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Endothelial Signaling in Vascular Dysfunction and Disease

Endothelial Signaling in Vascular Dysfunction and Disease
  • Author : Shampa Chatterjee
  • Publisher :Unknown
  • Release Date :2021-01-20
  • Total pages :274
  • ISBN : 9780128163825
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Summary : Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestations of clinical disease Presents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular disease Includes recent findings on the relationship between endothelial signaling, chemotherapy and radiation induced endothelial dysfunction

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases
  • Author : Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
  • Publisher :Unknown
  • Release Date :2018-02-03
  • Total pages :758
  • ISBN : 9780128125519
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Summary : Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes

Mechanisms of Vascular Disease

Mechanisms of Vascular Disease
  • Author : Robert Fitridge,Matthew Thompson
  • Publisher :Unknown
  • Release Date :2011-01-01
  • Total pages :587
  • ISBN : 9781922064004
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Summary : New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Endothelial Dysfunction

Endothelial Dysfunction
  • Author : Helena Lenasi
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :430
  • ISBN : 9781789842531
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Summary : The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Vascular Development

Vascular Development
  • Author : Derek J. Chadwick,Jamie A. Goode
  • Publisher :Unknown
  • Release Date :2007-08-20
  • Total pages :260
  • ISBN : 9780470319420
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Summary : The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Ion Channels and Calcium Signaling in the Microcirculation

Ion Channels and Calcium Signaling in the Microcirculation
  • Author : William F. Jackson
  • Publisher :Unknown
  • Release Date :2020-06
  • Total pages :310
  • ISBN : 9780128200902
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Summary : Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more. Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.

Endothelium

Endothelium
  • Author : Ayse Basak Engin,Atilla Engin
  • Publisher :Unknown
  • Release Date :2013-05-29
  • Total pages :468
  • ISBN : 9781466582798
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Summary : The function and life span of endothelial cells have a large impact upon the quality and expectancy of an individual's life. During low perfusion, the adaptation of different cells to hypoxia precipitate the aggressive progression of diseases. Although the clinical studies have convincingly shown that endothelial dysfunction occurs whenever the biological functions or bioavailability of nitric oxide are impaired, in all these scenarios, the role of endothelial cell-destructive process cross-talk is yet poorly understood. This book focuses on the contribution of molecular mechanisms to endothelial dysfunction in related metabolic disorders.

Biomedical Index to PHS-supported Research

Biomedical Index to PHS-supported Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :229
  • ISBN : MINN:31951P003778522
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Summary :

Calcium and Signal Transduction

Calcium and Signal Transduction
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :202
  • ISBN : 9781789842494
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Summary : Since the development of microelectronic clamping methodology and fluorescent indicators for direct measurement of dynamic intracellular calcium transients, our understanding of biological signal transduction has progressed dramatically since the 1980s. Calcium is a universal signal in biology that modulates gene expression, transmitter and hormone release, muscular movement, and even "programmed" cell death. This book represents a compilation of chapters from a diverse set of expert biologists throughout the world who have conducted research in the general area of calcium signaling in organisms ranging from bacteria to humans. In accord with priorities of resolving human disease, the reader will also benefit from learning calcium's role in cellular signaling pathology relating to acute or chronic conditions such as vomiting, sepsis, obesity, hypertension, and cancer.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
  • Author : Wolfgang B. Liedtke, MD, PH.D.
  • Publisher :Unknown
  • Release Date :2006-09-29
  • Total pages :467
  • ISBN : 9781420005844
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Summary : Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :229
  • ISBN : UIUC:30112047003154
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Summary :

Endothelial Dysfunction and Inflammation

Endothelial Dysfunction and Inflammation
  • Author : Shauna Dauphinee,Aly Karsan
  • Publisher :Unknown
  • Release Date :2010-09-24
  • Total pages :234
  • ISBN : 9783034601689
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Summary : Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.

Pediatric Hypertension

Pediatric Hypertension
  • Author : Ronald J. Portman,Jonathan M. Sorof,Julie R. Ingelfinger
  • Publisher :Unknown
  • Release Date :2004-06-12
  • Total pages :492
  • ISBN : 9781592597970
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Summary : The importance of hypertension in children and adolescents is becoming incre- ingly recognized by physicians and scientists in the 21st century. However, in contrast to the attention that hypertension has received in the adult population for the past three decades since the first Joint National Committee (JNC) report, research and clinical knowledge that involves hypertension in children is still very much in its own childhood. Pediatric Hypertension, edited by Drs. Portman, Sorof, and Ingelfinger, is undoubtedly the most up-to-date and clinically relevant contribution to the field of hypertension in children available because it brings together the numerous pathophysiologic, diagnostic, and therapeutic advances in the evaluation of high blood pressure in infants, children, and adolescents. The editors have carefully organized their volume into sections that cover blood pressure regulation in infants and children, blood pressure measurement issues, pat- physiology and clinical assessment for essential and secondary forms of hypertension during childhood, and nonpharmacologic and pharmacologic approaches to the tre- ment of hypertension in children.

Sudden Coronary Death

Sudden Coronary Death
  • Author : Henry M. Greenberg,Edward M. Dwyer
  • Publisher :Unknown
  • Release Date :1982
  • Total pages :484
  • ISBN : 0897661532
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Summary :

Microvascular Research: Biology and Pathology, Two-Volume Set

Microvascular Research: Biology and Pathology, Two-Volume Set
  • Author : David Shepro
  • Publisher :Unknown
  • Release Date :2005-11-17
  • Total pages :1296
  • ISBN : 9780126395105
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Summary : The microvasculature refers to the smallest blood vessels, arterial and venous, that nurture the tissues of each organ. Apart from transport, they also contribute to the systematic regulation of the body. In everyday terminology, the microcirculation is "where the action is." Microcirculation is directly involved in such disease states as Alzheimers, inflammation, tumor growth, diabetic retinopathy, and wound healing- plus cardiovascular fitness is directly related to the formation of new capillaries in large muscles. Microvascular Research is the first book devoted exclusively to this vital systemic component of the cardiovascular system and provides up to date mini-reviews of normal functions and clinical states. The contributing authors are senior scientists with international reputation in their given disciplines. This two-volume set is a broad, interdisciplinary work that encompasses basic research and clinical applications equally. * Broad coverage of both basic and clinical aspects of microvasculature research * Contains 167 chapters from over 300 international authors * Each chapter includes key figures and annotated references

Endothelial Signaling in Development and Disease

Endothelial Signaling in Development and Disease
  • Author : Mirko HH Schmidt,Stefan Liebner
  • Publisher :Unknown
  • Release Date :2015-10-08
  • Total pages :401
  • ISBN : 9781493929078
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Summary : This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.

Vasculitis In Practice

Vasculitis In Practice
  • Author : Reem Mohammed
  • Publisher :Unknown
  • Release Date :2018-09-19
  • Total pages :112
  • ISBN : 9781789236989
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Summary : "Vasculitis" describes an inflammatory process that involves the blood vessels and contributes to vascular damage. Autoimmunity, infections, drugs, and malignancies have been considered among potential etio-pathogenic factors. In vasculitis, the inflammation might develop in either a systemic or an organ-specific form and might exist as an independent pathology "primary vasculitis" or as a presentation of an existing primary pathology, that is, "secondary vasculitis". This book Vasculitis In Practice-An Update on Special Situations - Clinical and Therapeutic Considerations unlike many publications in the field, uses a different evidence-based approach to organ-specific vascular inflammatory diseases. The authors highlighted the unmet needs from the 1994 Chapel Hill Consensus Conference introducing the latest clinically relevant definitions for the different forms of vasculitis revised in 2012. The identification, classification, and management of kidney disease with different types of vasculitis with an evidence-based update on proposed therapeutic strategies are presented in this publication.

Studies on Atherosclerosis

Studies on Atherosclerosis
  • Author : Martin Rodriguez-Porcel,Alejandro R. Chade,Jordan D. Miller
  • Publisher :Unknown
  • Release Date :2016-12-22
  • Total pages :138
  • ISBN : 9781489976932
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Summary : This volume explores the role free radicals and antioxidants within the development of vascular disease, examining fundamental research and translating preclinical knowledge to clinical trials. The expertly authored chapters describe the relationship of oxidative stress to atherosclerosis and the cardiovascular system, exploring its role in cardiac fibrosis, renovascular disease, hypertension, and regulation of blood pressure and cerebral vascular tone. The concluding chapter discusses the current state of clinical research, contextualizing clinical trials within the existing theoretical framework and analyzing attempts to preserve oxidant stress under various conditions. With its concise and authoritative analysis of pre-clinical research and clinical results, Studies in Atherosclerosis – part of the bestselling Oxidative Stress in Basic Research and Clinical Practice series – is essential for researchers and clinicians focusing in cardiology, nephrology, or oxidative stress.

Vascular Responses to Pathogens

Vascular Responses to Pathogens
  • Author : Felicity N.E. Gavins,Karen Y. Stokes
  • Publisher :Unknown
  • Release Date :2015-10-31
  • Total pages :252
  • ISBN : 9780128013250
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Summary : Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs

Endothelial Cells in Health and Disease

Endothelial Cells in Health and Disease
  • Author : William C. Aird
  • Publisher :Unknown
  • Release Date :2005-02-28
  • Total pages :512
  • ISBN : 9781135534608
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Summary : This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

Physiologic and Pathologic Angiogenesis

Physiologic and Pathologic Angiogenesis
  • Author : Dan Simionescu,Agneta Simionescu
  • Publisher :Unknown
  • Release Date :2017-04-05
  • Total pages :464
  • ISBN : 9789535130239
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Summary : The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.