mittra,Christopher-Paul Milne
  • Publisher :Unknown
  • Release Date :2016-04-19
  • Total pages :294
  • ISBN : 9789814364843
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Summary : This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Designing and Conducting Gender, Sex, and Health Research

Designing and Conducting Gender, Sex, and Health Research
  • Author : John L. Oliffe,Lorraine Greaves
  • Publisher :Unknown
  • Release Date :2011-04-18
  • Total pages :280
  • ISBN : 9781452236551
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Summary : This book provides the first resource dedicated to critically examining gender and sex in study designs, methods, and analysis in health research. In order to produce ethical, accurate, and effective research findings it is vital to integrate both sex (biological characteristics) and gender (socially constructed factors) into any health study. This book draws attention to some of the methodological complexities in this enterprise and offers ways to thoughtfully address these by drawing on empirical examples across a range of topics and disciplines.

Journal of the National Cancer Institute

Journal of the National Cancer Institute
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :229
  • ISBN : NYPL:33433078243049
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Summary :

Translational Medicine in CNS Drug Development

Translational Medicine in CNS Drug Development
  • Author : George G. Nomikos,Douglas E. Feltner
  • Publisher :Unknown
  • Release Date :2019-06-18
  • Total pages :458
  • ISBN : 9780128031643
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Summary : Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia

Clinical and Translational Science

Clinical and Translational Science
  • Author : David Robertson,Gordon H. Williams
  • Publisher :Unknown
  • Release Date :2016-11-25
  • Total pages :808
  • ISBN : 9780128021118
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Summary : Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Neuroepidemiology

Neuroepidemiology
  • Author : Lorene M. Nelson
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :461
  • ISBN : 9780195133790
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Summary : This fine text provides a comprehensive overview of methods for epidemiologic and clinical research on neurological disorders. The book focuses on classic principles of study design in epidemiologic research, strategies for avoiding study biases, methods for conducting clinical trials and prognostic studies, and principles of evidence-based medicine in neurology. The text gives neurologists, epidemiologists, and their students the foundation for conducting rigorous epidemiologic and clinical research on neurologic disorders.

The CTSA Program at NIH

The CTSA Program at NIH
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences
  • Publisher :Unknown
  • Release Date :2013-10-09
  • Total pages :178
  • ISBN : 9780309284745
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Summary : In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Mixed Methods Applications in Action Research

Mixed Methods Applications in Action Research
  • Author : Nataliya V. Ivankova
  • Publisher :Unknown
  • Release Date :2014-09-25
  • Total pages :472
  • ISBN : 9781483322124
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Summary : This first-of-its-kind book provides readers with the information they need to design and conduct a mixed methods action research (MMAR) study in a practical and pragmatic manner. Using a multidisciplinary focus, the author provides a scholarly and applied orientation to meet the varied epistemological and professional needs of scholar practitioners. The book is applicable to broad audiences with different levels of research skills, including students learning how to conduct research in practical settings, practitioners faced with the need to address pertinent issues in their professional practices, community leaders seeking to inform policy changes, and college faculty who teach research methods and conduct funded research in collaboration with practitioner-researchers and community stakeholders. A wide variety of pedagogical features make it appropriate for use as an instructional text aimed at developing skills in designing, conducting, implementing, and reporting an action research study that integrates mixed methods.

Conducting Clinical Research

Conducting Clinical Research
  • Author : Judy Stone
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :427
  • ISBN : UOM:39015064808861
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Summary : In Conducting Clinical Research: A Practical Guide for Physicians, Nurses, Study Coordinators, and Investigators you will discover how to Attract drug companies to your site Land a study on good terms Recruit patient volunteers—and keep them happy! Implement easy strategies for coordinating studies Organize your clinical trial activities Demystify regulatory requirements Conducting Clinical Research is a practical, user-friendly how-to manual for medical professionals—physicians, nurses, study coordinators and investigators—who are interested in learning what it takes to carry out clinical trials. Everything is covered—from how drugs are developed to how to attract drug companies to a site, land a study, recruit volunteers, coordinate studies, organize clinical trial activities, and navigate regulatory requirements. Even ethical and social issues are discussed. Comprehensive appendices offer essential background, resources, sample forms and worksheets, and information about careers and training programs. The book was a Ben Franklin Awards 2007 Finalist, and a 2007 Finalist in ForeWord Magazine's reference category for professional/technical books.

American Journal of Public Health

American Journal of Public Health
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2000-07
  • Total pages :229
  • ISBN : NWU:35556030904502
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Summary :

Conducting Research in Anaesthesia and Intensive Care Medicine

Conducting Research in Anaesthesia and Intensive Care Medicine
  • Author : Michael H. Gerardi
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :550
  • ISBN : UOM:39015042256480
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Summary : * Provides a single resource for those starting out in research * Practical advice for both clinical and scientific research * Comprehensive accounts of topics not easily accessed elsewhere * Points out the major pitfalls to the inexperienced * Presents the experts view and the hard facts * Presents the experts' view from a team of international contributors * Provides a single resource for all researchers, especially those starting out in research * Practical advice for both clinical and experimental research

Design, Evaluation, and Translation of Nursing Interventions

Design, Evaluation, and Translation of Nursing Interventions
  • Author : Souraya Sidani,Carrie Jo Braden
  • Publisher :Unknown
  • Release Date :2011-10-11
  • Total pages :304
  • ISBN : 9780813820323
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Summary : Nurse-led intervention research is a core component of the globalinitiative to improve quality of care. Though research in this areahas already contributed much to the advancement of patient care,future strides depend on the dissemination practical, how-toinstruction on this important area of research. Design,Evaluation, and Translation of Nursing Interventions aids inthis endeavor by presenting both general approaches and specificmethods for developing nursing interventions. Logically organized to facilitate ease of use, the book ispartitioned into four sections. The introduction provides a firmgrounding in intervention science by situating it within thebroader topics of evidence-based practice, client-centered care,and quality of care. Section two describes each step ofintervention design including correct identification of the healthissue or problem, clarification of the elements comprising anintervention, and application of theory. Section three centers onimplementation, highlighting such topics as development of theintervention manual, training interventionists, and interventionfidelity. The book concludes with methods to evaluate interventionsenacted and suggestions for their translation into practice. Design, Evaluation, and Translation of NursingInterventions distills the authors’ years of expertise inintervention research into comprehensive, easy-to-follow chapters.It is a must-have resource for students, researchers and healthcareprofessionals wishing to impact the future of patient care. Key Features: Provides a thorough foundation in nursing intervention researchand its impact on improving standards of care Segments the multifaceted process of intervention developmentinto easy-to-follow, step-by-step chapters Presents methods for the evaluation of interventionsdeveloped Written by experts in the field

National Institute of Justice Journal

National Institute of Justice Journal
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : IND:30000046859538
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Summary :

Guiding School Improvement with Action Research

Guiding School Improvement with Action Research
  • Author : Richard Sagor
  • Publisher :Unknown
  • Release Date :2000-05-15
  • Total pages :217
  • ISBN : 9781416615903
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Summary : Action research, explored in this book, is a seven-step process for improving teaching and learning in classrooms at all levels. Through practical examples, research tools, and easy-to-follow "implementation strategies," Richard Sagor guides readers through the process from start to finish. Learn how to uncover and use the data that already exist in your classrooms and schools to answer significant questions about your individual or collective concerns and interests. Sagor covers each step in the action research process in detail: selecting a focus, clarifying theories, identifying research questions, collecting data, analyzing data, reporting results, and taking informed action. Drawing from the experience of individual teachers, faculties, and school districts, Sagor describes how action research can enhance teachers' professional standing and efficacy while helping them succeed in settings characterized by increasingly diverse student populations and an emphasis on standards-based reform. The book also demonstrates how administrators and policymakers can use action research to bolster efforts related to accreditation, teacher supervision, and job-embedded staff development. Part how-to guide, part inspirational treatise, Guiding School Improvement with Action Research provides advice, information, and encouragement to anyone interested in reinventing schools as learning communities and restructuring teaching as the true profession it was meant to be.

APS Observer

APS Observer
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : MINN:31951P010630319
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Summary :

Population Crisis

Population Crisis
  • Author : United States. Congress. Senate. Committee on Government Operations. Subcommittee on Foreign Aid Expenditures
  • Publisher :Unknown
  • Release Date :1967
  • Total pages :229
  • ISBN : LOC:00173025762
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Summary :

Research Report

Research Report
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :229
  • ISBN : CHI:58625848
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Summary :

The University of Virginia Record

The University of Virginia Record
  • Author : University of Virginia
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : UVA:X030050611
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Summary :