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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780123944054
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Summary : Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Jenny Hsieh,Hongjun Song
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058473
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Summary :

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Tie Yuan Zhang,Christian Caldji,Josie C. Diorio,Sabine Dhir,Gustavo Turecki,Michael J. Meaney
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058398
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Summary :

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : J. David Sweatt,Eric J. Nestler,Michael J. Meaney,Schahram Akbarian
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058367
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Summary :

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Jeremy J. Day,J. David Sweatt
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058404
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Morgan Bridi,Ted Abel
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058374
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Isabelle M. Mansuy,Rahia Mashoodh,Frances A. Champagne
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058480
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Michael J. Meaney,Schahram Akbarian,Eric J. Nestler,J. David Sweatt
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058497
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Rahul Bharadwaj,Cyril J. Peter,Schahram Akbarian
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058428
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Weston T. Powell,Janine M. LaSalle
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058459
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Alfred J. Robison,Jian Feng,Eric J. Nestler
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058411
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Michael J. McConnell,Fred H. Gage
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058466
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Quan Lin,Yi E. Sun
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058442
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Junjie U. Guo,Guo-li Ming,Hongjun Song
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058381
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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System
  • Author : Alexi Nott,Daniel M. Fass,Stephen J. Haggarty,Li-Huei Tsai
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :374
  • ISBN : 9780128058435
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Summary :

Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System

Epigenetic Regulation of Oligodendrocyte Development and Regeneration in the Central Nervous System
  • Author : Danyang He
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :145
  • ISBN : OCLC:1080644320
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Summary :

Epigenetic Gene Regulation in the Mammalian Central Nervous System and Its Implications in Rett Syndrome

Epigenetic Gene Regulation in the Mammalian Central Nervous System and Its Implications in Rett Syndrome
  • Author : Keri Martinowich
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :288
  • ISBN : UCLA:L0096927363
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Summary :

Transcriptional and Epigenetic Regulation of Axon Regeneration

Transcriptional and Epigenetic Regulation of Axon Regeneration
  • Author : Marcus Mahar
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :146
  • ISBN : OCLC:1141793931
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Summary : The mammalian nervous system is a highly intricate network consisting of over a hundred billion specialized cells called neurons. One unique characteristic of neurons is their highly polarized morphology; unlike other cells, neurons project long axonal extensions. These structures allow them to connect and communicate with not only other neurons, but also various cell types in the body and give rise to all motor, sensory, and higher order function. Because axons can extend up to three feet, they are also vulnerable to injury from sources such as traumatic brain and spinal cord injuries, stroke, or neurodegenerative diseases. Indeed, patients who have experienced these injuries often suffer debilitating, irreversible loss of function. Interestingly, whereas neurons which reside in the central nervous system are incapable of regenerating after axon injury, neurons of the peripheral nervous system activate a robust pro-regenerative response capable of promoting long distance regeneration and functional recovery. The molecular mechanisms which underlie this pro-regenerative response may provide key insights into how a pro-regenerative response could be stimulated in injured central nervous system neurons. A comprehensive overview of the known molecular mechanisms involved in this response is reviewed in Chapter 1.As mammals age, the synaptic connections between neurons mature. Following axon injury in peripheral nervous system neurons, the genes involved in synaptic function are turned off and genes required for inducing axon growth are activated. These widespread epigenetic and transcriptional changes require a coordinated effort of epigenetic and transcriptional regulators including epigenetic modifiers, transcription factors, and microRNAs. In Chapter 2, we demonstrated that these changes are, in part, a result of the rapid downregulation of microRNA-9 which occurs following axon injury. At baseline in adult peripheral nervous system neurons, microRNA-9 is highly expressed and actively represses various genes including REST and UHRF1. When microRNA-9 expression decreases following injury, both REST and UHRF1 increase with UHRF1also repressing REST and restricting REST expression to a tight temporal window. During this time, REST binds to and represses various genes involved in synaptic function such as ion channels; a process necessary for peripheral nervous system regeneration. This complete published work can be found in Chapter 2.In coordination with epigenetic modifiers such as UHRF1, various transcription factors are activated following axon injury and promote the expression of pro-growth genes. Various studies have worked to identify the transcription factors involved in this process as exogenous overexpression of transcription factors has been shown to confer specific phenotypes of interest, such as the conversion of one cell type to another, when the correct combination of transcription factors is manipulated. To further this work, in Chapter 3 I used bioinformatics analysis to identify 27 transcription factors putatively involved in the establishment of the pro-regenerative response. Using two complimentary in vitro screens, determined which transcription factors were both necessary for peripheral nervous system axon regeneration and sufficient to drive central nervous system axon regeneration. By pairing these results with network-based bioinformatics analysis, we identified Creb1 as a transcription factor which sits atop the pro-regenerative gene regulatory network. Follow-up studies in which we overexpressed Creb1during optic nerve regeneration demonstrated Creb1 is sufficient to promote central nervous system axon regeneration in vivo. This work provides exciting new insight into the various transcription factors regulating this response as well as their putative genetic relationships.

Epigenetics, Brain and Behavior

Epigenetics, Brain and Behavior
  • Author : Paolo Sassone Corsi,Yves Christen
  • Publisher :Unknown
  • Release Date :2012-10-19
  • Total pages :166
  • ISBN : 9783642279133
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Summary : Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

Epigenetic Gene Regulation in Mouse Embryonic Stem Cells and the Developing Central Nervous System

Epigenetic Gene Regulation in Mouse Embryonic Stem Cells and the Developing Central Nervous System
  • Author : Shaun David Fouse
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :316
  • ISBN : UCLA:L0099890899
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Summary :

Neuroepigenomics in Aging and Disease

Neuroepigenomics in Aging and Disease
  • Author : Raul Delgado-Morales
  • Publisher :Unknown
  • Release Date :2017-05-18
  • Total pages :525
  • ISBN : 9783319538891
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Summary : Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.