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• Author : Michael Donnenberg
• Publisher :Unknown
• Release Date :2013-06-12
• Total pages :612
• ISBN : 9780123977779

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Summary : The 2e of Escherichia coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. This work concludes with a presentation of virulence factors common to two or more pathotypes. The book is a great resource for references and up-to-date knowledge for anyone who studies E. coli pathogenesis, either as established investigators or investigators new to the field. It is also an excellent text for those who teach mechanisms of pathogenesis to graduate students and medical students and wish to have a source of knowledge from which to develop lectures. Offers a single source of information of E. coli pathogenesis written by expert authors Presents comprehensive coverage on molecular mechanisms, biology, evolution and genomics and recent advances

• Author : Amidou Samie
• Publisher :Unknown
• Release Date :2017-07-12
• Total pages :434
• ISBN : 9789535133292

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Summary : Escherichia coli is a versatile organism and very diverse. Members of this species vary from very pathogenic agents causing different types of diseases including meningitis, gastroenteritis, and septicemia, just to cite a few, to harmless organisms living in the intestines of both humans and animals. E. coli has also been used as a model organism for most bacteria except a few. For this reason, its study provides a huge advantage and can help understand the mechanisms involved in different processes such as pathogenesis, environmental disinfection, nutrient utilization, antibiotic resistance, and diagnostic/detection methods, and these are indeed the topics discussed in this book. The book has been divided into four main sections representing the different facets of E. coli applications, which include disease, biotechnology, environmental engineering and innovative approaches to detection, and lastly its physiology and cell biology. Such processes can be applied to the study of other organisms as well considering the development of diversity; for example, many organisms are capable of horizontal gene transfer, which is capable of increasing the fitness of the bacterial organisms involved and has a great impact on the control of such bacterial organism.

• Author : Ellen Kay Miller
• Publisher :Unknown
• Release Date :1994
• Total pages :64
• ISBN : MINN:31951D01743675C

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• Author : Bernard T. Nolan,Charles R. Kratzer,Donna S. Francy,Sharon E. Kroening,Dina K. Saleh,Kerie J. Hitt,R. M. Goldstein,Celia Zamora,Kathy E. Lee,Robert A. Darner
• Publisher :Unknown
• Release Date :2003
• Total pages :31
• ISBN : OSU:32435071965701

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• Author : Julia Rohlhill
• Publisher :Unknown
• Release Date :2020
• Total pages :163
• ISBN : 1392745322

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Summary : Together, we show these approaches to significantly improve the utilization of methanol carbon and energy in E. coli. Future attempts to create a pure synthetic methylotrophy will likely need to continue focusing on regulation and the adequate expression of relevant enzymes for sustained methanol assimilation and growth.

• Author : Cheryl A. Silcox,Bret A. Robinson,Timothy C. Willoughby
• Publisher :Unknown
• Release Date :2002
• Total pages :45
• ISBN : IND:30000085827123

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• Author : Cheryl A. Silcox,David C. Voelker,Timothy C. Willoughby
• Publisher :Unknown
• Release Date :2000
• Total pages :52
• ISBN : IND:30000078833096

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• Author : Nadia Boisen,Karen A. Krogfelt,James P. Nataro
• Publisher :Unknown
• Release Date :2013-06-12
• Total pages :612
• ISBN : 9780128061824

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Summary : Enteroaggregative Escherichia coli (EAEC) are among the most prevalent enteric pathogens worldwide. The pathotype has been implicated in endemic diarrhea in both developing and industrialized populations, epidemic diarrhea, and traveler’s diarrhea. A recent outbreak of Shiga toxin-producing EAEC adds a new dimension to the epidemiology of this pathotype. Although the pathogenesis of this pathotype is not fully understood, a number of putative virulence factors have been described. The aggregative adherence fimbriae (AAF) are mucosal adhesins that also elicit inflammatory responses from infected mucosal surfaces. Expression of AAF adhesins is induced by the transcriptional activator AggR, which activates expression of several other secreted, but as yet relatively cryptic, proteins. EAEC-induced histopathology includes exfoliation of enterocytes, which has been linked to the action of serine protease autotransporter toxins. Epidemiologic evidence supports a model of EAEC pathogenesis comprising the concerted action of multiple virulence factors.

• Author : Amie M. G. Brady
• Publisher :Unknown
• Release Date :2007
• Total pages :26
• ISBN : OCLC:182553602

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• Author : Sang Yup Lee
• Publisher :Unknown
• Release Date :2009-03-20
• Total pages :462
• ISBN : 9781402093944

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Summary : Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.

• Author : Michael Donnenberg
• Publisher :Unknown
• Release Date :2002-10-09
• Total pages :417
• ISBN : 9780080494814

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Summary : Although most strains of E. coli bacteria are harmless and live in the intestines of healthy humans and animals, several strains can produce powerful toxins and cause severe illness in humans. This versatile pathogen is best known for being transmitted to humans through contaminated foods — such as undercooked meat and unpasteurized fruit juice — and has attracts much attention when serious outbreaks occur. E. coli is capable of causing a wide variety of diseases — from urinary tract infections to meningitis. A considerable amount of media coverage has recently been devoted to one particular strain of E. coli, responsible for an estimated 73,000 cases of infection and 61 deaths in the United States each year. Knowing more about the biology, the evolution, and the genetic basis of this pathogen is crucial to future prevention of infection and illness. Pathogenic E. coli is a unique, comprehensive analysis of the biology and molecular mechanisms that enable this ubiquitous organism to thrive. Leading investigators in the field discuss the molecular basis of E. coli pathogenesis followed by chapters on genomics and evolution. Detailed descriptions of distinct strains reveal the molecular pathogenesis of each and the causes of intestinal and extra-intestinal infections in humans. Pathogenic E. coli concludes with a presentation of virulance factors, common to two or more pathotypes. This unique collection presents timely and vital information on understanding the inner workings of E. coli, which will lend key insights into disease prevention research. Single source of information of E. coli pathogenesis Expert authors Comprehensive coverage Molecular mechanisms Biology, evolution and genomics Recent advances

• Author : Steven L. Percival,Marylynn V. Yates,David Williams,Rachel Chalmers,Nicholas Gray
• Publisher :Unknown
• Release Date :2013-11-08
• Total pages :696
• ISBN : 9780124159761

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Summary : The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters

• Author : Alfredo G. Torres
• Publisher :Unknown
• Release Date :2016-10-14
• Total pages :384
• ISBN : 9783319450926

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Summary : Bacterial diarrheal diseases remain an important leading cause of preventable death, especially among children under five in developing countries. In the American continent, diarrheal disease and other health complications caused by Escherichia coli constitute a major public health problem, and, therefore, several research groups have dedicated their effort to understand this pathogen and provide feasible solutions to prevent, treat and reduce E. coli infections. The Latin American Coalition for Escherichia coli Research (LACER) was created as a multidisciplinary network of international research groups working with E. coli with the ultimate goal of advancing understanding of E. coli, and to prepare the next generation of American E. coli investigators. As such, this book compiles the knowledge of these investigators about E. coli, a commensal bacteria living inside its host, and a pathogen causing disease in animals and humans. Escherichia coli in the Americas contains a series of 15 chapters written by experts, covering basic concepts regarding the different categories of E. coli, including their environmental niche, virulence mechanisms, host reservoir, and disease outcomes, as well as diagnosis, vaccine development and treatment. This book's target audience include trainees and students learning about the basic and clinical aspects of E. coli pathogenesis, as well as experts around the globe who wish to learn more about this pathogen and the public health impact this bacteria has in America.

• Author : Jen Shu
• Publisher :Unknown
• Release Date :1989
• Total pages :376
• ISBN : CORNELL:31924052472267

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• Author : Maria J. Schilstra
• Publisher :Unknown
• Release Date :1986
• Total pages :123
• ISBN : CORNELL:31924059882336

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• Author : Debora Ruth Channing
• Publisher :Unknown
• Release Date :2010
• Total pages :229
• ISBN : OCLC:757115990

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Summary : Although bacteria do not contain ubiquitin or ubiquitin homologues, the accurate proteolytic processing of ubiquitin precursors and ubiquitin fusion proteins in lab strains of Escherichia coli has previously been noted. We provide evidence that a novel ubiquitin-fusion processing activity in E. coli substrain RosettaTM2(DE3) represents a specific DUB activity against linear (peptide-linked) ubiquitin fusions. Fusions of ubiquitin linked to an ATP-binding cassette protein (LmrC) or to enhanced green fluorescent protein (EGFP), expressed in RosettaTM2(DE3) were cleaved precisely after the C-terminal Gly76 of ubiquitin. The use of gene knock-out showed that the source of the ubiquitin-fusion processing activity in RosettaTM2(DE3) is the ubiquitin-like protease, elaD; as specific ubiquitin-fusion processing was ablated by the inactivation of the elaD gene. Whilst this study was in progress, Catic et al. showed that elaD is present in the commensal E. coli strain K12 and intestinal pathogenic strains, but absent from extraintestinal pathogenic strains, and exhibits deubiquitinating activity in vitro against the generic substrate ubiquitin-AMC14. Our study has demonstrated that elaD not only exhibits deubiquitinating activity against linear ubiquitin fusions, but also possesses isopeptidase activity, with a preference for unanchored Lys63-linked poly-ubiquitin chains over Lys48-linked forms. GST-elaD has also been shown in this study to bind specifically to immobilised mammalian ubiquitin in pull-down assays. Thus, elaD is a bacterial enzyme which has the ability to functionally interact with the highly conserved eukaryotic ubiquitin protein and indicate that elaD may have a role in regulating host-microbe interactions.

• Author : Centers for Disease Control and Prevention CDC
• Publisher :Unknown
• Release Date :2017-04-17
• Total pages :672
• ISBN : 9780190628635

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Summary : THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

• Author : E. C. C. Lin,A. Simon Lynch
• Publisher :Unknown
• Release Date :2012-12-06
• Total pages :592
• ISBN : 9781468486018

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Summary : This up-to-date guide focuses on the understanding of key regulatory mechanisms governing gene expression in Escherichia coli. Studies of E. coli not only provide the first models of gene regulation, but research continues to yield different control mechanisms.

• Author : Max Sussman,Professor of Bacteriology Department of Microbiology Max Sussman
• Publisher :Unknown
• Release Date :1997-03-27
• Total pages :639
• ISBN : 0521453615

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Summary : This comprehensive compilation, written by an authoritative team of international contributors, surveys the role E. coli plays in health and disease. First, the diseases in humans and animals attributable to E. coli are described in general terms, including a discussion of the part it plays in the normal flora of humans and animals. The next section is devoted to each of the recognized virulence factors and mechanisms, including capsules, adhesins, hemolysins, endotoxins and exotoxins, and iron scavenging. The third section covers in detail various diseases and their mechanisms. The final section addresses the host responses to infection and the design of vaccines.

• Author : National Research Council,Division on Engineering and Physical Sciences,Space Studies Board,Commission on Physical Sciences, Mathematics, and Applications,Steering Group for the Workshop on Size Limits of Very Small Microorganisms
• Publisher :Unknown
• Release Date :1999-09-13
• Total pages :164
• ISBN : 0309172748

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Summary : How small can a free-living organism be? On the surface, this question is straightforward-in principle, the smallest cells can be identified and measured. But understanding what factors determine this lower limit, and addressing the host of other questions that follow on from this knowledge, require a fundamental understanding of the chemistry and ecology of cellular life. The recent report of evidence for life in a martian meteorite and the prospect of searching for biological signatures in intelligently chosen samples from Mars and elsewhere bring a new immediacy to such questions. How do we recognize the morphological or chemical remnants of life in rocks deposited 4 billion years ago on another planet? Are the empirical limits on cell size identified by observation on Earth applicable to life wherever it may occur, or is minimum size a function of the particular chemistry of an individual planetary surface? These questions formed the focus of a workshop on the size limits of very small organisms, organized by the Steering .Group for the Workshop on Size Limits of Very Small Microorganisms and held on October 22 and 23, 1998. Eighteen invited panelists, representing fields ranging from cell biology and molecular genetics to paleontology and mineralogy, joined with an almost equal number of other participants in a wide-ranging exploration of minimum cell size and the challenge of interpreting micro- and nano-scale features of sedimentary rocks found on Earth or elsewhere in the solar system. This document contains the proceedings of that workshop. It includes position papers presented by the individual panelists, arranged by panel, along with a summary, for each of the four sessions, of extensive roundtable discussions that involved the panelists as well as other workshop participants.

• Author : William Lee Klein
• Publisher :Unknown
• Release Date :1973
• Total pages :229
• ISBN : OCLC:890252279

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Summary :