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Genome Chaos

Genome Chaos
  • Author : Henry H. Heng
  • Publisher :Unknown
  • Release Date :2019-05-25
  • Total pages :556
  • ISBN : 9780128136362
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Summary : Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Genome

Genome
  • Author : Matt Ridley
  • Publisher :Unknown
  • Release Date :2013-03-26
  • Total pages :368
  • ISBN : 9780062253460
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Summary : The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

Intratumor Diversity and Clonal Evolution in Cancer

Intratumor Diversity and Clonal Evolution in Cancer
  • Author : David Gisselsson
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :368
  • ISBN : 9780123876881
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Summary : This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to update the reader on novel findings as well as giving a historical perspective to the field. It thereby offers an excellent starting point for young scientists entering this field of research Contributors: many of the contributors are renowned cancer researchers with long-term experience. To bring in new ideas to the field, these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise

Debating Cancer

Debating Cancer
  • Author : Henry H Heng
  • Publisher :Unknown
  • Release Date :2015-10-08
  • Total pages :464
  • ISBN : 9789814520867
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Summary : Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research. Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers. Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research

Genome Research

Genome Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :229
  • ISBN : 10889051
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Summary :

Molecular Neuroendocrinology

Molecular Neuroendocrinology
  • Author : David Murphy,Harold Gainer
  • Publisher :Unknown
  • Release Date :2016-03-07
  • Total pages :488
  • ISBN : 9781118760376
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Summary : "Discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification"--

Computational Biology and Genome Informatics

Computational Biology and Genome Informatics
  • Author : Jason T. L. Wang,Cathy H. Wu,Paul P. Wang
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :257
  • ISBN : 9789812564498
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Summary : This book contains articles written by experts on a wide range oftopics that are associated with the analysis and management ofbiological information at the molecular level. It contains chapters onRNA and protein structure analysis, DNA computing, sequence mapping, genome comparison, gene expression data mining, metabolic networkmodeling, and phyloinformatics

Evolution

Evolution
  • Author : James A. Shapiro
  • Publisher :Unknown
  • Release Date :2011-06-08
  • Total pages :256
  • ISBN : 9780132780995
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Summary : James A. Shapiro proposes an important new paradigm for understanding biological evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular evidence that tests the conventional scientific view of evolution based on the neo-Darwinian synthesis, shows why this view is inadequate to today's evidence, and presents a compelling alternative view of the evolutionary process that reflects the shift in life sciences towards a more information- and systems-based approach in Evolution: A View from the 21st Century. Shapiro integrates advances in symbiogenesis, epigenetics, and saltationism into a unified approach that views evolutionary change as an active cell process, regulated epigenetically and capable of making rapid large changes by horizontal DNA transfer, inter-specific hybridization, whole genome doubling, symbiogenesis, or massive genome restructuring. Evolution marshals extensive evidence in support of a fundamental reinterpretation of evolutionary processes, including more than 1,100 references to the scientific literature. Shapiro's work will generate extensive discussion throughout the biological community, and may significantly change your own thinking about how life has evolved. It also has major implications for evolutionary computation, information science, and the growing synthesis of the physical and biological sciences.

Computational Methods for Understanding Bacterial and Archaeal Genomes

Computational Methods for Understanding Bacterial and Archaeal Genomes
  • Author : Ying Xu,J. Peter Gogarten
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :473
  • ISBN : 9781860949821
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Summary : Over 500 prokaryotic genomes have been sequenced to date, and thousands more have been planned for the next few years. While these genomic sequence data provide unprecedented opportunities for biologists to study the world of prokaryotes, they also raise extremely challenging issues such as how to decode the rich information encoded in these genomes. This comprehensive volume includes a collection of cohesively written chapters on prokaryotic genomes, their organization and evolution, the information they encode, and the computational approaches needed to derive such information. A comparative view of bacterial and archaeal genomes, and how information is encoded differently in them, is also presented. Combining theoretical discussions and computational techniques, the book serves as a valuable introductory textbook for graduate-level microbial genomics and informatics courses.

Genome Transcriptome and Proteome Analysis

Genome Transcriptome and Proteome Analysis
  • Author : Alain Bernot
  • Publisher :Unknown
  • Release Date :2007-12-10
  • Total pages :248
  • ISBN : 9780470299562
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Summary : Genome Transcriptome and Proteome Analysis is aconcise introduction to the subject, successfully bringing togetherthese three key areas of research. Starting with a revision ofmolecular genetics the book offers clear explanations of the toolsand techniques widely used in genome, transcriptome and proteomeanalysis. Subsequent chapters offer a broad overview of linkagemaps, physical maps and genome sequencing, with a final discussionon the identification of genes responsible for disease. An invaluable introduction to the basic concepts of the subject,this text offers the student an excellent overview of currentresearch methods and applications and is a good starting point forthose new to the area. A clear, concise introduction to the subject of modern genomicanalysis A technology-oriented approach including the latestdevelopments in the field Invaluable to those students taking courses in Bioinformatics,Human Genetics, Biochemistry and Molecular Biology

The Handbook of Plant Genome Mapping

The Handbook of Plant Genome Mapping
  • Author : Khalid Meksem,Guenter Kahl
  • Publisher :Unknown
  • Release Date :2006-03-06
  • Total pages :402
  • ISBN : 9783527604432
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Summary : While the complete sequencing of the genomes of model organisms such as a multitude of bacteria and archaea, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the mouse and human genomes have received much public attention, the deciphering of plant genomeswas greatly lagging behind. Up to now, only two plant genomes, one of the model plant Arabidopsis thaliana and one of the crop species rice (Oryza sativa) have been sequenced, though a series of other crop genome sequencing projects are underway. Notwithstanding this public bias towards genomics of animals and humans, it is nevertheless of great importance for basic and applied sciences and industries in such diverse fields as agriculture, breeding in particular, evolutionary genetics, biotechnology, and food science to know the composition of crop plant genomes in detail. It is equally crucial for a deeper understanding of the molecular basis of biodiversity and synteny. The Handbook of Genome Mapping: Genetic and Physical Mapping is the first book on the market to cover these hot topics in considerable detail, and is set apart by its combination of genetic and physical mapping. Throughout, each chapter begins with an easy-to-read introduction, also making the book the first reference designed for non-specialists and newcomers, too. In addition to being an outstanding bench work reference, the book is an excellent textbook for learning and teaching genomics, in particular for courses on genome mapping. It also serves as an up-to-date guide for seasoned researchers involved in the genetic and physical mapping of genomes, especially plant genomes.

Dear Professor Dyson

Dear Professor Dyson
  • Author : Freeman John Dyson
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :386
  • ISBN : 9789814759090
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Summary : "Freeman Dyson has designed nuclear reactors and bomb-powered spacecraft; he has studied the origins of life and the possibilities for the long-term future; he showed quantum mechanics to be consistent with electrodynamics and started cosmological eschatology; he has won international recognition for his work in science and for his work in reconciling science to religion; he has advised generals and congressional committees. An STS (Science, Technology, Society) curriculum or discussion group that engages topics such as nuclear policies, genetic technologies, environmental sustainability, the role of religion in a scientific society, and a hard look towards the future, would count itself privileged to include Professor Dyson as a class participant and mentor. In this book, STS topics are not discussed as objectified abstractions, but through personal stories. The reader is invited to observe Dyson's influence on a generation of young people as they wrestle with issues of science, technology, society, life in general and our place in the universe. The book is filled with personal anecdotes, student questions and responses, honest doubts and passions"--

The Deeper Genome

The Deeper Genome
  • Author : John Parrington
  • Publisher :Unknown
  • Release Date :2017-10-06
  • Total pages :368
  • ISBN : 9780192552471
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Summary : Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought — just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.

Chaos and Order

Chaos and Order
  • Author : Friedrich Cramer
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :249
  • ISBN : 1560818123
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Summary : Molecular biologist Cramer explores how recent revelations about nonlinear systems enhance our perceptions of nature. Each chapter begins with a semi-fictitious dialogue and ends with a poem by the likes of Yeats, Dickinson, and Stevens. Of interest to specialist and nonspecialist scientists and to general readers who are basically familiar with scientific principles. Annotation copyright by Book News, Inc., Portland, OR

Principles of Genome Analysis and Genomics

Principles of Genome Analysis and Genomics
  • Author : Sandy B. Primrose,Richard Twyman
  • Publisher :Unknown
  • Release Date :2009-04-01
  • Total pages :288
  • ISBN : 9781444311280
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Summary : With the first draft of the human genome project in the publicdomain and full analyses of model genomes now available, thesubject matter of 'Principles of Genome Analysis and Genomics' iseven 'hotter' now than when the first two editions were publishedin 1995 and 1998. In the new edition of this very practical guideto the different techniques and theory behind genomes and genomeanalysis, Sandy Primrose and new author Richard Twyman provide afresh look at this topic. In the light of recent excitingadvancements in the field, the authors have completely revised andrewritten many parts of the new edition with the addition of fivenew chapters. Aimed at upper level students, it is essential thatin this extremely fast moving topic area the text is up to date andrelevant. Completely revised new edition of an establishedtextbook. Features new chapters and examples from exciting new researchin genomics, including the human genome project. Excellent new co-author in Richard Twyman, also co-author ofthe new edition of hugely popular Principles of GeneManipulation. Accompanying web-page to help students deal with this difficulttopic at www.blackwellpublishing.com/primrose

Welcome to the Genome

Welcome to the Genome
  • Author : Robert DeSalle,Michael Yudell
  • Publisher :Unknown
  • Release Date :2020-04-21
  • Total pages :280
  • ISBN : 9781118107652
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Summary : The popular introduction to the genomic revolution for non-scientists—the revised and updated new edition Welcome to the Genome is an accessible, up-to-date introduction to genomics—the interdisciplinary field of biology focused on the structure, function, evolution, mapping, and editing of an organism's complete set of DNA. Written for non-experts, this user-friendly book explains how genomes are sequenced and explores the discoveries and challenges of this revolutionary technology. Genomics is a mixture of many fields, including not only biology, engineering, computer science, and mathematics, but also social sciences and humanities. This unique guide addresses both the science of genomics and the ethical, moral, and social questions that rise from the technology. There have been many exciting developments in genomics since this book's first publication. Accordingly, the second edition of Welcome to the Genome offers substantial new and updated content to reflect recent major advances in genome-level sequencing and analysis, and demonstrates the vast increase in biological knowledge over the past decade. New sections cover next-generation technologies such as Illumina and PacBio sequencing, while expanded chapters discuss controversial ethical and philosophical issues raised by genomic technology, such as direct-to-consumer genetic testing. An essential resource for understanding the still-evolving genomic revolution, this book: Introduces non-scientists to basic molecular principles and illustrates how they are shaping the genomic revolution in medicine, biology, and conservation biology Explores a wide range of topics within the field such as genetic diversity, genome structure, genetic cloning, forensic genetics, and more Includes full-color illustrations and topical examples Presents material in an accessible, user-friendly style, requiring no expertise in genomics Discusses past discoveries, current research, and future possibilities in the field Sponsored by the American Museum of Natural History, Welcome to the Genome: A User's Guide to the Genetic Past, Present, and Future is a must-read book for anyone interested in the scientific foundation for understanding the development and evolutionary heritage of all life.

The Brassica Genome

The Brassica Genome
  • Author : Xiaowu Wang
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9782889191369
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Summary :

Monkey Trap

Monkey Trap
  • Author : Lee Denning
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :423
  • ISBN : 193120134X
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Summary : "This is an immensely exciting SF thriller..." ~ Dr. Bob Rich.

Human Genetics and Genomics

Human Genetics and Genomics
  • Author : Bahar Taneri,Esra Asilmaz,Türem Delikurt,Pembe Savas,Seniye Targen,Yagmur Esemen
  • Publisher :Unknown
  • Release Date :2020-02-12
  • Total pages :160
  • ISBN : 9783527682652
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Summary : Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.

Crumbling Genome

Crumbling Genome
  • Author : Alexey S. Kondrashov
  • Publisher :Unknown
  • Release Date :2017-07-12
  • Total pages :296
  • ISBN : 9781118952115
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Summary : A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by preï¿1⁄2]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.

Handbook of Graphs and Networks

Handbook of Graphs and Networks
  • Author : Stefan Bornholdt,Heinz Georg Schuster
  • Publisher :Unknown
  • Release Date :2006-03-06
  • Total pages :417
  • ISBN : 9783527606337
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Summary : Complex interacting networks are observed in systems from such diverse areas as physics, biology, economics, ecology, and computer science. For example, economic or social interactions often organize themselves in complex network structures. Similar phenomena are observed in traffic flow and in communication networks as the internet. In current problems of the Biosciences, prominent examples are protein networks in the living cell, as well as molecular networks in the genome. On larger scales one finds networks of cells as in neural networks, up to the scale of organisms in ecological food webs. This book defines the field of complex interacting networks in its infancy and presents the dynamics of networks and their structure as a key concept across disciplines. The contributions present common underlying principles of network dynamics and their theoretical description and are of interest to specialists as well as to the non-specialized reader looking for an introduction to this new exciting field. Theoretical concepts include modeling networks as dynamical systems with numerical methods and new graph theoretical methods, but also focus on networks that change their topology as in morphogenesis and self-organization. The authors offer concepts to model network structures and dynamics, focussing on approaches applicable across disciplines.