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Drug-Induced Liver Disease

Drug-Induced Liver Disease
  • Author : Neil Kaplowitz
  • Publisher :Unknown
  • Release Date :2002-10-16
  • Total pages :784
  • ISBN : 9780203909126
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Summary : Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Drug-Induced Liver Disease

Drug-Induced Liver Disease
  • Author : Neil Kaplowitz,Laurie D. DeLeve
  • Publisher :Unknown
  • Release Date :2013-04-18
  • Total pages :776
  • ISBN : 9780123878182
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Summary : This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease. A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject

Hepatotoxicity

Hepatotoxicity
  • Author : Hyman J. Zimmerman
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :789
  • ISBN : 0781719526
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Summary : Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Drug-induced Liver Disease

Drug-induced Liver Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :11
  • ISBN : OCLC:260186776
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Summary :

Pharmacotherapy Casebook: A Patient-Focused Approach, 9/E

Pharmacotherapy Casebook: A Patient-Focused Approach, 9/E
  • Author : Terry L. Schwinghammer,Julia M. Koehler
  • Publisher :Unknown
  • Release Date :2014-04-28
  • Total pages :496
  • ISBN : 0071830138
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Summary : More than 150 cases help develop the skills you need to identify and resolve the most common drug therapy problems The perfect study companion to DiPiro's Pharmacotherapy: A Pathophysiologic Approach More than 40 all-new cases! Pharmacotherapy Casebook: A Patient-Focused Approach delivers 157 patient cases designed to teach you how to apply the principles of pharmacotherapy to real-world clinical practice. The case chapters in this book are organized into organ system sections that correspond to those of the DiPiro textbook. By reading the relevant chapters in Pharmacotherapy: A Pathophysiologic Approach you will be able to familiarize yourself with the pathophysiology and pharmacology of each disease state included in this casebook. Each case teaches you how to: Identify real or potential drug therapy problems Determine the desired therapeutic outcome Evaluate therapeutic alternatives Design an optimal individualized pharmacotherapeutic plan Develop methods to evaluate the therapeutic outcome Provide patient education Communicate and implement the pharmacotherapeutic plan Everything you need to develop expertise in pharmacotherapy decision making: Realistic patient presentations include medical history, physical examination, and laboratory data, followed by a series of questions using a systematic, problem-solving approach Compelling range of cases – from the uncomplicated (a single disease state) to the complex (multiple disease states and drug-related problems) Diverse authorship from more than 190 clinicians from nearly 100 institutions Coverage that integrates the biomedical and pharmaceutical sciences with therapeutics Appendices containing valuable information on pharmacy abbreviations, laboratory tests, mathematical conversion factors, anthropometrics, and complementary and alternative therapies

Diagnosis of Liver Disease

Diagnosis of Liver Disease
  • Author : Etsuko Hashimoto,Paul Y. Kwo,Arief A. Suriawinata,Wilson M.S. Tsui,Masaki Iwai
  • Publisher :Unknown
  • Release Date :2019-07-18
  • Total pages :304
  • ISBN : 9789811368066
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Summary : This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described.The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.

Yamada's Atlas of Gastroenterology

Yamada's Atlas of Gastroenterology
  • Author : Daniel K. Podolsky
  • Publisher :Unknown
  • Release Date :2016-01-14
  • Total pages :976
  • ISBN : 9781118512012
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Summary : Access to accurate, high-quality images is vital for ensuring effective management of patients with GI complaints. The fifth edition of Yamada's Atlas of Gastroenterology sees the return of the gold-standard multi-media atlas that provides gastroenterologists with an outstanding visual tool covering all facets of the field. Every GI disorder from liver abscesses, endocrine neoplasms of the pancreas, to motility disorders of the esophagus are fully illustrated through the use of endoscopic ultrasonographs, computed tomography scans, magnetic resonance images, radionuclide images, and angiograms.

Schiff's Diseases of the Liver

Schiff's Diseases of the Liver
  • Author : Eugene R. Schiff,Michael F. Sorrell,Willis C. Maddrey
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :1576
  • ISBN : 0781760402
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Summary : The premier clinical hepatology reference for 50 years, Schiff's Diseases of the Liver is in its Tenth Edition—now in full color throughout. This edition features a major new transplant section focusing on pre-transplant and post-transplant evaluation and management. Also included are updates on key topics such as hepatitis, NASH, and drug-induced pathologies. The first third of the book covers anatomy, pathology, testing, imaging, and effects of liver disease on other organs. Subsequent sections address specific diseases and clinical syndromes. Each of the 12 sections begins with an overview, and each chapter starts with an outline of key concepts. Numerous clinical algorithms appear throughout the text.

Drug-Induced Liver Injury

Drug-Induced Liver Injury
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2019-07-13
  • Total pages :288
  • ISBN : 9780128173176
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Summary : Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Drug-Induced Liver Toxicity

Drug-Induced Liver Toxicity
  • Author : Minjun Chen,Yvonne Will
  • Publisher :Unknown
  • Release Date :2018-03-21
  • Total pages :667
  • ISBN : 1493976761
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Summary : This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com.

Liver Diseases

Liver Diseases
  • Author : Florentina Radu-Ionita,Nikolaos T. Pyrsopoulos,Mariana Jinga,Ion C. Tintoiu,Zhonghua Sun,Ecaterina Bontas
  • Publisher :Unknown
  • Release Date :2020-01-10
  • Total pages :827
  • ISBN : 9783030244323
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Summary : This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.

Liver and Biliary Diseases

Liver and Biliary Diseases
  • Author : Neil Kaplowitz
  • Publisher :Unknown
  • Release Date :1992
  • Total pages :732
  • ISBN : UOM:39015025159412
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Summary :

Drug-Induced Hepatotoxicity

Drug-Induced Hepatotoxicity
  • Author : Ross Cameron,George Feuer,Felix de la Iglesia
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :681
  • ISBN : 9783642610134
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Summary : The advances in science and medicine we are now experiencing are unprec edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease. This is well recognized and is very important; indeed, removal of the offending agent can often lead to reversal of the adverse effect. This is an area of hepatology where we can really make a difference.

Pharmacokinetics and Adverse Effects of Drugs

Pharmacokinetics and Adverse Effects of Drugs
  • Author : Ntambwe Malangu
  • Publisher :Unknown
  • Release Date :2018-05-23
  • Total pages :162
  • ISBN : 9781789231380
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Summary : This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Diseases of the Liver and Biliary System in Children

Diseases of the Liver and Biliary System in Children
  • Author : Deirdre A. Kelly
  • Publisher :Unknown
  • Release Date :2008-04-15
  • Total pages :512
  • ISBN : 9781405140270
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Summary : An extremely practical text, this new edition of Diseases of the Liver and Biliary System in Children covers the essentials of paediatric hepatology. The range of material is wide and has been revised and updated to include the latest advances. Many helpful algorithms and tables are included and the references at the end of each chapter have been carefully selected so as to provide the most up-to-date information available. A concluding section comprising some 100 carefully annotated plates, completes this text. Containing the contributions of 23 internationally acclaimed authorities, active both clinically and in research, the book provides an essential guide to the diagnosis and management of paediatric liver diseases, both common and uncommon for all those involved in the care of the child with liver disease. Diseases of the Liver and Biliary System in Children has become THE REFERENCE of choice for the paediatric gastroenterologist, hepatologist and surgeon.

Drug Hepatotoxicity, an Issue of Clinics in Liver Disease

Drug Hepatotoxicity, an Issue of Clinics in Liver Disease
  • Author : Nicholaos Pyrsopoulos
  • Publisher :Unknown
  • Release Date :2013-11-28
  • Total pages :508
  • ISBN : 9780323261067
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Summary : Dr. Pyrsopolous has created a comprehensive review on the most important and timely topics in drug heptatotoxicity. He has arraanged for there to be a full span of very basic articles that discuss drug metabolism, hepatotoxicity, and drug-induced acute liver failure as well as other important articles devoted to clinical manifestations and treatment of drug induced hepatotoxicity; Pathological manifestations of drug induced hepatotoxicity; Drug induced cholestasis; Lipid lowering agents induced hepatotoxicity; Herbal ,complementary and alternative medicine induced liver injury; Antiretroviral and anti - HCV DAA related hepatotoxicity; Antibiotic related hepatotoxicity; Acetaminophen related hepatoxicity; NSAIDS induced hepatoxocity; Chemotherapy induced hepatotoxicity; Anti epileptic induced hepatotoxicity; and steatohepatitis induced by drugs.

Drug Hepatotoxicity, An Issue of Clinics in Liver Disease,

Drug Hepatotoxicity, An Issue of Clinics in Liver Disease,
  • Author : Nicholaos Pyrsopoulos
  • Publisher :Unknown
  • Release Date :2013-10-17
  • Total pages :298
  • ISBN : 9780323261074
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Summary : Dr. Pyrsopolous has created a comprehensive review on the most important and timely topics in drug heptatotoxicity. He has arraanged for there to be a full span of very basic articles that discuss drug metabolism, hepatotoxicity, and drug-induced acute liver failure as well as other important articles devoted to clinical manifestations and treatment of drug induced hepatotoxicity; Pathological manifestations of drug induced hepatotoxicity; Drug induced cholestasis; Lipid lowering agents induced hepatotoxicity; Herbal ,complementary and alternative medicine induced liver injury; Antiretroviral and anti - HCV DAA related hepatotoxicity; Antibiotic related hepatotoxicity; Acetaminophen related hepatoxicity; NSAIDS induced hepatoxocity; Chemotherapy induced hepatotoxicity; Anti epileptic induced hepatotoxicity; and steatohepatitis induced by drugs.

Liver Pathophysiology

Liver Pathophysiology
  • Author : Pablo Muriel
  • Publisher :Unknown
  • Release Date :2017-03-02
  • Total pages :914
  • ISBN : 9780128043219
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Summary : Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Handbook of Liver Disease

Handbook of Liver Disease
  • Author : Lawrence Samuel Friedman,Emmet B. Keeffe
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :481
  • ISBN : 0443066337
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Summary : Here's instant access to the symptoms, signs, differential diagnosis, and treatment for the full range of liver disorders. Written by an international 'who's who' of hepatology-and now in full color-this new 2nd Edition provides readers with top-notch, authoritative guidance they can count on! Discusses the hottest topics in the field, such as non-alcoholic steatohepatitis (NASH) and the latest information on liver transplantation. Includes expanded coverage of chronic hepatitis C, most notably the use of combination therapy with peginterferon and ribavirin and improvements in the management of the side effects of antiviral therapy. Offers the most recent therapeutic options for the management of chronic hepatitis B and advances in the understanding of the molecular biology of this virus. Updates the approach to the diagnosis of many liver diseases due to newer tests based on molecular techniques and advances in imaging. Features over 340 full-color illustrations. Uses a redesigned templated, outline format that makes reference a snap. Presents a concise, in-depth clinical summary-in an outline format-of the current practice of hepatology for each major disease entity. Provides a liberal use of tables, algorithms, and figures, rendering complex concepts understandable. Includes key point boxes at the beginning of each chapter, providing at-a-glance access to vital information. Includes alert symbols that highlight information that's critical to patient safety.

Mitochondria in Liver Disease

Mitochondria in Liver Disease
  • Author : Derick Han,Neil Kaplowitz
  • Publisher :Unknown
  • Release Date :2015-10-28
  • Total pages :485
  • ISBN : 9781482236989
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Summary : "...excellent, well-organized, and timely." —Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible. The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion–fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system. Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

Cholestatic Liver Disease

Cholestatic Liver Disease
  • Author : Elizabeth J. Carey,Keith D. Lindor
  • Publisher :Unknown
  • Release Date :2014-07-18
  • Total pages :259
  • ISBN : 9781493910137
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Summary : Since the publication of the first edition, there have been advances in both the diagnosis and the management of many of the cholestatic liver diseases. Cholestatic Liver Disease, Second Edition thoroughly updates the topics previously addressed, such as primary biliary cirrhosis, primary sclerosing cholangitis and cholestatic variants of drug hepatotoxicity and viral disease. New treatments, such as the development of the farnesoid X receptor agonists for the treatment of PBC, are highlighted. Current guidelines and areas of uncertainty are also covered. Additionally, new chapters have been added to reflect the changing landscape of cholestatic liver disease. Cholestatic Liver Disease, Second Edition is a concise yet comprehensive summary of the current status of the field and is of value to clinicians and researchers interested in patients with cholestatic liver disease provide that will help to guide patient management and stimulate investigative efforts.