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Early Vascular Aging (EVA)

Early Vascular Aging (EVA)
  • Author : Peter M Nilsson,Michael Hecht Olsen,Stephane Laurent
  • Publisher :Unknown
  • Release Date :2015-08-06
  • Total pages :376
  • ISBN : 9780128016763
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Summary : Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures. Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

Early Vascular Aging (Eva)

Early Vascular Aging (Eva)
  • Author : Peter M. Nilsson,Michael Hect Olsen,Stephane Laurent
  • Publisher :Unknown
  • Release Date :2015-08-06
  • Total pages :376
  • ISBN : 0128013877
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Summary : Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures. Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

Textbook of Vascular Medicine

Textbook of Vascular Medicine
  • Author : Rhian M. Touyz,Christian Delles
  • Publisher :Unknown
  • Release Date :2019-08-02
  • Total pages :503
  • ISBN : 9783030164812
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Summary : This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Arterial Aging and Age-Associated Arterial Diseases

Arterial Aging and Age-Associated Arterial Diseases
  • Author : Mingyi Wang,Jiguang Wang,Gianfranco Pintus,Cuntai Zhang
  • Publisher :Unknown
  • Release Date :2019-01-24
  • Total pages :229
  • ISBN : 9782889456925
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Summary : The underlying mechanisms behind aging has long been a great scientific mystery that the biomedical research community has long studied. In developed nations, as the population grows older, increases in life expectancy is increasingly limited by our relatively poor control of chronic aging-associated diseases such as arterial aging. Among age-related conditions that negatively influence longevity. Growing evidence demonstrates that arterial aging is fundamentally caused by a proinflammatory process that begins at birth and results in detrimental effects that affects every organ system. Vascular aging is the leading risk factor for quintessential cardiovascular diseases such as hypertension and atherosclerosis. With aging, vascular walls develop a pro-inflammatory and stressed microenvironment characterized by both an upregulation of pro-inflammatory chemokines and cytokines as well as a down-regulation anti-inflammatory counterparts. This chronic imbalance in inflammatory regulatory networks is the key driver of changes at the cellular and molecular level that result in hypertensive and atherosclerotic arterial. Thus, an intervention of proinflammation may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases. In this eBook, we aim to supply an updated overview of the physiological and biochemical mechanisms that affect inflammation and vascular aging. We believe that this eBook will contribute to the understanding of the pathogenesis of many chronic or age-related diseases, as well as to their treatment with both current and new therapeutic approaches.

Endothelial Dysfunction

Endothelial Dysfunction
  • Author : Helena Lenasi
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :430
  • ISBN : 9781789842531
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Summary : The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

The Cambridge Handbook of Successful Aging

The Cambridge Handbook of Successful Aging
  • Author : Rocío Fernández-Ballesteros,Athanase Benetos,Jean-Marie Robine
  • Publisher :Unknown
  • Release Date :2019-01-24
  • Total pages :229
  • ISBN : 9781108641432
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Summary : Recent studies show that more people than ever before are reaching old age in better health and enjoying that health for a longer time. This Handbook outlines the latest discoveries in the study of aging from bio-medicine, psychology, and socio-demography. It treats the study of aging as a multidisciplinary scientific subject, since it requires the interplay of broad disciplines, while offering high motivation, positive attitudes, and behaviors for aging well, and lifestyle changes that will help people to stay healthier across life span and in old age. Written by leading scholars from various academic disciplines, the chapters delve into the most topical aspects of aging today - including biological mechanisms of aging, aging with health, active and productive aging, aging with satisfaction, aging with respect, and aging with dignity. Aimed at health professionals as well as general readers, this Cambridge Handbook offers a new, positive approach to later life.

Aging and Aging-Related Diseases

Aging and Aging-Related Diseases
  • Author : Zhao Wang
  • Publisher :Unknown
  • Release Date :2018-09-19
  • Total pages :282
  • ISBN : 9789811311178
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Summary : This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

The Biology of Human Longevity

The Biology of Human Longevity
  • Author : Caleb E. Finch
  • Publisher :Unknown
  • Release Date :2010-07-28
  • Total pages :640
  • ISBN : 0080545947
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Summary : Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Brain Aging

Brain Aging
  • Author : David R. Riddle
  • Publisher :Unknown
  • Release Date :2007-04-19
  • Total pages :408
  • ISBN : 1420005529
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Summary : Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Vascular Aging: Facts and Factors

Vascular Aging: Facts and Factors
  • Author : Elisabet Vila,Francesc Jiménez-Altayó,Paula Dantas
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9782889190522
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Summary : The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.

Cardiovascular Issues in Endocrinology

Cardiovascular Issues in Endocrinology
  • Author : R. Granata,J. Isgaard
  • Publisher :Unknown
  • Release Date :2014-06-12
  • Total pages :174
  • ISBN : 9783318026740
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Summary : Most endocrine diseases, if not treated or controlled, have cardiovascular manifestations. Both GH deficiency and GH excess impair cardiovascular functions, e.g. in patients with acromegaly, who have a shortened life expectancy and increased mortality mostly due to cardiovascular complications in uncontrolled disease. Moreover, Cushing’s syndrome and diabetes are well known for metabolic and cardiovascular manifestations, as well as hypo- and hyperthyroidism. Both adipose tissue and the heart have been increasingly recognized as organs with partially endocrine functions, which produce adipokines and brain natriuretic peptide, respectively, and influence a number of cardiovascular parameters. Primary aldosteronism as a cause for secondary hypertension is still a great challenge to detect and diagnose properly; however, new important discoveries have been made regarding the genetics of this probably underestimated cause of hypertension. Written by distinguished researchers in their respective fields, this book will give both researchers and clinicians an excellent update on all these topics, as well as provide insight into the use of hormones as treatment tools in more controversial areas.

Aging and Health - A Systems Biology Perspective

Aging and Health - A Systems Biology Perspective
  • Author : A.I. Yashin,S.M. Jazwinski
  • Publisher :Unknown
  • Release Date :2014-10-09
  • Total pages :206
  • ISBN : 9783318027303
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Summary : Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.

Circadian Rhythms and Their Impact on Aging

Circadian Rhythms and Their Impact on Aging
  • Author : S. Michal Jazwinski,Victoria P Belancio,Steven M Hill
  • Publisher :Unknown
  • Release Date :2017-10-24
  • Total pages :361
  • ISBN : 9783319645438
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Summary : Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

Handbook of Research on Geriatric Health, Treatment, and Care

Handbook of Research on Geriatric Health, Treatment, and Care
  • Author : Prasad, Barre Vijaya,Akbar, Shamsi
  • Publisher :Unknown
  • Release Date :2018-03-30
  • Total pages :604
  • ISBN : 9781522534815
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Summary : Mental and physical disorders are common in old age but frequently remain undetected and untreated. Managing treatment and controlling symptoms of these disorders is imperative to the longevity and quality of life of patients. The Handbook of Research on Geriatric Health, Treatment, and Care provides emerging research on promoting health in older adults by preventing and treating diseases and disabilities. By highlighting topics such as alternative treatment, clinical diagnosis, and positive psychology, this publication explores the methods and approaches of identifying and diagnosing epidemiological factors that contribute to geriatric health issues. This book is an important resource for healthcare professionals, academicians, medical practitioners, researchers, and students seeking current research on the methods and strategies for maintaining healthy and successful care for the elderly.

A Life Course Approach to Healthy Ageing

A Life Course Approach to Healthy Ageing
  • Author : Yoav Ben-Shlomo
  • Publisher :Unknown
  • Release Date :2014-01
  • Total pages :282
  • ISBN : 9780199656516
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Summary : This title investigates the lifetime determinants of healthy ageing and their implications for policy and practice, bringing together authorities in ageing research and knowledge transfer from across the world.

DHEA in Human Health and Aging

DHEA in Human Health and Aging
  • Author : Ronald Ross Watson
  • Publisher :Unknown
  • Release Date :2011-07-22
  • Total pages :472
  • ISBN : 9781439838846
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Summary : Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, an

Gerontology

Gerontology
  • Author : Grazia D’Onofrio,Daniele Sancarlo,Antonio Greco
  • Publisher :Unknown
  • Release Date :2018-07-04
  • Total pages :276
  • ISBN : 9781789232523
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Summary : Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.

Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher :Unknown
  • Release Date :2011-04-28
  • Total pages :1075
  • ISBN : 0080460062
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Summary : The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

The Tobacco Epidemic

The Tobacco Epidemic
  • Author : R. Loddenkemper,M. Kreuter
  • Publisher :Unknown
  • Release Date :2015-03-13
  • Total pages :276
  • ISBN : 9783318026573
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Summary : This completely revised and enlarged 2nd edition of The Tobacco Epidemic provides a comprehensive update of the clinical, public health and political aspects of tobacco smoking. Since its 1st edition in 1997, knowledge on the health hazards of tobacco and nicotine addiction has increased considerably, but recent data has shown that the global problem has become more aggravated in low- and middle-income countries: if current trends continue, tobacco smoking will be responsible for the deaths of 1 billion people in the 21st century. Written by outstanding international experts, the book covers the history of tobacco production and use, the economics of tobacco use and control, as well as the health consequences of active and passive smoking in both adults and children. Special chapters discuss the impact of media, movies and TV on tobacco consumption in young people, the patterns and predictors of smoking cessation in the general population and in different social subgroups, and initiatives supported by the WHO Framework Convention on Tobacco Control. Readers will find the latest information on how nicotine dependence is treated with nicotine replacement products, what role health care professionals play in helping smokers to quit and what effects smoke-free environments, advertising bans and price increases have on smoking prevalence. The potential harms and benefits of smokeless tobacco, waterpipe tobacco smoking and electronic cigarettes are also evaluated. This book is a must-read for anyone in the medical profession who treats patients with smoking-related diseases and for those engaged in tobacco control. It will also be appreciated by interested nonmedical readers like journalists and legislators.

Cardiovascular Medicine

Cardiovascular Medicine
  • Author : James T. Willerson,Jay N. Cohn,Hein J.J. Wellens,David R. Holmes
  • Publisher :Unknown
  • Release Date :2007-12-06
  • Total pages :2926
  • ISBN : 9781846287152
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Summary : This book offers the most up-to-date, user-friendly guidance on the evaluation, diagnosis and medical and surgical treatment of heart and vascular disease. The book and DVD package is designed to provide comprehensive coverage of every aspect of cardiovascular medicine. The book has consistent chapter organization relevant to modern cardiovascular practice, clear design and engaging text. The reader will have all the guidance to diagnose and manage the full range of cardiovascular conditions in one textbook resource, while also benefiting from access to additional video material from the integral DVD-ROM. This includes over 100 individual heart sounds.

Biophysical Regulation of Vascular Differentiation and Assembly

Biophysical Regulation of Vascular Differentiation and Assembly
  • Author : Sharon Gerecht
  • Publisher :Unknown
  • Release Date :2011-01-06
  • Total pages :254
  • ISBN : 1441978356
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Summary : Because of their ability to differentiate and develop into functional vasculature, stem cells hold tremendous promise for therapeutic applications. However, the scientific understanding and the ability to engineer these cellular systems is still in its early stages, and must advance significantly for the therapeutic potential of stem cells to be realized. Stem cell differentiation and function are exquisitely tuned by their microenvironment. This book will provide a unique perspective of how different aspect of the vasculature microenvironment regulates differentiation and assembly. Recent efforts to exploits modern engineering techniques to study and manipulate various biophysical cues will be described including: oxygen tension during adult and embryonic vasculogenesis (Semenza and Zandstra), extracellular matrix during tube morphogenesis and angiogenesis (Wirtz, Davis, Ingber), surface topography and modification (Chen and Gerecht), shear stress and cyclic strain effect on vascular assembly and maturation (Vunjak-Novakovic and Niklason), and three dimensional space for angio-andvasculogensis (Ferreria and Fischbach).