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Intelligent Computing in Bioinformatics

Intelligent Computing in Bioinformatics
  • Author : De-Shuang Huang,Kyungsook Han,Michael Gromiha
  • Publisher :Unknown
  • Release Date :2014-07-03
  • Total pages :510
  • ISBN : 9783319093307
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Summary : This book – in conjunction with the volumes LNCS 8588 and LNAI 8589 – constitutes the refereed proceedings of the 10th International Conference on Intelligent Computing, ICIC 2014, held in Taiyuan, China, in August 2014. The 58 papers of this volume were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections such as machine learning; neural networks; image processing; computational systems biology and medical informatics; biomedical informatics theory and methods; advances on bio-inspired computing; protein and gene bioinformatics: analysis, algorithms, applications.

Senile Dementias

Senile Dementias
  • Author : André Bès
  • Publisher :Unknown
  • Release Date :1986
  • Total pages :641
  • ISBN : UOM:39015012556620
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Summary :

Alzheimer's Disease

Alzheimer's Disease
  • Author : Inga Zerr
  • Publisher :Unknown
  • Release Date :2015-07-01
  • Total pages :372
  • ISBN : 9789535121374
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Summary : There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

Early Diagnosis of Alzheimer's Disease

Early Diagnosis of Alzheimer's Disease
  • Author : Leonard F. M. Scinto,Kirk R. Daffner
  • Publisher :Unknown
  • Release Date :2000-02-09
  • Total pages :359
  • ISBN : UOM:39015048543303
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Summary : Strategies for the early diagnosis of Alzheimer's disease are among the most important and most discussed topics in dementia care today. In Early Diagnosis of Alzheimer's Disease, Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of today's new diagnostic approaches to Alzheimer's disease. Leaders in the field critically survey the most promising clinical research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. In addition, there are reviews of current clinical practice in the diagnosis of Alzheimer's disease, the major theories about its pathophysiology, and the therapeutic and ethical implications of early diagnosis. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this highly prevalent disease. Addressed to clinicians caring for an aging population, researchers developing new therapeutics, and policymakers concerned about the impact of early diagnosis on the delivery of health care, this timely, state-of-the-art volume constitutes a new standard reference guide for all those working with Alzheimer's patients today.

Intelligent Data Analysis

Intelligent Data Analysis
  • Author : Deepak Gupta,Siddhartha Bhattacharyya,Ashish Khanna,Kalpna Sagar
  • Publisher :Unknown
  • Release Date :2020-07-07
  • Total pages :400
  • ISBN : 9781119544456
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Summary : This book focuses on methods and tools for intelligent data analysis, aimed at narrowing the increasing gap between data gathering and data comprehension, and emphasis will also be given to solving of problems which result from automated data collection, such as analysis of computer-based patient records, data warehousing tools, intelligent alarming, effective and efficient monitoring, and so on. This book aims to describe the different approaches of Intelligent Data Analysis from a practical point of view: solving common life problems with data analysis tools.

Alzheimer's Disease

Alzheimer's Disease
  • Author : Robert Becker
  • Publisher :Unknown
  • Release Date :1990-09-19
  • Total pages :300
  • ISBN : 0844816590
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Summary : This book examines the relevance of current research for the early diagnosis of Alzheimer disease. It uncovers the present lack of clinical utility in research methodologies such as neuroimaging, drug challenges, electroencephalographs studies, and brain biopsy.

Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications

Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications
  • Author : Wu, Jinglong
  • Publisher :Unknown
  • Release Date :2011-05-31
  • Total pages :480
  • ISBN : 9781609605605
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Summary : "This book provides a comprehensive collection for experts in the Neuroscience and Biomedical technology fields, outlining various concepts from cognitive neuroscience and dementia to neural technology and rehabilitation"--Provided by publisher.

Mild Cognitive Impairment and Early Alzheimer's Disease

Mild Cognitive Impairment and Early Alzheimer's Disease
  • Author : Jeffrey M. Burns,John C. Morris
  • Publisher :Unknown
  • Release Date :2008-05-27
  • Total pages :148
  • ISBN : IND:30000122910106
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Summary : Written by leading authorities in the field, this book describes the cognitive changes associated with age, the earliest detectable stages of Alzheimer’s, and the relationship of these conditions to MCI. The authors review the latest advances in our understanding of MCI, its prevalence, evaluation, management, and outcomes and in so doing provide practising physicians with a useful resource that assists them in identifying those MCI patients who will progress to recognised Alzheimer’s Disease. Beautifully presented in full colour, Early Diagnosis and Treatment of Mild Cognitive Impairment includes case studies and discusses future therapeutic and diagnostic strategies. It is an invaluable resource for postgraduates and professionals, for specialist physicians in neurology and psychiatric medicine, geriatric medicine and general practice.

Emerging Technologies for Diagnosing Alzheimer's Disease

Emerging Technologies for Diagnosing Alzheimer's Disease
  • Author : Marianne Boenink,Harro van Lente,Ellen Moors
  • Publisher :Unknown
  • Release Date :2016-09-13
  • Total pages :286
  • ISBN : 9781137540973
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Summary : This book explores international biomedical research and development on the early diagnosis of Alzheimer's disease. It offers timely, multidisciplinary reflections on the social and ethical issues raised by promises of early diagnostics and asks under which conditions emerging diagnostic technologies can be considered a responsible innovation. The initial chapters in this edited volume provide an overview and a critical discussion of recent developments in biomedical research on Alzheimer's disease. Subsequent contributions explore the values at stake in current practices of dealing with Alzheimer's disease and dementia, both within and outside the biomedical domain. Novel diagnostic technologies for Alzheimer's disease emerge in a complex and shifting field, full of controversies. Innovating with care requires a precise mapping of how concepts, values and responsibilities are filled in through the confrontation of practices. In doing so, the volume offers a practice-based approach of responsible innovation that is also applicable to other fields of innovation.

Early Diagnosis and Intervention in Predementia Alzheimer's Disease, An Issue of Medical Clinics,

Early Diagnosis and Intervention in Predementia Alzheimer's Disease, An Issue of Medical Clinics,
  • Author : Jose L. Molinuevo,Jeffrey I. Cummings,Bruno Dubois,Philip Scheltens
  • Publisher :Unknown
  • Release Date :2013-05-11
  • Total pages :156
  • ISBN : 9781455772032
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Summary : This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

The End of Alzheimer’s

The End of Alzheimer’s
  • Author : Thomas J. Lewis,Clement L. Trempe
  • Publisher :Unknown
  • Release Date :2017-05-12
  • Total pages :482
  • ISBN : 9780128121139
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Summary : The End of Alzheimer’s: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer’s outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer’s disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer’s outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer’s, and will hopefully redirect many into new avenues of cellular research and discovery. Comprehensive literature-based summary of the current state of molecular Alzheimer’s disease research Details the shortcomings of the prevailing model and therapeutics in development Reviews blood-based biomarkers for Alzheimer’s and their link to amyloid- and Tau-independent causes outside the brain Describes the tissues outside the brain impacted by Alzheimer’s and the underlying molecular causes Explains the whole-body risks associated with Alzheimer’s, along with concomitant measures to slow or prevent the disease Provides a protocol to properly research, evaluate, measure, diagnose, and potentially treat Alzheimer’s patients

Alzheimer’s Disease Theranostics

Alzheimer’s Disease Theranostics
  • Author : Magisetty Obulesu
  • Publisher :Unknown
  • Release Date :2019-01-20
  • Total pages :80
  • ISBN : 9780128167397
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Summary : Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

VA Research on Alzheimer's Disease, Parkinson's Disease, and Diabetes

VA Research on Alzheimer's Disease, Parkinson's Disease, and Diabetes
  • Author : United States. Congress. House. Committee on Veterans' Affairs. Subcommittee on Oversight and Investigations
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :90
  • ISBN : PURD:32754077972879
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Summary :

Biomedical Index to PHS-supported Research

Biomedical Index to PHS-supported Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :229
  • ISBN : IND:30000090515432
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Summary :

Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher :Unknown
  • Release Date :2016-09-28
  • Total pages :558
  • ISBN : 9789535126546
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Summary : The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Alzheimer's Disease

Alzheimer's Disease
  • Author : Harald Hampel,Maria C. Carrillo
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :193
  • ISBN : 9783805598026
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Summary : How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Diagnosis and Treatment of Senile Dementia

Diagnosis and Treatment of Senile Dementia
  • Author : Manfred Bergener,Barry Reisberg
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :396
  • ISBN : 9783642466588
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Summary : Senile dementia is one of the major health problems confronting mankind in this century. To some extent the problem has, of course, always existed. The condition was sufficiently troubling to classical philosophers and jurists to have apparently provoked comments by Solon in approximately 500 B. C. and Plato in the fourth century B. C. (Plutarch 1967 translation; Plato 1921 translation). Medical recognition can be traced at least as far back as the second century A. D. (Adams 1861). However, several factors have converged in this century to extend the absolute dimensions of the problem of senile dementia and to increase societal, medical, and scientific recogni tion of the magnitude of the condition. Perhaps the most important factor relating to the present importance of senile dementia is demographic. Although the human population has been increasing since the mid-eighteenth century, it has only been since the advent of the twentieth century that a decrease in mortality has been noted for those over the age of 45 (McKeown 1976). Consequently, the absolute number of aged persons and the proportion of increasingly aged persons in the populations of the world's industrial nations have been steadily increasing. For example, in the United States, 4% ofthe population was over the age of 65 in 1900. In the 1970 census, this proportion had grown to 10%.

Decision Analytics and Optimization in Disease Prevention and Treatment

Decision Analytics and Optimization in Disease Prevention and Treatment
  • Author : Nan Kong
  • Publisher :Unknown
  • Release Date :2018-03-13
  • Total pages :432
  • ISBN : 9781118960127
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Summary : A systematic review of the most current decision models and techniques for disease prevention and treatment Decision Analytics and Optimization in Disease Prevention and Treatment offers a comprehensive resource of the most current decision models and techniques for disease prevention and treatment. With contributions from leading experts in the field, this important resource presents information on the optimization of chronic disease prevention, infectious disease control and prevention, and disease treatment and treatment technology. Designed to be accessible, in each chapter the text presents one decision problem with the related methodology to showcase the vast applicability of operations research tools and techniques in advancing medical decision making. This vital resource features the most recent and effective approaches to the quickly growing field of healthcare decision analytics, which involves cost-effectiveness analysis, stochastic modeling, and computer simulation. Throughout the book, the contributors discuss clinical applications of modeling and optimization techniques to assist medical decision making within complex environments. Accessible and authoritative, Decision Analytics and Optimization in Disease Prevention and Treatment: Presents summaries of the state-of-the-art research that has successfully utilized both decision analytics and optimization tools within healthcare operations research Highlights the optimization of chronic disease prevention, infectious disease control and prevention, and disease treatment and treatment technology Includes contributions by well-known experts from operations researchers to clinical researchers, and from data scientists to public health administrators Offers clarification on common misunderstandings and misnomers while shedding light on new approaches in this growing area Designed for use by academics, practitioners, and researchers, Decision Analytics and Optimization in Disease Prevention and Treatment offers a comprehensive resource for accessing the power of decision analytics and optimization tools within healthcare operations research.

The Dementias 2

The Dementias 2
  • Author : John Herbert Growdon,Martin Rossor
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :435
  • ISBN : 9780750675420
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Summary : This volume in the Blue Books of Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and treatment of all forms of dementia, including Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and many others. Organized by the most common neurodegenerative diseases, it reflects new insights regarding commonalities among the neurodegenerative diseases, and clusters them according to their dominant molecular pathologic signatures, so you can best treat any dementia you see. Differentiate among various forms of dementia and provide the appropriate management strategy. Correlate neuroimaging with neuropsychological testing to form more accurate diagnoses. Administer the latest approved drugs to improve your patients' brain function. A new two-color design and full-color images throughout helps you access information more easily. New chapters and new authors help you incorporate the latest information and fresh perspectives into your practice.

Biomarkers in Alzheimer's Disease

Biomarkers in Alzheimer's Disease
  • Author : Tapan Khan
  • Publisher :Unknown
  • Release Date :2016-08-02
  • Total pages :276
  • ISBN : 9780128051474
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Summary : Biomarkers in Alzheimer’s Disease provides a comprehensive overview of all modalities of Alzheimer’s disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer’s disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer’s disease, and for differential diagnosis of Alzheimer’s disease with other non-Alzheimer’s dementia. Presents a comprehensive overview detailing all modalities of Alzheimer’s disease biomarkers Written for neuroscience researchers and clinicians studying or treating patients with Alzheimer’s Disease Integrates, in each chapter, the molecular/cellular abnormality due to Alzheimer’s disease and the technological advancement of biomarkers techniques

Biomarkers for Early Diagnosis of Alzheimer's Disease

Biomarkers for Early Diagnosis of Alzheimer's Disease
  • Author : Daniela Galimberti,Elio Scarpani
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :307
  • ISBN : IND:30000122535812
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Summary : Alzheimer's disease (AD) is characterized by the deposition into the brain of amyloid peptide, which originates a cascade of inflammatory events leading eventually to neuronal death. These pathological events likely occur several years before the clinical manifestation of the disease, implying that potential therapeutical interventions are currently started too late to give beneficial results. Recently, growing attention has been paid to the Mild Cognitive Impairment (MCI), considered the prodromal phase of AD, as 80% of subjects with MCI have been shown to develop AD within 5 years. Several studies aimed to identify biological markers to differentiate between normal aging and incipient AD have been carried out, including cerebrospinal fluid (CSF) analysis and neuroimaging. In particular, the evaluation of CSF Amyloid beta (1-42) levels, together with tau and phospotau, are of help for recognizing early AD. Besides, a number of additional molecules are altered in CSF. Other early modifications have been observed in peripheral cells, such as fibroblasts and leukocytes, as well as in serum from patients. Biomarkers for AD represent important tools supporting the clinical diagnosis and the choice of potential therapeutic options. Moreover, they would be of great help for the selection of cohorts of homogeneous patients for clinical trials with new disease-modifying compounds. This book is aimed to give an update about MCI as prodromal Alzheimer's disease (AD), to discuss the main known pathological mechanisms at the basis of AD and to describe the possible biomarkers to be used for an early diagnosis of the disease.