Download Drug Biomembrane Interaction Studies Book PDF

Download full Drug Biomembrane Interaction Studies books PDF, EPUB, Tuebl, Textbook, Mobi or read online Drug Biomembrane Interaction Studies anytime and anywhere on any device. Get free access to the library by create an account, fast download and ads free. We cannot guarantee that every book is in the library.

Drug-Biomembrane Interaction Studies

Drug-Biomembrane Interaction Studies
  • Author : Rosario Pignatello
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :440
  • ISBN : 9781908818348
GET BOOK HERE

Summary : The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : M. Grazia Sarpietro,F. Castelli
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :440
  • ISBN : 9780128091869
GET BOOK HERE

Summary : This chapter describes a method for evaluating the release of a drug by different delivery systems to biomembrane models made of multilamellar and unilamellar vesicles, using DSC techniques. First, different delivery systems as well as biomembrane models are described followed by a detailed description of the experimental protocols that are the basis of the technique. A drug-loaded delivery system is incubated with the biomembrane model and drug release is evaluated by considering the effect of the drug on the biomembrane’s thermotropic behaviour, and comparing the experimental data with those of the free drug. Finally, examples of the application of this technique are given.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : A. Fortunato
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :440
  • ISBN : 9780128091807
GET BOOK HERE

Summary : In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of the nineteenth century, DSC has been improved and optimized. With the numerous technological innovations, in both hardware and software, it can explore new and demanding applications. Different measurement principles, sensors, signal processing, accessories, and evaluation capabilities make differential scanning calorimetry one of the most common and versatile techniques in material characterization. Today DSC benefits from technological solutions used previously for other applications (MEMS technology, optical devices, and parameter estimation methods).

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : M.H. Chiu,N.S. Berezowski,E.J. Prenner
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :440
  • ISBN : 9780128091821
GET BOOK HERE

Summary : DSC is a straightforward, non-perturbing thermodynamic technique first developed in the early 1960s. The large number of parameters and the high sensitivity has made DSC one of the key calorimetric tools used for investigating thermodynamic properties of biopolymers, proteins, peptides and nucleic acids. There are numerous reviews covering the different macromolecular applications of DSC: this chapter will primarily focus on proteins and nucleic acids.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : C. Carbone,R. Pignatello
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :440
  • ISBN : 9780128091814
GET BOOK HERE

Summary : Interest in using DSC to study the interaction between different compounds and biomembrane models has increased in the last 20years. This is confirmed by the number of published research studies concerning the feasibility of investigating the behavior of different molecules, such as local anesthetics, anticancer drugs, anti-inflammatory drugs, antioxidants, antibiotics, peptides, proteins, polymers, surfactants, genetic materials, macromolecules, and also drug delivery systems (DDSs). This chapter provides a general consideration of the current applications of DSC in evaluating the interaction of different biomolecules and biomembrane models, which will be presented more thoroughly in the succeeding chapters. In particular, a detailed description of the DSC technique for studying the interaction of surfactants, genetic materials, polymers, and DDSs with biomembrane models and biomolecule toxicity studies will be provided, taking into consideration the most recent literature.

Drug–biomembrane interaction studies

Drug–biomembrane interaction studies
  • Author : R. Pignatello
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :440
  • ISBN : 9780128091784
GET BOOK HERE

Summary : DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.

Drug-Membrane Interactions

Drug-Membrane Interactions
  • Author : Joachim K. Seydel,Michael Wiese
  • Publisher :Unknown
  • Release Date :2009-07-10
  • Total pages :367
  • ISBN : 9783527616497
GET BOOK HERE

Summary : Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Drug-Membrane Interactions

Drug-Membrane Interactions
  • Author : Joachim K. Seydel,Michael Wiese
  • Publisher :Unknown
  • Release Date :2009-07-10
  • Total pages :367
  • ISBN : 9783527616497
GET BOOK HERE

Summary : Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Indian Journal of Pure & Applied Physics

Indian Journal of Pure & Applied Physics
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :229
  • ISBN : UOM:39015035155475
GET BOOK HERE

Summary :

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
GET BOOK HERE

Summary :

Structure and Dynamics of Membranes

Structure and Dynamics of Membranes
  • Author : R. Lipowsky,E. Sackmann
  • Publisher :Unknown
  • Release Date :1995-06-15
  • Total pages :1052
  • ISBN : 0080541917
GET BOOK HERE

Summary : The first volume of the Handbook deals with the amazing world of biomembranes and lipid bilayers. Part A describes all aspects related to the morphology of these membranes, beginning with the complex architecture of biomembranes, continues with a description of the bizarre morphology of lipid bilayers and concludes with technological applications of these membranes. The first two chapters deal with biomembranes, providing an introduction to the membranes of eucaryotes and a description of the evolution of membranes. The following chapters are concerned with different aspects of lipids including the physical properties of model membranes composed of lipid-protein mixtures, lateral phase separation of lipids and proteins and measurement of lipid-protein bilayer diffusion. Other chapters deal with the flexibility of fluid bilayers, the closure of bilayers into vesicles which attain a large variety of different shapes, and applications of lipid vesicles and liposomes. Part B covers membrane adhesion, membrane fusion and the interaction of biomembranes with polymer networks such as the cytoskeleton. The first two chapters of this part discuss the generic interactions of membranes from the conceptual point of view. The following two chapters summarize the experimental work on two different bilayer systems. The next chapter deals with the process of contact formation, focal bounding and macroscopic contacts between cells. The cytoskeleton within eucaryotic cells consists of a network of relatively stiff filaments of which three different types of filaments have been identified. As explained in the next chapter much has been recently learned about the interaction of these filaments with the cell membrane. The final two chapters deal with membrane fusion.

Methods in Membrane Lipids

Methods in Membrane Lipids
  • Author : Alex Dopico
  • Publisher :Unknown
  • Release Date :2007-08-30
  • Total pages :621
  • ISBN : 9781588296627
GET BOOK HERE

Summary : This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.

Indian Science Abstracts

Indian Science Abstracts
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :229
  • ISBN : UCBK:C047332394
GET BOOK HERE

Summary :

Liposomes, Lipid Bilayers and Model Membranes

Liposomes, Lipid Bilayers and Model Membranes
  • Author : Georg Pabst,Norbert Kučerka,Mu-Ping Nieh,John Katsaras
  • Publisher :Unknown
  • Release Date :2014-03-04
  • Total pages :478
  • ISBN : 9781466507098
GET BOOK HERE

Summary : As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert. Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively. Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.

Dosage Forms—Advances in Research and Application: 2013 Edition

Dosage Forms—Advances in Research and Application: 2013 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2013-06-21
  • Total pages :163
  • ISBN : 9781481699563
GET BOOK HERE

Summary : Dosage Forms—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Dosage Forms—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dosage Forms—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Peptide-Lipid Interactions

Peptide-Lipid Interactions
  • Author : Sidney A. Simon,Thomas J. McIntosh
  • Publisher :Unknown
  • Release Date :2002-11-13
  • Total pages :601
  • ISBN : 0080925855
GET BOOK HERE

Summary : This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction

Inclusion Aspects of Membrane Chemistry

Inclusion Aspects of Membrane Chemistry
  • Author : T. Osa,J.L Atwood
  • Publisher :Unknown
  • Release Date :1991-04-30
  • Total pages :290
  • ISBN : UCAL:B5133548
GET BOOK HERE

Summary : There is no doubt that the field of artificial membrane transport using synthetic ionophores has advanced remarkably in the past 15 years due primarily to the synthesis of new ionophores. Even though the theoretical framework substantially predated this activity, the merging of theory with transport experiment has often been sketchy. The purpose of this outline has been to examine key examples to illustrate the underlying principles and to suggest how experimental variables dominate the results obtained. To a very good approximation the assumption of a "diffusion" regime is often justified, is easily confirmed experimentally and provides a clear framework for exploitation of the inherent selectivity of a given ionophore. Thus for synthetic chemists who wish a "quick and nasty" experiment to examine the question of selectivity, the recipe is clear: a mixture containing all ions of interest in a standard experiment for each ligand of interest using a moderately stirred (100-200 rpm) cell and analysis of the mixture produced on the OUT side of the cell at a fixed, small extent of transport. Together with duplicates and controls, this modest set of experiments will place the results on an unambiguous footing from which clear conclusions about each ionophore's characteristics are readily obtained. For those with more detailed interests in the transport process the demands are correspondingly higher.

Peptide Drug Discovery and Development

Peptide Drug Discovery and Development
  • Author : Miguel Castanho,Nuno Santos
  • Publisher :Unknown
  • Release Date :2011-10-24
  • Total pages :390
  • ISBN : 9783527636747
GET BOOK HERE

Summary : Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery
  • Author : Ali Demir Sezer
  • Publisher :Unknown
  • Release Date :2014-07-25
  • Total pages :554
  • ISBN : 9789535116288
GET BOOK HERE

Summary : This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Viral Membrane Proteins: Structure, Function, and Drug Design

Viral Membrane Proteins: Structure, Function, and Drug Design
  • Author : Wolfgang B. Fischer
  • Publisher :Unknown
  • Release Date :2007-08-02
  • Total pages :292
  • ISBN : 0387281460
GET BOOK HERE

Summary : In Viral Membrane Proteins: Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and functional knowledge of membrane proteins encoded by viruses. In addition, contributors to the book address questions about proteins as potential drug targets. The range of information covered includes signal proteins, ion channels, and fusion proteins. This book has a place in the libraries of researchers and scientists in a wide array of fields, including protein chemistry, molecular biophysics, pharmaceutical science and research, bioanotechnology, molecular biology, and biochemistry.

Thermal Analysis in Research and Industry

Thermal Analysis in Research and Industry
  • Author : Indra K. Varma,A. C. Momin
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :424
  • ISBN : UOM:39015034439599
GET BOOK HERE

Summary :