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Dyneins

Dyneins
  • Author : Stephen M. King,King M. Stephen
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :639
  • ISBN : 9780123820044
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Summary : With an accompanying Web site showing more than 100 streaming videos of cell dynamic behavior for best comprehension of material, "Dyneins" is the only reference covering the structure, biology, and application of dynein research to human disease. From bench to bedside, this book offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics, and medicine.

Dyneins

Dyneins
  • Author : Stephen M. King
  • Publisher :Unknown
  • Release Date :2017-11-28
  • Total pages :530
  • ISBN : 9780128097014
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Summary : Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease. Presents a broad-based and up-to date view of dynein mechanics, dysfunction, and disease Contains approaches from genetics, molecular biology, biochemistry, and biophysics discussed Provides companion website with movies of dynamic cell behavior Includes extensive chapters written by leading, global experts

Dyneins

Dyneins
  • Author : Stephen M. King
  • Publisher :Unknown
  • Release Date :2017-11-22
  • Total pages :684
  • ISBN : 9780128097021
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Summary : Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology. Presents a broad-based, up-to date view of the biology of dynein motors Discusses approaches from genetics, molecular biology, biochemistry and biophysics Includes a companion website with movies of dynamic cell behavior Covers the topic in comprehensive chapters written by world experts

Molecular Motors

Molecular Motors
  • Author : Manfred Schliwa
  • Publisher :Unknown
  • Release Date :2006-03-06
  • Total pages :604
  • ISBN : 9783527605651
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Summary : The latest knowledge on molecular motors is vital for the understanding of a wide range of biological and medical topics: cell motility, organelle movement, virus transport, developmental asymmetry, myopathies, and sensory defects are all related to the function or malfunction of these minute molecular machines. Since there is a vast amount of information on motor mechanisms and potential biomedical and nanobiotechnological applications, this handbook fulfills the need for a collection of current research results on the functionality, regulation, and interactions of cytoskeletal, DNA, and rotary motors. Here, leading experts present a concise insight, ranging from atomic structure, biochemistry, and biophysics to cell biology, developmental biology and pathology. Basic principles and applications make this book a valuable reference tool for researchers, professionals, and clinicians alike - all set to become a "classic" in the years to come.

Cytoskeleton

Cytoskeleton
  • Author : Jose C. Jimenez-Lopez
  • Publisher :Unknown
  • Release Date :2017-05-17
  • Total pages :342
  • ISBN : 9789535131694
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Summary : The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.

Cell Physiology Source Book

Cell Physiology Source Book
  • Author : Nicholas Sperelakis
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :1235
  • ISBN : 9780080574554
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Summary : This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
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Summary :

Cilia: Structure and Motility

Cilia: Structure and Motility
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009-11-27
  • Total pages :344
  • ISBN : 0080961061
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Summary : Along with its companion volume on intraflagellar transport, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella. * Covers protocols for cilia and flagella across systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Brain Diseases and Metalloproteins

Brain Diseases and Metalloproteins
  • Author : David R. Brown
  • Publisher :Unknown
  • Release Date :2012-08-07
  • Total pages :300
  • ISBN : 9789814316019
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Summary : This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.

Encyclopedia of Cell Biology

Encyclopedia of Cell Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2015-08-07
  • Total pages :3008
  • ISBN : 9780123947963
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Summary : The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Case Studies in Cell Biology

Case Studies in Cell Biology
  • Author : Merri Lynn Casem
  • Publisher :Unknown
  • Release Date :2016-03-15
  • Total pages :406
  • ISBN : 9780128016848
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Summary : Case Studies in Cell Biology presents real world scenarios to help readers use science process and reasoning skills. The case studies require application and analyzation of concepts beyond rote memory of biological concepts. The book is based on the student learning outcomes from the American Society for Cell Biology, offering practical application for both the classroom and research laboratory. Guides the reader in applying knowledge directly to real world scenarios Includes case studies to bridge foundational cell biological concepts to translational science Aids students in synthesizing information and applying science processes

Biophysical Techniques for Structural Characterization of Macromolecules

Biophysical Techniques for Structural Characterization of Macromolecules
  • Author : Edward H. Egelman,H. Jane Dyson
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :617
  • ISBN : 0123749204
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Summary :

Cilia and Flagella

Cilia and Flagella
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995-08-31
  • Total pages :603
  • ISBN : 0080859453
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Summary : Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

The Cytoskeleton

The Cytoskeleton
  • Author : Thomas Pollard,Robert Goldman
  • Publisher :Unknown
  • Release Date :2016-12-31
  • Total pages :600
  • ISBN : 1621820165
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Summary : The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

Homocysteine in Protein Structure/Function and Human Disease

Homocysteine in Protein Structure/Function and Human Disease
  • Author : Hieronim Jakubowski
  • Publisher :Unknown
  • Release Date :2013-06-20
  • Total pages :166
  • ISBN : 9783709114100
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Summary : Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease. ​

Basic Neurochemistry

Basic Neurochemistry
  • Author : Scott T. Brady,George J. Siegel
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :1096
  • ISBN : 9780123749475
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Summary : Includes bibliographical references and index.

Eukaryotic Membranes and Cytoskeleton

Eukaryotic Membranes and Cytoskeleton
  • Author : Gáspár Jékely
  • Publisher :Unknown
  • Release Date :2008-09-08
  • Total pages :145
  • ISBN : 9780387740218
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Summary : The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow the cellular machineries present in the last common ancestor of eukaryotes to be accurately reconstructed. Such a reconstruction is fundamental in order to understand eukaryotic diversification, since this is the ancestral cell from which all diversity arose. This book discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective.

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
  • Author : Deric L. Wheeler,Yosef Yarden
  • Publisher :Unknown
  • Release Date :2014-11-26
  • Total pages :440
  • ISBN : 9781493920532
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Summary : Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease, for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases. And over the last decade they have become the Number 1 targets of cancer drugs. To be able to conduct fundamental research or to attempt to develop pharmacological agents able to enhance or intercept them, it is essential first to understand the evolutionary origin of the 58 RTKs and their roles in invertebrates and in humans, as well as downstream signaling pathways. The assembly of chapters is written by experts and underscores commonalities between and among the RTKs. It is an ideal companion volume to The Receptor Tyrosine Kinase: Families and Subfamilies, which proceeds, family by family through all of the specific subfamilies of RTKs, along with their unique landmarks.

Disorders of the Respiratory Tract in Children: Pediatric otolaryngology

Disorders of the Respiratory Tract in Children: Pediatric otolaryngology
  • Author : Edwin L. Kendig,Charles F. Ferguson
  • Publisher :Unknown
  • Release Date :1972
  • Total pages :229
  • ISBN : UCAL:B4333563
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Summary :

Some Critical Questions in Biological Physics

Some Critical Questions in Biological Physics
  • Author : Tom A. Waigh
  • Publisher :Unknown
  • Release Date :2017-09-29
  • Total pages :204
  • ISBN : 0750313757
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Summary : Some Critical Questions in Biological Physics discusses eighteen key questions in biological physics, each forming independent chapters that will, by presenting the research in terms of key, unsolved problems, encourage interest in the field. It also provides useful reading for undergraduate physical scientists considering a career in this area.

Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes

Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes
  • Author : Adam Liwo
  • Publisher :Unknown
  • Release Date :2013-07-17
  • Total pages :810
  • ISBN : 9783642285547
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Summary : Since the second half of the 20th century machine computations have played a critical role in science and engineering. Computer-based techniques have become especially important in molecular biology, since they often represent the only viable way to gain insights into the behavior of a biological system as a whole. The complexity of biological systems, which usually needs to be analyzed on different time- and size-scales and with different levels of accuracy, requires the application of different approaches, ranging from comparative analysis of sequences and structural databases, to the analysis of networks of interdependence between cell components and processes, through coarse-grained modeling to atomically detailed simulations, and finally to molecular quantum mechanics. This book provides a comprehensive overview of modern computer-based techniques for computing the structure, properties and dynamics of biomolecules and biomolecular processes. The twenty-two chapters, written by scientists from all over the world, address the theory and practice of computer simulation techniques in the study of biological phenomena. The chapters are grouped into four thematic sections dealing with the following topics: the methodology of molecular simulations; applications of molecular simulations; bioinformatics methods and use of experimental information in molecular simulations; and selected applications of molecular quantum mechanics. The book includes an introductory chapter written by Harold A. Scheraga, one of the true pioneers in simulation studies of biomacromolecules.