Download Emerging Concepts In Ribosome Structure Biogenesis And Function Book PDF

Download full Emerging Concepts In Ribosome Structure Biogenesis And Function books PDF, EPUB, Tuebl, Textbook, Mobi or read online Emerging Concepts In Ribosome Structure Biogenesis And Function anytime and anywhere on any device. Get free access to the library by create an account, fast download and ads free. We cannot guarantee that every book is in the library.

Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Emerging Concepts in Ribosome Structure, Biogenesis, and Function
  • Author : Vijay Kumar
  • Publisher :Unknown
  • Release Date :2019-11
  • Total pages :500
  • ISBN : 012816364X
GET BOOK HERE

Summary : Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research.

The Biogenesis of Cellular Organelles

The Biogenesis of Cellular Organelles
  • Author : Chris Mullins
  • Publisher :Unknown
  • Release Date :2007-03-06
  • Total pages :181
  • ISBN : 9780387268675
GET BOOK HERE

Summary : The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.

The Nucleolus

The Nucleolus
  • Author : Mark O. J. Olson
  • Publisher :Unknown
  • Release Date :2011-09-15
  • Total pages :414
  • ISBN : 9781461405146
GET BOOK HERE

Summary : Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Affect Regulation and the Origin of the Self

Affect Regulation and the Origin of the Self
  • Author : Allan N. Schore
  • Publisher :Unknown
  • Release Date :2012-08-06
  • Total pages :736
  • ISBN : 9781135693923
GET BOOK HERE

Summary : During the past decade a diverse group of disciplines have simultaneously intensified their attention upon the scientific study of emotion. This proliferation of research on affective phenomena has been paralleled by an acceleration of investigations of early human structural and functional development. Developmental neuroscience is now delving into the ontogeny of brain systems that evolve to support the psychobiological underpinnings of socioemotional functioning. Studies of the infant brain demonstrate that its maturation is influenced by the environment and is experience-dependent. Developmental psychological research emphasizes that the infant's expanding socioaffective functions are critically influenced by the affect-transacting experiences it has with the primary caregiver. Concurrent developmental psychoanalytic research suggests that the mother's affect regulatory functions permanently shape the emerging self's capacity for self-organization. Studies of incipient relational processes and their effects on developing structure are thus an excellent paradigm for the deeper apprehension of the organization and dynamics of affective phenomena. This book brings together and presents the latest findings of socioemotional studies emerging from the developmental branches of various disciplines. It supplies psychological researchers and clinicians with relevant, up-to-date developmental neurobiological findings and insights, and exposes neuroscientists to recent developmental psychological and psychoanalytic studies of infants. The methodology of this theoretical research involves the integration of information that is being generated by the different fields that are studying the problem of socioaffective development--neurobiology, behavioral neurology, behavioral biology, sociobiology, social psychology, developmental psychology, developmental psychoanalysis, and infant psychiatry. A special emphasis is placed upon the application and incorporation of current developmental data from neurochemistry, neuroanatomy, neuropsychology, and neuroendocrinology into the main body of developmental theory. More than just a review of several literatures, the studies cited in this work are used as a multidisciplinary source pool of experimental data, theoretical concepts, and clinical observations that form the base and scaffolding of an overarching heuristic model of socioemotional development that is grounded in contemporary neuroscience. This psychoneurobiological model is then used to generate a number of heuristic hypotheses regarding the proximal causes of a wide array of affect-related phenomena--from the motive force that drives human attachment to the proximal causes of psychiatric disturbances and psychosomatic disorders, and indeed to the origin of the self.

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : STANFORD:36105122112191
GET BOOK HERE

Summary :

Advances in Cell Biology

Advances in Cell Biology
  • Author : Josef Berger
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :184
  • ISBN : WISC:89081602898
GET BOOK HERE

Summary :

The Eukaryotic Ribosome

The Eukaryotic Ribosome
  • Author : H. Bielka
  • Publisher :Unknown
  • Release Date :2011-11-23
  • Total pages :338
  • ISBN : 364268274X
GET BOOK HERE

Summary : Contents References 11 II. A short historical survey 13 References 16 III. Ribosomes within the cell 20 1. Proportion of ribosomes in tissues 21 2. Free and membrane-bound ribo- mes 22 3. Ribosomes in nucleoli 26 4. Structure of polysomes in the cell 26 5. Ribosomal crystals 33 6. References 33 IV. Some general properties of ribosomes 41 1. Physical characteristics 41 2. Chemical characteristics 43 3. References 44 V. Morphology of ribosomes and poly somes 47 1. Electron microscopy 47 a) The small ribosomal subunit 48 b) The large ribosomal subunit 48 c) The monomeric ribosome 52 d) Three-dimensional models 54 e) Polysomes 55 2. Small-angle X-ray scattering 55 a) The monomeric ribosome 56 b) Polysomes 57 3. References 57 VI. Chemical components 61 1. Ribosomal proteins 61 a) Electrophoretic separation and num ber 61 b) Preparation of single ribosomal pro teins 67 c) Molecular weights 68 d) Amino acid composition and amino acid sequences 71 e) Stoichiometry 71 f) Posttranslational modifications 72 g) Comparison of ribosomal proteins of different tissues 73 h) Species specificities and evolution 74 i) Ribosomal proteins of mitochondria and chloroplasts 75 k) Ribosomal mutants with altered pro teins 75 5 3. Formation of preribosomal 2. Phosphorylation of ribosomal prote particles 139 ins 76 4. References 141 a) In vitro phosphorylation and de phosphorylation 76 VIII. Dissociation - reassociation processes b) In vivo phosphorylation 77 of ribosomal particles 151 c) Phosphorylation of ribosomal pro tein S 6 78 1.

ASM News

ASM News
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :229
  • ISBN : UCLA:L0058111113
GET BOOK HERE

Summary :

Visions of the Cell Nucleus

Visions of the Cell Nucleus
  • Author : Peter Hemmerich,Stephan Diekmann
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :319
  • ISBN : STANFORD:36105114298271
GET BOOK HERE

Summary : Visions of the Cell Nucleus brings together scientists working on different aspects of structure and function of the mammalian cell nucleus. The goal of this book is to give a state-of-the-art overview on chromatin organization, function and dynamics of subnuclear structures, gene expression, DNA distribution, and disease. Emphasis is put on new ideas of dynamic structure/function relationships revealed by the recent advent of new microscopy techniques as well as on subnuclear pathology and disease associations. The book provides all the information researchers, scientists and professionals need for this rapidly growing field. This is the most up-to-date reference on latest and emerging new research aspects of mammalian cell nucleus. It has 18 state-of-the-art review chapters written by world-renowned experts from universities and research institutes.

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
GET BOOK HERE

Summary :

The Translational Apparatus

The Translational Apparatus
  • Author : K.H. Nierhaus,F. Franceschi,A.R. Subramanian,Volker Alfred Erdmann,Brigitte Wittmann-Liebold
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :746
  • ISBN : 9781461524076
GET BOOK HERE

Summary : Proceedings of an international conference held in Berlin, Germany, October 31-November 5, 1992

Regulatory Nascent Polypeptides

Regulatory Nascent Polypeptides
  • Author : Koreaki Ito
  • Publisher :Unknown
  • Release Date :2014-08-19
  • Total pages :315
  • ISBN : 9784431550525
GET BOOK HERE

Summary : This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.

Ribosomes Structure, Function, and Dynamics

Ribosomes Structure, Function, and Dynamics
  • Author : Marina V. Rodnina,Wolfgang Wintermeyer,Rachel Green
  • Publisher :Unknown
  • Release Date :2011-12-10
  • Total pages :442
  • ISBN : 9783709102152
GET BOOK HERE

Summary : The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

The Plasticity of Skeletal Muscle

The Plasticity of Skeletal Muscle
  • Author : Kunihiro Sakuma
  • Publisher :Unknown
  • Release Date :2017-03-01
  • Total pages :292
  • ISBN : 9789811032929
GET BOOK HERE

Summary : This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demands, appears to endocrine various myokines, which flow into blood to protect the recognizing function of brain and inhibit the appearance of several cancer tumorigenesis. The book deals with current stem-cell based, pharmacological, and nutritional therapies for muscle wasting (sarcopenia, cachexia, and muscular dystrophy). It also explains the roles of biological mediators such as PGC-1, transient receptor potential cation channels (TRPC), and AMPK in modulating muscle function. The functional roles of ubiquitin-proteasome system, autophagy-dependent signaling in muscle homeostasis, ribosome biogenesis, and redox regulation of mechanotransduction to modulate skeletal muscle mass are also covered. It is an essential resource for physicians, researchers, post-docs as well as graduate students in the field of sports science including rehabilitation therapy, exercise physiology, exercise biochemistry, and molecular biology dealing with skeletal muscle.

The Membranes of Cells

The Membranes of Cells
  • Author : Philip Yeagle
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :349
  • ISBN : UOM:39015026979164
GET BOOK HERE

Summary : In this new edition of The Membranes of Cells, all of the chapters have been updated, some have been completely rewritten, and a new chapter on receptors has been added. The book has been designed to provide both the student and researcher with a synthesis of information from a number of scientific disciplines to create a comprehensive view of the structure and function of the membranes of cells. The topics are treated in sufficient depth to provide an entry point to the more detailed literature needed by the researcher. Key Features * Introduces biologists to membrane structure and physical chemistry * Introduces biophysicists to biological membrane function * Provides a comprehensive view of cell membranes to students, either as a necessary background for other specialized disciplines or as an entry into the field of biological membrane research * Clarifies ambiguities in the field

Regulating with RNA in Bacteria and Archaea

Regulating with RNA in Bacteria and Archaea
  • Author : Gisela Storz,Kai Papenfort
  • Publisher :Unknown
  • Release Date :2020-07-10
  • Total pages :400
  • ISBN : 9781683670247
GET BOOK HERE

Summary : Revealing the many roles of RNA in regulating gene expression For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation. All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. Divided into eight sections-RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources-this book serves as an excellent resource for established RNA biologists and for the many scientists who are studying regulated cellular systems. It is no longer a fair assumption that gene expression regulation is the provenance of proteins only or that control is exerted primarily at the level of transcription. This book makes clear that regulatory RNAs are key partners along with proteins in controlling the complex interactions and pathways found within prokaryotes.

Translation Mechanisms and Control

Translation Mechanisms and Control
  • Author : Michael B. Mathews,Nahum Sonenberg,John W. B. Hershey
  • Publisher :Unknown
  • Release Date :2018-09-30
  • Total pages :499
  • ISBN : 1621821862
GET BOOK HERE

Summary : A subject collection from Cold Spring Harbor Perspectives in Biology.

The Functional Nucleus

The Functional Nucleus
  • Author : David P. Bazett-Jones,Graham Dellaire
  • Publisher :Unknown
  • Release Date :2016-10-17
  • Total pages :513
  • ISBN : 9783319388823
GET BOOK HERE

Summary : This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics
  • Author : Anita Göndör
  • Publisher :Unknown
  • Release Date :2016-10-25
  • Total pages :496
  • ISBN : 9780128034026
GET BOOK HERE

Summary : Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy
  • Author : Steven Gray
  • Publisher :Unknown
  • Release Date :2015-07-01
  • Total pages :748
  • ISBN : 9780128002247
GET BOOK HERE

Summary : Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Trafficking Inside Cells

Trafficking Inside Cells
  • Author : Nava Segev
  • Publisher :Unknown
  • Release Date :2010-05-30
  • Total pages :445
  • ISBN : 9780387938776
GET BOOK HERE

Summary : This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.