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Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Mahendra Rai,Kateryna Kon
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0124017088
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Summary : Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : M. Fawzi Mahomoodally,Ameenah Gurib-Fakim
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066865
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Summary : Infectious diseases are responsible for one in every two deaths in many developing countries, but people in sub-Saharan Africa are particularly vulnerable, as poverty is rampant and access to health care is limited. Additionally, the unregulated use of antibiotics in some parts of Africa has led to the emergence of resistance in pathogens. Indeed, one of the biggest pandemics is malaria, which kills millions annually. Currently, artemisinin (effective against chloroquine-resistant Plasmodium) is the only weapon available to fight this pandemic, yet the World Health Organization has reported with concern that some countries in Southeast Asia are beginning to witness resistance to artemisinin. As a consequence, increasing attention is being drawn to botanicals, as they have the potential to provide alternative and complementary therapies, as well as potential leads to address emerging infections and resistance. This chapter will review some medicinal plants from the African Herbal Pharmacopoeia that show promise for containing existing and emerging infectious diseases.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Kateryna Volodymyrivna Kon,Mahendra Kumar Rai
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066814
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Summary : High prevalence of multidrug-resistant microorganisms in the etiologic structure of different infectious processes significantly decreases the effectiveness of the treatment and enhances the probability of an unfavorable outcome from the infection. Combinations between antibiotics and other antimicrobial agents represent one of the most promising approaches for combating multidrug-resistant bacteria. A high therapeutic potential exists for combinations of antibiotics and natural antimicrobial substances with complex mechanisms of action and multiple healing properties, such as plant essential oils. The purpose of the present chapter is to review published studies on antibiotic-essential oil combinations and discuss the prospects for future studies. In general, many studies have shown the potential for essential oils to act synergistically with antibiotics in vitro. The main proposed mechanism of this beneficial effect is through inhibition of efflux pumps by some essential oils, which restores the activity of the antibiotic. Future efforts should be directed into further studies of antibiotic-essential oil combinations against multidrug-resistant bacteria, with an emphasis on understanding the mechanisms of the produced effect. Combinations of essential oils with different types of antimicrobial agents, such as bacteriophages, nanoparticles, and quorum-sensing inhibitors, require greater attention and are worthy of future investigations.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Lyndy McGaw
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066849
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Summary : Many bacterial diseases affect animals, causing important economic losses in livestock. Subtherapeutic antibiotic use in production animals as antibiotic growth promoters has been implicated as a causative factor in the development of resistance of bacterial pathogens toward several classes of antimicrobials, some of which are used therapeutically in humans. This has led to the banning of antibiotic growth promoters by the European Union, and such a precedent may be followed in other countries. Alternatives to antibiotic growth promoters are necessary to enable the production of animal protein to keep pace with the expanding world population. One approach is to use plant extracts or essential oils as supplements to provide beneficial effects, including direct antibacterial activity and stimulation of the immune system, or enhancement of ruminal digestion. The risk of resistance developing to a combination of phytochemicals is lower than the risk of resistance against a single antibiotic, and synergistic effects of plant constituents may contribute to the overall activity of the preparation.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Philip G. Kerr
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066768
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Summary : In the search for successful antitubercular treatments, investigators have often turned their efforts to ethnobotany, ethnopharmacology, and phytochemistry. Since many of the world’s peoples have well-developed systems of traditional medicine with plants and their extracts as a major component and many of these plants have been used to treat tuberculosis, indigenous herbal medicine is a logical starting point for a research program. The major aims in this chapter are to summarize current antitubercular treatments; look for structural patterns in molecules that have been used successfully in the therapeutics of tuberculosis; examine published evidence of natural products derived principally from macrophytic species with an anecdotal reputation as antitubercular treatments or that have been deliberately tested for antitubercular activity; and identify promising structural classes of plant metabolites that can serve as lead compounds. Finally, I would like to indicate some of the directions being followed by leading researchers in the field and suggest ways forward in drug discovery to treat multidrug-resistant tuberculosis.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Victor Kuete
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066741
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Summary : The development of vancomycin resistance by some microbial strains has made the treatment of some infections more difficult and, in many cases, impossible. Although the search for new drugs against vancomycin-resistant organisms has been very successful, resistance can arise against many of these compounds. Natural products are an invaluable source of a diversity of biologically active compounds for addressing the challenges facing drug development initiatives to combat vancomycin-resistant enterococcal infections. Despite the fact that scientific data on plant metabolites active against vancomycin-resistant enterococci remain scarce, some compounds (including terpenoids and phenolics) have been reported to have inhibitory effects at various levels. This chapter describes the state of the art of research into plant bioactive metabolites against vancomycin-resistant enterococci, highlighting the hit compounds.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Adil M. Allahverdiyev,Melahat Bagirova,Serkan Yaman,Rabia Cakir Koc,Emrah Sefik Abamor,Sezen Canim Ates,Serap Yesilkir Baydar,Serhat Elcicek,Olga Nehir Oztel
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066881
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Summary : Herpes simplex virus (HSV) infections comprise one of the most important health problems worldwide. HSV-1 and HSV-2 that are the types most frequently seen in disease, manifested by sores and blisters on the mouth, tongue, skin, and genitals of infected individuals. Moreover, herpetic infections can reach life-threatening levels; for instance, HSV-2 prevalence has increased greatly in human immunodeficiency virus-positive patients. This indicates that the herpetic infection could be a major cause of morbidity in immunosuppressed patients. Unfortunately, resistance against antiherpetic drugs has recently been reported. Therefore there is an immediate need to search for new antiviral agents in order to cope with HSV infections. Recently, it has been demonstrated that traditional medicinal plants have strong antiviral activity and some are already being used in the treatment of viral infections, including herpes simplex infections. Accordingly, this chapter aims to present published information on various herbal compounds, investigate the antiherpetic effectiveness of these compounds, and determine the potential of plants as herpetic treatments in the future.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Luiz Felipe Domingues Passero,Márcia D. Laurenti,Gabriela Santos-Gomes,Bruno Luiz Soares Campos,Patrícia Sartorelli,João Henrique G. Lago
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066784
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Summary : Leishmaniasis is an infectious disease caused by parasites belonging to the Leishmania genus. This disease has a prevalence that exceeds 12 million, and approximately 350 million individuals are currently residing in areas at risk for contracting the infection. The standard drugs employed in the treatment pose serious side effects for patients. Moreover, some reports suggested that the Leishmania species present different degrees of resistance to conventional drugs, which justifies the ongoing search for novel leishmanicidal molecules. In only a few decades, the available research pertaining to plant-derived leishmanicidal compounds has increased considerably; however, the majority of bioguided studies have only shown antileishmanial activity in vitro, thus ignoring the potential in vivo effects of different classes of plant-derived compounds on Leishmania species. This chapter will discuss the main findings of works published from 2002 to 2012 on purified plant compounds and their leishmanicidal effects in vivo.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : M.L. Faleiro,M.G. Miguel
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066776
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Summary : Aromatic and medicinal plants, through their secondary metabolism, provide a complex mixture of volatile molecules known as essential oils. These volatile molecules exert antibacterial activity that has been used in folk medicine for centuries. During the last few decades, the emergence of antibacterial resistance has forced us to search for new and efficient antimicrobial agents. The significant number of studies on the use of essential oils and their components against multidrug-resistant bacteria, such as Acinetobacter baumannii, methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, and Pseudomonas aeruginosa show the exceptional potential of these natural products to curb the development of antibacterial resistance. Moreover, the use of essential oils and their components in combination with antibiotics may increase bacterial susceptibility, thus limiting resistance.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Valerie Edwards-Jones
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066725
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Summary : The global increase in antimicrobial resistance has led to renewed interest in alternative antimicrobial treatment strategies. Research is being done into a wide range of possible treatment regimens, including phage therapy, novel vaccines, and novel peptides, to name a few. Many microbiologists continue to lobby their governments to ensure that the available antibiotics are retained for the treatment of serious infections and their inappropriate use is stopped. In addition, large pharmaceutical companies are being encouraged to develop new treatments for the future. Much research now focuses on medicinal plants and essential oils. These and other alternative approaches are outlined in this chapter.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
  • Author : Ali Parsaeimehr,Elmira Sargsyan,Amir Reza Jassbi
  • Publisher :Unknown
  • Release Date :2013-05-24
  • Total pages :296
  • ISBN : 0128066830
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Summary : In today’s world, multidrug resistance appears to be one of the major health problems; however, screening, discovering and presenting novel effectual phytochemicals from medicinal plants have provided a promising outlook. Phytomedicines have been used for treating diseases and infections since time immemorial, but identifying new phytochemicals and effectual treatment strategies are essential in the fight against multidrug-resistant bacteria. Currently, isolated compounds such as α-mangostin, carnosic acid, epigallocatechin gallate, linalool, myricetin, novoimanin, α-terpineol, and totarol, have exhibited synergistic activity with antibiotics against resistant bacteria. This chapter presents information on multidrug-resistant Gram-negative bacteria and the use of herbal extracts against them.

Antibiotic Resistance

Antibiotic Resistance
  • Author : Kateryna Kon,Mahendra Rai
  • Publisher :Unknown
  • Release Date :2016-06-14
  • Total pages :436
  • ISBN : 0128036680
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Summary : Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections. Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance. Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistance Provides information on modern methods used to fight antibiotic resistance Covers a wide range of alternative methods to fight bacterial resistance, offering the most complete information available Discusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developments Offers the most up-to-date information in fighting antibiotic resistance Includes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries

Natural Antimicrobial Agents

Natural Antimicrobial Agents
  • Author : Jean-Michel Mérillon,Céline Riviere
  • Publisher :Unknown
  • Release Date :2018-02-08
  • Total pages :337
  • ISBN : 331967045X
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Summary : Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Antibacterial Drug Discovery to Combat MDR

Antibacterial Drug Discovery to Combat MDR
  • Author : Iqbal Ahmad,Shamim Ahmad,Kendra P. Rumbaugh
  • Publisher :Unknown
  • Release Date :2019-11-09
  • Total pages :680
  • ISBN : 9811398712
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Summary : This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Essential Oils and Nanotechnology for Treatment of Microbial Diseases

Essential Oils and Nanotechnology for Treatment of Microbial Diseases
  • Author : Mahendra Rai,Susana Zacchino,Marcos Derita
  • Publisher :Unknown
  • Release Date :2017-10-03
  • Total pages :326
  • ISBN : 1351806068
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Summary : There has been emergence of multidrug resistance problem all over the world due to overuse or underuse of antibiotics. Most microbes including bacteria, fungi, protozoans and others have developed resistance to antibiotics, and therefore, this problem is now recognized to be of global concern. Ubiquitous occurrence of multidrug-resistant bacteria decreases effectiveness of current treatment, which results in thousands of deaths all over the world. Hence, investigations for new alternatives and novel strategies are urgently needed to address the problem of multidrug resistance. The antimicrobial potential of essential oils and metallic nanoparticles represent an effective solution for microbial resistance. Moreover, the use of essential oils in combination with metallic nanoparticles may exert synergistic antimicrobial effects and would be a novel approach. Essential oils (EOs) are volatile, natural, aromatic oily liquids that can be obtained from several parts of plants especially the aerial ones such as leaves and flowers. They are derived from complex metabolic pathways in order to protect plants from diverse pathogenic microorganisms. In fact, the bioactivity of EOs have been confirmed by several studies which have demonstrated their antibacterial, antiviral, anti-inflammatory, antifungal, antimutagenic, anticarcinogenic, and antioxidant properties. Nanotechnology is one of the most important and emerging technologies, which has brought about a technological revolution in the world. It has enormous applications in the field of medicine. Nanoparticles are very important tools in curing different diseases in general and microbial diseases in particular due to their significantly novel and improved chemical, physical and biological properties and high surface area-to-volume ratio. Among these, metal nanoparticles are known to play pivotal role in various biomedical applications. In this context, nanoparticles such as silver have shown their potential and could emerge as the new generation of antimicrobials. Silver nanoparticles have broad-spectrum biological activities and hence are used in many biomedical applications. The various biomedical applications of silver nanoparticles include treatment of wounds, burns, in water-disinfecting systems, in nanobased bone implantations, in dentistry for the development of dental materials and as antibacterial, antivirals, anti-protozoals, anti-arthropods and anticancerous agents. Apart from silver, noble metal nanoparticles like gold and platinum and other nanoparticles copper, oxides of different metals, etc. have been also the materials of choice for many scientists for their biological applications. The book will be of interest to chemists, microbiologists, biotechnologist, food technologists, nanotechnologists, pharmacologists, clinicians and those interested in nature cure. Students will find this book useful and reader friendly.

Challenges to Tackling Antimicrobial Resistance

Challenges to Tackling Antimicrobial Resistance
  • Author : Michael Anderson,Michele Cecchini,Elias Mossialos
  • Publisher :Unknown
  • Release Date :2020-04-30
  • Total pages :240
  • ISBN : 1108799450
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Summary : An accessible overview of the challenges in tackling AMR and the economic and policy responses of the 'One Health' approach. It will appeal to policy-makers seeking to strengthen national and local polices tackling AMR, as well as students and academics who want an overview of the latest scientific evidence regarding effective AMR policies.

Dietary Phytochemicals and Microbes

Dietary Phytochemicals and Microbes
  • Author : Amlan K. Patra
  • Publisher :Unknown
  • Release Date :2012-03-21
  • Total pages :400
  • ISBN : 9400739265
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Summary : Humans have utilized the bioactive principles of different plants for various beneficial physiological properties including antimicrobial properties for many centuries. However, interests of using medicinal plants declined in the 20th century with the availability of effective synthetic antimicrobial drugs. The development of microbial resistance to various drugs has accelerated research interests towards the use of phytochemicals as alternatives to synthetic drugs in the recent years. This book presents an comprehensive reviews on the antimicrobial and antiviral properties of numerous recently reported phytochemicals, and their mechanisms of antimicrobial actions. Some of the chapters have critically discussed the beneficial and adverse effects of antibacterial, and stimulatory activities of dietary phytochemicals on rumen microbial populations, and gut microbial populations of humans and animals. Microbial adaptation and resistance of microbes to phytochemicals has also been highlighted. On the applied apects, the use of phytochemicals against drug resistance microbes, to treat microbial diseases, for food preservation, to inhibit methanogenic archaea in the rumen, and to modulate lipid biohydrogenating microbial populations to increase conjugated linoleic acids in animal-derived foods have been presented in different chapters.

Dendrology: Cones, Flowers, Fruits and Seeds

Dendrology: Cones, Flowers, Fruits and Seeds
  • Author : Marilena Idžojtić
  • Publisher :Unknown
  • Release Date :2019-06-28
  • Total pages :800
  • ISBN : 0128196459
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Summary : Dendrology: Cones, Flowers, Fruits and Seeds offers a comprehensive overview of the morphology of reproductive organs of woody plants of Europe in one resource. The book contains 2020 woody taxa (845 species, 58 subspecies, 38 varieties, 13 forms, 40 hybrids and 1026 cultivars), belonging to 400 genera and 121 families. It includes 447 taxa of trees and shrubs that are autochthonous in Europe and numerous ornamental species that originate from North America, Asia, South America, Australia and Africa, along with invasive woody species. Accompanied by thousands of original photographs, the book is designed to efficiently guide the reader to accurate identification. Other features include taxa organized in alphabetical order of their botanical names, flowering and fruiting time, mode of fruit or seed dispersal, and distribution range, making this a must-have reference for students and researchers in dendrology, botany, forestry, forest management and conservation, arboriculture and horticulture. Includes 2,020 taxa of trees and shrubs important for the European dendrology Provides detailed descriptions of reproductive organs and data on the reproductive biology of the described taxa Contains 6,644 original, high-quality photographs of habits, cones, flowers, fruits and seeds

Pathogenicity and Drug Resistance of Human Pathogens

Pathogenicity and Drug Resistance of Human Pathogens
  • Author : Saif Hameed,Zeeshan Fatima
  • Publisher :Unknown
  • Release Date :2020-01-23
  • Total pages :404
  • ISBN : 9813294493
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Summary : The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.

Biotechnology and Production of Anti-Cancer Compounds

Biotechnology and Production of Anti-Cancer Compounds
  • Author : Sonia Malik
  • Publisher :Unknown
  • Release Date :2017-04-21
  • Total pages :328
  • ISBN : 3319538802
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Summary : This book discusses cancers and the resurgence of public interest in plant-based and herbal drugs. It also describes ways of obtaining anti-cancer drugs from plants and improving their production using biotechnological techniques. It presents methods such as cell culture, shoot and root culture, hairy root culture, purification of plant raw materials, genetic engineering, optimization of culture conditions as well as metabolic engineering with examples of successes like taxol, shikonin, ingenol mebutate and podophylotoxin. In addition, it describes the applications and limitations of large-scale production of anti-cancer compounds using biotechnological means. Lastly, it discusses future economical and eco-friendly strategies for obtaining anti-cancer compounds using biotechnology.

Low-dose antibiotics: current status and outlook for the future

Low-dose antibiotics: current status and outlook for the future
  • Author : Robert Paul Hunter, Carlos F Amábile-Cuevas,Jun Lin,Joshua D Nosanchuk, Rustam Aminov
  • Publisher :Unknown
  • Release Date :2014-12-01
  • Total pages :229
  • ISBN : 2889193551
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Summary : Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low- dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses to modulation of bacterial virulence factors to acquisition of antibiotic resistance genes.