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Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
  • Author : Kenneth K.W. To,William C.S. Cho
  • Publisher :Unknown
  • Release Date :2020-07-29
  • Total pages :458
  • ISBN : 9780128199039
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Summary : Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
  • Author : Kenneth K.W. To,William C.S. Cho
  • Publisher :Unknown
  • Release Date :2020-08-17
  • Total pages :458
  • ISBN : 9780128196687
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Summary : Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
  • Author : Farid A. Badria
  • Publisher :Unknown
  • Release Date :2017-07-05
  • Total pages :316
  • ISBN : 9789535133131
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Summary : This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Metallo-Drugs: Development and Action of Anticancer Agents

Metallo-Drugs: Development and Action of Anticancer Agents
  • Author : Astrid Sigel,Helmut Sigel,Eva Freisinger,Roland K.O. Sigel
  • Publisher :Unknown
  • Release Date :2018-02-05
  • Total pages :588
  • ISBN : 9783110470734
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Summary : Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH-Interfering Agents as Chemosensitizers in Cancer Therapy
  • Author : Claudiu Supuran,Simone Carradori
  • Publisher :Unknown
  • Release Date :2020-09-15
  • Total pages :228
  • ISBN : 9780128209288
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Summary : pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

In Silico Drug Design

In Silico Drug Design
  • Author : Kunal Roy
  • Publisher :Unknown
  • Release Date :2019-02-12
  • Total pages :886
  • ISBN : 9780128163771
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Summary : In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

Drug Repositioning: Current Advances and Future Perspectives

Drug Repositioning: Current Advances and Future Perspectives
  • Author : Yuhei Nishimura,Hideaki Hara
  • Publisher :Unknown
  • Release Date :2019-01-11
  • Total pages :229
  • ISBN : 9782889456963
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Summary : Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Conference on Drug Design and Discovery Technologies

Conference on Drug Design and Discovery Technologies
  • Author : Manikanta Murahari,Lakshmi Sundar,Soma Chaki,Vasanthanathan Poongavanam,Pritesh Bhat,Usha Y Nayak
  • Publisher :Unknown
  • Release Date :2019-11-20
  • Total pages :350
  • ISBN : 9781788018623
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Summary : This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.

Drug Repositioning

Drug Repositioning
  • Author : Michael J. Barratt,Donald E. Frail
  • Publisher :Unknown
  • Release Date :2012-05-29
  • Total pages :477
  • ISBN : 9780470878279
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Summary : With Viagra the most famous example, drug repositioning has been growing in importance for pharmaceutical companies seeking to reinvigorate development pipelines. This book provides a broad overview of drug repositioning including the business reasons and unique opportunities and challenges. Its coverage also presents a number of current and emerging technologies that are being applied, along with relevant case studies, as well as neglected diseases to consider. Pharmaceutical researchers will learn how to use drug repositioning techniques to increase the lifespan and applications of their drugs, and also decrease both costs and development time.

Multiple Myeloma as an Example of Drug Repurposing for Cancer Treatment

Multiple Myeloma as an Example of Drug Repurposing for Cancer Treatment
  • Author : Charlotte Driessen
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :229
  • ISBN : OCLC:1183922985
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Summary :

Colorectal Cancer

Colorectal Cancer
  • Author : Jindong Chen
  • Publisher :Unknown
  • Release Date :2018-05-16
  • Total pages :128
  • ISBN : 9781789231007
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Summary : With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

Surviving Cancer, Covid-19, and Disease

Surviving Cancer, Covid-19, and Disease
  • Author : Justus Hope
  • Publisher :Unknown
  • Release Date :2020-09-20
  • Total pages :229
  • ISBN : 0998055425
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Summary :

How to Starve Cancer

How to Starve Cancer
  • Author : Jane McLelland
  • Publisher :Unknown
  • Release Date :2020-10-13
  • Total pages :420
  • ISBN : 0951951742
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Summary : After being given a terminal diagnosis with only a few weeks to live, Jane dug up research, some decades old, in her quest to survive. Rather than aiming to cure cancer, which in many cases is unachievable, Jane's approach was to stop it growing. Remarkably her approach not only stopped it growing, it disappeared altogether. There are now clinics following her protocol, achieving remarkable successes. This book is a game-changing new dawn in the treatment of cancer. An international publishing sensation. This page-turning inspirational read is updated with a new 'Metro Map', Jane's unique and revolutionary route map to starving cancer. A glossary and index will also be included. Written in two sections, in Part 1 Jane intertwines her remarkable life story of 'terminal cancer' to full recovery, describing how she discovered a unique cocktail of off label drugs (drugs usually prescribed for other conditions) and supplements that effectively starve the cancer stem cell, the cell left behind by conventional treatment. Treatment for the stem cell is hailed as the Holy Grail, so this book plugs the missing piece into why we do not have a cure for cancer. Lead cancer researchers at top oncology centers are now using this book as a guide and Jane has a huge following of tens of thousands on Facebook. Testimonials abound from happy and delighted recovered patients and from oncologists who use her methods. National press, TV and radio have already covered Jane's ground-breaking research. Much more is in the pipeline with two documentaries and a possible movie in the future. Jane won the 'Amazing Women Global' Lifetime Achievement 2019 and the New York Big Book Award 2019

A Global Scientific VisionPrevention, Diagnosis, and Treatment of Lung Cancer

A Global Scientific VisionPrevention, Diagnosis, and Treatment of Lung Cancer
  • Author : Marta Adonis
  • Publisher :Unknown
  • Release Date :2017-03-01
  • Total pages :230
  • ISBN : 9789535129653
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Summary : Lung cancer is the number one cause of cancer deaths around the world. This devastating disease takes strength not only in people who smoke but also in poor people that eat polluted food and use heating sources, and in those exposed naturally to toxic compounds present in indoor and outdoor environments. Lung cancer patients and their families wait actions from the science that give not only answer to their demands but also a light of hope at the moment of receiveing the diagnosis. This book meets the experience of several researchers who dedicate many hours a day to find not only the cure of lung cancer but also the way to convert the pathology of this chronic disease. In 12 chapters, the lectures will give information related to the relationship of lung cancer and smoking habit, the crucial role of the image technology for diagnosis of lung cancer, and a molecular vision of prevention, diagnosis, and treatment of lung cancer. The authors with a clinic and/or lab vision and with a great spirit to collaborate with the science and with each past, present, and future patient and their families have dedicated many hours to write each chapter. Probably, the final answer to find the cure of lung cancer is not in this book. However, the lectures will give scientific information that will contribute in the near future improvement to the life quality of the patients.

Oncologic Therapies

Oncologic Therapies
  • Author : Everett E. Vokes,Harvey M. Golomb
  • Publisher :Unknown
  • Release Date :2002-11-21
  • Total pages :659
  • ISBN : 3540434615
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Summary : This second edition has been updated in a user-friendly layout that makes its comprehensive information extremely accessible. The handbook, written for all physicians who treat cancer patients, provides a survey of current therapeutic concepts of solid tumors and hematologic malignancies in internal oncology. Each individual chapter of this shortened new edition is structured in the same way and features a brief outline or tabular summary of the main aspects of epidemiology, pathology, staging, and diagnosis. The main focus is on the therapeutic strategy, i.e., an interdisciplinary approach to systemic drug therapy. Surgical and radiological concepts of treatment are also covered, as are supportive care, pain relief methods and ethical problems. This title is a must for clinicians and practitioners as well as interns, residents and postgraduate students.

Drug Repurposing and Repositioning

Drug Repurposing and Repositioning
  • Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
  • Publisher :Unknown
  • Release Date :2014-08-08
  • Total pages :118
  • ISBN : 9780309302074
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Summary : Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.

Molecular Docking

Molecular Docking
  • Author : Dimitrios Vlachakis
  • Publisher :Unknown
  • Release Date :2018-07-11
  • Total pages :188
  • ISBN : 9781789233544
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Summary : Molecular docking has always been and will be on the forefront of developments in the eminent field of drug design and medicinal chemistry. At the early days, drug discovery was based on blackboard drawings and expert intuition. However, as times move on, the amount of available information and overall knowledge base that needs to be analyzed cannot be processed manually. This, coupled by the rapid growth in computational infrastructure and processing power, has allowed for the efficient use of molecular docking tools and algorithms to be considered in the greater field of drug discovery. In the postgenomic era, molecular docking has become the key player for the screening of hundreds of thousands of compounds against a repertoire of pharmacological targets.

Polypharmacology in Drug Discovery

Polypharmacology in Drug Discovery
  • Author : Jens-Uwe Peters
  • Publisher :Unknown
  • Release Date :2012-03-13
  • Total pages :510
  • ISBN : 9780470590904
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Summary : "Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology"--Provided by publisher.

Resistance to Targeted Therapies Against Adult Brain Cancers

Resistance to Targeted Therapies Against Adult Brain Cancers
  • Author : Amanda Tivnan
  • Publisher :Unknown
  • Release Date :2016-11-26
  • Total pages :260
  • ISBN : 9783319465050
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Summary : This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Making Better Drugs for Children with Cancer

Making Better Drugs for Children with Cancer
  • Author : National Research Council,Institute of Medicine,National Cancer Policy Board,Committee on Shortening the Time Line for New Cancer Treatments
  • Publisher :Unknown
  • Release Date :2005-03-31
  • Total pages :56
  • ISBN : 0309181860
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Summary : The successes that have been achieved in treating childhood cancers stand as beacons against the less dramatic improvements for adults with cancer. Progress began to accelerate in the 1960s and 1970s, as treatment regimens were built up, primarily by building combinations of chemotherapeutic drugs. However the near absence of research in pediatric cancer drug discovery threatens to halt the progress in childhood cancer treatment achieved during the past four decades. Making Better Drugs for Children with Cancer identifies the major issues to be addressed in developing new agents for childhood cancers, the gaps in research and development, and the steps that have been suggested to move the process forward. This report also makes a new proposal to capitalize on today's science to bring new treatments to children's cancers.

Artificial Intelligence in Drug Discovery

Artificial Intelligence in Drug Discovery
  • Author : Nathan Brown
  • Publisher :Unknown
  • Release Date :2020-11-11
  • Total pages :406
  • ISBN : 9781839160547
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Summary : Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.