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Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Stanton L. Gerson,Edmund C. Lattime
  • Publisher :Unknown
  • Release Date :2002-04-04
  • Total pages :534
  • ISBN : 0080491367
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Summary : The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Edmund C. Lattime,Stanton L. Gerson
  • Publisher :Unknown
  • Release Date :2013-08-28
  • Total pages :554
  • ISBN : 9780123946324
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Summary : Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Gene Therapy for Cancer

Gene Therapy for Cancer
  • Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
  • Publisher :Unknown
  • Release Date :2007-10-26
  • Total pages :469
  • ISBN : 9781597452229
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Summary : The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Wolfgang Walther,Ulrike Stein
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :645
  • ISBN : 9781592590865
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Summary : In Gene Therapy of Cancer: Methods and Protocols, Wolfgang Walther and Ulrike Stein survey the rapidly evolving field cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being widely applied in cancer gene therapy investigations, including immunotherapy and tumor vaccination, suicide gene therapy, antioncogene therapy, and antisense and ribozyme gene therapy. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies. Gene Therapy of Cancer: Methods and Protocols offers basic and clinical researchers a broad ranging overview and collection of the most recent advances in gene transfer techniques. Written by leading international authorities, its readily reproducible, cutting-edge methods constitute today's most valuable tools for the study of cancer gene therapy in both the laboratory and clinical trials.

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Wolfgang Walther,Ulrike Stein
  • Publisher :Unknown
  • Release Date :2000-02-17
  • Total pages :645
  • ISBN : 0896038432
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Summary : Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.

Cancer Gene Therapy

Cancer Gene Therapy
  • Author : David T. Curiel,Joanne T. Douglas
  • Publisher :Unknown
  • Release Date :2007-11-03
  • Total pages :490
  • ISBN : 9781592597857
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Summary : A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Gene Therapy

Gene Therapy
  • Author : Doaa Hashad
  • Publisher :Unknown
  • Release Date :2015-11-26
  • Total pages :218
  • ISBN : 9789535122210
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Summary : Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression.

Cancer Gene Therapy by Viral and Non-viral Vectors

Cancer Gene Therapy by Viral and Non-viral Vectors
  • Author : Malcolm Brenner,Mien-Chie Hung
  • Publisher :Unknown
  • Release Date :2014-02-25
  • Total pages :176
  • ISBN : 9781118501658
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Summary : Provides expert, state-of-the-art insight into the currentprogress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era ofpersonalized or precision medicine. No longer a one-size-fits-allapproach, the treatment of cancer is now based on an understandingof underlying biologic mechanisms and is increasingly beingtailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinentmolecular discoveries in the cancer field and explains how theseare being used for gene-based cancer therapies. Designed as avolume in the Translational Oncology book series, Cancer GeneTherapy by Viral and Non-viral Vectors deals with the practiceof gene-therapy, with reference to vectors for gene expression andgene transfer, as well as viral therapy. It covers the history andcurrent and future applications of gene transfer in cancer, andprovides expert insight on the progress of viral and non-viral genetherapy with regard to delivery system, vector design, potentialtherapeutic genes, and principles and regulations for cancer genetherapy. Presented in three parts, Cancer Gene Therapy by Viral andNon-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viraland Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy ofCancer • Cancer Therapy with RNAi delivered by Non-viralMembrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific andCancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectorsand Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in GeneTherapy • Remaining Obstacles to the Success of Cancer GeneTherapy Focusing on speeding the process in clinical cancer care bybringing therapies as quickly as possible from bench to bedside,Cancer Gene Therapy by Viral and Non-viral Vectors is anabsolutely vital book for physicians, clinicians, researchers, andstudents involved in this area of medicine.

Textbook of Palliative Medicine

Textbook of Palliative Medicine
  • Author : Eduardo Bruera,Irene Higginson,Charles F von Gunten
  • Publisher :Unknown
  • Release Date :2009-01-30
  • Total pages :1024
  • ISBN : 9780340966242
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Summary : Textbook of Palliative Medicine provides an alternative, truly international approach to this rapidly growing specialty. This textbook fills a niche with its evidence-based, multi-professional approach and global perspective ensured by the international team of editors and contributing authors. In the absence of an international curriculum for the study of palliative medicine, this textbook provides essential guidance for those both embarking upon a career in palliative medicine or already established in the field, and the structure and content have been constructed very much with this in mind. With an emphasis on providing a service anywhere in the world, including the important issue of palliative care in the developing nations, Textbook of Palliative Medicine offers a genuine alternative to the narrative approach of its competitors, and is an ideal complement to them. It is essential reading for all palliative care physicians in training and in practice, as well as palliative care nurses and other health professionals in the palliative care team

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Peter Walden,Uwe Trefzer,Wolfram Sterry,Farzin Farzaneh
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :568
  • ISBN : 9781461553571
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Summary : The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

Gene Regulation and Therapeutics for Cancer

Gene Regulation and Therapeutics for Cancer
  • Author : Surinder K. Batra,Moorthy Palanimuthu Ponnusamy
  • Publisher :Unknown
  • Release Date :2021-03-22
  • Total pages :322
  • ISBN : 9781351778329
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Summary : Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy
  • Author : Roland W. Herzog,Sergei Zolotukhin
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :388
  • ISBN : 9789814280914
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Summary : Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Gene Therapy for Cancer

Gene Therapy for Cancer
  • Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
  • Publisher :Unknown
  • Release Date :2007-02-02
  • Total pages :469
  • ISBN : 1588294722
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Summary : The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Intercellular Communication in Cancer

Intercellular Communication in Cancer
  • Author : Mustapha Kandouz
  • Publisher :Unknown
  • Release Date :2015-11-20
  • Total pages :366
  • ISBN : 9789401773805
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Summary : Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.

Fusion Genes And Cancer

Fusion Genes And Cancer
  • Author : Kunnumakkara Ajaikumar B,Padmavathi Ganesan,Roy Nand Kishor
  • Publisher :Unknown
  • Release Date :2017-04-07
  • Total pages :432
  • ISBN : 9789813200951
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Summary : Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis. Concept of 'fusion genes' seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic. Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date. Contents:Cancer — An Overview and Molecular Alterations in Cancer (Nand K Roy, Devivasha Bordoloi, Javadi Monisha, Anand Anip, Ganesan Padmavathi and Ajaikumar B Kunnumakkara)Basic Concepts of Fusion Genes and Their Classification (Ganesan Padmavathi, Nand K Roy, Devivasha Bordoloi, Javadi Monisha and Ajaikumar B Kunnumakkara)Techniques to Identify Novel Fusion Genes and to Detect Known Fusion Genes (Nand K Roy, Ganesan Padmavathi, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)The Receptor Tyrosine Kinase ALK — Its Fusion Partners and Their Implication in Various Cancers(Ganesan Padmavathi, Krishan Kumar Thakur, Anand Anip, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)Role of BCR-ABL Fusion Kinase in the Development of Leukemia (Ganesan Padmavathi, Kishore Banik, Nand K Roy, Javadi Monisha and Ajaikumar B Kunnumakkara)BRD4-NUT Fusion Oncoprotein and Its Significance in the Initiation and Progression of NUT Midline Carcinoma (Ganesan Padmavathi, Devivasha Bordoloi, Kishore Banik and Ajaikumar B Kunnumakkara)Importance of CBFB-MYH11 — A Chimeric Transcriptional Regulator in Leukemia (Ganesan Padmavathi, Choudhary Harsha, Devivasha Bordoloi, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Rearrangements Involving ETS Family of Genes and Their Role in Different Cancers (Ganesan Padmavathi, Javadi Monisha, Kishore Banik, Choudhary Harsha, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)Translocation of FET Family Members with Various Partner Genes and Their Role in Cancer Development (Ganesan Padmavathi, Devivasha Bordoloi, Anand Anip, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Translocations of FGF and FGFR Proteins and Their Effect in Cancer (Ganesan Padmavathi, Javadi Monisha, Choudhary Harsha and Ajaikumar B Kunnumakkara)IG/MYC and Its Implication in Cancer (Ganesan Padmavathi, Kishore Banik, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Chimeric RAF Kinases in the Development of Cancer (Ganesan Padmavathi, Kishore Banik, Devivasha Bordoloi, Choudhary Harsha and Ajaikumar B Kunnumakkara)Mucoepidermoid Carcinoma (MEC) and Associated MAML2 Fusion Genes (Ganesan Padmavathi, Choudhary Harsha, Devivasha Bordoloi, Kishore Banik and Ajaikumar B Kunnumakkara)Mixed Lineage Leukemia/AF9 Fusion and Associated Leukemia (Ganesan Padmavathi, Choudhary Harsha and Ajaikumar B Kunnumakkara)MYB-NFIB Fusion Gene — Hallmark of Adenoid Cystic Carcinoma (ACC) (Ganesan Padmavathi, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Translocations Involving PAX Family Genes and Their Effect in Cancer (Ganesan Padmavathi, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)Retinoic Acid Receptor Alpha (RARα) Fusion Genes in Leukemia (Ganesan Padmavathi, Javadi Monisha, Anand Anip, Krishan Kumar Thakur and Ajaikumar B Kunnumakkara)RET/PTC Translocations and Thyroid Malignancies (Ganesan Padmavathi, Devivasha Bordoloi, Anand Anip, Choudhary Harsha and Ajaikumar B Kunnumakkara)RUNX1 or AML1 Fusion Genes in Leukemia and Other Cancers (Ganesan Padmavathi, Javadi Monisha, Kishore Banik, Choudhary Harsha, Devivasha Bordoloi and Ajaikumar B Kunnumakkara)Recently Discovered Fusion Genes and Their Implications in Cancer (Ganesan Padmavathi, Devivasha Bordoloi, Javadi Monisha, Nand K Roy, Choudhary Harsha and Ajaikumar B Kunnumakkara)Targeting Fusion Genes for Cancer Therapy (Nand K Roy, Devivasha Bordoloi, Ganesan Padmavathi and Ajaikumar B Kunnumakkara) Readership: Scientists working in the field of cancer biology, cancer genomics and proteomics. Also specialists and researchers in diverse fields of disease pathogenesis as it provides collective information about fusion genes and cancer from the basics to the targeted therapies.

Anticancer Genes

Anticancer Genes
  • Author : Stefan Grimm
  • Publisher :Unknown
  • Release Date :2014-07-08
  • Total pages :283
  • ISBN : 9781447164586
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Summary : This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

Cancer Gene Therapy

Cancer Gene Therapy
  • Author : Nagy Habib
  • Publisher :Unknown
  • Release Date :2000-04-30
  • Total pages :496
  • ISBN : 9780306461910
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Summary : With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies

1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies
  • Author : Tomaz Jarm,Peter Kramar
  • Publisher :Unknown
  • Release Date :2015-08-31
  • Total pages :455
  • ISBN : 9789812878175
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Summary : This volume presents the proceedings of the 1st World Congress on Electroporation and Pulsed Electric Fields in Biology, Medicine and Food & Environmental Technologies (WC2015). The congress took place in Portorož, Slovenia, during the week of September 6th to 10th, 2015. The scientific part of the Congress covered different aspects of electroporation and related technologies and included the following main topics: · Application of pulsed electric fields technology in food: challenges and opportunities · Electrical impedance measurement for assessment of electroporation yield · Electrochemistry and electroporation · Electroporation meets electrostimulation · Electrotechnologies for food and biomass treatment · Food and biotechnology applications · In vitro electroporation - basic mechanisms · Interfacial behaviour of lipid-assemblies, membranes and cells in electric fields · Irreversible electroporation in clinical use · Medical applications: electrochemotherapy · Medical applications: gene therapy · Non-electric field-based physical methods inducing cell poration and enhanced molecule transfer · Non-thermal plasmas for food safety, environmental applications and medical treatments · PEF for the food industry: fundamentals and applications · PEF proce ss integration - complex process chains and process combinations in the food industry · Predictable animal models · Pulsed electric fields and electroporation technologies in bioeconomy · Veterinary medical applications

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Nucleic Acids as Gene Anticancer Drug Delivery Therapy
  • Author : Loutfy H. Madkour
  • Publisher :Unknown
  • Release Date :2019-08-27
  • Total pages :650
  • ISBN : 9780128197783
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Summary : Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)
  • Author : Daniel Scherman
  • Publisher :Unknown
  • Release Date :2019-07-16
  • Total pages :636
  • ISBN : 9781786346896
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Summary : This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

Gene Therapy in Cancer

Gene Therapy in Cancer
  • Author : Grace W. Redberry
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :228
  • ISBN : 1594542880
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Summary : Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book offers the latest research in a field bursting with new developments, hope and expectations.