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Dynemicin A, Uncialamycin and Analogues

Dynemicin A, Uncialamycin and Analogues
  • Author : Daniel Best,Mickael Jean,Pierre Van De Weghe
  • Publisher :Unknown
  • Release Date :2016-06-14
  • Total pages :144
  • ISBN : 9780081010860
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Summary : Enediynes are natural products with highly active cytotoxicity and antibacterial activity, and thus have significant potential in the development of anti-cancer treatments. However, they are not readily available and can degrade rapidly during isolation; one solution is to produce them using total synthesis. Dynemicin A and uncialamycin are two such enediynes, with similar structures, for which total synthesis has been achieved. This book presents the isolation and preparation of these two compounds and their analogues through various synthesis strategies. Details of the structural elements essential to their anti-cancer activity are presented, with the objective of explaining and optimizing their biological activities and potential development as drugs. Presents two natural ènediynes with similar structures whose total syntheses have been accomplished Explores structural analogs of preparation for purposes of optimizing the anti-cancer activity Describes the total syntheses of dynemicin A, the uncialamycine, as well as analogs by emphasizing the synthesis strategies adopted Features studies of the biological activities and data to bring out the structural elements of these essential compounds

Anticancer Agents from Natural Products, Second Edition

Anticancer Agents from Natural Products, Second Edition
  • Author : Gordon M. Cragg,David G. I. Kingston,David J. Newman
  • Publisher :Unknown
  • Release Date :2011-10-10
  • Total pages :767
  • ISBN : 9781439813836
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Summary : The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Introduction to Bioorganic Chemistry and Chemical Biology

Introduction to Bioorganic Chemistry and Chemical Biology
  • Author : David Van Vranken,Gregory A. Weiss
  • Publisher :Unknown
  • Release Date :2018-10-08
  • Total pages :504
  • ISBN : 9781135054823
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Summary : Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Chemical Biology of Natural Products

Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher :Unknown
  • Release Date :2017-09-22
  • Total pages :622
  • ISBN : 9781351643283
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Summary : Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

Magic Molecules

Magic Molecules
  • Author : Susan Aldridge,Aldridge Susan
  • Publisher :Unknown
  • Release Date :1998-09-28
  • Total pages :269
  • ISBN : 0521584140
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Summary : All of us are drug users, in the broadest sense of the word. Drugs can be medicines, they can be used for pleasure, and they can also be used to protect our long-term health. It is important that we are well informed about the drugs we use - how they work, their benefits and their risks. This book is a unique guide for the general science reader to the drugs of everyday life - from the main types of medicine through to recreational drugs and food supplements. It looks at how drugs interact with their targets in the body, where they come from, how they are developed and what drugs to expect in the future. All the major pharmaceutical medicines are reviewed - painkillers, antibiotics, anti-cancer drugs, anti depressants, heart drugs, tranquillizers and hormones. However this book is much more than a consumer handbook - it also conveys the fascinating science of drug discovery in an easily accessible way.

A Theoretical Study of Pd-Catalyzed C-C Cross-Coupling Reactions

A Theoretical Study of Pd-Catalyzed C-C Cross-Coupling Reactions
  • Author : Max García Melchor
  • Publisher :Unknown
  • Release Date :2013-10-04
  • Total pages :136
  • ISBN : 9783319014906
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Summary : Find out how theoretical calculations are used to determine, elucidate and propose mechanisms for Pd-catalyzed C-C cross-coupling reactions in Max Garcia Melchor's outstanding thesis. Garcia Melchor investigates one of the most significant and useful types of reactions in modern organic synthesis; the Pd-cross coupling reaction. Due to its versatility, broad scope and selectivity under mild conditions, this type of reaction can now be applied in fields as diverse as the agrochemical and pharmaceutical industry. Garcia Melchor studies the reaction intermediates and transition states involved in the Negishi, the copper-free Sonogashira and the asymmetric version of Suzuki-Miyaura coupling. He also characterizes and provides a detailed picture of the associated reaction mechanisms. The author has won numerous prizes for this work which has led to over eight publications in internationally renowned journals.

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
  • Author : Carmen Avendano,J. Carlos Menendez
  • Publisher :Unknown
  • Release Date :2015-06-11
  • Total pages :768
  • ISBN : 9780444626677
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Summary : Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

The Australian Drug Guide

The Australian Drug Guide
  • Author : Jonathan Upfal
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :818
  • ISBN : 1863951741
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Summary : Every year up to 140,000 Australians are rushed to hospital due to medication errors and misunderstandings. The new 2006 edition of The Australian Drug Guidecontains over 800 pages of up-to-the-minute information that could mean the difference between life and death for you or someone you know. You'll find the answers to all your questions about the medicines prescribed for you and your family in The Australian Drug Guide. It's you and your family's 'health insurance' in one easy-to-use reference.

Classics in Total Synthesis

Classics in Total Synthesis
  • Author : K. C. Nicolaou,E. J. Sorensen
  • Publisher :Unknown
  • Release Date :1996-04-11
  • Total pages :821
  • ISBN : 9783527292318
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Summary : K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.

Biphasic Chemistry and The Solvent Case

Biphasic Chemistry and The Solvent Case
  • Author : Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
  • Publisher :Unknown
  • Release Date :2020-01-09
  • Total pages :230
  • ISBN : 9781119695042
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Summary : Biphasic Chemistry and The Solvent Case examines recent improvements in reaction conditions, in order to affirm the role of chemistry in the sustainable field. This book shows that those who work within the chemistry industry support limits for the use of toxic or flammable solvents, since it reduces the purifications to simple filtrations. Thanks to commercial scavengers, solid phase syntheses are now available to all. Fluorine biphasic catalysis enables extremely efficient catalyst recycling and has a high applicability potential at the industrial level. This book also reviews the many studies that have shown that water is a solvent of choice for most synthetic reactions. Particular traits can be obtained and the effects on thermodynamics make it possible to operate at lower temperatures, thereby achieving energy savings. Finally the great diversity of application of the reactions without solvents is illustrated.

Building a Practical Information Security Program

Building a Practical Information Security Program
  • Author : Jason Andress,Mark Leary
  • Publisher :Unknown
  • Release Date :2016-11-01
  • Total pages :202
  • ISBN : 9780128020883
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Summary : Building a Practical Information Security Program provides users with a strategic view on how to build an information security program that aligns with business objectives. The information provided enables both executive management and IT managers not only to validate existing security programs, but also to build new business-driven security programs. In addition, the subject matter supports aspiring security engineers to forge a career path to successfully manage a security program, thereby adding value and reducing risk to the business. Readers learn how to translate technical challenges into business requirements, understand when to "go big or go home," explore in-depth defense strategies, and review tactics on when to absorb risks. This book explains how to properly plan and implement an infosec program based on business strategy and results. Provides a roadmap on how to build a security program that will protect companies from intrusion Shows how to focus the security program on its essential mission and move past FUD (fear, uncertainty, and doubt) to provide business value Teaches how to build consensus with an effective business-focused program

Pincer and Pincer-Type Complexes

Pincer and Pincer-Type Complexes
  • Author : Kálmán J. Szabó,Ola F. Wendt
  • Publisher :Unknown
  • Release Date :2014-06-10
  • Total pages :320
  • ISBN : 9783527681334
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Summary : This new book on this hot topic summarizes the key achievements for the synthesis and catalytic applications of pincer and pincer-type complexes, providing readers with the latest research highlights. The editors have assembled an international team of leaders in the field, and their contributions focus on the application of various pincer complexes in modern organic synthesis and catalysis, such as C-C and C-X bond forming reactions, C-H bond functionalization, and the activation of small molecules, as well as asymmetric catalysis. A must-have for every synthetic chemist in both academia and industry intending to develop new catalysts and improved synthetic protocols.

Anionic Annulations in Organic Synthesis

Anionic Annulations in Organic Synthesis
  • Author : Dipakranjan Mal
  • Publisher :Unknown
  • Release Date :2018-10-25
  • Total pages :464
  • ISBN : 9780128138014
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Summary : Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the best annulations for the construction of cyclic structures and their applications in the total synthesis of functional molecules. The reactions described in the work are particularly useful for the synthesis of polyoxygenated polycyclic compounds, including tetracyclines, angucyclines, uncialamycins, and lignans, among other compounds. Included in detail are the Hauser, Robinson, Sammes and Meyers annulations, all of which can be effectively used to construct substrates with complex molecular structures. This work provides the tools to master anionic organic chemistry, ortho-lithiation, lateral lithaition/metalation and organic selectivity issues, like chemoselectivity, regioselectivity and stereoselectivity. This book is a valuable resource for organic chemists, researchers and students seeking a complete and detailed understanding of anionic annulations. Provides a comprehensive review of anionic cyclization for chemical construction of a variety of cyclic scaffolds involved in many kinds of biologically active natural products and pharmaceutical drugs Serves as a useful tool to academic and industrial researchers working on the synthesis of cyclic compounds as their targets Includes many examples of anionic annulations and practical information on how to use them in research and industry Features anionic annulations that are particularly useful for the synthesis of polyoxygenated polycyclic compounds, including tetracyclines, angucyclines, uncialamycins and lignans

Mechanochemical Organic Synthesis

Mechanochemical Organic Synthesis
  • Author : Davor Margetic,Vjekoslav Štrukil
  • Publisher :Unknown
  • Release Date :2016-04-23
  • Total pages :386
  • ISBN : 9780128025253
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Summary : Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area. Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactions Integrates advances in green chemistry research into industrial applications and process development Focuses on designing techniques in organic synthesis directed toward mild reaction conditions Includes global coverage of mechanochemical synthetic protocols for the generation of organic compounds

Preparative Carbohydrate Chemistry

Preparative Carbohydrate Chemistry
  • Author : Stephen Hanessian
  • Publisher :Unknown
  • Release Date :1997-01-02
  • Total pages :648
  • ISBN : 0824798023
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Summary : Detailing commonly used methods and procedures, this reference discusses the reactions and derivative forms of carbohydrates. Preparative Carbohydrate Chemistry covers the formation, cleavage, and reactions of derivatives and illustrates bond-forming reactions of SN2 types, free radicals, chain extensions, and branching. The contents include: sugar derivatives; selected reactions in carbohydrate chemistry; chemical synthesis of oligosaccharides and O-and N -glycosyl compounds; enzymatic synthesis of sialic acid, KDO, and related deoxyulosonic acids, and of oligosaccharides; synthesis of -glycosyl compounds; carbocycles from carbohydrates; and total synthesis of sugars from non-sugars. This authoritative reference offers relevant chapters on reactions and derivative forms of carbohydrates, including commonly used methods as well as new experimental procedures. It also contains insightful chapter commentaries and succinct topic histories.

Computational Organic Chemistry

Computational Organic Chemistry
  • Author : Steven M. Bachrach
  • Publisher :Unknown
  • Release Date :2014-03-03
  • Total pages :632
  • ISBN : 9781118671221
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Summary : The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.

Microbial Resources

Microbial Resources
  • Author : Ipek Kurtböke
  • Publisher :Unknown
  • Release Date :2017-03-31
  • Total pages :354
  • ISBN : 9780128051405
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Summary : Microbial Resources: From Functional Existence in Nature to Applications provides an exciting interdisciplinary journey through the rapidly developing field of microbial resources, including relationships to aspects of microbiology. Covers the functional existence of microorganisms in nature, as well as the transfer of this knowledge for industrial and other applications. Examines the economic perspective of revealing the potential value of microbial material and figuring it into socio-economic value; legal perspectives; and how to organize a fair allotment of socio-economic benefits to all stakeholders who have effectively contributed to the preservation, study, and exploitation of microbiological material. Covers aspects of foundational information related to microbiology, microbial ecology, and diversity, as well as new advances in microbial genomics Provides information on the utilization of microbial resources in biotechnology Covers legislative issues and related law in biodiscovery Fills a need for a very broad audience and is a good resource for microbiologists seeking to know the extent of microbiology approaches, the policies associated with microbiology, and potential career paths for researchers Has significant added value due to the inclusion of comprehensive coverage of the biology, ecology, biochemistry and international legislation surrounding these applications

Molecules That Changed the World

Molecules That Changed the World
  • Author : K. C. Nicolaou,Tamsyn Montagnon
  • Publisher :Unknown
  • Release Date :2008-03-17
  • Total pages :385
  • ISBN : 3527309837
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Summary : K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read.

The Australian Drug Guide

The Australian Drug Guide
  • Author : Jonathan Upfal
  • Publisher :Unknown
  • Release Date :1997-09-01
  • Total pages :735
  • ISBN : 1863954007
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Summary :

Methods and Applications of Cycloaddition Reactions in Organic Syntheses

Methods and Applications of Cycloaddition Reactions in Organic Syntheses
  • Author : Nagatoshi Nishiwaki
  • Publisher :Unknown
  • Release Date :2013-12-17
  • Total pages :672
  • ISBN : 9781118778203
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Summary : Advanced tools for developing new functional materials andapplications in chemical research, pharmaceuticals, and materialsscience Cycloadditions are among the most useful tools for organicchemists, enabling them to build carbocyclic and heterocyclicstructures. These structures can then be used to develop a broadrange of functional materials, including pharmaceuticals,agrochemicals, dyes, and optics. With contributions from aninternational team of leading experts and pioneers in cycloadditionchemistry, this book brings together and reviews recent advances,trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions inOrganic Syntheses focuses on two component cycloadditions, withchapters covering such topics as: N1 unit transfer reaction to C–C doublebonds [3+2] Cycloaddition of α, β-unsaturatedmetal-carbene complexes Formal [3+3] cycloaddition approach to natural productsynthesis Development of new methods for the construction of heterocyclesbased on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of largeπ-conjugated compounds Transition metal-catalyzed or mediated [5+1]cycloadditions Readers will learn methods for seamlessly executing importantreactions such as Diels-Alder and stereoselective dipolar reactionsin order to fabricate heterocyclic compounds, natural products, andfunctional molecules. The book not only features cutting-edgetopics, but also important background information, such as thecontributors’ process for developing new methodologies, tohelp novices become fully adept in the field. References at the endof each chapter lead to original research papers and reviews forfacilitating further investigation of individual topics. Covering the state of the science and technology, Methods andApplications of Cycloaddition Reactions in Organic Synthesesenables synthetic organic chemists to advance their research anddevelop new functional materials and applications in chemicalresearch, pharmaceuticals, and materials science.

Medicinal Plant Research in Africa

Medicinal Plant Research in Africa
  • Author : Victor Kuete
  • Publisher :Unknown
  • Release Date :2013-06-19
  • Total pages :916
  • ISBN : 9780124059368
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Summary : The pharmacopoeias of most African countries are available and contain an impressive number of medicinal plants used for various therapeutic purposes. Many African scholars have distinguished themselves in the fields of organic chemistry, pharmacology, and pharmacognosy and other areas related to the study of plant medicinal plants. However, until now, there is no global standard book on the nature and specificity of chemicals isolated in African medicinal plants, as well as a book bringing together and discussing the main bioactive metabolites of these plants. This book explores the essence of natural substances from African medicinal plants and their pharmacological potential. In light of possible academic use, this book also scans the bulk of African medicinal plants extract having promising pharmacological activities. The book contains data of biologically active plants of Africa, plant occurring compounds and synthesis pathways of secondary metabolites. This book explores the essence of natural substances from African medicinal plants and their pharmacological potential The authors are world reknowned African Scientists.