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Genetic Diseases of the Kidney

Genetic Diseases of the Kidney
  • Author : Richard P. Lifton,Stefan Somlo,Gerhard H. Giebisch,Donald W. Seldin
  • Publisher :Unknown
  • Release Date :2009-02-25
  • Total pages :848
  • ISBN : 0080924271
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Summary : Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease. More than 2,000 disease genes have been identified in the last 20 years, providing important new insight into the pathophysiology of diseases in every field of medicine. Genetic Diseases of the Kidney offers expert insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease. Genetic abnormalities are carefully presented within the appropriate physiologic context so that readers will understand not only which genes are linked to which diseases but also which pathways lead from a genetic “disturbance” to the systemic appearance of disease. * Lays the essential foundation of mammalian genetics principles for medical professionals with little or no background in genetics * Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes *World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

Genetic Diseases of the Kidney

Genetic Diseases of the Kidney
  • Author : Richard P. Lifton
  • Publisher :Unknown
  • Release Date :2009-01
  • Total pages :829
  • ISBN : 0124498515
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Summary : Genetic Diseases of the Kidney identifies and analyzes genetic abnormalities causing renal diseases in human subjects. Although in a sense the genome contains all the instructions required for the formation of a phenotype, the information is encoded in an extremely complicated fashion. In primary genetic diseases, the genetic instruction specifies a phenotype clearly linked with a discreet lesion confined to the kidney. However, the genetic disturbance may be imbedded in a complicated physiologic ensemble, so that the nexus between the genetic disturbance and the phenotype may be obscured; in consequence, the causal sequence is extremely difficult to unravel. In many instances the renal disease is one component of a complicated systemic hereditary disease, either monogenic or polygenic. Indeed, renal disease may arise as the sum of minor inputs from many different, seemingly unrelated genes, so that the genetic contributions may be difficult to identify. Confounding the problem further are environmental influences, originating either in the chromosomal environment from modifier genes, or in the extra-chromosomal environmental from intrauterine or postnatal influences. These considerations have determined both the organization of the text as well as the detailed description of the genetic disorders and the physiologic derangements that emerge. * Lays the essential foundation of mammalian genetics principles for medical professionals with little to no background in genetics * Analyzes specific renal diseases - both monogenic disorders confined to the kidney as well as systemic diseases with renal involvement - and explains their genetic causes. *World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

Genetic Diseases of the Kidney

Genetic Diseases of the Kidney
  • Author : Richard P. Lifton,Stefan Somlo,Gerhard H. Giebisch,Martin R. Pollak,Donald W. Seldin
  • Publisher :Unknown
  • Release Date :2008-12-29
  • Total pages :832
  • ISBN : 0124079407
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Summary : The second edition of Genetic Diseases of the Kidney explains how the latest technologies in genetics and genomics have had a tremendous impact on the understanding of kidney disease. In the last 5 years, two new generations of genetic and genomic technology have come into wide use that have had a dramatic impact on the understanding of human renal disease. GWAS have led to the identification of more than 1200 robust associations of common genetic variants with common disease – diseases of the kidney have been major beneficiaries of this technology. Common variants contributing to IgA nephropathy and blood pressure have provided new insights into disease pathogenesis. Major new findings also explain the long-recognized but previously unexplained increase in the prevalence of hypertensive end-stage renal disease among people of African ancestry. The last decade has also brought a new era of personal genomics into view and has reduced the cost of DNA sequencing all the genes in the genome to less than $1000. This has dramatically advanced the ability to identify rare mutations that cause or contribute to human disease. The second edition of Genetic Diseases of the Kidney will outline how this work has already made substantial contributions to the understanding of renal cancer, tumors that cause hypertension, and a number of other kidney diseases. New and extensively updated chapters will discuss how these new technologies point toward broader use of genome-level sequencing for diagnosis and therapeutics tailored to underlying mutation. Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes All disease-specific chapters have been updated to explain the use of genetic and genomic technologies in the routine diagnosis of common renal diseases and how new therapeutics are emerging based on genetic and genomic insights Four new chapters and all other extensively updated chapters explore how new findings in genetic and genomic technology have changed our understanding of the need for dialysis or transplantation and the ethnic variation in ESRD

Molecular and Genetic Basis of Renal Disease

Molecular and Genetic Basis of Renal Disease
  • Author : David B. Mount,Martin R. Pollak
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :582
  • ISBN : 9781416002529
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Summary : This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.

Chronic Renal Disease

Chronic Renal Disease
  • Author : Paul L. Kimmel,Mark E. Rosenberg
  • Publisher :Unknown
  • Release Date :2019-08-28
  • Total pages :1390
  • ISBN : 9780128158777
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Summary : Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation. Includes case studies and questions which can be used as a teaching tool for medical students and resident Provides coverage of classification and measurement, epidemiology, pathophysiology, complications of CKD, fluid/electrolyte disorders in CKD, CKD and systemic illnesses, clinical considerations, therapeutic considerations, and special considerations

Polycystic Kidney Disease

Polycystic Kidney Disease
  • Author : Jinghua Hu,Yong Yu
  • Publisher :Unknown
  • Release Date :2019-11-13
  • Total pages :346
  • ISBN : 9780429888946
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Summary : This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

Kidney Development, Disease, Repair and Regeneration

Kidney Development, Disease, Repair and Regeneration
  • Author : Melissa Helen Little
  • Publisher :Unknown
  • Release Date :2015-08-06
  • Total pages :614
  • ISBN : 9780128004388
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Summary : Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Genetic Diseases of the Kidney

Genetic Diseases of the Kidney
  • Author : Wadi N. Suki,C. Thomas Caskey
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :85
  • ISBN : OCLC:20152855
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Genetic Diseases of the Kidney

Genetic Diseases of the Kidney
  • Author : Elsevier Science & Technology Books
  • Publisher :Unknown
  • Release Date :2018
  • Total pages :229
  • ISBN : 0124078710
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Genetic Diseases of the Kidney

Genetic Diseases of the Kidney
  • Author : Lisa M. Guay-Woodford,Vicente E. Torres,American Society of Nephrology
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :78
  • ISBN : OCLC:500309657
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Summary :

Chronic Kidney Disease

Chronic Kidney Disease
  • Author : Thomas Rath
  • Publisher :Unknown
  • Release Date :2018-02-21
  • Total pages :306
  • ISBN : 9789535138433
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Summary : Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

Nephrology Secrets

Nephrology Secrets
  • Author : Edgar V. Lerma,Allen R. Nissenson
  • Publisher :Unknown
  • Release Date :2011-06-21
  • Total pages :647
  • ISBN : 9781416033622
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Summary : Nephrology Secrets, 3rd Edition, by Drs. Edgar V. Lerma and Allen R. Nissenson, gives you the nephrology answers you need to succeed on your rotations and boards.. Its unique, highly practical question-and-answer format, list of the "Top 100 Nephrology Secrets," and user-friendly format make it perfect for quick reference. Get the most return for your study time with the proven Secrets® format -- concise, easy to read, and highly effective. Skim the "Top 100 Secrets" and "Key Points" boxes for a fast overview of the secrets you must know for success on the boards and in practice. Enjoy faster, easier review and master the top issues in nephrology with mnemonics, lists, quick-reference tables, and an informal tone that sets this review book apart from the rest. Carry it with you in your lab coat pocket for quick reference or review anytime, anywhere. Handle each clinical situation with confidence with chapters completely updated to reflect the latest information. Find the answers you need faster thanks to a new, more streamlined and problem-based organization. Get the high-yield answers you need to address top nephrology questions

Inheritance of Kidney and Urinary Tract Diseases

Inheritance of Kidney and Urinary Tract Diseases
  • Author : Adrian Spitzer,Ellis D. Avner
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :450
  • ISBN : 9781461316039
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Summary : Genetic disorders have emerged as a prominent cause of morbidity and mor tality among infants and adults. As many as 10% to 20% of hospital admis sions and at least 10% of the mortality in this age group are due to inherited diseases. There are at least two factors that have brought genetic disorders into the forefront of pediatrics. One is a great reduction in childhood mortality due to infections and nutritional deficiency states, and the other is the rapid progress made in the identification of genetic defects. Amniocentesis, chorionic villus sampling, and recombinant DNA technology have already had a tremendous impact on the practice of medicine. This is why the first two chapters of this volume are dedicated to general principles of molecular genetics and to a description of the techniques used to diagnose genetic disorders at the DNA level. The relevance of this new area of science to the study of inherited renal diseases is reflected in the large body of knowledge that has been generated regarding the association between various glomerular nephritides and genetic markers such as the HLA system, and even more impressively in the direct or indirect identification of abnormal genes or gene products in Alport's syn drome, autosomal dominant polycystic kidney disease, and Lowe's syndrome. These discoveries figure prominently in the pages of this book. Yet, the progress we have made has barely scratched the surface of the problem.

Chronic Kidney Disease in Disadvantaged Populations

Chronic Kidney Disease in Disadvantaged Populations
  • Author : Guillermo Garcia-Garcia,Lawrence Agodoa,Keith C. Norris
  • Publisher :Unknown
  • Release Date :2017-07-08
  • Total pages :398
  • ISBN : 9780128043820
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Summary : Chronic Kidney Disease in Disadvantaged Populations investigates the increased incidence and prevalence of kidney disease in vulnerable populations world-wide. The volume explores the complex interactions of genetic, biologic, cultural and socioeconomic factors such as the environment, and specific health behaviors that seem to be responsible for a significant proportion of the health disparities in these communities. Each chapter is written by leading experts in the field and analyzes the prevalence and incidence of pre-dialysis kidney disease in disadvantaged populations across both developed and developing countries. In addition, each contribution analyzes differentiated risk factors and compares the disparities in access to screening, prevention strategies, treatment protocols and renal replacement therapies. Chronic Kidney Disease in Disadvantaged Populations is essential reading for residents, fellows, clinicians and biomedical researchers working in nephrology, internal medicine, and epidemiology, especially those working in areas with high concentrations of disadvantaged populations. Presents a comprehensive account of both traditional and non-traditional risk factors for kidney disease Explores the mechanisms by which poverty increases the burden of kidney disease in these populations, barriers to access to renal health care, including renal replacement therapies, organ donation, and organ commercialization Offers the latest perspectives on outcomes in renal replacement therapies as well as prevention strategies

Pediatric Kidney Disease

Pediatric Kidney Disease
  • Author : Denis F. Geary,Franz Schaefer
  • Publisher :Unknown
  • Release Date :2017-02-16
  • Total pages :2005
  • ISBN : 9783662529720
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Summary : The new edition of this valuable clinical resource offers a state of the art, comprehensive review on every clinical condition encountered in pediatric nephrology. International experts present the latest knowledge on epidemiology, diagnosis, management, and prognosis in one concise, clinically focused text, in which care has been taken to couple just the right amount of "need-to-know" basic science with practical clinical guidance that will enable the reader to make efficient, informed decisions. The topics covered include: disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, hypertension, chronic and end-stage renal disease, and renal replacement therapy. The full-color, highly visual, meticulously crafted format will ensure that the practitioner is able to source and apply information with remarkable ease.

Comprehensive Clinical Nephrology E-Book

Comprehensive Clinical Nephrology E-Book
  • Author : Richard J. Johnson,John Feehally,Jurgen Floege
  • Publisher :Unknown
  • Release Date :2014-09-05
  • Total pages :1320
  • ISBN : 9780323242875
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Summary : Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. The right amount of basic science and practical clinical guidance assists in making efficient and informed decisions. Extensive updates on key topics keep you at the forefront of the field. New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury. Over 1,500 color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Hundreds of color coded algorithms promote quick reference and to help you retain concepts. Over 400 NEW self-assessment questions available at Expert Consult.

Recent Advances in the Field of Urinary Tract Infections

Recent Advances in the Field of Urinary Tract Infections
  • Author : Thomas Nelius
  • Publisher :Unknown
  • Release Date :2013-07-10
  • Total pages :186
  • ISBN : 9789535111801
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Summary : Urinary tract infections (UTI) continue to be under the most common bacterial infections worldwide. Diagnostic and treatment have substantial financial burden on society. In the USA, UTIs are responsible for more than 7 million physician visits annually and about 15% of all community-prescribed antibiotics in the USA are dispensed for UTIs. About 50% of women will experience at least one UTI episode during lifetime, about 1 million emergency department visits due to UTI in the USA alone, resulting in more than 100 000 hospital admissions annually, most often for pyelonephritis. Moreover, UTIs are also the leading cause of hospital-acquired infections, accounting for approximately 40% of all such cases. The majority of these cases are catheter-associated. Therefore, nosocomial UTIs comprise perhaps the largest institutional reservoir for nosocomial antibiotic-resistant pathogens. Beside the economic impact, UTIs affect also significantly the quality of life of the affected population. The aim of this book is to highlight problematic aspects and recent advances in the field of UTIs. The book is divided in three parts.

Seldin and Giebisch's The Kidney

Seldin and Giebisch's The Kidney
  • Author : Robert J. Alpern,Steven C. Hebert
  • Publisher :Unknown
  • Release Date :2007-10-10
  • Total pages :2928
  • ISBN : 9780080559506
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Summary : A classic nephrology reference for over 20 years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information. * Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic. * Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics. * Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.

Pediatric Hypertension: Update

Pediatric Hypertension: Update
  • Author : Ibrahim F. Shatat,Tammy M. Brady
  • Publisher :Unknown
  • Release Date :2018-11-16
  • Total pages :229
  • ISBN : 9782889456543
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Summary :

Diseases of the Kidney & Bladder

Diseases of the Kidney & Bladder
  • Author : Wei Li (L.Ac.),David Frierman,Ben Luna,Bob Flaws
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :322
  • ISBN : 1891845373
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Summary :

Pediatric Nephrology

Pediatric Nephrology
  • Author : Ellis D. Avner,William E. Harmon,Patrick Niaudet,Norishige Yoshikawa
  • Publisher :Unknown
  • Release Date :2009-08-20
  • Total pages :2063
  • ISBN : 9783540763277
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Summary : Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.