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From Molecules to Networks

From Molecules to Networks
  • Author : John H. Byrne,Ruth Heidelberger,M. Neal Waxham
  • Publisher :Unknown
  • Release Date :2014-05-23
  • Total pages :694
  • ISBN : 9780123982674
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Summary : An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes

From Molecules to Networks

From Molecules to Networks
  • Author : Ruth Heidelberger,M. Neal Waxham,John H. Byrne,James L. Roberts
  • Publisher :Unknown
  • Release Date :2003-11-10
  • Total pages :583
  • ISBN : 0080491359
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Summary : An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference. * Highly referenced for readers to pursue topics of interest in greater detail * Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks * Richly illustrated, four color presentation throughout * Includes CD-ROM of all of the illustrations

Cellular and Molecular Neurophysiology

Cellular and Molecular Neurophysiology
  • Author : Constance Hammond
  • Publisher :Unknown
  • Release Date :2014-12-30
  • Total pages :444
  • ISBN : 9780123973221
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Summary : Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations Fifteen appendices describing neurobiological techniques are interspersed in the text

Handbook of Systems Biology

Handbook of Systems Biology
  • Author : Marian Walhout,Marc Vidal,Job Dekker
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :552
  • ISBN : 9780123859457
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Summary : This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers

Structural Approaches to Sequence Evolution

Structural Approaches to Sequence Evolution
  • Author : Ugo Bastolla,Markus Porto,Eduardo Roman,Michele Vendruscolo
  • Publisher :Unknown
  • Release Date :2007-05-26
  • Total pages :367
  • ISBN : 9783540353065
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Summary : Recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists.

Molecular Gels

Molecular Gels
  • Author : Richard G. Weiss,Pierre Terech
  • Publisher :Unknown
  • Release Date :2006-06-30
  • Total pages :978
  • ISBN : 9781402036897
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Summary : "Molecular Gels: Materials with Self-Assembled Fibrillar Networks" is a comprehensive treatise on gelators, especially low molecular-mass gelators and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of low molecular-mass gelators are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SANS, SAXS, WAXS, UV-vis absorption, fluorescence and CD spectroscopies, scanning electron, transmission electron and optical microscopies, and molecular modeling) are presented didactically and in-depth, as are several of the theories of the stages of aggregation of individual low molecular-mass gelator molecules leading to SAFINs. Several actual and potential applications of molecular gels in disparate fields (from silicate replication of nanostructures to art conservation) are described. Special emphasis is placed on perspectives for future developments. This book is an invaluable resource for researchers and practitioners either already researching self-assembly and soft matter or new to the area. Those who will find the book useful include chemists, engineers, spectroscopists, physicists, biologists, theoreticians, and materials scientists.

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
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Summary :

Computational Systems Biology

Computational Systems Biology
  • Author : Andres Kriete,Roland Eils
  • Publisher :Unknown
  • Release Date :2013-11-26
  • Total pages :548
  • ISBN : 9780124059382
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Summary : This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Emerging Concepts in Analysis and Applications of Hydrogels

Emerging Concepts in Analysis and Applications of Hydrogels
  • Author : Sutapa Biswas Majee
  • Publisher :Unknown
  • Release Date :2016-08-24
  • Total pages :266
  • ISBN : 9789535125099
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Summary : This book is an Up-to-date and authoritative account on physicochemical principles, pharmaceutical and biomedical applications of hydrogels. It consists of eight contributions from different authors highlighting properties and synthesis of hydrogels, their characterization by various instrumental methods of analysis, comprehensive review on stimuli-responsive hydrogels and their diverse applications, and a special section on self-healing hydrogels. Thus, this book will equip academia and industry with adequate basic and applied principles related to hydrogels.

Hydrogen Bond Networks

Hydrogen Bond Networks
  • Author : M.C. Bellissent-Funel,J.C. Dore
  • Publisher :Unknown
  • Release Date :2013-04-17
  • Total pages :558
  • ISBN : 9789401583329
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Summary : The almost universal presence of water in our everyday lives and the very `common' nature of its presence and properties possibly deflects attention from the fact that it has a number of very unusual characteristics which, furthermore, are found to be extremely sensitive to physical parameters, chemical environment and other influences. Hydrogen-bonding effects, too, are not restricted to water, so it is necessary to investigate other systems as well, in order to understand the characteristics in a wider context. Hydrogen Bond Networks reflects the diversity and relevance of water in subjects ranging from the fundamentals of condensed matter physics, through aspects of chemical reactivity to structure and function in biological systems.

Models of the Ecological Hierarchy

Models of the Ecological Hierarchy
  • Author : Ferenc Jordán,Sven Erik Jorgensen
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :562
  • ISBN : 9780444593962
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Summary : "Based on selected papers covering the presentations at the 7th European Conference on Ecological Modelling, organized by ISEM and hosted by The Microsoft Research--University of Trento Center for Computational and Systems Biology from 30 May to 2 June, 2011 in Riva del Garde, Italy"--P. xi.

Network Neuroscience

Network Neuroscience
  • Author : Flavio Fröhlich
  • Publisher :Unknown
  • Release Date :2016-09-20
  • Total pages :482
  • ISBN : 9780128015865
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Summary : Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader’s background. Dr. Flavio Frohlich (www.networkneuroscientist.org) wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab (www.frohlichlab.org) pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology. Easy-to-read, comprehensive introduction to the emerging field of network neuroscience Includes 27 chapters packed with information on topics from single neurons to complex network disorders such as depression and autism Features 12 toolboxes serve as primers to provide essential background knowledge in the fields of biology, mathematics, engineering, and physics

Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery
  • Author : Juan Bueno
  • Publisher :Unknown
  • Release Date :2020-01-22
  • Total pages :192
  • ISBN : 9780128189290
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Summary : Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
  • Author : Asfar Azmi
  • Publisher :Unknown
  • Release Date :2014-04-14
  • Total pages :458
  • ISBN : 9780124079465
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Summary : Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Discovering the Brain

Discovering the Brain
  • Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
  • Publisher :Unknown
  • Release Date :1992-01-01
  • Total pages :194
  • ISBN : 9780309045292
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Summary : The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brain--an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attention--and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniques--what various technologies can and cannot tell us--and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakers--and many scientists as well--with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Network Medicine

Network Medicine
  • Author : Joseph Loscalzo
  • Publisher :Unknown
  • Release Date :2017-02-01
  • Total pages :500
  • ISBN : 9780674436534
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Summary : Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.

Deep Learning for the Life Sciences

Deep Learning for the Life Sciences
  • Author : Bharath Ramsundar,Peter Eastman,Patrick Walters,Vijay Pande
  • Publisher :Unknown
  • Release Date :2019-04-10
  • Total pages :238
  • ISBN : 9781492039808
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Summary : Deep learning has already achieved remarkable results in many fields. Now it’s making waves throughout the sciences broadly and the life sciences in particular. This practical book teaches developers and scientists how to use deep learning for genomics, chemistry, biophysics, microscopy, medical analysis, and other fields. Ideal for practicing developers and scientists ready to apply their skills to scientific applications such as biology, genetics, and drug discovery, this book introduces several deep network primitives. You’ll follow a case study on the problem of designing new therapeutics that ties together physics, chemistry, biology, and medicine—an example that represents one of science’s greatest challenges. Learn the basics of performing machine learning on molecular data Understand why deep learning is a powerful tool for genetics and genomics Apply deep learning to understand biophysical systems Get a brief introduction to machine learning with DeepChem Use deep learning to analyze microscopic images Analyze medical scans using deep learning techniques Learn about variational autoencoders and generative adversarial networks Interpret what your model is doing and how it’s working

Where Good Ideas Come From

Where Good Ideas Come From
  • Author : Steven Johnson
  • Publisher :Unknown
  • Release Date :2010-10-05
  • Total pages :336
  • ISBN : 9781101444207
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Summary : A fascinating deep dive on innovation from the New York Times bestselling author of How We Got To Now and Unexpected Life The printing press, the pencil, the flush toilet, the battery--these are all great ideas. But where do they come from? What kind of environment breeds them? What sparks the flash of brilliance? How do we generate the breakthrough technologies that push forward our lives, our society, our culture? Steven Johnson's answers are revelatory as he identifies the seven key patterns behind genuine innovation, and traces them across time and disciplines. From Darwin and Freud to the halls of Google and Apple, Johnson investigates the innovation hubs throughout modern time and pulls out the approaches and commonalities that seem to appear at moments of originality.

Molecular Cell Biology

Molecular Cell Biology
  • Author : Harvey F. Lodish,Berk Lodish (Zipursky, Matsudaria, Baltimore, Darnell),Arnold Berk,James E. Darnell,S. Lawrence Zipursky,David Baltimore,Paul Matsudaira
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :1084
  • ISBN : UCSD:31822041121997
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Summary : With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, "Molecular Cell Biology" has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.

Machine Learning Meets Quantum Physics

Machine Learning Meets Quantum Physics
  • Author : Kristof T. Schütt,Stefan Chmiela,O. Anatole von Lilienfeld,Alexandre Tkatchenko,Koji Tsuda,Klaus-Robert Müller
  • Publisher :Unknown
  • Release Date :2020-06-03
  • Total pages :467
  • ISBN : 9783030402457
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Summary : Designing molecules and materials with desired properties is an important prerequisite for advancing technology in our modern societies. This requires both the ability to calculate accurate microscopic properties, such as energies, forces and electrostatic multipoles of specific configurations, as well as efficient sampling of potential energy surfaces to obtain corresponding macroscopic properties. Tools that can provide this are accurate first-principles calculations rooted in quantum mechanics, and statistical mechanics, respectively. Unfortunately, they come at a high computational cost that prohibits calculations for large systems and long time-scales, thus presenting a severe bottleneck both for searching the vast chemical compound space and the stupendously many dynamical configurations that a molecule can assume. To overcome this challenge, recently there have been increased efforts to accelerate quantum simulations with machine learning (ML). This emerging interdisciplinary community encompasses chemists, material scientists, physicists, mathematicians and computer scientists, joining forces to contribute to the exciting hot topic of progressing machine learning and AI for molecules and materials. The book that has emerged from a series of workshops provides a snapshot of this rapidly developing field. It contains tutorial material explaining the relevant foundations needed in chemistry, physics as well as machine learning to give an easy starting point for interested readers. In addition, a number of research papers defining the current state-of-the-art are included. The book has five parts (Fundamentals, Incorporating Prior Knowledge, Deep Learning of Atomistic Representations, Atomistic Simulations and Discovery and Design), each prefaced by editorial commentary that puts the respective parts into a broader scientific context.

The Hydrogen Bond and the Water Molecule

The Hydrogen Bond and the Water Molecule
  • Author : Yves Marechal
  • Publisher :Unknown
  • Release Date :2007-01-11
  • Total pages :318
  • ISBN : UCSD:31822034789909
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Summary : The water molecule, H20, is one of the most familiar molecules, yet it is considered a molecule with almost no interest and which can be consequently ignored. The aim of this book is to present our present view of this molecule, in the hope that it is no longer ignored where it intervenes, and also to show what we still have to learn about it.