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Ecology and Evolution of Cancer

Ecology and Evolution of Cancer
  • Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
  • Publisher :Unknown
  • Release Date :2017-02-08
  • Total pages :290
  • ISBN : 0128043806
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Summary : Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

The Cheating Cell

The Cheating Cell
  • Author : Athena Aktipis
  • Publisher :Unknown
  • Release Date :2020-03-24
  • Total pages :256
  • ISBN : 0691163847
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Summary : A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Frontiers in Cancer Research

Frontiers in Cancer Research
  • Author : Carlo C. Maley,Mel Greaves
  • Publisher :Unknown
  • Release Date :2016-11-21
  • Total pages :258
  • ISBN : 1493964607
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Summary : This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.

The Emperor of All Maladies

The Emperor of All Maladies
  • Author : Siddhartha Mukherjee
  • Publisher :Unknown
  • Release Date :2011-08-09
  • Total pages :573
  • ISBN : 1439170916
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Summary : An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the development of present-day treatments. Reprint. Best-selling winner of the Pulitzer Prize. Includes reading-group guide.

Evolution in Health and Disease

Evolution in Health and Disease
  • Author : Stephen C. Stearns,Jacob C. Koella
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :374
  • ISBN : 0199207453
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Summary : A fully revised edition of a volume written by the world's leading authorities on this subject. It discusses how the evolution of humans and their pathogens have generated important medical issues, covering both infectious and degenerative diseases. It presents important ideas that are not yet sufficiently appreciated in the medical community.

Cancer Evolution

Cancer Evolution
  • Author : Charles Swanton
  • Publisher :Unknown
  • Release Date :2017
  • Total pages :350
  • ISBN : 9781621821434
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Summary : Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Exam Prep Flash Cards for Ecology and Evolution of Cancer

Exam Prep Flash Cards for Ecology and Evolution of Cancer
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Evolutionary Dynamics

Evolutionary Dynamics
  • Author : Martin A. Nowak
  • Publisher :Unknown
  • Release Date :2006-09-29
  • Total pages :377
  • ISBN : 0674417755
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Summary : At a time of unprecedented expansion in the life sciences, evolution is the one theory that transcends all of biology. Any observation of a living system must ultimately be interpreted in the context of its evolution. Evolutionary change is the consequence of mutation and natural selection, which are two concepts that can be described by mathematical equations. Evolutionary Dynamics is concerned with these equations of life. In this book, Martin A. Nowak draws on the languages of biology and mathematics to outline the mathematical principles according to which life evolves. His work introduces readers to the powerful yet simple laws that govern the evolution of living systems, no matter how complicated they might seem. Evolution has become a mathematical theory, Nowak suggests, and any idea of an evolutionary process or mechanism should be studied in the context of the mathematical equations of evolutionary dynamics. His book presents a range of analytical tools that can be used to this end: fitness landscapes, mutation matrices, genomic sequence space, random drift, quasispecies, replicators, the Prisoner’s Dilemma, games in finite and infinite populations, evolutionary graph theory, games on grids, evolutionary kaleidoscopes, fractals, and spatial chaos. Nowak then shows how evolutionary dynamics applies to critical real-world problems, including the progression of viral diseases such as AIDS, the virulence of infectious agents, the unpredictable mutations that lead to cancer, the evolution of altruism, and even the evolution of human language. His book makes a clear and compelling case for understanding every living system—and everything that arises as a consequence of living systems—in terms of evolutionary dynamics.

Felines of the World

Felines of the World
  • Author : Giovanni G. Bellani
  • Publisher :Unknown
  • Release Date :2019-09-19
  • Total pages :486
  • ISBN : 0128172770
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Summary : Felines of the World: Discoveries in Taxonomic Classification and History provides the most recent taxonomic, paleontological, phylogenetic and DNA advances of wild felid and domestic cat species following guidelines dictated by the IUCN SSC Cat Specialist Group. It highlights the importance of felines and their role as predators in maintaining the ecological biome balance in which they have evolved. The book delves into the anatomical, evolutionary and zoogeographic features of fossil and current felid species. Each species is described in detail, detailing its classification, habitat and biological habits. This book also presents the most updated threat and conservation status of each species. This book is an ideal resource for zoologists and paleontologists, primarily those interested in the evolution and features of extinct and extant felines. Details the lineage, features and habits of over 40 felid species Covers all species within the Felidae family, including lions, lynxes, pumas and domestic cats Features detailed and colorful illustrations, diagrams and species location maps Informs readers on endangered species, current threats and conservation efforts

Debating Cancer

Debating Cancer
  • Author : Henry H Heng
  • Publisher :Unknown
  • Release Date :2015-10-08
  • Total pages :464
  • ISBN : 9814520861
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Summary : Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research. Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers. Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research

Frontiers in Ecology, Evolution and Complexity

Frontiers in Ecology, Evolution and Complexity
  • Author : Mariana Benítez,Octavio Miramontes,Alfonso Valiente-Banuet
  • Publisher :Unknown
  • Release Date :2014-07-08
  • Total pages :266
  • ISBN : 1938128052
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Summary : Advances in molecular biology, remote sensing, systems biology, bioinformatics, non-linear science, the physics of complex systems and other fields have rendered a great amount of data that remain to be integrated into models and theories that are capable of accounting for the complexity of ecological systems and the evolutionary dynamics of life. It is thus necessary to provide a solid basis to discuss and reflect on these and other challenges both at the local and global scales. This volume aims to delineate an integrative and interdisciplinary view that suggests new avenues in research and teaching, critically discusses the scope of the diverse methods in the study of complex systems, and points at key open questions. Finally, this book will provide students and specialists with a collection of high quality open access essays that will contribute to integrate Ecology, Evolution and Complexity in the context of basic research and in the field of Sustainability Sciences.

Microphysics of Clouds and Precipitation

Microphysics of Clouds and Precipitation
  • Author : H.R. Pruppacher,J.D. Klett
  • Publisher :Unknown
  • Release Date :2010-06-25
  • Total pages :954
  • ISBN : 0306481006
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Summary : Cloud physics has achieved such a voluminous literature over the past few decades that a significant quantitative study of the entire field would prove unwieldy. This book concentrates on one major aspect: cloud microphysics, which involves the processes that lead to the formation of individual cloud and precipitation particles. Common practice has shown that one may distinguish among the following addi tional major aspects: cloud dynamics, which is concerned with the physics respon sible for the macroscopic features of clouds; cloud electricity, which deals with the electrical structure of clouds and the electrification processes of cloud and precipi tation particles; and cloud optics and radar meteorology, which describe the effects of electromagnetic waves interacting with clouds and precipitation. Another field intimately related to cloud physics is atmospheric chemistry, which involves the chemical composition ofthe atmosphere and the life cycle and characteristics of its gaseous and particulate constituents. In view of the natural interdependence of the various aspects of cloud physics, the subject of microphysics cannot be discussed very meaningfully out of context. Therefore, we have found it necessary to touch briefly upon a few simple and basic concepts of cloud dynamics and thermodynamics, and to provide an account of the major characteristics of atmospheric aerosol particles. We have also included a separate chapter on some of the effects of electric fields and charges on the precipitation-forming processes.

Cancer

Cancer
  • Author : Mel Greaves
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :276
  • ISBN : 9780192628343
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Summary : In this fascinating and highly readable new book, Mel Greaves shows how the origins of cancer are inextricably linked with our evolutionary heritage, and considers the implications of this theory for future research and treatment.

The Complexity Paradox

The Complexity Paradox
  • Author : Kenneth Mossman
  • Publisher :Unknown
  • Release Date :2014-08-26
  • Total pages :240
  • ISBN : 0199330360
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Summary : Living systems exhibit a fundamental contradiction: they are highly stable and reliable, yet they have the capacity to adapt to changing environmental conditions. This paradoxical behavior arises from the complexity of life--a high degree of order and cooperation that emerges from relatively simple interactions among cellular components. The Complexity Paradox proposes inventive, interdisciplinary approaches to maintaining health and managing and preventing disease by considering the totality of human biology, from the cellular level on up to entire populations of individuals. From the perspective of complexity, which acknowledges that there are limits to what we can know, Kenneth L. Mossman opens the door to understanding essential life processes in new and extraordinary ways. By tying together evolution, functional dynamics, and investigations into how the body processes energy and uses genetic information, Mossman's analysis expresses a unified theory of biology that fills a critical niche for future research in biology, medicine, and public health.

Unsolved Problems in Ecology

Unsolved Problems in Ecology
  • Author : Andrew Dobson,David Tilman,Robert D. Holt
  • Publisher :Unknown
  • Release Date :2020-06-02
  • Total pages :229
  • ISBN : 0691195323
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Summary : Leading ecologists discuss some of the most compelling open questions in the field today Unsolved Problems in Ecology brings together many of the world's leading ecologists to discuss the most fundamental research questions confronting the field today. This diverse and thought-provoking collection of essays spans virtually all of the key subfields of the discipline, from behavioral and evolutionary ecology to population biology, community ecology, ecosystem ecology, disease ecology, and conservation biology. These essays are intended to stoke curiosity, challenge prevailing wisdom, and provoke new ways of thinking about ecology in light of new technologies and unprecedented environmental challenges brought on by climate and land-use change. Authoritative and accessible, Unsolved Problems in Ecology is ideal for graduate students in the early stages of their scientific careers and an essential resource for seasoned ecologists looking for exciting new directions to take their research. Sheds light on modern ecology's most important and compelling open questions Features thought-provoking contributions from more than two dozen world-class ecologists Covers behavior, evolution, communities, ecosystems, resource management, and more Discusses ways to raise the financial and intellectual profile of the discipline An invaluable resource for graduate students as well as seasoned ecologists

Ramón María Del Valle-Inclán

Ramón María Del Valle-Inclán
  • Author : Carol Maier,Roberta L. Salper
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :264
  • ISBN : 9780838752616
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Summary : "This book is a collection of eleven essays devoted to the work of Ramon del Valle-Inclan (1866-1936). Long the recipient of critical analyses from various perspectives, Valle-Inclan's writing has nevertheless been virtually neglected in the gender-based criticism that has given rise to important studies of his contemporaries in other European literatures. This means that his diverse female characters have not been fully examined, that many scholars continue to consider him an unqualified misogynist, and that a marked effort to surmount gender constraints, present throughout his work, has not been acknowledged, much less explicated. This lack of study is intimately related to a much broader lacuna in Hispanic literature and scholarship, for the working of gender norms and their interaction with economic, religious, and political institutions inscribed in the literature of turn-of-the-century Spain have only recently begun to receive detailed study." "The essays in this volume identify, explore, and interrogate issues of gender with respect to Valle-Inclan's writing. The results offer an altered portrait of Valle-Inclan in which attitudes attributed to him are questioned and reevaluated. In particular, studies of several strong female characters indicate that he envisioned a far more complex role for women than has formerly been recognized." "Three previously published essays were chosen to provide a grounding in work on gender and Valle-Inclan. The remaining essays were written for this volume. As an orientation for the reader and in order to assure that the collection will be of use and interest to non-Hispanists as well as specialized readers, an introduction to the collection defines the intentions of the editors, discusses the essays with respect to current criticism, and places Valle-Inclan and his writing in turn-of-the-century Spanish history and aesthetics. As a whole, the collection reads as far more than the sum of its individual essays, prompting a fuller appreciation of both Valle-Inclan and the social and cultural system to which he belongs."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 9780815332183
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Summary :

The Spirit of the Hive

The Spirit of the Hive
  • Author : Robert E. Page Jr.
  • Publisher :Unknown
  • Release Date :2013-06-01
  • Total pages :240
  • ISBN : 0674075544
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Summary : How can 40,000 bees working in the dark, by instinct alone, construct a honey comb? Synthesizing decades of experiments, The Spirit of the Hive presents the genetic and physiological mechanisms underlying the division of labor in honey bee colonies and explains how it is an inevitable product of group living, evolving over millions of years.

Phishing Exposed

Phishing Exposed
  • Author : Lance James
  • Publisher :Unknown
  • Release Date :2005-11-21
  • Total pages :450
  • ISBN : 9780080489537
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Summary : Phishing Exposed unveils the techniques phishers employ that enable them to successfully commit fraudulent acts against the global financial industry. Also highlights the motivation, psychology and legal aspects encircling this deceptive art of exploitation. The External Threat Assessment Team will outline innovative forensic techniques employed in order to unveil the identities of these organized individuals, and does not hesitate to remain candid about the legal complications that make prevention and apprehension so difficult today. This title provides an in-depth, high-tech view from both sides of the playing field, and is a real eye-opener for the average internet user, the advanced security engineer, on up through the senior executive management of a financial institution. This is the book to provide the intelligence necessary to stay one step ahead of the enemy, and to successfully employ a pro-active and confident strategy against the evolving attacks against e-commerce and its customers. * Unveils the techniques phishers employ that enable them to successfully commit fraudulent acts * Offers an in-depth, high-tech view from both sides of the playing field to this current epidemic * Stay one step ahead of the enemy with all the latest information

The Challenge of Problem-based Learning

The Challenge of Problem-based Learning
  • Author : David Boud,Grahame Feletti
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :344
  • ISBN : 9780749425609
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Summary : Looks at this method both systematically and critically to highlight its significance, its uses, its strengths, and limitations. Looks at issues such as: conversion to PBL; organizational and institutional hostility; accreditation and assessment; issues in implementation and the furure of PBL.

T. S. Eliot, Anti-Semitism, and Literary Form

T. S. Eliot, Anti-Semitism, and Literary Form
  • Author : Anthony Julius
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :308
  • ISBN : 9780521586733
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Summary : Julius's critically acclaimed study (looking both at the detail of Eliot's deployment of anti-Semitic discourse and at the role it played in his greater literary undertaking) has provoked a reassessment of Eliot's work among poets, scholars, critics and readers, which will invigorate debate for some time to come.