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Fed-Batch Fermentation

Fed-Batch Fermentation
  • Author : G G Moulton
  • Publisher :Unknown
  • Release Date :2014-10-16
  • Total pages :188
  • ISBN : 1908818336
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Summary : Fed-batch Fermentation is primarily a practical guide for recombinant protein production in E. coli using a Fed-batch Fermentation process. Ideal users of this guide are teaching labs and R&D labs that need a quick and reproducible process for recombinant protein production. It may also be used as a template for the production of recombinant protein product for use in clinical trials. The guide highlights a method whereby a medium cell density - final Ods = 30-40 (A600) - Fed-batch Fermentation process can be accomplished within a single day with minimal supervision. This process can also be done on a small (2L) scale that is scalable to 30L or more. All reagents (media, carbon source, plasmid vector and host cell) used are widely available and are relatively inexpensive. This method has been used to produce three different protein products following cGMP guidelines for Phase I clinical studies. This process can be used as a teaching tool for the inexperienced fermentation student or researcher in the fields of bioprocessing and bioreactors. It is an important segue from E. coli shake flask cultures to bioreactor The fed-batch fermentation is designed to be accomplished in a single day with the preparation work being done on the day prior The fed-batch fermentation described in this book is a robust process and can be easily scaled for CMO production of protein product

Fed-Batch Cultures

Fed-Batch Cultures
  • Author : Henry C. Lim,Hwa Sung Shin
  • Publisher :Unknown
  • Release Date :2013-04-22
  • Total pages :229
  • ISBN : 1107328128
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Summary : Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

A Cell Engineering Approach to Enzyme-based Fed-batch Fermentation

A Cell Engineering Approach to Enzyme-based Fed-batch Fermentation
  • Author : Michael Sibley
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Control of the Quasi-steady State in Fed-batch Fermentation

Control of the Quasi-steady State in Fed-batch Fermentation
  • Author : Nicolas Kalogerakis
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :282
  • ISBN : 09876543XX
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Summary :

Application of Neural Networks to Fed-batch Fermentation

Application of Neural Networks to Fed-batch Fermentation
  • Author : Tammy Yut-Ling Chan
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :476
  • ISBN : 09876543XX
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Summary :

Model Predictive Control on Fed-batch Penicillin Fermentation Process

Model Predictive Control on Fed-batch Penicillin Fermentation Process
  • Author : Li Mei Chew
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :85
  • ISBN : 09876543XX
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Summary : In this research study the development of optimization strategies for a fed-batch penicillin fermentation process using model predictive controller was simulated using MATLAB 7.1 software. To facilitate the study, model predictive control (MPC) based on unstructured model for penicillin production in a fed-batch fermentor has been developed. A mathematical model of the system is derived based on published materials, the data is generated using PENSIM, dynamic response is analyzed, transfer function is developed and finally the MPC is implemented into the fermentation process. MPC offers an adaptive and optimizing control strategy which deals with multiple goals and constraints. The results of a study of the applicability of Model Predictive Control (MPC) in the process were obtainable. In order to obtain best optimization result for the fed-batch penicillin fermentation process, two optimization algorithms were selected. First, dynamic optimization using direct shooting method and second is implementation single step ahead Dynamic Matrix Control (DMC). Comparison of these two different approaches shows that DMC algorithm showed the best result with an optimization procedure.

The Systematic Consideration of the Large-scale Fed-batch Fermentation Inhomogeneities Using a Genetically Modified C. Glutamicum Strain as a Model Organism

The Systematic Consideration of the Large-scale Fed-batch Fermentation Inhomogeneities Using a Genetically Modified C. Glutamicum Strain as a Model Organism
  • Author : Williams C. Olughu
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Batch Fermentation

Batch Fermentation
  • Author : Ali Cinar,Satish J. Parulekar,Cenk Undey,Gulnur Birol
  • Publisher :Unknown
  • Release Date :2003-04-01
  • Total pages :648
  • ISBN : 9780203911358
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Summary : Illustrating techniques in model development, signal processing, data reconciliation, process monitoring, quality assurance, intelligent real-time process supervision, and fault detection and diagnosis, Batch Fermentation offers valuable simulation and control strategies for batch fermentation applications in the food, pharmaceutical, and chemical

Increasing Final Concentration of L-lactic Acid Via Fed-batch Fermentation by Bacillus Aerolacticus BC-001

Increasing Final Concentration of L-lactic Acid Via Fed-batch Fermentation by Bacillus Aerolacticus BC-001
  • Author : Anunyaporn Wutthimongkholchai
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Intensification of Biobased Processes

Intensification of Biobased Processes
  • Author : Andrzej Gorak,Andrzej Stankiewicz
  • Publisher :Unknown
  • Release Date :2018-06-18
  • Total pages :518
  • ISBN : 1788010329
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Summary : In recent years bioprocessing has increased in popularity and importance, however, bioprocessing still poses various important techno-economic and environmental challenges, such as product yields, excessive energy consumption for separations in highly watery systems, batch operation or the downstream processing bottlenecks in the production of biopharmaceutical products. Many of those challenges can be addressed by application of different process intensification technologies discussed in the present book. The first book dedicated entirely to this area, Intensification of Biobased Processesprovides a comprehensive overview of modern process intensification technologies used in bioprocessing. The book focusses on four different categories of biobased products: bio-fuels and platform chemicals; cosmeceuticals; food products; and polymers and advanced materials. It will cover various intensification aspects of the processes concerned, including (bio)reactor intensification; intensification of separation, recovery and formulation operations; and process integration. This is an invaluable source of information for researchers and industrialists working in chemical engineering, biotechnology and process engineering.

Advanced Instrumentation, Data Interpretation, and Control of Biotechnological Processes

Advanced Instrumentation, Data Interpretation, and Control of Biotechnological Processes
  • Author : J.F. van Impe,P.A. Vanrolleghem,D.M. Iserentant
  • Publisher :Unknown
  • Release Date :2013-06-29
  • Total pages :464
  • ISBN : 9401591113
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Summary : This book is the outgrowth of the COMETT II Course on Advanced Instru mentation, Data Interpretation, and Control of Biotechnological Processes organized by the Katholieke Universiteit Leuven and the Universiteit Gent, and held at Gent, Belgium, October 1994. The editors of the present volume were very fortunate to find all invited speakers prepared to write state-of-the-art expositions based on their lec tures. Special thanks are due to all of them. The result is an account of recent advances in instrumentation, data interpretation, and model based op timization and control of bioprocesses. For anyone interested in this emerg ing field, this text is of value and provides comprehensive reviews as well as new and important trends and directions for the future, motivated and illustrated by a wealth of applications. The typesetting of all this material represented a tremendous amount of work. I am most grateful to my wife, Myriam Uyttendaele, and to Kurt Gheys, who did most of the proof-reading. Their efforts have increased a lot the uniformity in style and presentation of the different manuscripts. Many thanks also to the co-editors, for their continued support. Kluwer Academic Publishers is gratefully acknowledged for publishing this book, thus contributing to the transfer of the latest research results into large scale industrial applications.

Rhamnolipid Production by Pseudomonas Aeruginosa USM-AR2 in Fed-batch Fermentation and Application in Crude Oil Distillation

Rhamnolipid Production by Pseudomonas Aeruginosa USM-AR2 in Fed-batch Fermentation and Application in Crude Oil Distillation
  • Author : Nur Asshifa Md Noh
  • Publisher :Unknown
  • Release Date :2014
  • Total pages :390
  • ISBN : 09876543XX
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Summary :

Biomass Now

Biomass Now
  • Author : Miodrag Darko Matovic
  • Publisher :Unknown
  • Release Date :2013-04-30
  • Total pages :554
  • ISBN : 9535111051
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Summary : This two-volume book on biomass is a reflection of the increase in biomass related research and applications, driven by overall higher interest in sustainable energy and food sources, by increased awareness of potentials and pitfalls of using biomass for energy, by the concerns for food supply and by multitude of potential biomass uses as a source material in organic chemistry, bringing in the concept of bio-refinery. It reflects the trend in broadening of biomass related research and an increased focus on second-generation bio-fuels. Its total of 40 chapters spans over diverse areas of biomass research, grouped into 9 themes.

On-line Estimation and Adaptive Control of Bioreactors

On-line Estimation and Adaptive Control of Bioreactors
  • Author : G. Bastin
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :394
  • ISBN : 1483290980
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Summary : This book deals with monitoring and control of biotechnological processes. Different methods are proposed which are based on the nonlinear structure of the process and do not require any a priori knowledge of the fermentation parameters. The theoretical stability and convergence properties of the proposed algorithms are analysed and their performances are illustrated by simulation results and, in many instances, by real life experiments. The concept of software sensors is introduced; these are algorithms based on the nonlinear model of the process and designed for on-line estimation of the biological variables and/or the fermentation parameters. In order to deal with process nonstationarities and parameter uncertainties, reference is made to adaptive estimation and control techniques. The book is the result of an intensive joint research effort by the authors during the last decade. It is intended as a graduate level text for students of bioengineering as well as a reference text for scientists and engineers involved in the design and optimization of bioprocesses.

Biochemical Engineering for 2001

Biochemical Engineering for 2001
  • Author : Shintaro Furusaki,Isao Endo,Ryuichi Matsuno
  • Publisher :Unknown
  • Release Date :2011-12-14
  • Total pages :847
  • ISBN : 9784431681823
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Summary : Biochemical engineering forms a bridge between fundamental biochemical research and large scale biotechnology processes. It covers genetic and protein engineering, cell culture, bioprocess and reactor design, separation and modelling. Research work in biochemical engineering is an investment in the future, when conventional resources will have to be replaced with renewable ones. In this book the papers presented at the Asia-Pacific Biochemical Engineering Conference (Yokohama, Japan 1992) are collected. This collection is unique in its wide coverage of topics and it gives an overview of the current trends of research in an important area.

Pichia Protocols

Pichia Protocols
  • Author : James M Cregg
  • Publisher :Unknown
  • Release Date :2007-08-08
  • Total pages :268
  • ISBN : 1588294293
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Summary : This book focuses on recent developments of Pichia pastoris as a recombinant protein production system. Highlighted topics include a discussion on the use of fermentors to grow Pichia pastoris, information on the O- and N-linked glycosylation, methods for labeling Pichia pastoris expressed proteins for structural studies, and the introduction of mutations in Pichia pastoris genes by the methods of restriction enzyme-mediated integration (REMI). Each chapter presents cutting-edge and cornerstone protocols for utilizing P. pastoris as a model recomibinant protein production system. This volume fully updates and expands upon the first edition.

Environmental Biotechnology

Environmental Biotechnology
  • Author : Marian Petre
  • Publisher :Unknown
  • Release Date :2013-02-07
  • Total pages :312
  • ISBN : 9535109723
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Summary : Taking into consideration the outstanding importance of studying and applying the biological means to remove or mitigate the harmful effects of global pollution on the natural environment, as direct consequences of quantitative expansion and qualitative diversification of persistent and hazardous contaminants, the present book provides useful information regarding New Approaches and Prospective Applications in Environmental Biotechnology. This volume contains twelve chapters divided in the following three parts: biotechnology for conversion of organic wastes, biodegradation of hazardous contaminants and, finally, biotechnological procedures for environmental protection. Each chapter provides detailed information regarding scientific experiments that were carried out in different parts of the world to test different procedures and methods designed to remove or mitigate the impact of hazardous pollutants on environment. The book is addressed to researchers and students with specialties in biotechnology, bioengineering, ecotoxicology, environmental engineering and all those readers who are interested to improve their knowledge in order to keep the Earth healthy.

Fermentation Processes

Fermentation Processes
  • Author : Angela Jozala
  • Publisher :Unknown
  • Release Date :2017-02-08
  • Total pages :312
  • ISBN : 9535129279
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Summary : Fermentation is a theme widely useful for food, feed and biofuel production. Indeed each of these areas, food industry, animal nutrition and energy production, has considerable presence in the global market. Fermentation process also has relevant applications on medical and pharmaceutical areas, such as antibiotics production. The present book, Fermentation Processes, reflects that wide value of fermentation in related areas. It holds a total of 14 chapters over diverse areas of fermentation research.

Industrial Biotechnology

Industrial Biotechnology
  • Author : Christoph Wittmann
  • Publisher :Unknown
  • Release Date :2017-03-06
  • Total pages :640
  • ISBN : 3527341811
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Summary : The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.

Biopolyesters

Biopolyesters
  • Author : Wolfgang Babel,Alexander Steinbüchel
  • Publisher :Unknown
  • Release Date :2003-07-01
  • Total pages :342
  • ISBN : 3540400214
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Summary : Living systems synthesize seven different classes of polymers. They provide structure and form for cells and organisms, function as catalysts and energy storage and carry the genetic information. All these polymers possess technically interesting properties. Some of these biopolymers are already used commercially. This special volume of Advances in Biochemical Engineering/Biotechnology comprises 10 chapters. It gives an overview of the water insoluble biopolyesters, in particular of the microbially synthesized poly-hydroxyalkanoate (PHA) family. It reports the state of the art of metabolism, regulation and genetic background, the latest advances made in genetic optimization of bacteria, "construction" of transgenic plants and in vitro synthesis by means of purified enzymes. Furthermore, it describes relevant technologies and evaluates perspectives concerning increasing the economic viability and competitiveness of PHA and discusses applications in medicine, packaging, food and other fields.

Handbook of Cellulosic Ethanol

Handbook of Cellulosic Ethanol
  • Author : Ananda S. Amarasekara
  • Publisher :Unknown
  • Release Date :2013-12-17
  • Total pages :608
  • ISBN : 1118878426
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Summary : Comprehensive coverage on the growing science and technologyof producing ethanol from the world's abundant cellulosicbiomass The inevitable decline in petroleum reserves and its impact ongasoline prices, combined with climate change concerns, havecontributed to current interest in renewable fuels. Bioethanol isthe most successful renewable transport fuel—with corn andsugarcane ethanol currently in wide use as blend-in fuels in theUnited States, Brazil, and a few other countries. However, thereare a number of major drawbacks in these first-generation biofuels,such as their effect on food prices, net energy balance, and poorgreenhouse gas mitigation. Alternatively, cellulosic ethanol can beproduced from abundant lignocellulosic biomass forms such asagricultural or municipal wastes, forest residues, fast growingtrees, or grasses grown in marginal lands, and should be produciblein substantial amounts to meet growing global energy demand. The Handbook of Cellulosic Ethanol covers all aspects ofthis new and vital alternative fuel source, providing readers withthe background, scientific theory, and recent research progress inproducing cellulosic ethanol via different biochemical routes, aswell as future directions. The seventeen chapters includeinformation on: Advantages of cellulosic ethanol over first-generation ethanolas a transportation fuel Various biomass feedstocks that can be used to make cellulosicethanol Details of the aqueous phase or cellulolysis route,pretreatment, enzyme or acid saccharification, fermentation,simultaneous saccharification fermentation, consolidatedbioprocessing, genetically modified microorganisms, and yeasts Details of the syngas fermentation or thermochemical route,gasifiers, syngas cleaning, microorganisms for syngas fermentation,and chemical catalysts for syngas-to-ethanol conversion Distillation and dehydration to fuel-grade ethanol Techno-economical aspects and the future of cellulosicethanol Readership Chemical engineers, chemists, and technicians working onrenewable energy and fuels in industry, research institutions, anduniversities. The Handbook can also be used by studentsinterested in biofuels and renewable energy issues.