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Developing Costimulatory Molecules for Immunotherapy of Diseases

Developing Costimulatory Molecules for Immunotherapy of Diseases
  • Author : Manzoor Ahmad Mir
  • Publisher :Unknown
  • Release Date :2015-05-25
  • Total pages :322
  • ISBN : 9780128026755
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Summary : Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases. Highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy Provides the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families Targets new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases

Nanoformulation Strategies for Cancer Treatment

Nanoformulation Strategies for Cancer Treatment
  • Author : Sarwar Beg,Mahfoozur Rahman,Hani Choudhry,Eliana B. Souto,Farhan J. Ahmad
  • Publisher :Unknown
  • Release Date :2020-11-20
  • Total pages :402
  • ISBN : 9780128210963
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Summary : Nanoformulation Strategies for Cancer Treatment provides an up-to-date review on current developments and regulatory and clinical challenges in the field of nanopharmaceuticals and the effective treatment of diverse varieties of cancer. This important reference source is ideal for biomaterials scientists and pharmaceutical scientists working in the area of cancer diagnosis and therapy. Due to the high cost of traditional cancer treatment types, researchers have increasingly looked for new ways to augment the therapeutic performance of existing drug candidates. The use of nanotechnology-based approaches have gained significant momentum, thus leading to the launch of a series of new drug products. As nanopharmaceuticals improve the therapeutic performance of cancer therapy drugs, but also provide opportunities for site-specific drug targeting in tumors, this work is a welcomed resource on the topics discussed. Highlights the application of nanoformulations, including liposomes, nanoparticles and nanobiomaterials for targeted drug delivery to cancer cells Explores recent advances made using novel nanoformulations containing herbal drugs and biotechnology based therapeutic strategies for cancer treatment Assesses the regulatory hurdles that are necessary for the successful clinical translation of nanomedicines from the laboratory into the market

The Cytokines of the Immune System

The Cytokines of the Immune System
  • Author : Zlatko Dembic
  • Publisher :Unknown
  • Release Date :2015-05-23
  • Total pages :320
  • ISBN : 9780124200104
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Summary : The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine

Immunoregulatory Aspects of Immunotherapy

Immunoregulatory Aspects of Immunotherapy
  • Author : Seyyed Shamsadin Athari
  • Publisher :Unknown
  • Release Date :2018-08-01
  • Total pages :240
  • ISBN : 9781789235081
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Summary : Immunotherapy is an innovative, leading and valuable approach to the treatment and control of many diseases. It can solve many problems of public health worldwide. Many people in numerous countries are suffering from a wide range of diseases (communicable and non-communicable) that can be cured or controlled by the immune system and immunotherapy. Some immunological diseases (i.e. allergic reactions and asthma, autoimmune disease, immunodeficiency disease, hypersensitivity reactions, etc.) have immune response pathophysiology and by controlling immune system mechanisms, these diseases can be controlled and cured. Immunoregulatory Aspects of Immunotherapy focuses on immune system mechanism, diagnosis, treatment and other related problems. The chapters have applicable and scientific data in immunotherapeutic approaches based on medical sciences, and would be of benefit to all researchers in immunology, allergy and asthma fields. The book discusses the prevention, diagnosis, treatment and follow-up of patients who have dangerous diseases. We hope this book will be a new approach to the immunotherapy of diseases and will improve public health and wellbeing.

Treating Infectious Diseases in a Microbial World

Treating Infectious Diseases in a Microbial World
  • Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
  • Publisher :Unknown
  • Release Date :2006-01-03
  • Total pages :102
  • ISBN : 0309180686
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Summary : Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Immunotherapy

Immunotherapy
  • Author : Krassimir Metodiev
  • Publisher :Unknown
  • Release Date :2017-04-26
  • Total pages :414
  • ISBN : 9789535131052
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Summary : This is another attempt of InTechOpen to continue the dissemination of international knowledge and experience in the field of immunology. The present book includes a number of modern concepts of specialists and experts in the field of immunotherapy, covering the major topics and analyzing the history, current stage, and future ideas of application of modern immunomodulation. It is always a benefit, but also a compliment, to gather a team of internationally distinguished authors and to motivate them to reveal their expertise for the benefit of medical science and health practice. On behalf of all readers, immunologists, immunogeneticists, biologists, oncologists, microbiologists, virologists, hematologists, chemotherapists, health-care experts, as well as students and medical specialists, also on my personal behalf, I would like to extend my gratitude and highest appreciation to InTechOpen for giving me the unique chance to be the editor of this exclusive book.

The Immune Response

The Immune Response
  • Author : Tak W. Mak,Mary E. Saunders
  • Publisher :Unknown
  • Release Date :2005-11-11
  • Total pages :1216
  • ISBN : 9780080534480
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Summary : The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique ‘single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an ‘Immunology Primer' before topics are discussed in more detail

Autoimmune Liver Diseases

Autoimmune Liver Diseases
  • Author : Edward L. Krawitt,Russell H. Wiesner,Mikio Nishioka
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :656
  • ISBN : 0444828036
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Summary : The second edition, which appears seven years after the first, is a more comprehensive text and addresses the many recent advances in basic and clinical science applicable to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune aspects of viral-, drug- and alcohol-induced liver disease and hepatocellular cancer. Pathogenesis, diagnosis and treatment are discussed in depth in light of current understanding of the molecular mechanisms of autoimmunity as it applies to liver disease.

Regulatory T Cells in Health and Disease

Regulatory T Cells in Health and Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2015-11-26
  • Total pages :300
  • ISBN : 9780128034194
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Summary : Regulatory T Cells in Health and Disease focuses on the mechanism by which T cells become regulatory T cells, the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer. Contains contributions from leading authorities in the field of regulatory T cell biology Informs and updates on all the latest developments in the field Explores the processes which control the number of regulatory T cells in the blood and tissue, and the ways in which regulatory T cell prevent autoimmune disease and interact with infections and cancer

Asthma--a Link Between Environment, Immunology, and the Airways

Asthma--a Link Between Environment, Immunology, and the Airways
  • Author : Hugo E. Neffen
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :270
  • ISBN : UOM:39015048855178
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Summary : This volume, released at the Congress, contains the most important papers delivered during the XVIth World Congress of Asthma. Includes current research and details the state of the art in research and clinical aspects of asthma and related diseases. Includes extensive references and halftone illustrations.

Immunopathology and Immunomodulation

Immunopathology and Immunomodulation
  • Author : Krassimir Metodiev
  • Publisher :Unknown
  • Release Date :2015-11-18
  • Total pages :312
  • ISBN : 9789535122104
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Summary : This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors.

Tumor-Induced Immune Suppression

Tumor-Induced Immune Suppression
  • Author : Dmitry I. Gabrilovich,Arthur Andrew Hurwitz
  • Publisher :Unknown
  • Release Date :2014-02-10
  • Total pages :464
  • ISBN : 9781489980564
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Summary : Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.

Neuroblastoma

Neuroblastoma
  • Author : Chandrika Gowda
  • Publisher :Unknown
  • Release Date :2017-10-25
  • Total pages :168
  • ISBN : 9789535135838
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Summary : Neuroblastoma (NBL) is the most common extracranial solid tumor of childhood, with about 700 new cases of neuroblastoma seen each year in the United States. The 5-year survival rate for children with high-risk NBL is only 50-60%, and this survival rate has not improved over the last 10 years. High-risk patients receive multimodality treatment, including chemotherapy, surgery, radiation therapy, biologic therapy and immunotherapy, all of which are associated with significant morbidity. Recent years have seen many advances in treatment of neuroblastoma, including therapeutic MIBG, immunotherapy, and personalized targeted therapy based on the genetic alterations seen in the tumor. The primary objective of this book is to provide the readers with a comprehensive review of neuroblastoma, from clinical aspects and the currently available treatment to recent advancements and future directions in the field of NBL treatment. The topics and chapters have been compiled keeping in mind a diverse group of readers in different areas of specialty such as pediatric oncology, surgery, radiation oncology, and immunology, as well as physician scientists and basic researchers working in the field of neuroblastoma.

Hematology

Hematology
  • Author : American Society of Hematology. Education Program
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :229
  • ISBN : UOM:39015053094572
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Summary :

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
  • Author : Anirban Ghosh
  • Publisher :Unknown
  • Release Date :2017-05-10
  • Total pages :172
  • ISBN : 9789535131236
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Summary : Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.

Immunization

Immunization
  • Author : Ning Wang,Ting Wang
  • Publisher :Unknown
  • Release Date :2018-11-28
  • Total pages :122
  • ISBN : 9781789845389
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Summary : Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Translational Immunology

Translational Immunology
  • Author : Seng-Lai Tan
  • Publisher :Unknown
  • Release Date :2015-11-18
  • Total pages :384
  • ISBN : 9780128017579
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Summary : Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression Provides information on new strategies and outstanding issues that should be addressed in future research

Cancer Forum

Cancer Forum
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :229
  • ISBN : NWU:35558004411878
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Cancer Vaccines and Immunotherapy

Cancer Vaccines and Immunotherapy
  • Author : Peter L. Stern,Peter C. L. Beverley,Miles Carroll
  • Publisher :Unknown
  • Release Date :2000-08-17
  • Total pages :286
  • ISBN : 0521622638
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Summary : This book provides an essential introduction and guide for oncologists, immunologists and clinicians treating cancer patients.

The B7-CD28 Family Molecules

The B7-CD28 Family Molecules
  • Author : Lieping Chen
  • Publisher :Unknown
  • Release Date :2003-10-31
  • Total pages :141
  • ISBN : 0306478420
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Summary : The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This is evident from the explosive accumulation of literature, particularly in the last ten years. Recent years have witnessed rapid discoveries and characterization of new receptors and ligands in the family. These new pathways, although still in their infancy, have already brought much excitement to the field. However, until now, there has been no single volume to cover this entire area. This book was created to bring together state-of-the-art information and critical thinking from the leading investigators. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases. This is an excellent handbook and reference for immunologists, health professionals as well as medical students and graduate students in life science field.

Chemical Immunology

Chemical Immunology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :219
  • ISBN : 3805559763
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Summary :